archive-org.com » ORG » B » BALSINDE.ORG

Total: 23

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • The Eicosanoid Research Division @ IBGM - Home
    or comments about this website Optimized for Google Chrome and a screen resolution of at least 1024 x 768 The site works in IExplorer and Mozilla Firefox but might not look as nice Copyright 2002 2016 Jesús Balsinde Valladolid Spain

    Original URL path: http://www.balsinde.org/ (2016-02-12)
    Open archived version from archive


  • The Eicosanoid Research Division @ IBGM - Introduction
    Spanish National Research Council CSIC by its initials in Spanish The University of Valladolid provides physical space For everything else our Division depends only on the CSIC Valladolid our home town is the historical capital of the ancient kingdom of Castile León nowadays an Autonomous Region within Spain Valladolid was founded by the Castilians in the 11th century but its name is thought to derive from the Celtic Roman Valle Tolitum Watery Valley or perhaps the Arabic Velad Walid Lands of the Governor which suggests that the area had been inhabited much before the Castilians settled in Natives of Valladolid are called vallisoletanos Famous vallisoletanos include Kings Philip II and Philip IV of Spain conquistadors Ponce de León and Pánfilo de Narváez poets José Zorrilla and Jorge Guillén novelist Miguel Delibes and high school attendant Sofía Balsinde The Eicosanoid Research Division consists of two research laboratories one headed by Dr Jesús Balsinde and the other by Dr María Balboa The Balsinde Lab leans toward basic chemistry biochemistry and pharmacology strategies while the Balboa Lab places more emphasis on molecular cell biology approaches Nonetheless a great deal of interaction exists between the two labs Work in the Eicosanoid Research Division is

    Original URL path: http://www.balsinde.org/intro.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - Personnel
    E mail jrubio ibgm uva es Alma Astudillo Postdoctoral Arrived Jan 2015 Hometown Valladolid Spain Degree PhD Microbiology University of Valladolid Phone 34 983 186 494 E mail alma ibgm uva es Javier Casas Postdoctoral Arrived Nov 2015 Hometown Valladolid Spain Degree PhD Immunology University of Valladolid Phone 34 983 186 494 E mail Technical Support Montserrat Duque Laboratory Technician Arrived Jun 2004 Hometown Valladolid Spain Degree B A University of Valladolid Phone 34 983 184 834 E mail mduque ibgm uva es Yolanda Noriega Laboratory Technician Arrived Nov 2012 Hometown Valladolid Spain Degree B S Complutense University of Madrid Phone 34 983 184 832 E mail ynoriega ibgm uva es Graduate Students Carlos Guijas Graduate Student Arrived May 2010 Hometown Palencia Spain Degree MSc Biophysics Autonomous University of Madrid Phone 34 983 186 494 E mail cguijas ibgm uva es Gema Lordén Graduate Student Arrived Oct 2010 Hometown León Spain Degree MSc Biology University of León Phone 34 983 184 832 E mail glorden ibgm uva es Patricia Lebrero Graduate Student Arrived Sep 2014 Hometown Valladolid Spain Degree MSc Medical Biology University of Valladolid Phone 34 983 186 494 E mail plebrero ibgm uva es Nagore de Pablo Graduate

    Original URL path: http://www.balsinde.org/personnel.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - Research
    such as saturated free fatty acids typically present at elevated amounts in obese individuals O ur current research focuses primarily on the lipid signaling enzymes phospholipase A 2 and phosphatidate phosphohydrolase phosphatidic acid specific phospholipase C lipin The latter is a key enzyme in the de novo pathway for glycerolipid biosynthesis providing an excellent example that enzymes involved in this pathway may also act to initiate intracellular signaling General events that we are interested in include i the spatiotemporal regulation of these phospholipases in a cellular context which we study utilizing advanced microscopy techniques ii pharmacological manipulation of enzymatic activity both in intact cells and in vitro iii analysis of lipid metabolite production by state of the art mass spectrometry lipidomics metabolipidomics and iv the physiological functioning of phospholipases in animal models Ongoing studies in our labs focus on the localization and stimulus driven translocation of different members of the phospholipase A 2 and lipin families Phospholipase A 2 s cleave the fatty acid at the sn 2 position of phospholipids and thus constitute the earliest regulatory point of the eicosanoid biosynthetic cascade Lipins dephosphorylate phosphatidic acid to form diacylglycerol which can be used for the biosynthesis of glycerophospholipids and triacylglycerol and may function as intracellular signalers as well Current studies are being carried out by transfecting chimeric constructs of green fluorescent protein GFP or any of its colored varieties with the appropriate phospholipase GFP is placed at either the N or C termini of the enzymes These constructs provide a very useful tool to visualize the intracellular movements of the enzymes in response to the different stimuli Mutagenesis studies are also being conducted to pinpoint the specific amino acids of the phospholipase A 2 s and lipins that are implicated in the movement among intracellular compartments Another of our goals is to apply a lipidomics approach to the study of the mechanisms governing the availability and oxidative metabolism of free arachidonic acid during activation of macrophages by stimuli of the innate immune response Availability of free arachidonate is a limiting step for the synthesis of eicosanoids While the pathways of fatty acid uptake incorporation and remodeling in glycerolipids are well documented the individual lipid species in which arachidonate is stored and released from have not been identified This is so because of the impossibility of traditional methods for lipid separation i e thin layer chromatography liquid chromatography to differentiate among individual lipids within various classes and subclasses This is now possible with the advent of electrospray mass spectrometry ESI MS Application of this technology to the field of lipid biochemistry has been a major breakthrough in profiling the lipidomes of cells and tissues in physiological and pathophysiological conditions We are conducting lipidomic analyses of all the lipid molecular species involved in arachidonic acid homeostasis from those that act as acceptors of the fatty acid to those from which the fatty acid is liberated for subsequent eicosanoid synthesis and including as well a full survey of arachidonate derived oxygenated metabolites

    Original URL path: http://www.balsinde.org/research.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - Publications
    reduced eicosanoid synthesis J Biol Chem 286 35299 35307 Valdearcos M Esquinas E Meana C Gil de Gómez L Guijas C Balsinde J Balboa M A 2011 Subcellular localization and role of lipin 1 in human macrophages J Immunol 186 6004 6013 Astudillo A M Pérez Chacón G Balgoma D Gil de Gómez L Ruipérez V Guijas C Balboa M A Balsinde J 2011 Influence of cellular arachidonic acid levels on phospholipid remodeling and CoA independent transacylase activity in human monocytes and U937 cells Biochim Biophys Acta 1811 97 103 Balgoma D Montero O Balboa M A Balsinde J 2010 Review Lipidomic approaches to the study of phospholipase A 2 regulated phospholipid fatty acid incorporation and remodeling Biochimie 92 645 650 Balgoma D Astudillo A M Pérez Chacón G Montero O Balboa M A Balsinde J 2010 Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid containing phospholipids J Immunol 184 3857 3865 Casas J Valdearcos M Pindado J Balsinde J Balboa M A 2010 The cationic cluster of group IVA phospholipase A 2 Lys488 Lys541 Lys543 Lys544 is involved in translocation of the enzyme to phagosomes in human macrophages J Lipid Res 51 388 399 Pérez Chacón G Astudillo A M Ruipérez V Balboa M A Balsinde J 2010 Signaling role for lysophospholipid acyltransferase 3 in receptor regulated arachidonic acid reacylation reactions in human monocytes J Immunol 184 1071 1078 Pérez Chacón G Astudillo A M Balgoma D Balboa M A Balsinde J 2009 Review Control of free arachidonic acid levels by phospholipases A 2 and lysophospholipid acyltransferases Biochim Biophys Acta 1791 1103 1113 Casas J Meana C Esquinas E Valdearcos M Pindado J Balsinde J Balboa M A 2009 Requirement of JNK mediated phosphorylation for translocation of group IVA phospholipase A 2 to phagosomes in human macrophages J Immunol 183 2767 2774 Ruipérez V Astudillo A M Balboa M A Balsinde J 2009 Coordinate regulation of Toll like receptor mediated arachidonic acid mobilization in macrophages by group IVA and group V phospholipase A 2 s J Immunol 182 3877 3883 Balgoma D Montero O Balboa M A Balsinde J 2008 Calcium independent phospholipase A 2 mediated formation of 1 2 diarachidonoyl glycerophosphoinositol in human monocytes FEBS J 275 6180 6191 Balboa M A Pérez R Balsinde J 2008 Calcium independent phospholipase A 2 mediates proliferation of human promonocytic U937 cells FEBS J 275 1915 1924 Pindado J Balsinde J Balboa M A 2007 TLR3 dependent induction of nitric oxide synthase in RAW 264 7 macrophage like cells via a cytosolic phospholipase A 2 cyclooxygenase 2 pathway J Immunol 179 4821 4828 Ruipérez V Casas J Balboa M A Balsinde J 2007 Group V phospholipase A 2 derived lysophosphatidylcholine mediates cyclooxygenase 2 induction in lipopolysaccharide stimulated macrophages J Immunol 179 631 638 Balsinde J Pérez R Balboa M A 2006 Review Calcium independent phospholipase A 2 and apoptosis Biochim Biophys Acta 1761 1344 1350 Balboa M A Balsinde J 2006 Review Oxidative stress and arachidonic acid mobilization

    Original URL path: http://www.balsinde.org/publications.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - Contacts
    follow this map after entering Valladolid Departing from Madrid Valladolid can also easily be reached by public transportation either train or bus Being not familiar with the latter we have to strongly recommend the former In working days no less than ten trains connect Madrid with Valladolid both ways High speed rail transport AVE in Spanish was introduced in December 2007 With the AVE moving in between the two cities

    Original URL path: http://www.balsinde.org/contact.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - Links
    science clinical impact Nice Blood Journal of the American Society of Hematology FEBS Letters Pretty convenient when something requires urgent publication FEBS Journal Formerly known as European Journal of Biochemistry Molecular Biology of the Cell Published by the American Society for Cell Biology Molecular and Cellular Biology Published by the American Society of Microbiology Cell Metabolism Metabolic biology from molecules and cells to translational studies Lipid Sites International Conference on the Bioscience of Lipids The international forum for lipid research Lipid Maps American research consortium dedicated to study the macrophage lipidome Lipid Bank for Web Database of the Japanese Conference on the Biochemistry of Lipids Cyberlipid Center Despite its amateurish looks this site deserves all the praise it can get Lipid Library Lipid chemistry biology technology and analysis Eicosanoid Research Foundation Organizers of the International Conference on Bioactive Lipids Friends Colleagues Edward Dennis Group University of California San Diego La Jolla California Research Unit on BioActive Molecules Chemical and Environmental Research Institute Barcelona Eicosanoids and Vascular Pharmacology INSERM U698 Bichat Hospital Paris Blázquez Alabadí Laboratory Plant Molecular and Cell Biology Institute Valencia Membrane Trafficking Signaling Proliferation University of Barcelona School of Medicine Barcelona Miscellaneous Institutions Organizations Universidad de Valladolid Our hosts Consejo Superior de Investigaciones Científicas Our employers University of California San Diego Lots of good memories Junta de Castilla y León Website of the Regional Government of Castile and León Research Institutes in Spain National Center for Cardiovascular Research CNIC High research hopes in the heart of Madrid Research Center Príncipe Felipe CIPF In the beautiful city of Valencia in front of the dolphins Severo Ochoa Center for Molecular Biology CBM In the Autonomous University of Madrid campus Alberto Sols Institute for Biomedical Research IIB Also linked to the Autonomous University of Madrid National Center for Biotechnology CNB Also

    Original URL path: http://www.balsinde.org/links.htm (2016-02-12)
    Open archived version from archive

  • The Eicosanoid Research Division @ IBGM - News
    and non microbe thioglycollate induced inflammation with emphasis on eicosanoid and docosanoid production Their results provide elegant demonstration that resolution of inflammation may be shaped in a stimulus specific manner and that the tissues surrounding the inflammatory site may also contribute to the process This is the article we have selected as Paper of the Year 2015 January 11 2016 No me moleste mosquito just let me eat my burrito no me moleste mosquito why don t you go home Krieger Densmore Manzarek keeping it psychedelic Winter 2016 group meeting schedule here December 22 2015 The future is decided in the laboratory four researchers from the IBGM highlight the role of Research Development in social development Pretty cool but December 18 2015 When you News Archive thought you had seen alm ost everything about bizarre behavior in a research institute there goes the all time freakest show December 13 2015 Dozens of storks perched on the roofs of the Health Sciences Building of the School of Medicine Since the University Hospital is just across the street it is likely that the storks are resting up there after delivering the babies in full agreement with the theory of scientific storkism December 3 2015 Many things in life have their abc s group IV phospholipase A 2 for example The Spanish National Research Council s ruling guys have decided that our institution also has to have its own a s and b s and c s but the way they wanted to implement the scores is awkward to say the least No matter what they say apples are apples and oranges are oranges December 1 2015 An old woman and an old man were going to Albacete and halfway he stuck his hand into the pocket and reached for a ticket November

    Original URL path: http://www.balsinde.org/news.htm (2016-02-12)
    Open archived version from archive



  •