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  • Hollie Chandler | Cancer Research UK - Science blog
    Challenge award View all schemes and deadlines Applying for funding Start your application online Guide to filling in your application form How to make a successful application Funding committees Manage your research grant Manage your grant online Guide to managing a grant online Notify us of new publications Update your profile How we deliver research Our research strategy Our institutes Our centres Our research partnerships More Drug discovery and development Recently funded awards Researcher case studies ABOUT US What we do We beat cancer We fundraise We develop policy Our organisation Our strategy Our Trustees CEO and Executive Board Annual report and accounts Annual review Current jobs Graduates and interns Your development Benefits Cancer news Science blog Latest press releases Latest news reports Search all news More Contact Us Press office Publications HOME ABOUT CANCER SUPPORT US NEWS RESOURCES FUNDING RESEARCH ABOUT US You are here Home border 0 Support us Home About us Cancer news Science blog Author Hollie Chandler Author Hollie Chandler A welcome review of how treatments get to patients Category Science blog December 8 2014 Hollie Chandler The UK Government has announced it will review the process for getting new cancer treatments to patients more quickly so what happens next Read More Scheme for early access to drugs is a step in the right direction Category Science blog March 14 2014 Hollie Chandler The Early Access to Medicines scheme launching in April is great news for cancer patients but what more could be done Read More We need to get new drugs to patients faster but how Category Science blog December 11 2013 Hollie Chandler The research community and the government want to speed up how quickly cancer patients can access new drugs we discuss the latest thinking Read More Older Posts Newer Posts Popular posts

    Original URL path: http://scienceblog.cancerresearchuk.org/author/holliechandler/ (2016-02-11)
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  • We need to get new drugs to patients faster, but how? - Cancer Research UK - Science blog
    Access scheme and adaptive licensing This group formed in 2012 as a result of David Cameron s pledge to investigate access to drugs The Expert Group recently published a report making several recommendations to the government that would allow patients to access new treatments more quickly Let s take a look at the findings in this report and some of the unanswered questions about how such drug access schemes would work What happens now First though a whistle stop tour of the system the existing process for developing a new treatment means the medicine goes through four tiers of clinical trials that gather data about the safety and effectiveness of a new drug It can take up to two years for regulators to check the data and license the drug allowing it to be prescribed Following this there is an assessment to determine whether the drug is cost effective In England this assessment is made by NICE And in England patients can get access to certain treatments before NICE approval through the Cancer Drugs Fund The Early Access scheme proposed by the government would allow UK patients with little or no other treatment options to be prescribed a drug once its clinical trials had been completed but before being formally licensed This would mean patients could have certain medicines around a year earlier Early Access scheme far enough Providing access to medicines is an important issue It s a tricky balance to ensure that we have enough information on the benefits and risks of a drug while giving patients speedy access to potentially effective treatments We re glad that serious attention is being given to this challenge But there are unanswered questions Most importantly who would pay for treatments being provided through an Early Access scheme This has been a sticking point in discussions by the government The Expert Group supports an Early Access scheme and has urged the government to launch it as soon as possible Although the scheme could allow patients to have some treatments slightly sooner we don t think it goes far enough to enable promising drugs to get to patients at a much earlier stage But we do think this could be achieved through adaptive licensing Adaptive licensing Broadly this means licensing a drug early in its development for a specific group of patients and or treatment settings The drug s safety and effectiveness is closely monitored throughout its development and used to adapt the drug s license Adaptive licensing could offer more options to patients over the Early Access scheme because it gives them the chance of promising treatments at an earlier stage in development before every phase of the clinical trial is complete The Expert Group believes that existing flexibilities in European law support the idea of adaptive licensing But there s little awareness especially among smaller companies and academics about how to use such flexibilities The group has recommended that the agency responsible for regulating all medicines in the UK the Medicines

    Original URL path: http://scienceblog.cancerresearchuk.org/2013/12/11/we-need-to-get-new-drugs-to-patients-faster-but-how/ (2016-02-11)
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  • Encouraging healthier diets: Traffic light labelling could get the go-ahead - Cancer Research UK - Science blog
    green and labelled high medium and low making it easy for people to see exactly what they re getting This consultation is a great opportunity to bring in a scheme that will make it easier for people to make healthy choices about what they eat and we ve recommended what we think is the best approach And it s absolutely vital because obesity is the biggest preventable cause of cancer in the UK after smoking contributing to around one in twenty cancers Obesity and Cancer A quarter of all people in England are classed as obese and it s a significant and growing health problem Research shows that in 2010 17 000 cancer cases were linked to excessive bodyweight and for women it s the second most significant cancer risk factor after smoking Obesity is linked with seven types of cancer namely breast bowel womb food pipe pancreatic kidney and gallbladder In particular over a third of all womb cancers are associated with being overweight While obesity is a problem there s more to eating a healthy diet than just keeping an eye on the calories For example eating more than six grammes of salt a day is linked to almost 1 700 cases of stomach cancer a year in the UK Obesity is a complex problem with few simple solutions Ultimately we all make our own choices about what we eat and what we do But we all know that it can be hard to make healthy decisions how many of us would plump for chocolate rather than fruit if given the choice Here s where legislation can help us to think about the choices we make Of course we re not talking about laws restricting people s freedom to choose what they want to eat nobody wants to see cakes or crisps outlawed But to tackle obesity effectively we think that the Government needs to introduce measures that create an environment where healthy choices are easy choices to empower people to make good decisions about what they eat Our view People say they find guideline daily amounts GDAs confusing Clear and consistent nutritional labelling is one part of this healthy environment In our response to the food labelling consultation we ve asked that the Government recommends a traffic light system for food labels along with the words high medium and low allowing people to make a quick assessment of the relative healthiness of contents of their shopping basket This approach is also supported by the Food Standards Agency as well as a recent report from the House of Lords Science and Technology Committee A traffic light labelling system would also clear up some of the confusion caused by Guideline Daily Amounts GDAs which are currently used on some food packs A study in Australia showed that just under two thirds of people with a university level education would use GDAs to guide their shopping falling to around a third of people with only primary school education This highlights

    Original URL path: http://scienceblog.cancerresearchuk.org/2012/08/16/encouraging-healthier-diets-traffic-light-labelling-could-get-the-go-ahead/ (2016-02-11)
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  • ‘Giving sugar its fix’: Public Health England recommends halving sugar consumption targets - Cancer Research UK - Science blog
    happens next And how is this linked to cancer anyway A growing problem Importantly there isn t conclusive evidence that sugar itself causes cancer cells to grow or spread despite persistent myths that claim there is But what is crystal clear is that eating more sugary food and drink increases total energy intake which can lead to being overweight or obese the biggest preventable cause of cancer after smoking Being overweight and not having a healthy balanced diet causes 49 100 extra cases of cancer every year So will the recommendations help the UK keep a healthier waistline Energy intake The UK consumes too much sugar The National Diet and Nutrition Survey shows that every age group exceeded even the previous guidelines that people should get no more than 10 of their energy intake from free sugars This is a particular problem for teenagers who appear to get more than 15 of their energy intake from free sugars three times the new guideline The new guidelines also reaffirm a definition for free sugars which until now has not been a well understood term The Committee recommends that free sugars are defined as both sugars which are added to food by the cook customer or manufacturer sugars like glucose and fructose and sugars naturally present in products like honey syrups and unsweetened fruit juices Halving the recommended maximum level of sugar intake is a clear statement that the Committee agrees with the evidence that reducing the amount of sugar in our diets can have clear benefits for a person s health Sugary drinks At face value fizzy drinks are an odd thing to drink They add virtually no nutrition to your diet help you put on weight and can be incredibly high in sugar sometimes containing up to 35g or 9 teaspoons per 330ml can Even so over 5 6 million litres of sugary drinks are consumed each year in the UK And it s young people who consume the most with sugary drinks being responsible for about a third of a teenager s sugar intake So helping people especially teenagers to cut down on consuming sugary drinks for example encouraging them to replace them with sugar free squash is a great way to make it easier to keep a healthy weight Increasing fibre Our average fibre intake in the UK is low even falling below the previous guideline of 18g Because of this the Committee s recommendation of increasing the recommended fibre in our diet to 30g a day demonstrates the importance they put on eating a high fibre diet From a cancer prevention point of view we think this is a good idea as there is evidence that high levels of fibre can reduce the risk of developing bowel cancer More than 1 in 10 bowel cancers are linked to a low fibre diet and if the UK had a diet high in fibre could avoid up to 5 100 cases of cancer every year Fruit and vegetables are

    Original URL path: http://scienceblog.cancerresearchuk.org/2015/07/17/giving-sugar-its-fix-public-health-england-recommends-halving-sugar-consumption-targets/ (2016-02-11)
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  • Obesity and cancer – report highlights three things the Government could do - Cancer Research UK - Science blog
    these include being a non smoker eating a healthy diet drinking less alcohol being safe in the sun and being physically active We know it can be hard to lose weight if you are overweight But ultimately making lasting changes to your lifestyle is the most effective way to maintain a healthy weight But while making healthy choices as individuals is crucial to reducing the number of people who are overweight or obese in the UK we can t just rely on individual action to bring about positive change And that s where government comes in It can play a big role in helping us to maintain a healthy weight by making evidence based changes to help make sure that keeping a healthy weight becomes the norm once again MPs agree obesity matters In another announcement you may have missed this week the government s Health Select Committee an influential group of MPs who oversee the government s health policies published their recommendations about the impact of diet and exercise on health Among a range of recommendations they ve emphasised the importance of physical activity in improving our health and the benefits of preventing obesity at an early stage before reaching the need for avoidable weight loss surgery We submitted evidence to the Committee last year and we re delighted to see they support the need for more preventative action We know there are no quick fixes when it comes to tackling obesity But there is growing evidence about what works A recent report from management consultants McKinsey highlighted that Governments should not seek the single best intervention but aim to do as much as possible as soon as possible Reviewing 44 different possible policies the report found that all of them were cost effective in reducing obesity and that implementing all of them together could reduce the number of people who are overweight or obese by a fifth saving the NHS over 800m a year 44 interventions might sound like a daunting list to any government so here are the three things we think are most important A healthy environment can help people stay active 1 Helping people to stay active in their communities An important part of tackling obesity as well staying healthy in general is to help people stay active At a local level the Government can make it easier for people to build physical activity into their daily lives This means investing in sports facilities open space and environments where we can travel actively for example by walking or cycling which will help more people to meet the Chief Medical Officer s recommended guidelines for physical activity It will also help these options become a more central part of our commutes neighbourhoods and playgrounds Local authorities should create supportive environments which promote physical activity 2 Cut consumption of high sugar drinks Higher taxes on sugary drinks should be on the table Another opportunity for action is tackling the affordability of sugary drinks As a nation we

    Original URL path: http://scienceblog.cancerresearchuk.org/2015/03/27/obesity-and-cancer-three-things-the-government-should-do/ (2016-02-11)
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  • The gap between rich and poor: yet more misleading information from the tobacco industry - Cancer Research UK - Science blog
    tobacco companies who submitted evidence are responsible for nine out of every 10 cigarettes sold in the UK And their views were striking if unsurprising Despite the clear impact of deprivation and inequality on lung cancer all seven submissions argued that these inequalities meant that the government should tackle inequality by relaxing policies aimed at reducing smoking Their underlying point appears to be that smoking is merely a symptom of a wider problem that causes inequality and so tobacco control policies are a wasted effort as they don t get to the root of this Government they feel should cast its efforts elsewhere rather than treating the mere symptoms of inequality The graphic below disproves this by showing how smoking rates have changed as tobacco control policies have come in and how that s affected lung cancer rates over the same period Let s look at the tobacco industry s specific points Blame According to the report the tobacco industry s submissions tried hard to shift the blame for inequalities onto others and refused to accept its own role in creating them One submission from FOREST a campaigning group funded by the tobacco industry even attacked the Department of Health s work on tobacco control for help ing to stigmatise people on low incomes But the fact is the tobacco industry has directly contributed to worsening these inequalities Keeping you hooked The researchers also found the tobacco industry arguing that increasing tax on cigarettes burdens the poor communities and exacerbates health inequalities But this goes against published evidence which suggests that increasing the price of cigarettes is one of the most effective ways to reduce smoking related health inequalities by providing a price incentive to quit smoking And when faced with past tax increases some tobacco companies have actually lowered their prices to absorb the tax hike Another related argument they used is that raising the price of tobacco furthers inequalities according to the tobacco company Philip Morris the widespread availability of cheap smuggled and counterfeit cigarettes is accessible to public and minors alike This is a key argument used again and again by the industry But when you look at the statistics official figures show that the size of the illicit trade market has more than halved since its peak from 21 per cent in 2001 to 10 per cent in 2013 14 and is set to continue to do so The industry s argument here doesn t stand up Protecting our next generation The report uncovered one submission that claimed that children don t take up smoking because of advertising displays and packaging of cigarettes but rebelliousness and risk taking instead This is important rates of smoking among kids from socially deprived communities can be well above the average But childhood mischievousness is highly unlikely to be the cause As we ve blogged about before and as this video highlights an independent review of the evidence has shown that tobacco marketing can appeal to children and that plain

    Original URL path: http://scienceblog.cancerresearchuk.org/2015/01/20/the-gap-between-rich-and-poor-yet-more-misleading-information-from-the-tobacco-industry/ (2016-02-11)
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  • New study marks major advance in bowel cancer screening - Cancer Research UK - Science blog
    a bowel screening programme It uses a different test called the faecal occult blood test or FOBT which looks for hidden traces of blood in stools In England and Wales people are invited for screening between the ages of 60 and 69 They are sent a kit to use in the privacy of their own homes and results are sent to a lab for testing The FOBT is also an effective way of screening for bowel cancer Trials have found that it can reduce death rates from the disease by around 25 per cent and countries all over the world have used it as the basis of bowel cancer screening programmes However Prof Atkin s latest results suggest that the Flexi Scope is even more effective And crucially it can prevent bowel cancer as well as detecting it after it has appeared The two tests should complement each other well The Flexi Scope can only scan the lower part of the bowel It won t be able to detect polyps or cancers in the upper reaches so the FOBT still has a role in detecting early cancers there The Flexi Scope test is currently available in the UK but only for people with symptoms or after a referral from a GP or specialist Based on the new results this could change in the future In fact Cancer Research UK thinks the findings are so promising that we are calling on the UK governments to incorporate the Flexi Scope as part of the national screening programme for bowel cancer alongside the FOBT test We think the Flexi Scope test should probably be offered to people from their late 50s This is because most polyps appear in the lower bowel before the age of 60 and slowly develop into cancer over the next few decades Will it be acceptable A key question is whether people will accept the new test The signs suggest they will In an earlier study of 4 400 people who went through Flexi Scope screening Prof Atkin showed that virtually all of them were glad they had the test and were satisfied with the procedure Meanwhile 91 per cent reported mild or no pain and 97 per cent said they felt little or no embarrassment The risks of the test appear to be small Removing a polyp can cause a small amount of bleeding and there is around a 1 in 50 000 chance that the tube can tear the bowel There isn t really a risk of a false positive because doctors can only detect and remove polyps if they are there And to top off the good news the Flexi Scope test could be very cost effective especially since it only needs to be done once in an 11 year span The test s costs would probably be outweighed by the fact that fewer people need to be treated and treatments are cheaper for early stage cancers In 2006 a study commissioned by the UK Department of Health suggested that a Flexi Scope screening programme would actually save 28 for every person who was screened Of course Prof Atkin says that there are many practical choices that would affect these calculations and they would need to be repeated using data from the actual trials There s also the pressing need to train people with the endoscopes if Flexi Scope becomes more widely used The new results have closed the door on 16 years of research and opened new and exciting ones The big question now is whether the country will step through them Ed More from Cancer Research UK Information for people affected by bowel cancer Video How to spot bowel cancer early Bowel cancer key facts Support a bowel cancer research project Our current research on bowel cancer Bowel cancer awareness leaflet pdf Reference Atkin W et al 2010 Once only flexible sigmoidoscopy screening in prevention of colorectal cancer a multicentre randomised controlled trial The Lancet 10 1016 S0140 6736 10 60551 X Share this article More on this topic Tags Bowel cancer Cancer in the news Cancer Research UK funded research Clinical trials Early detection Policy Preventing cancer Screening Comments Click here to cancel reply Della January 12 2011 thank you a very interesting article Nicky January 6 2011 My mum died of bowel cancer at age of 46 17yrs ago now and although I am 40 myself later this year I am terrified of getting this cancer myself Mum s was undiagnosed and only detected when undergoing private health care By time they operated thinking it was ovarian cancer it was too late She died 3 weeks later Maybe if the doctors at our local surgery had discovered it sooner over 5month period she would still be here today At 35 I went to my doctors asking to be screened as I was told you could be if it was a parent who had died On completing various NHS forms and although there is a history of it in both sides of my family and due to limited info known by myself as other family members have since died I was declined stating I wasn t considered to be at risk It doesnt stop me worrying and anything that is available to help screen people of a younger age in the same position as me I would welcome Mum s my proof that you dont have to be over 50 years of age to become a victim of this awfully cruel disease But 17yrs on I am so greatful to the advances in medicine for Bowel cancer from cancer research and it s re assurring so many more people are now surviving it I wish everyone well who has ever fought it or whoever is battling it now DLB November 18 2010 Also do your research before agreeing to mammograms The Nordic Cochrane Institute were so concerned at the lack of real information getting to women that they produced The risks and benefits

    Original URL path: http://scienceblog.cancerresearchuk.org/2010/04/28/new-study-marks-major-advance-in-bowel-cancer-screening/ (2016-02-11)
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  • New bowel screening test introduced in England - Cancer Research UK - Science blog
    many years But what is new is using it in this way to screen the population before they even have symptoms And this could have a huge impact on bowel cancer in this country When will it be available This is the first of six pilot centres which will iron out any potential problems in the system before rolling out BSS to the rest of the country Over the next few months another five centres will then start to offer Bowel Scope Screening By 2016 everyone in England should be invited to have a test at the age of 55 What does it mean for me Bowel Scope Screening adds to the existing bowel screening programme which uses the Faecal Occult Blood Test FOBT which looks for blood in your stools People are invited from age 60 to participate or age 50 in Scotland Under the new plans if you live in England you ll be invited to be screened using BSS when you turn 55 If you decide not to go and it is your decision you can change your mind up until you turn 60 At that point you ll be invited to take part in the existing bowel screening programme Whether or not you decide to have BSS you will still be invited to take part in the existing screening programme at 60 to help spot any cancer that might develop later on Although it hasn t been shown to prevent cancer in the same way as BSS FOBT is still an important way of helping to diagnose bowel cancer at an early stage when treatment is more likely to be successful The evidence so far suggests it s made a big impact already and BSS takes this a step further What s next This is an important first step Now we need to make sure that everyone can benefit from Bowel Scope Screening At the moment BSS is only being rolled out in England We want to see Scotland Wales and Northern Ireland develop their own plans for BSS including making sure they have the right facilities available If this test is made available across the UK thousands of deaths will be prevented and even better potentially thousands of people will be spared from ever having to experience this terrible disease Dan Dan Hughes Morgan is a policy adviser at Cancer Research UK Share this article More on this topic Tags Bowel cancer Cancer Research UK funded research Diagnosing cancer Early detection Preventing cancer Screening Comments Click here to cancel reply Carol April 15 2013 Just wondered why they are not including the NW in the pilot group I am a 50yr old female and have lost a grandad three of his daughters and one of their daughters to colon cancer between ages 51 70 does this put me into a higher risk category Dawn Witney April 12 2013 This is wonderful news and needs to be rolled out across the UK asap My husband died

    Original URL path: http://scienceblog.cancerresearchuk.org/2013/03/21/new-bowel-screening-test-introduced-in-england/ (2016-02-11)
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