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  • Evidence Based Health Care Quality Help: Little EBM Test Answer
    you is a case series Want to read more about case series Return to delfini org 2002 2016 Delfini Group LLC All Rights Reserved Worldwide Dolphin photo for Dolphins Poolside attributed to RevolverOcelo Delfini Boat thanks to Dr Bat Shunatona

    Original URL path: http://www.delfini.org/page_Nuevo_Magico_Answer.htm (2016-02-01)
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  • Delfini IBS Documentation
    2003 additions were made on 07 06 for herbal preparations and 04 07 due to a medication withdrawal from market Ask Questions regarding natural history prognosis diagnosis non drug and drug therapy and follow up were addressed to the medical literature see Search Strategy below Acquire Appraise Studies were filtered excluding case series editorials and opinions Meta analyses and systematic reviews without lethal threats to validity were prioritized and utilized when possible RCTs were used when published subsequent to systematic reviews or when systematic reviews were not available The evidence was evaluated for relevance and internal validity and evidence summary documents were developed for the best available evidence An evidence grading methodolog y was used to filter and grade the evidence for validity and usability See Guideline Notes and also Delfini Information Decision Aid for Patients and Practitioners Guideline recommendations were based on systematic reviews and RCTs when available but expert opinion was utilized in parts of the guideline when evidence was not available or not usable because of threats to validity The strength of the evidence is noted in the guideline and decision support Guideline Decision Making Process All decisions were made by consensus using the best available evidence along with expert opinion when evidence was not sufficient to guide recommendations Guideline Peer Review The original guideline was reviewed for relevance and validity by David Bjorkman MD MSPH SM Professor of Medicine University of Utah School of Medicine Walter Peterson MD Professor of Medicine University of Texas Southwestern School of Medicine and co editor of Alimentary Pharmacology and Therapeutics Following guideline development we also invited comments from a gastroenterologist medical director at Novartis and accepted those changes we independently deemed to be guideline improvements We are also grateful to various medical leaders and other participants of the community practice meetings who contributed their input and made suggestions Funding Delfini Group LLC was invited by Novartis to independently develop an evidence based clinical guideline Prior to agreeing and at risk without compensation Delfini first evaluated the evidence available for IBS basing a decision to proceed only upon meeting rigorous requirements 1 that there be sufficient valid and relevant evidence available 2 that there be sufficiently important results e g statistical significance clinical relevance and patient centeredness and 3 which Delfini agreed would be a guideline worth developing irrespective of any remuneration This guideline is based on the principles and rigorous systematic methods for explicit evidence based guidelines first conceptualized by David Eddy MD PhD and subsequently operationalized and used by Dr Michael Stuart during his career at Group Health Cooperative in Seattle Washington Delfini has licensed this guideline to Novartis Pharmaceuticals manufacturer of Zelnorm tegaserod Delfini has received no further funding since the development of the guideline but continues to update it as a public service Potential Conflicts of Interest See Funding We believe this guideline has been developed with no conflict of interest and stand fully behind it based on precepts of the most rigorous practice of evidence based

    Original URL path: http://www.delfini.org/page_IBS_Documentation.htm (2016-02-01)
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