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  • EMMA - the European Mouse Mutant Archive
    conditions for submission pdf file 29 KB and distribution pdf file 29 KB of EMMA strains are available via the displayed links EMMA lines are supplied to qualified researchers as a service to the scientific community at large solely for research purposes and not for commercial use The legally binding EMMA conditions further state that individual laboratories or institutions may not transfer or sell these mice or their progeny to any third party outside the recipient institution Any existing MTAs will remain in full force and effect Donor MTA documents can be downloaded from the respective strain description pages Policy on licensing and use restriction EMMA is committed to advancing biomedical research and makes every effort to distribute mouse strains that are unencumbered by license restrictions However some institutions and companies have created genetically engineered strains or have developed patented technology that has been used to create genetically engineered mice and require that users obtain licenses to use those strains To expedite distribution of new strains EMMA asks users to work directly with the institutions or companies requiring licenses to obtain user licenses A license agreement is required for EMMA strains using TET System technology Licenses for strains using TET System technology Not for profit and academic research institutions are granted an automatic license to use the TET System only for internal academic research purposes with the purchase of this product which license specifically excludes the right to sell or otherwise transfer the TET System or its component parts to third parties In accepting this license all users acknowledge that the TET System is experimental in nature and that the product will not be used in humans TET Systems Holding makes no warranties express or implied of any kind and hereby disclaims all warranties representations or guarantees of any kind

    Original URL path: http://strains.emmanet.org/procedures/legal-restrictions.php (2016-02-17)
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  • EMMA - the European Mouse Mutant Archive
    Training courses Bibliography Links Internal Site EMMA procedures Health monitoring Brief description of housing system health monitoring program and health status of the EMMA SPF live colonies Type of facility Animals distributed by EMMA are bred in SPF Specific Pathogen Free barriered facilities in which all materials are sterilized before entry Staff entering the barriered areas must shower and change into clean unit clothing Where appropriate staff working within the units is also required to wear gloves face masks mob caps and over shoes Housing system Animals are maintained in either flexible film isolators or IVCs Individually Ventilated Cages or in conventional cages in barriered areas under positive pressure and are given autoclaved bedding autoclaved or irradiated food and filtered or chlorinated water Animals reared in IVCs are cage changed under laminar flow hoods Sentinel program The health status of each animal room is monitored on a regular basis e g 4 times per year when mice are reared in IVCs or monthly when mice are bred in conventional cages in barriered areas These screening progammes involve exposing sentinel animals to dirty bedding collected from other IVCs within the mouse room Some colonies e g those reared in isolators are

    Original URL path: http://strains.emmanet.org/procedures/health-monitoring.php (2016-02-17)
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  • EMMA - the European Mouse Mutant Archive
    About EMMA EMMA partners EMMA projects Costs EMMA procedures costs Legal restrictions Health monitoring Ethics Deposit mice Order mice EMMA axenic germ free service FAQs EMMA protocols Cryopreservation workshop Training courses Bibliography Links Internal Site EMMA procedures Ethical and safety aspects The EMMA repository by definition involves the handling of genetically manipulated organisms Although the repository will store and distribute these mice it will not create them All animal work within the repository will be conducted in strict accord with the established rules and procedures of the host nation Each laboratory that contributes animals to the repository or receives them from it must ensure that the European Directive 86 609 EEC and all relevant national and European rules and regulations are complied with Accordingly the repository will seek appropriate assurances from all those who contribute animals to it or receive animals from it but EMMA cannot be held responsible for the conduct of national laboratories over which it has no control The regulation 93 88 EEC of 12 October 1993 amending Directive 90 679 EEC on the protection of workers from risks related to exposure to biological agents at work will be enforced Agreement by the local Ethical Committee when

    Original URL path: http://strains.emmanet.org/procedures/ethics.php (2016-02-17)
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  • EMMA - the European Mouse Mutant Archive
    Cryopreservation workshop Training courses Bibliography Links Internal Site Submissions to EMMA Please use the online submission form to submit your strains Receipt of the online submission form will be confirmed by an automatic Email notification For more information about the submission process please check the FAQs section Evaluation Mouse strains submitted for archiving are evaluated by EMMA s external scientific committee The committee comprises experts in the field of mouse genetics They evaluate each submission to the EMMA repository thereby ensuring that the research community has access to valuable mouse mutant strains with significance for current and future genetic research Within 60 days EMMA will inform depositors about the outcome of the evaluation Costs The EMMA cryopreservation service is free of charge However customers have to cover the actual costs for shipping material to the EMMA facilities Archiving slots are funded by the EMMAservice project a four year Integrated Infrastructure Initiative I3 project that started in January 2009 EMMAservice is funded by the EC s FP7 Capacities Specific Programme Requirements for cryopreservation Once approval has been granted depositors are asked to send mice of breeding age to one of the EMMA partners for embryo or spermatozoa cryopreservation If embryos are

    Original URL path: http://strains.emmanet.org/submissions.php (2016-02-17)
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  • Confirm conditions
    at http www emmanet org EMMA maintained lines are supplied to interested institutions investigators as a non profit service to the research community at large by the respective research facility that submits the mouse line Provider EMMA coordinates requests and acts as the distributor of mouse lines stored with EMMA Distributor The submitted Material shall consist of live mice Material unless otherwise accepted by Distributor The Provider who submits Material to EMMA hereby expressly agrees to the following conditions 1 Except where specifically authorized by the Provider the Distributor is authorized to distribute the Material upon request from third parties for use in non Commercial activities only under the LEGALLY BINDING GENERAL CONDITIONS CONCERNING THE REQUEST AND TRANSFER OF MUTANT MOUSE LINES FROM THE EUROPEAN MOUSE MUTANT ARCHIVE To avoid doubt at the written request of the Provider initial distribution of the Material may be delayed for a period of up to two 2 years from the date of deposition to allow the Provider to i publish research associated with such mouse strain or ii register the intellectual property rights associated with such mouse strain 2 If requested by the Provider prior to the submission of the Material to the Distributor the Distributor will furbish to the recipient institution including its employees and other researchers under its control Recipient the Provider s Material Transfer Agreement Requests will not be processed by the Distributor until two 2 duly executed copies of such agreement have been received by the Distributor 3 The Provider declares that they have complied with all relevant National International and European rules with regard to the breeding handling and storage of the Material e g Directive 86 609 EEC amended by Directive 2010 63 UE 4 All relevant non confidential information about the Material shall be provided by the Provider to the Distributor This information is made accessible via the EMMA and IMSR International Mouse Strain Resource homepage to the best of the Distributor s knowledge 5 After submitting Material to the Distributor the Material will be dealt with by the Distributor according to the applicable scientific and ethical standards 6 The Distributor reserves the right to withdraw the Material from the archive due to scientific reasons The Distributor shall inform the Provider of any decision in this respect To avoid doubt at any time the Provider shall be entitled to demand that the Materials be withdrawn from the archive for any reason 7 If the Material is subject to patents or any other intellectual property right owned by the Provider and or third party ies or such rights have been licensed and or assigned to third party ies it is in the responsibility of the Provider to ensure that the transfer and use of such Material to by the Distributor does not infringe such intellectual property rights To avoid doubt should the existence of proprietary rights of a third party restrict global distribution of the Materials at the time of deposit or arise subsequent to such deposition

    Original URL path: http://strains.emmanet.org/cgi-bin/confirmConditions.cgi?form=submission (2016-02-17)
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  • Search, browse strains or genes in the EMMA database
    e g Apoe click on the Configure this page link near the bottom of the left hand menu and activate the EMMA checkbox Ensembl Das Please view our strain ordering information page for details on delivery time shipment costs and service charges To order a mouse strain from the list click on the order link of appropriate strain To express interest on a mouse strain in the pipeline please fill our express interest form Browse by Strains Browse by Genes Browse by Phenotypes Browse by Human Diseases Mutation Types Targeted Mutant Strains all of the targeted knock out knock in targeted conditional targeted non conditional point mutation conditional mutation other targeted Gene trap strains Transgenic strains Chemically radiation induced strains all of the induced chemically radiation Chromosome anomalies Spontaneous Other Research Tools Cre recombinase expressing strains Strains with TET expression system FLP recombinase expressing strains Wellcome Trust knockout mice Deltagen strains Lexicon strains EUCOMM strains Full strain list A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 0 9 Search MP terms by name or ID eg adipose or 5375 w o MP

    Original URL path: http://strains.emmanet.org/mutant_types.php (2016-02-17)
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  • EMMA - the European Mouse Mutant Archive
    to facilitate fast delivery to the customers For all other EMMA strains a rederivation service is provided EMMA screens and distributes mice in accordance with FELASA protocols and guarantees that mice leaving the EMMA institutions are free of pathogens as specified by FELASA EMMA does not generally offer breeding services to e g generate cohorts of homozygous mutants However such a service and fees may be negotiated with the respective EMMA distribution centre List of available EMMA strains Search engine Please submit your strain requests by following the order link from the list of available EMMA strains EMMA will contact you within one week after receipt of your EMMA Mutant Request Form For more information about the order process please check the FAQs section In general service requests will not be processed until a fully executed Material Transfer Agreement MTA has been received where applicable and either a billing address or a purchase order number has been provided by the customer In case of cancellations of service requests EMMA reserves the right to charge customers for incurred costs The individual EMMA repositories will each bill customers separately Service charges Note On the 4th of May 2011 EMMA increased its service charges for embryo rederivation and the provision of a breeding nucleus of up to 3 pairs of SPF mice The price for this service now stands at 2400 This price increase was necessary to enable the EMMA partners to recover their costs and to ensure EMMA maintains a sustainable distribution service Standard fees Kind of material Quantity Delivery time after paperwork in place Price EMMA resource Shipment costs Frozen embryos 40 50 embryos 4 weeks 1100 customer Frozen sperm 2 straws vials 4 weeks 1100 customer Live mice on shelf 2 3 breeding pairs 4 weeks 2400 customer Rederivation of

    Original URL path: http://strains.emmanet.org/strains.php (2016-02-17)
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  • EMMA Axenic Service Request Form
    interest in the European Mouse Mutant Archive Scientist s Title Mr Mrs Ms Prof Dr Firstname Surname E mail Phone Fax Institution Department Address line 1 Address line 2 County Province Town Postcode Country Shipping Contact s Title Mr Mrs Ms Prof Dr Firstname Surname E mail Phone Fax Institution Department Address line 1 Address line 2 County Province Town Postcode Country Axenic conversion of strain Original owner s title Mr Mrs Ms Prof Dr Firstname Surname Do you have the permission to use the strains for the germ free service Yes No Your strain line name Description of the mutation s and the construct s Is are the mutation s dominant recessive Chromosomal mapping of the mutation s if known 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 X Y Mutant phenotype Are homozygous mice viable Yes No Not known Are homozygous mice fertile Yes No Not known Phenotype description Relevant bibliographic database references PubMed IDs insert the numeric ID and divide by semicolon if more than one Look it up in PubMed a service of the National Library of Medicine Reference s description Strain genetic background On

    Original URL path: http://strains.emmanet.org/cgi-bin/axenicForm.pl (2016-02-17)
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