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  • One Strike and You’re Out: CTCF is a Haploinsufficient Tumor Suppressor - authors@Fred Hutch
    Published Version Available under License Creative Commons Attribution Non commercial No Derivatives Download 248Kb Preview Article URL http www sciencedirect com science article pii S Item Type Article Additional Information Kemp CJ Moore JM Moser R Bernard B Teater M Smith LE Rabaia NA Gurley KE Guinney J Busch SE Shaknovich R Lobanenkov VV Liggitt D Shmulevich I Melnick A Filippova GN 2014 CTCF Haploinsufficiency Destabilizes DNA Methylation and Predisposes to Cancer Cell Rep 1020 9 doi 10 1016 j celrep 2014 04 004 See also Filippova GN Lindblom A Meincke LJ Klenova EM Neiman PE Collins SJ Doggett NA Lobanenkov VV 1998 A widely expressed transcription factor with multiple DNA sequence specificity CTCF is localized at chromosome segment 16q22 1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers Genes Chromosomes Cancer 22 1 26 36 Filippova GN 2008 Genetics and epigenetics of the multifunctional protein CTCF Curr Top Dev Biol 80 337 60 Moore JM Rabaia NA Smith LE Fagerlie S Gurley K Loukinov D Disteche CM Collins SJ Kemp CJ Lobanenkov VV Filippova GN 2012 Loss of maternal CTCF is associated with peri implantation lethality of Ctcf null embryos PLoS

    Original URL path: http://authors.fhcrc.org/653/ (2016-05-01)
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  • PTEN Inactivation Accelerates Lung Cancer Progression - authors@Fred Hutch
    Cancer Progression Brennan Greg 2014 PTEN Inactivation Accelerates Lung Cancer Progression Science Spotlight 4 3 Preview Text PTEN Inactivation Accelerates Lung Cancer Progression pdf Published Version Available under License Creative Commons Attribution Non commercial No Derivatives Download 268Kb Preview Article URL http mcr aacrjournals org content 12 5 654 abstr Item Type Article Additional Information Cui M Augert A Rongione M Conkrite K Parazzoli S Nikitin AY Ingolia N Macpherson D 2014 PTEN is a Potent Suppressor of Small Cell Lung Cancer Molecular Cancer Research Epub ahead of print Doi 10 1158 1541 7786 MCR 13 0554 See also Yokomizo A Tindall DJ Drabkin H Gemmill R Franklin W Yang P et al 1998 PTEN MMAC1 mutations identified in small cell but not in non small cell lung cancers Oncogene 17 475 9 See also Shibata T Kokubu A Tsuta K Hirohashi S 2009 Oncogenic mutation of PIK3CA in small cell lung carcinoma a potential therapeutic target pathway for chemotherapy resistant lung cancer Cancer letters 283 203 11 Collections Science Spotlight Depositing User Ben Abraham Date Deposited 19 Mar 2015 19 13 Last Modified 19 Mar 2015 19 13 URI http authors fhcrc org id eprint 686 Repository Administrators Only

    Original URL path: http://authors.fhcrc.org/686/ (2016-05-01)
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  • Phosphorylating Communication - authors@Fred Hutch
    Lampe PD Injury triggered Akt phosphorylation of Cx43 a ZO 1 driven molecular switch that regulates gap junction size J Cell Sci 127 455 464 See also Dunn CA Su V Lau AF Lampe PD 2012 Activation of Akt not connexin 43 protein ubiquitination regulates gap junction stability J Biol Chem 287 4 2600 7 See also Rhett JM Jourdan J Gourdie RG 2011 Connexin 43 connexon to gap junction

    Original URL path: http://authors.fhcrc.org/705/ (2016-05-01)
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  • Quantifying Biomarker Risks and Benefits - authors@Fred Hutch
    Version Available under License Creative Commons Attribution Non commercial No Derivatives Download 319Kb Preview Article URL http www biomedcentral com 1472 6947 14 15 abstr Item Type Article Additional Information Li X Blount PL Reid BJ Vaughan TL 2014 Quantification of population benefit in evaluation of biomarkers practical implications for disease detection and prevention BMC Med Inform Decis Mak 1 15 Collections Science Spotlight Depositing User Ben Abraham Date Deposited

    Original URL path: http://authors.fhcrc.org/674/ (2016-05-01)
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  • SAMHD1 Antagonism is Conserved in Non-Human Lentiviruses - authors@Fred Hutch
    Antagonism is Conserved in Non Human Lentiviruses Brennan Greg 2014 SAMHD1 Antagonism is Conserved in Non Human Lentiviruses Science Spotlight 4 2 Preview Text SAMHD1 Antagonism is Conserved in Non Human Lentiviruses pdf Published Version Available under License Creative Commons Attribution Non commercial No Derivatives Download 229Kb Preview Article URL http www pnas org content 110 52 21136 abs Item Type Article Additional Information Spragg C J and Emerman M 2013 Antagonism of SAMHD1 is actively maintained in natural infections of Simian Immunodeficiency Virus Proc Natl Acad Sci USA 21136 21141 See also Etienne L Hahn B H Sharp P M Matsen F A and Emerman M 2013 Gene loss and adaptation to hominids underlie the ancient origin of HIV 1 Cell Host Microbe 85 92 See also Fregoso O I Ahn J Wang C Mehrens J Skowronski J and Emerman M 2013 Evolutionary Toggling of Vpx Vpr Specificity Results in Divergent Recognition of the Restriction Factor SAMHD1 PLOS Pathog DOI 10 1371 journal ppat 1003496 Collections Science Spotlight Depositing User Ben Abraham Date Deposited 19 Mar 2015 19 22 Last Modified 19 Mar 2015 19 22 URI http authors fhcrc org id eprint 697 Repository Administrators Only View Item

    Original URL path: http://authors.fhcrc.org/697/ (2016-05-01)
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  • Superinfection Impacts Laboratory, Not Clinical Measures of HIV Progression - authors@Fred Hutch
    com aidsonline pages articlevi Item Type Article Additional Information Ronen K Richardson BA Graham SM Jaoko W Mandaliya K Mcclelland RS Overbaugh J 2014 HIV 1 superinfection is associated with an accelerated viral load increase but has a limited impact on disease progression AIDS Epub ahead of print doi 10 1097 QAD 0000000000000422 See also Sagar M Lavreys L Baeten JM Richardson BA Mandaliya K Chohan BH Kreiss JK Overbaugh

    Original URL path: http://authors.fhcrc.org/720/ (2016-05-01)
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  • A Tale of Two Species - authors@Fred Hutch
    ncurrent Item Type Article Additional Information Arnegard ME McGee MD Matthews B Marchinko KB Conte GL Kabir S Bedford N Bergek S Chan YF Jones FC Kingsley DM Peichel CL Schluter D 2014 Genetics of ecological divergence during speciation Nature Epub ahead of print doi 10 1038 nature13301 See also Orr HA 2005 The genetic theory of adaptation a brief history Nat Rev Genet 119 27 See also Schluter D

    Original URL path: http://authors.fhcrc.org/592/ (2016-05-01)
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  • Targeting Proteins Computationally - authors@Fred Hutch
    Shen BW Song Y Frayo S Convertine AJ Margineantu D Booth G Correia BE Cheng Y Schief WR Hockenbery DM Press OW Stoddard BL Stayton PS Baker D 2014 A computationally designed inhibitor of an Epstein Barr viral Bcl 2 protein induces apoptosis in infected cells Cell 1644 56 See also Procko E Hedman R Hamilton K Seetharaman J Fleishman SJ Su M Aramini J Kornhaber G Hunt JF Tong

    Original URL path: http://authors.fhcrc.org/637/ (2016-05-01)
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