archive-org.com » ORG » I » IMGS.ORG

Total: 854

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • The 16th International Mouse Genome Conference (2002)
    R 1 Andersen B 1 Derfus M 2 Teboul M 2 Ailhaud G 3 Jones B 1 Moustaid Moussa N 1 University of Tennessee 2 CNRS 3 Oak Ridge National Labs Adipose tissue expresses high levels of angiotensinogen agt the only known precursor of angiotensin II Ang II and we have shown that this hormone plays a paracrine role in regulation of adipocyte metabolism and gene expression To address the role of agt in regulating lipid metabolism in vivo we studied the effects of low and high fat diets on adult agt knockout agt compared to wild type wt mice Since recent studies by Massiera et al 2001 demonstrated that reexpression of agt in adipose tissue of agt mice normalized adiposity blood pressure and kidney abnormalities associated with agt inactivation we used microarray analysis to investigate changes in gene expression profile in kidneys of agt vs agt which reexpress agt in adipose tissue Although body weight adiposity and insulin level were significantly decreased p 0 01 in agt mice fed a chow diet compared to wt mice circulating leptin levels were comparable Compared with wt mice fed a high fat diet agt mice on a low fat diet exhibited significantly

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file155.shtml (2016-02-17)
    Open archived version from archive

  • The 16th International Mouse Genome Conference (2002)
    is a neurodevelopmental disorder characterized by social deficits abnormalities in communication and stereotypic ritualized behaviors The severity of these behaviors varies widely from patient to patient and can even be found to some extent in unaffected family members The spectrum of autistic behaviors makes it an ideal problem to address in the mouse model system We have undertaken a large scale behavioral and expression analysis of 20 inbred mouse strains

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file156.shtml (2016-02-17)
    Open archived version from archive

  • The 16th International Mouse Genome Conference (2002)
    NOT ANEMIA J Naessens ILRI Nakamura Y Iraqi F ILRI We used a mouse model comparing susceptible A J and more resistant C57BL 6 mice to identify genes that confer resistance to trypanosomosis In previous studies three major QTL were identified in A J x C57BL 6 crosses based on the longer survival time of C57BL 6 mice To find out whether survival time depends on control of parasitemia or control of anemia a series of infections with Trypanosoma congolense a ruminant parasite and T brucei rhodesiense a human parasite were compared between A J and C57BL 6 Parasitemias were much higher in A J mice than in C57BL 6 although this was less considerable for T b rhodesiense The first wave of parasitemia coincided with a first peak of mortality amongst the A J suggesting that they died as a consequence of high trypanosome numbers A second phase of mortality occurred during the later parasitemic waves In contrast anemia was more severe in the resistant C57BL 6 The resistant mice were able to control trypanosome numbers but not the associated anemia It is possible that they died as a result of severe anemia or other harmful side effects associated

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file157.shtml (2016-02-17)
    Open archived version from archive

  • The 16th International Mouse Genome Conference (2002)
    IN MOUSE Y G Park LPG CCR NCI NIH 1 Lyu M S 2 Montagna C 1 Lukes L 3 Ried T 1 Hunter KW 1 LPG CCR NCI NIH 2 MB NCI NIH 3 GB NCI NIH The ability of a tumour to metastasize is the major determinant of cancer patient mortality Therefore elucidation of the metastasis pathway is an important priority for cancer biology Studies have demonstrated that tumour progression from normal epithelium to metastastic cell is a complex multi step process with many different barriers for a tumor to successfully colonize a distant site To further explore the molecular and genetic events required for tumor dissemination our laboratory uses the highly metastatic MMTVPyMT634Mul transgenic mouse mammary tumor model LOH and cytogenetic analysis has demonstrated unlike human solid tumors the tumors of this mouse model are diploid or near diploid with few translocations or chromosomal aberrations We have taken advantage of this low level of genomic instability to search for specific genomic changes associated with metastatic progression Using matched primary and metastatic tumor cell cultures representational difference analysis RDA has been performed A number of the products have been demonstrated to lie near genes previously associated with metastatic

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file158.shtml (2016-02-17)
    Open archived version from archive

  • The 16th International Mouse Genome Conference (2002)
    LS Gwynn B Ciciotte SL Peters LL The Jackson Laboratory Platelet storage pool deficiencies SPDs are a group of heritable bleeding disorders resulting from abnormal platelet structure and or function SPDs are the second most frequent genetic bleeding disorder in humans and are caused by a reduction in the number or contents of the platelet dense granules and or a granules which leads to abnormal platelet aggregation and prolonged bleeding SPDs are a complex group of diseases representing a wide diversity of phenotypes The Hermansky Pudlak Syndrome HPS is one of the most severe of the SPDs and is characterized by defects in the lysosome related organelles lysosomes melanosomes and platelet dense bodies leading to abnormal lysosome secretion varying degrees of oculocutaneous albinism and prolonged bleeding HPS is genetically heterogeneous To date four human HPS genes have been identified and there are at least 15 mouse models for HPS The cloning of several of these mutations has led directly to the identification of homologous HPS causing genes in humans All of the human and murine HPS genes in which the protein product has a known or suspected function are involved in some way in vesicle trafficking We describe the genetic

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file159.shtml (2016-02-17)
    Open archived version from archive

  • The 16th International Mouse Genome Conference (2002)
    London 2 Pritchard C 2 Underhill P 2 Tymowska Lalanne Z 1 Dolphin A 1 Rees M 1 University College London 2 MRC Harwell The mouse mutant ducky du a model for absence epilepsy is characterised by spike wave seizures and ataxia Mutations in the Cacna2d2 gene were found to underlie the phenotype in the original du strain and its allele du2J Cacna2d2 encodes the a2d2 voltage dependent calcium channel subunit The a2 and d chains are derived from proteolytic cleavage of the gene product the d subunit acting as a membrane anchor for the extracellular a2 subunit Both mutations are predicted to result in the loss of the full length protein and hence the d subunit Cacna2d2 mRNA is strongly expressed in cerebellar Purkinje P cells and du du mice have abnormalities in their P cell dendritic tree In addition co expression of the truncated protein with the Cav2 1 ß4 channel combination in vitro leads to a reduction in current density To aid elucidation of the function of a2d2 we have performed microarray analysis at three different stages of development in du2J du2J mice embryonic post natal and adult We expect that those transcripts identified as up or

    Original URL path: http://www.imgs.org/Archive/abstracts/2002abstracts/file160.shtml (2016-02-17)
    Open archived version from archive



  •