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  • International Mammalian Genome Society 1999 Abstracts
    Michael Skynner Nick Allen Steve D M Brown and Karen P Steel FESA The Frozen Embryo and Sperm Archive at MRC Harwell UK Peter Glenister and Claire Thornton News From the Large Scale Munich ENU Mutagenesis Project Helmut Fuchs Dian Soewarto Christiane Fella Birgit Rathkolb Walter Pargent Stephan Heffner Eckhard Wolf Rudi Balling and Martin Hrabé de Angelis A Large Scale Mutagenesis Programme in the Mouse Jackie Hunter Jo Peters Lucie Vizor Claire Thornton Pete Glenister Simon Greenaway Rachael Selley Mark Strivens Pat Nolan Jo Martin Elizabeth Fisher Derek Rogers Jim Hagan Nigel Spurr Sohaila Rastan Mick Browne and Steve Brown Evaluation of Neurological Mouse Mutants Caused by ENU Mutagenesis A Isaacs A Potter M Masih L Vizor K E Davies J Peters P Nolan J E Martin F S Walsh S D M Brown and A J Hunter The Mouse Genome Project at Baylor College of Medicine Combining Gene Based and Phenotype Based Approaches for Functional Genomics Monica J Justice Binhai Zheng John S Weber Andrew Salinger Alea A Mills Jan Klysig Craig Chinault and Allan Bradley Mutagenesis Screens for Mouse Gametogenesis Mutants Brian Libby Robert Munroe Rebecca Bergstrom Andreas Lengeling Maja Bucan and John Schimenti Systematic Approaches to Identifying Novel Behavioural Mutations Using ENU Mutagenesis Pat Nolan Jo Peters Lucie Vizor Rebecca Washbourne Claire Thornton Pete Glenister Simon Greenaway Mazda Hewitt Rachael Selley Mark Strivens Jo Martin Elizabeth Fisher Derek Rogers Jim Hagan Nigel Spurr Sohaila Rastan Mick Browne Jackie Hunter and Steve Brown Mouse Mutants from Chemical Mutagenesis of ES Cells Robert J Munroe Rebecca A Bergstrom Qing Yin Zheng Richard Smith Simon W John Wayne F Frankel Kerry J Schimenti Lisa Tarantino Maja Bucan Victoria L Browning and John C Schimenti Mutagenesis Screen for Behavioral Mutations in Mice Lisa M Tarantino Gillian Leach John Schimenti and

    Original URL path: http://www.imgs.org/Archive/abstracts/99abstracts/toc_h.shtml (2016-02-17)
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  • International Mammalian Genome Society 1999 Abstracts
    Becker and M S H Ko Gene Expression Profiling Using Mouse Full Length 20K cDNA Microarray Yasushi Okazaki Rika Miki Yosuke Mizuno Yasushiro Tomaru Kouji Kadota Piero Carninci Kazuhiro Shibata Masayoshi Itoh Yasuhiro Ozawa Jun Kawai Hideaki Konno Yoshifumi Fukunishi Toshinori Kusumi Hitoshi Goto Hiroyuki Nitanda Youhei Hamaguchi Itaru Nishizuka Masami Muramatsu Jun Yoshiki Moriaki Kusakabe Josephe DeRisi Vishy Iyer Michael Eisen Patrick O Brown and Yoshihide Hayashizaki Moe1 An ENU Induced Mutation Isolated from a Modifier Screen for Enhancers of E2A in Lymphocyte Development Yuan Zhuang Andrew Peterson Nabil Habash and Mei Fang Dai Informatic Selection of a Neural Crest Melanocyte cDNA Set for Microarray Analysis S Loftus Y Chen G Gooden J Ryan G Birznieks M Hilliard A Baxevanis M Bittner P Meltzer J Trent and W Pavan Posters A High Density Transcript Map of the Mouse Using the T31 Radiation Hybrid Panel Philip Avner Isabelle Poras Shahinaz Gas William Saurin Jean Weissenbach Patricia Ruiz Giacomo Manenti Rosa Beddington Sally Dunwoodie Jean Morissette Lorraine Eley and Roger Cox Mapping of Transcripts from the Developing Pancreas Lorraine Eley Alison Hugill Lorraine Southam Eiifon Herbert Roger D Cox Philip Avner Isabelle Poras Gabor Gyapy Cecile Fizames Nunchanard Chianniluchai William Saurin Jean Weissenbach Giacomo Manenti Patricia Ruiz Michael Wiles Hans Lehrach Rosa Beddington Sally Dunwoodie Patricia Rodriguez Identification of Novel Target Proteins in Th2 Dominated Allergic Inflammatory Responses in a Mouse Model of Allergic Asthma Combining cDNA RDA and Micro Arrays Peter C Groot Wouter Gubbels Jeroen B Van Bergenhenegouwen Frans P Nijkamp and Antoon J M Van Oosterhout Gaping Lids A Recessive Mutation Causing Nonsyndromic Open Eyelids at Birth Maps to Centromeric Mouse Chromosome 11 Muriel J Harris Kathleen G Banks Diana M Juriloff 5 end Analysis for Cap Trapper Library Yuichi Sugahara Carninci Piero and Yoshihide Hayashizaki Radiation Hybrid

    Original URL path: http://www.imgs.org/Archive/abstracts/99abstracts/toc_i.shtml (2016-02-17)
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  • Index of /Archive/abstracts/2009abstracts/images
    Name Last modified Size Description Parent Directory San diego zoo pic1 jpg 13 Nov 2009 09 10 405K San diego zoo pic jpg 13 Nov 2009 09 09 748K Apache

    Original URL path: http://www.imgs.org/Archive/abstracts/2009abstracts/images/?C=N;O=D (2016-02-17)
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  • Index of /Archive/abstracts/2009abstracts
    Document Being Saved By TextEdit 03 Feb 2010 12 18 IMGC 2009 final pdf 21 Oct 2009 15 36 2 1M awards9 txt 03 Feb 2010 13 08 3 6K images 03 Feb 2010 14 59 index9 shtml html 03

    Original URL path: http://www.imgs.org/Archive/abstracts/2009abstracts/ (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    Sanger Institute Cambridge United Kingdom The human and mouse genome projects have provided a product of extraordinary scientific value Of the estimated 25 000 genes most have not been examined experimentally In parallel to the sequencing effort enormous progress has been made in our ability to examine gene function in mice by generating and analyzing mutations To accelerate genetic analysis further we have been using chromosome engineering to develop genetic resources based on strategies originally developed in Drosophila balancer chromosomes Our mouse balancers are tagged with coat colour genes enabling recessive mutations to be rapidly identified and maintained The availability of the mouse genome sequence has enabled us to develop indexed reagents allowing systematic approaches for generating knockouts and chromosomal rearrangements These reagents facilitate the rapid construction of knockouts 100 000 vectors are displayed in the Ensembl genome browser www ensembl org under the DAS source MICER Finally I will describe a strategy which enables recessive genetic screens to be conducted in cultured ES cells by passing the time consuming step of producing and inter crossing mutations in mice We have exploited the high rate of mitotic recombination in Blm deficient ES cells to generate a genome wide library of

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file2.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    Petkov PM Graber JH Churchill G The Jackson Laboratory Bar Harbor ME United States Typing 1508 SNPs chosen for high information content on 63 common and wild derived mouse strains chosen for maximum genetic diversity we find that over half the mouse genome presents as large blocks of linkage disequilibrium LD blocks averaging 5 Mb in length and 100 times the length of LD blocks typically observed in human studies The largest block 40 Mb is on the X chromosome LD blocks can be segmented containing short internal regions in linkage equilibrium and show internal haplotype switching Strong LD does not result from a deficiency of recombining ability in these regions as their average cM Mb is similar to the genome wide average nor does it appear to derive from the common genetic origins of laboratory inbred mice as only 12 13 of unlinked genes show LD Rather a compression of genetic distances in LD regions compared to non LD regions among RI lines indicates that LD arises from convergent selection of co adapted sets of alleles at functionally related linked genes during the intense reproductive selection applied during inbred strain formation allied with the pressures of survival as homozygotes

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file14.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    hybridizing RNA from diverse mouse tissues to custom Agilent oligonucleotide microarrays designed to detect computationally predicted genes In the first approach expression of 42 000 XM genes NCBI predictions was analyzed in 55 different tissues Using a stringent threshold 21 575 genes were detected as expressed among these more than 5 000 are not present in current cDNA databases and more than 3 000 are not present in EST databases Among the 2 000 that were represented by an EST but not a cDNA a random sampling demonstrated that more than half could be amplified by RT PCR In virtually all cases we confirmed the tissue specificity observed on microarrays which can be used to predict function In the second approach we are using the program QRNA Rivas and Eddy 2001 which seeks regions of phylogenetically conserved secondary structure to predicting noncoding RNAs Using a pilot microarray to querying over 3 000 QRNA predictions across ten tissues we detected fifty candidate noncoding RNAs as expressed Thus far we have confirmed three of these by Northern analysis that are between 50 100 nucleotides long and expressed at levels similar to the spliceosomal RNAs but do not overtly appear to be members

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file15.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    A 2 Halder T 2 Kersten M 2 Horsch M 1 Drobyshev A 1 Lottspeich F 3 Hrabe de Angelis M 1 Beckers J 1 1 Institute of Experimental Genetics GSF National Research Centre for Environment and Health Neuherberg Germany 2 TopLab GmbH Proteomics Division Martinsried Germany 3 Max Planck Institute for Biochemistry Martinsried Germany A major advantage of the mouse model system lies in the increasingly complete information on its genome transcriptome and proteome as well as in the availability of a fast growing number of mutant and genetically engineered alleles However little is known about the relationship between the transcriptional and post transcriptional regulation of gene expression Data from comparative transcriptome and proteome analyses in the mouse as mammalian model organism is very limited We use DNA chip based RNA expression profiling and 2D gelelectrophoresis combined with mass spectrometry of mouse liver and kidney extracts to explore the general feasibility of such comprehensive gene expression analyses Whereas protein analyses mostly identify known metabolic enzymes and structural proteins in these tissues transcriptome analyses reveal the differential expression of functionally diverse genes and in addition a significant number of genes that are not functionally described The comparative analysis of proteins

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file16.shtml (2016-02-17)
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