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  • 18th International Mouse Genome Conference (2004)
    Shiroishi T 1 1 Mouse Functional Genomics Research Group RIKEN GSC Tsukuba Japan 2 2Population and Quantitative Genomics Team RIKEN GSC Yokohama Japan Recent studies have demonstrated that psychiatric diseases such as schizophrenia and bipolar disorder have some genetic basis In human populations however identification of genes underlying psychiatric disorders is still difficult because of polygenic inheritance and gene environment interactions Genetic studies using mouse models have great advantage for identification of molecular pathways of behavior In order to establish mouse mutants modeling symptoms of psychiatric disorders we have initiated dominant behavioral screening in RIKEN ENU mutagenesis project One of our focuses was increased locomotor activity in a novel and or familiar environment because hyperactivity in mice has been associated with behavioral symptoms of several human psychiatric disorders e g hyperactivity in attention deficit hyperactivity disorder ADHD and psychomotor agitation in schizophrenia and mania We have screened about 1 500 G1 animals DBA 2J x mutagenized C57BL 6J for home cage activity and 2 000 G1s for open field activity Thirty phenodeviants with hyperactivity home cage 8 open field 22 were detected and mated with DBA 2J for inheritance testing Heritability of the seven lines home cage 1 open field

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file230.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    States Akt also known as protein kinase B PKB belongs to a serine threonine kinase subfamily So far three main isoforms of Akt have been identified in mammalian cells Akt1 Akt2 and Akt3 encoded by 3 separate genes Studies have shown that Akt in cells is activated by diverse stimuli such as hormones growth factors and extracellular matrix components and is a downstream target for phosphoinositide 3 kinase PI3K It

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file231.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    resource designed to support the use of the mouse as a model system of hereditary and induced cancers The database was designed around the principle that genetic background is a key factor influencing the kinds and onset of cancers observed in different strains of genetically defined mice MTB provides cancer genetics researchers with access to data regarding various mouse models for cancer including such information as tumor names and classifications tumor incidence and latency data in different strains of mice tumor pathology reports and images information on genetic factors associated with tumors and tumor development and literature references MTB provides users with a powerful web base query interface that supports complex ad hoc queries For example users can query the database with questions such as Which transgenic strains of mice have a high incidence of lung adenocarcinomas or Show me tumor records where a point mutation was detected in Kras2 or What spontaneous tumors are found in the inbred strain A J The key to enabling these sorts of queries in MTB is the integration of mouse tumor data from many sources primarily the published literature and the use of standardized nomenclature and controlled vocabularies Terms for classifying tumors organ

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file232.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    CMGCC is a cross disciplinary multi Institutional program that falls under the auspices of the NIEHS Environmental Genome Project This program was initiated in 2001 with the goal of developing transgenic and knockout mouse models based on human DNA sequence variants in the environmentally responsive genes discovered under phase I of the EGP Ultimately these models will be used as tools to improve our understanding of the biological significance of human DNA polymorphisms and the role of such variation in environmentally related diseases Initially this program has focused on DNA polymorphisms that occur in DNA repair and cell cycle environmentally responsive genes The Consortium is accomplishing its goals through mouse model development technology development and resources developed by the Consortium To date the Consortium has over 32 mouse models under development and has developed through its bioinformatics team a Mouse Federated database containing three major components 1 mouse phenotypic assessment that allows for functional prediction of gene variants to model 2 collection and analysis of phenotypic data including gene expression data and 3 mouse model dissemination Through this database SNPs are analyzed for their functional impact using SNP location and Haplotype frequency data structural analysis and prediction literature mining and

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file233.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    vascular patterning noninvasively Recently developed high frequency ultrasound microimaging UBM is well suited for the study of this process because the vascular networks of eye are comparativley superficial and are in juxtaposition to the echolucent tissues of the vitreous and lens Flow is easily measured in the hyaloid artery HA vasa hyaloidea propria VHP and tunica vasculosa lentis TVL and retina In this study flow waveforms at all 4 locations were measured in normal CD 1 and LHbTAg retinoblastoma mice over the period from birth to 4 5 months Ultrasound imaging and Doppler were performed with a Vevo 660 VisualSonics Toronto mouse scanner Contrast enhanced MicroCT was used as a gold standard for vessel structure and was performed with an MS8 scanner EVS now General Electric London Ontario All imaging was performed under an approved animal protocol Observations of normal mice showed marked remodeling of the hyaloid vasculature over the first 16 days Peak flow velocities in the hyaloid artery dropped from 3 0 1 0 cm s to 0 between P0 and P13 while peak velocities in the VHP and TVL dropped from 1 25 25 cm s to 0 from P0 to P13 No flow or evidence of

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file234.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    B Justice MJ Baylor College of Medicine Houston United States The mouse is a powerful animal model for studying diseases and defects analogous to those in humans By using a three generation mutagenesis screen after treatment of male mice with N ethyl N nitrosourea ENU we isolate many strains of mutant mice 10 of which have craniofacial abnormalities Craniofacial phenotypes can be caused by perturbations of many developmental processes including neural crest cell migration osteoblast differentiation tooth and palate formation and nasal and eye morphogenesis To rapidly classify and prioritize these mutants we have developed a novel method for characterizing mouse craniofacial mutations Our protocol combines observation with Cyberware 3 dimensional surface laser scanning and imaging coupled with morphometric analysis and Euclidean Distance Matrix Analysis EDMA Further classification of mouse mutants includes radiograph studies pathology and skeleton preparation Of particular interest for our initial studies are mutant lines that demonstrate 1 a possible CAP Syndrome model with severe craniosynostosis as well as frontal and parietal foramina 2 a patterning defect with vertebral and clavicle abnormalities 3 asymmetric facial development and 4 complete transformation to a different facial shape We have tested software for morphometric analysis of our mouse mutants and

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file235.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    Davisson MT The Jackson Laboratory Bar Harbor United States Targeted mutation and transgenic mutant mouse models serve as invaluable research tools to study human disease Recent advances in mouse genome manipulation and the information generated by the human and mouse genome projects have led to increased development and use of induced mutant mouse models As the number of mutant mouse strains grows cooperative accessible resources for these research tools are needed The Induced Mutant Resource IMR at The Jackson Laboratory imports preserves and distributes mouse strains important for biomedical research The IMR serves as a resource through which researchers can provide their strains to the rest of the scientific community Cryopreservation of each IMR strain ensures protection of genetic integrity and its continued availability in the future An online database of curated strain information is maintained as a resource for researchers Mutant strain records in the IMR database include phenotype descriptions transgene or targeted mutation information strain development and maintenance procedures references and links to other relevant online resources Currently the IMR contains over 1000 accepted strains and adds approximately 5 6 strains each month Over 130 000 mice are distributed each year from the IMR Newly acquired strains include

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file249.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    AND REDUCING ANIMAL POPULATIONS THROUGH TECHNOLOGY Drummond A Ferreira A Ferreira J Auckland University Auckland Netherlands Improving disease research capability while reducing the number of laboratory animals used in testing and is not only possible the two aims are synergistic This paper evaluates how post genomic Information Technology supports more cost effective high quality wet lab research while reducing use of animals to manageable proportions The paper demonstrates how this

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file236.shtml (2016-02-17)
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