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  • 18th International Mouse Genome Conference (2004)
    SJ 3 Woodgett JR 1 1 Department of Medical Biophysics University of Toronto Toronto Canada 2 Department of Pathobiology University of Guelph Guelph Canada 3 Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Canada The Wnt signaling pathway results in the activation of beta catenin a transactivator that works with members of the Tcf LEF family of transcription factors to drive gene transcription Negative regulators of beta catenin are frequently mutated in human cancer resulting in inappropriate beta catenin activation and subsequent gene expression of various downstream targets including many oncogenes Activating mutations of beta catenin itself has also been found in a variety of human tumors Here we illustrate that a phosphomutant version typical of what is seen in human cancers can induce mammary tumor formation in mice The development of mammary tumors in our MMTV beta catenin phosphomutant S33 37 41 45A occurs at a higher frequency in multiparous females than in nulliparous mice suggesting hormonal influences are at play Considering that the background strain of mice FVB tend to develop prolactin secreting pituitary adenomas that induce lobuloalveolar development typically seen in pregnant females and that 92 of tumor bearing females exhibit moderate to extreme lactational

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file237.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    kyphosis and a rigid gait accompanied by a reduction in calpain 3 CAPN3 levels in skeletal muscle The mdm mutation is a small in frame deletion within the CAPN3 binding N2A domain of the titin gene We are using a genetic approach to test two alternate hypotheses regarding the role of CAPN3 in the mdm disease mechanism First transgenic overexpression of CAPN3 in mdm mice will test the hypothesis that

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file238.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    1 Wattler S 1 Nehls M 1 1 Ingenium Pharmaceuticals Martinsried Germany 2 Pieris Proteolab AG Freising Weihenstephan Germany Controlled breeding of animals for scientific research is a logistic challenge For Ingenium Pharmaceuticals which generates hundreds of genetic rodent lines using ENU mutagenesis and performs complex phenotyping on thousands of mice both for in house research and also for collaborations the efficient management of the animal facility is essential With GENcyclopedia Ingenium has developed an electronic platform that supports all the comprehensive aspects of animal management and scientific research By supporting the manifold requirements of the different departments and research groups including project management animal handling phenotyping and genotyping all data are tightly linked and controlled by an accurate rules engine As one example project management is supported by generation of phenotyping schedules resulting in daily work lists for animal facility tasks The execution is monitored by feedback loops All activities are controlled and monitored by the middle tier engine according to genetic administrative and animal welfare rules Reporting tools and pedigree viewer are further benefits In addition GENcyclopedia is central for tracking HTS mutation detection of Ingenium s successful INGENOtyping platform As a cutting edge multi tier J2EE system

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file239.shtml (2016-02-17)
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  • 18th International Mouse Genome Conference (2004)
    STRAINS GENE MAPPING AND DISSECTION OF COMPLEX TRAITS Fortin A Skamene E Emerillon Therapeutics Inc Montreal Canada The AcB BcA gene discovery platform is a series of 36 Recombinant Congenic Strains which were produced from the second backcross generation of the two progenitor mouse strains A J and C57BL 6J Each individual inbred RCS carries 12 5 of the donor genome in 87 5 of the background genome As the two parental inbred strains A J and C57BL 6J are known to vary in the expression of resistance and susceptibility to a considerable number of mouse models of important human diseases the AcB BcA RCS platform represents a valuable and versatile genetic tool to study many different phenotypes The AcB BcA RCS platform was used by our group and others to study a series of complex phenotypes including malaria infection lipid metabolism nociception and osteoporosis In each case the survey of the RC strain panel led to the identification of informative pheno deviant strains which exhibit a phenotype significantly different from the background progenitor These strains were selected for further gene identification studies including linkage mapping in secondary crosses and gene expression analyses in targeted organs The development of a

    Original URL path: http://www.imgs.org/Archive/abstracts/2004abstracts/abs/file240.shtml (2016-02-17)
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    Original URL path: http://www.imgs.org/Archive/abstracts/2004images/index_3.shtml (2016-02-17)
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    Original URL path: http://www.imgs.org/Archive/abstracts/2004images/pages/steve_at_piano_002.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    Multifactorial Trait Analysis Nutrition and Metabolic Disease Phenotyping Methods Imaging The Genetics and Genomics of Infectious Disease Verne Chapman Memorial Lecture Table of Contents Sponsor Exhibitor List Awards Photographs PLENARY PRESENTATION MONDAY 10 NOVEMBER 09 00 09 30 HRS NEW RESEARCH INITIATIVES AT THE JACKSON LABORATORY Richard P Woychik The Jackson Laboratory Co Authors Scientific Staff Institutions The Jackson Laboratory There has been remarkable progress over the past several years in using the mouse as a model for studying human biology and disease New protocols and technologies for mutagenesis have accelerated the pace of generating mutant lines with Mendelian traits in the mouse Additionally access to the human genome sequence the draft sequence of the mouse an increasing number of mapped SNP s and powerful new bioinformatics data bases and computational tools have vastly improved our ability to analyze complex traits in the mouse New initiatives at The Jackson Laboratory are focusing on improved gene localization and cloning of genes responsible for phenotypic deviation in mice These initiatives are built on the experience gained with the phenotyping of mice from our ENU mutagenesis programs and from the Phenome Project which compares specific phenotypes of mice from inbred strains We expect

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file2.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    Bioinformatics Multigenic and Multifactorial Trait Analysis Nutrition and Metabolic Disease Phenotyping Methods Imaging The Genetics and Genomics of Infectious Disease Verne Chapman Memorial Lecture Table of Contents Sponsor Exhibitor List Awards Photographs PLENARY PRESENTATION MONDAY 10 NOVEMBER 12 15 13 00 HRS FINE MAPPING QTL USING HETEROGENEOUS STOCKS Richard Mott The Wellcome Trust Centre for Human Genetics Co Authors Binnaz Yalcin Jan Fullerton Leah Solberg William Valdar Jonathan Flint Institutions Wellcome Trust Centre for Human Genetics The major challenge of complex trait analysis is to map QTL to regions small enough that only a few candidate genes should lie in the region in order to identify the genes associated with the trait F2 intercrosses although ideal for detecting QTL lack the required resolution However outbred mouse populations such as Heterogeneous Stocks HS that contain many resolvable historical recombinants have proved to be a very powerful tool for fine mapping Here we describe our progress towards identifying genes associated with fearfulness in an HS experiment We describe how to integrate ancient strain haplotype information into the statistical analysis in order to eliminate polymorphisms which are unlikely to be functional based on their allelic distribution between the inbred strains We also describe

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file3.shtml (2016-02-17)
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