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  • 17th International Mouse Genome Conference (2003)
    Med Co Authors 1 Olson L E 2 Baxter L L 3 Carlson E J 3 Epstein CJ Institutions 1 Johns Hopkins Schl Med 2 National Institutes of Health 3 Univ California Sna Francisco The mechanisms by which trisomy 21 causes specific traits of Down syndrome DS are unknown One qualitative hypothesis proposes that one or a few genes cause specific phenotypes of DS while the quantitative hypothesis asserts that defects occur due to small effects of many genes We evaluated cerebellar phenotypes of DS using mouse models The Ts65Dn mouse is trisomic for approximately 113 genes found on HSA21 complementary subsets of 89 and 23 of these genes are trisomic in Ts1Cje and Ms1Cje Ts65Dn mice respectively We calculated total cerebellar volume and cell densities of granule cells and Purkinje cells in Ts1Cje and Ms1Cje Ts65Dn mice and previously in Ts65Dn Baxter et al Hum Mol Genet 2000 Cerebellar volume was reduced to the same extent in Ts65Dn and Ts1Cje mice but not reduced in Ms1Cje Ts65Dn Granule cell density was equally affected in Ts1Cje and Ms1Cje Ts65Dn but to a lesser degree than in Ts65Dn Purkinje cell density is significantly reduced in Ts65Dn mice but unaffected in either

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file194.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    Finger J H Hayamizu T F Hill D P Smith C M Beal J S Corbani L E Blake J A Eppig JT Kadin J A Richardson J E Institutions The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA The Gene Expression Database GXD collects and integrates different types of gene expression data from the laboratory mouse and thus provides information about expression profiles of transcripts and proteins in different mouse strains and mutants Integration with the other Mouse Genome Informatics Databases enables a combined analysis of genotype sequence expression and phenotype data Participation in the Gene Ontology project provides standardized search terms to query for genes involved with specific molecular functions biological processes and cellular components Extensive interconnections with other databases place the expression information in the larger biological and analytical context During the last year we have increased the utility of GXD by refining query and display interfaces and by making new data available on a daily basis Further we have developed an extensive anatomical dictionary for the adult mouse that organizes anatomical structures spatially and functionally The dictionary will be used to describe expression data for the adult mouse and phenotype data pertinent to anatomy

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file196.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    N University of Cambridge Co Authors 2 Rozell B 3 Bard J B L 4 Sundberg J 5 Ward J 6 Hoefler H 6 Goessner W 6 Quintanilla Fend L 1 Gruenberg M 7 Delvenne P 7 Boniver J 1 Orpin J 8 Covelli V 8 Mancuso M T 9 Ward A 10 Engstrom W 11 Sariola H 12 Ellender M 13 Hopewell J Institutions 2 Karolinska Institute Stockholm 3 University of Edinburgh 4 The Jackson Laboratory 5 National Cancer Institute Frederick 6 GSF Forschungszentrum für Umwelt und Gesundheit Instituet fur Pathologie Neuherberg 7 Dept of Pathology University Hospital of Liege 8 ENEA Casaccia Italy 9 University of Bath 10 Biocentrum University of Uppsala 11 University of Helsinki 12 National Radiological Protection Board UK 13 Churchill Hospital Oxford The flood of descriptive phenotypic data currently emerging from gene and phenotype driven post genomic analysis of gene function is now considerable and is expected to rise dramatically in the next few years Consequently there is a need to archive primary phenotype data in a way in which it is searchable and usable in the most flexible and least hypothesis dependent manner possible Pathbase http www pathbase net addresses this problem for mouse histopathology a key aspect of phenotype analysis The database is designed with images as the data objects each provided with a wide range of meta data describing the experimental manipulation the genes and alleles involved the anatomical site of the lesion and its pathogenesis amongst other aspects The new release of Pathbase will be described in which key meta data are provided through use of a series of orthogonal ontologies shared with other databases for example GO EMAGE and GXD allowing for full database interoperability The new release of the database contains over 1000 images of mouse lesions and

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file197.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    DATA Selley R L Jones PJR Mary Lyon Centre Medical Research Council Co Authors 1 Brundrett A C 1 Jones JD 1 Oxspring R J 1 Seymour M 2 Olver G H 2 Chandrasekar K 1 Johnson R Institutions 1 Mary Lyon Centre Medical Research Council 2 Prion Unit Medical Research Council AnonyMus is a laboratory information management system that is being developed for deployment at the end of 2003 in the Mary Lyon Centre at MRC Harwell a new facility for functional genomics The system has been developed to ensure real time collection collation and dissemination of data generated in the facility The building is of an SPF health status with AnonyMus helping to maintain a paper free environment AnonyMus consists of a database on a commercial quality relational database management system Sybase ASE and a web enabled user front end being developed using JavaTM technologies The software is being designed to ensure stability efficiency accuracy and ease of use in an online environment where animal husbandry phenotyping and facility management data are accessible alongside UK Home Office licensing data AnonyMus is currently being further developed for deployment at the MRC Prion Unit This involves accommodation of new working

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file198.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    R GSF National Research Centre for Environment and Health Neuherberg Co Authors Schneltzer E Tiedemann H Soewarto D Pargent W Schäble K F Lengger C Wagner S Hrabe de Angelis M Institutions GSF National Research Centre for Environment and Health Neuherberg A new sample tracking system was developed for sample and workflow management in an ENU mouse mutagenesis screen As a component of the overall MouseNet system STS links the functionality of AMS animal management system and RDS result documentation system Based on extensive filtering and querying methods STS supports the managers of our animal facility to recompile data from the AMS into worklists for our primary screening schedules Additionally special work order requests defined by the screeners within the RDS are taken into account STS is complemented by functions for the maintenance of our archive of cryopreserved sperm and tissue samples At any stage in the workflow lists can be printed exported from the system as csv file or sended by email As long as a list is not in the archived status it can be processed in different ways For example additional animals can be loaded from a catalogue or parameter requests for the screening can be updated

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file199.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    Center for Genome Research Cambridge MA 02141 USA Co Authors Kulbokas E J Kirby A Karlsson E Lander E S Lindblad Toh K Daly M J Institutions Whitehead Institute MIT Center for Genome Research Cambridge MA 02141 USA While decades of phenotyping and detailed analysis of crosses of inbred mice have enabled the initial localization of hundreds of loci involved in complex disease and quantitative phenotypes very few genes have been conclusively identified from these studies A clear understanding of the origin and structure of genetic variation in these strains provides a key missing piece of this puzzle Recent analysis of polymorphism across the draft mouse genome sequence Wade et al 2002 has established that the genomes of commonly used inbred strains are mostly consistent with being mosaics of long segments 2Mb that are predominantly derived from either western European M m domesticus or Asian M m musculus ancestry A critical implication of this observation is that nearly all variation among these strains is comprised of ancestral differences between these highly diverged subspecies and can be easily tracked with a sparse map of SNPs given the observed size of the ancestral segments To fully realize the power of the genome

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file200.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    The Sanger Institute is responsible for the sequencing analysis and annotation of 25 of the mouse genome comprising chromosomes 2 4 11 and X As part of the UK MRC Mouse Sequencing Consortium regions of chromosome 2 WAGR and 4 brown deletion complex are sequenced by the HGMP and analyzed in collaboration with the MRC Edinburgh and a region of chromosome 13 Del36h sequenced at the Sanger Institute and analyzed

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file201.shtml (2016-02-17)
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  • 17th International Mouse Genome Conference (2003)
    AND DISTRIBUTION OF MOUSE RESOURCE BY RIKEN BIORESOURCE CENTER OVERVIEW OF ITS ACTIVITY AND FACILITIES Yoshiki A RIKEN BioResource Center Co Authors Nakata H Ike F Hiraiwa N Yoshida Noro C Kazuyuki M Keiji M Yuichi Obata Kazuo M Institutions RIKEN BioResource Center Since 2002 fiscal year Experimental Animal Division of RIKEN BRC has been selected as a core center for experimental animal mouse by National BioResource Project operated by the Ministry of Education Culture Sports Science and Technology MEXT Our goal is to facilitate scientific research on human being and contribute to the human welfare and basic biological science Based on the needs from scientific community our division focuses on the mouse as the most important resource The Materials Transfer Agreement was prepared both in Japanese and English for collection and distribution of the mouse strains 343 strains were newly added in 2002 from universities and research institutes in Japan Along with 320 mouse strains maintained in our center 663 strains have been collected and maintained These mice including inbred wild mouse derived mutant genetically engineered strains are useful model mouse for the study of cancer immunity and allergy endocrine disease brain and neurological disorder development and differentiation abnormality

    Original URL path: http://www.imgs.org/Archive/abstracts/2003abstracts/file202.shtml (2016-02-17)
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