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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    will see towards the bottom of the page a proof of concept study In this study pig islets were encapsulated in the cell in a box It was then implanted in diabetic mice I believe the study lasted 180 days and responded well producing insulin When cell in a box was removed the pig islets were alive and doing well There is also a link at the bottom of that

    Original URL path: http://islet.org/forum/messages/56126.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    days in a mouse is impressive even though every mouse protocol so far has proven useless in humans But maybe it is the stepping stone to large animal and human trials Am I right that the purpose of the box as opposed to the encapsulation is primarily to ensure that the cancer causing cells do not escape into the host s body I am assuming that the box plays no

    Original URL path: http://islet.org/forum/messages/56128.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    12 24 In Reply to Re Video on PharmaCyte Biotech s Diabetes Treatment Program posted by Al Gordon every mouse protocol so far has proven useless in humans Well I am just wondering when the scientists finally found a cure will this cure heal mouses as well What if it s not Follow Ups Re Video on PharmaCyte Biotech s Diabetes Treatment Program Al Gordon 09 20 03 2015 12

    Original URL path: http://islet.org/forum/messages/56130.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    I cannot say if a cure for autoimmune diabetes in humans will also be a cure for autoimmune diabetes in mice If so then veterinary medicine will be able to reduce suffering for their mouse patients But what I CAN say with certainty is that not one of hundreds of protocols that have prevented or cured diabetes in mice has worked on people Not one Mice have proven to be

    Original URL path: http://islet.org/forum/messages/56132.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    but they are clearly outlined in section 1 5 of the agreement filed with the SEC http www sec gov Archives edgar data 1157075 000101968714003893 nuvilex 10k ex1011 htm Specific to your question in 5 in vivo Pig testing is included and planned section 1 5 3 Now some of the animal studies have concluded with results published such as the tumorigenicity of the Melligen cells positive results The timeline in the original work plan would indicate that the pig testing is either ongoing now or should be very soon The main point here is that they did recognize the need and it is in their plan Here is a quick summary from the doc Reversal of diabetes in diabetic pig models GIPRdn INSC4rS 49 50 using encapsulated insulin producing cells This will be done in collaboration with the Ludwig Maximillian University Munich Capsules will be implanted into diabetic pigs by the researcher with the assistance of the Institute of Virology team at the University of Veterinary Medicine Vienna Follow up by monitoring of blood glucose levels and C peptide showing that insulin is produced levels throughout the study period will be done by the collaborator s team Periodically capsules will be explanted and the blood glucose and C peptide levels of animals after explantation of capsules will be monitored We expect diabetes symptoms to recur after removal of encapsulated cells Viability and insulin secretion of explanted capsules will also be analysed Due to the clear phenotype One thing worth pointing out for those not familiar with PharmaCyte Biotech or their encapsulation technology is that they are working on treatments for both diabetes and cancer They have already successfully utilized their encapsulation technology in phase 2 human pancreatic cancer trials with NO immunosuppressive issues reported I m sure that should

    Original URL path: http://islet.org/forum/messages/56124.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    on 10 29 15 2015 12 19 In Reply to Re Video on PharmaCyte Biotech s Diabetes Treatment Program posted by Tony Rutherford Hi Al My apologies my response was to your question 4 not 5 why not test on larger animals than mice Thanks Tony Follow Ups Re Video on PharmaCyte Biotech s Diabetes Treatment Program Al Gordon 20 31 12 2015 12 22 0 Post a Followup Name

    Original URL path: http://islet.org/forum/messages/56125.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    of encapsulated Melligen cells in Vienna Are the animals spontaneously diabetic In other words will autoimmunity be present in the animal model 2 My comment on pig islets was NOT referring to testing cells in a box in pigs but in using pig islet cells to restore normal glucose control to people with type one diabetes Finding an immunobarrier that will protect pig islets in humans has been the Holy

    Original URL path: http://islet.org/forum/messages/56127.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    birth without the use of diabetes inducing drugs If I find further information I will let you know 2 To be clear to the best of my knowledge although they have shown their CIAB encapsulation technology COULD successfully encapsulate pig islets this will not be the diabetes treatment Pharmacyte Biotech pursues Their plan is to encapsulate a human derived insulin producing cell line called Melligen Cells Some of their reasons for steering away from pig islets are centered on the viruses and subsequent diseases that could be spread upon pig cell transplantation into humans Virologists are wary of the associated risks inherent when transferring organs or cells from animals to humans Beyond virologists the FDA has also been leerie of approving animal transplantation into humans The problem comes down to being able to produce in mass quantities with little or no risk to recipients absolutely clean disease free specimens at least that s my take on it I guess there is also a world of potential stigmas attached to this including but not limited to religious beliefs Pharmacyte Biotech s stance is that the best solution would be a human based situation The Melligen cell line is human derived genetically engineered from human liver cells is easily stored reproducible 100 of the time meaning you always get the same thing and easily produced in bulk to supply the demand Melligen cells themselves have shown immunity to cytokines but not to larger components of the immune system and that s where the CIAB encapsulation mechanism comes into play CIAB are really small round beads with small pores The pores are sized so that things can get out insulin but small enough to keep cells from the immune system out Therefore encapsulation of the cells are protecting them from immune rejection CIAB

    Original URL path: http://islet.org/forum/messages/56129.htm (2016-04-29)
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