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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    The fear of spreading a porcine zoonotic epidemic in humans has proven to be baseless Already hundreds of humans have received pig islet transplants with zero cases of infection In the last century tens of thousands of Europeans received so called Live Cell Therapy LCT in which cells from sheep pigs rabbits goats and other non pathogen free animals were injected into humans to treat various conditions LCT was pure

    Original URL path: http://islet.org/forum/messages/56131.htm (2016-04-29)
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  • Re: Video on PharmaCyte Biotech's Diabetes Treatment Program
    now the only one s that could answer that are Pharmcyte Biotech personnel Regarding 2 I ll certainly defer to your expertise on whether the fears are baseless or not Regardless the important point in trying to get a treatment to millions is whether the regulatory agencies believe the issues baseless This is from a document on FDA gov and kinda goes to the sticky point of getting by the FDA scrutiny that will be there The potential risks of xenotransplantation in the targeted patient population must be considered in the overall regulatory decision making process for permitting the initiation of a first in human clinical trial These risks include but are not necessarily limited to 1 the transmission of known pathogens 2 the potential for introducing a new infectious disease into the general population 3 the potential for adverse inflammatory and immunological responses of the host to the product or its secreted proteins 4 the potential for rejection of the source animal cells tissues organs and any associated adverse effects 5 the risks of using immunosuppressive agents in an attempt to prolong the transplanted graft and 6 potential zoonotic risks to personal contacts and healthcare professionals My only other

    Original URL path: http://islet.org/forum/messages/56133.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    the 1990s Dr Anthony Sun at University of Toronto who had worked under Dr Charles Best in the early 1950s experimented with both MACRO and MICRO encapsulation of pig islet cells He and other leaders including Living Cell Technologies LCT in New Zealand found that the older MACRO method resulted in central necrosis in which cells not positioned right against the membrane died of oxygen starvation After that the leaders in the field switched to a droplet generator technology that produced capsules containing only a single islet cell Sun s MICRO encapsulated islets successfully reversed autoimmune diabetes in spontaneously diabetic cymologous monkeys for up to 4 years JDRF worked diligently to discredit Sun s work and refused to fund his research He was quite old at the time and returned to China So past leaders in the field were using MICRO encapsulation and alginate based material Maybe the PharmaCyte polymer does not cause central narcosis while retaining the immunoprotective qualities of alginate As for pig islets as opposed to cancer causing engineered cell lines there is ample evidence that SPF pig islets do NOT infect humans and they can be produced in unlimited quantities in cGMP facilities Neither of those

    Original URL path: http://islet.org/forum/messages/56135.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    to the capsules fibrosis and state of the encapsulated cells alive or necrotic insulin production I also know that necrosis was looked at diligently in some prior preclinical tests from 2010 The results for Melligen cells vs others looked promising at that time The advances in encapsulation technologies and techniques have been substantial since the 1990 s and even 2010 so I m cautiously optimistic in 2 regards 1 They know it is something that needs to be looked at and verified and 2 Encapsulated cells used for cancer non Melligen cells using the same encapsulation technology and techniques showed no signs of this to the best of my knowledge in humans Regarding cancer causing engineered cell lines It was a substantial concern It was also the first preclinical study conducted after all no sense going forward if that s an issue They have publicized those results and determined that the Melligen cell line is as safe as the cancer fighting cells which were already used in human pancreatic cancer clinical trials and will be used in further human trials Q1 2016 Hopefully that concern at least for Melligen cells goes the way of virus spreading concerns for pig islets

    Original URL path: http://islet.org/forum/messages/56136.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    In Reply to Re PharmaCyte Diabetes Treatment posted by Tony Rutherford Thanks for the great discussion guys It has been a long time since we have had anything promising to debate question discuss Happy New Year Follow Ups Post a

    Original URL path: http://islet.org/forum/messages/56140.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    know of no organization that throws better gala balls A few years ago they bragged about having raised over a billion dollars from hopeful donors yet could not name a single advance toward a cure for diabetes other than for thousands of lucky diabetes free mice in which they had any significant role I would love to be proven wrong Follow Ups Re PharmaCyte Diabetes Treatment Rene 04 29 33

    Original URL path: http://islet.org/forum/messages/56137.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    toll but T1 for 40 years has still not taken away all my health or hope o As I posted back in 2014 from cure funding research JDRF have 15 of their annual budget applied to cure research projects But only 3 is applied to Practical Cure projects http islet org forum messages 55904 htm Been posting here for close to 18 years and the cure appears still ever elusive

    Original URL path: http://islet.org/forum/messages/56146.htm (2016-04-29)
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  • Re: PharmaCyte Diabetes Treatment
    12 17 36 2015 12 31 In Reply to Re PharmaCyte Diabetes Treatment posted by Al Gordon Great discussion Who besides JDRF is known to provide funding to move diabetes technologies forward PharmaCyte s technology looks promising but likely could benefit from some funding Got any ideas Follow Ups Re PharmaCyte Diabetes Treatment Al Gordon 13 03 23 2015 12 31 0 Post a Followup Name E Mail Optional Subject

    Original URL path: http://islet.org/forum/messages/56141.htm (2016-04-29)
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