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  • Re: PharmaCyte Diabetes Treatment
    23 2015 12 31 In Reply to Re PharmaCyte Diabetes Treatment posted by Joe Foley Perhaps playing Diabetes Research Institute DRI in Miami off against JDRF might be a viable funding strategy Follow Ups Post a Followup Name E Mail

    Original URL path: http://islet.org/forum/messages/56142.htm (2016-04-29)
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  • insulin requirements were reduced 29%
    it has been configured incorrectly If page does not display on your browser please CLICK HERE Medscape Medscape Access In order to use Medscape your browser must be set to accept cookies delivered by the Medscape site Medscape uses cookies to customize the site based on the information we collect at registration The cookies contain no personally identifiable information and have no effect once you leave the Medscape site Click

    Original URL path: http://islet.org/forum/messages/56118.htm (2016-04-29)
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  • PharmaCyte Biotech Update
    has proven safety and longevity in human trials pancreatic cancer application for two years as well as animal studies It has the advantage of delivering insulin first to the liver in a more natural manner thereby reducing glucose excursions and minimizing associated tiny blood vessel damage that cause eye and kidney impairment Melligen cells can be readily grown in culture and hence are available in unlimited supply The PharmaCyte team

    Original URL path: http://islet.org/forum/messages/56111.htm (2016-04-29)
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  • T-reg intervention restores islet function?
    tg pullquote144846368799993 innerHTML Now researchers at the University of California and Yale have shown that the T regs can be removed from the body increased by 1 500x in the laboratory and infused back into the bloodstream to restore normal function An initial trial of 14 people has shown that the therapy is safe and can last up to a year This could be a game changer said Dr Jeffrey Bluestone Professor in Metabolism and Endocrinology at the University of California San Francisco UCSF By using T regs to re educate the immune system we may be able to really change the course of this disease We expect T regs to be an important part of diabetes therapy in the future Sufferes of type 1 and type 2 diabetes may have to inject insulin daily Photo Alamy Not only does the treatment stop the need for regular insulin injections but it prevents the disease progressing which could save sufferers from blindness and amputation in later life Diabetes is an autoimmune disease The immune system usually defends against infections but in Type 1 diabetes the process goes awry and as well as fighting foreign invaders it also targets the body s own cells In the new procedure doctors removed around two cups of blood containing around two to four million T reg cells from 14 patients aged between 18 and 43 who had been recently diagnosed with diabetes Their T reg cells were separated from other cells and replicated in a growth medium before being infused back into the blood Child psychologist Mary Rooney 39 who was diagnosed with type diabetes in 2011 was the first trial participant and said the therapy had freed her from the daily grind of injections Speaking of her diagnosis she said After weeks of losing weight always being thirsty having blurry vision that would come and go and generally feeling run down I knew something wasn t right Type 1 diabetes was the furthest from my mind though Initially I was in a state of shock I didn t realize that you could be diagnosed with Type 1 diabetes as an adult My first thoughts were This sucks and This can t possibly be happening but I knew I couldn t just stay in a state of denial and disappointment forever Miss Rooney who worked as a researcher at the University of California soon learned that the institution was looking for patients for the T reg trial and asked to be enrolled By being that first patient I knew I was taking a chance And I have to be honest I was scared she added But I liked the fact that this experimental treatment involved using my own regulatory T cells which would be expanded in a lab and then re infused The theory behind this study really made sense to me The T reg intervention frees people like me from the daily grind of insulin therapy and lifelong fear of complication The team say that T Reg treatments also hold promise as treatments for other autoimmune diseases such as rheumatoid arthritis and lupus and even as therapies for cardiovascular disease neurological diseases and obesity The research was published in the journal Science Translational Medicine h3 was h3 h3 was h4 h3 was h5 h5 fm chart title h3 was h6 prev p empty css margin top 20px mainBodyArea storylist li wrapInner function d s id var js fjs d getElementsByTagName s 0 if d getElementById id return js d createElement s js id id js src connect facebook net en US sdk js xfbml 1 version v2 3 appId 1516273521924556 fjs parentNode insertBefore js fjs document script facebook jssdk telegraphsciencetech Follow telegraph function d s id var js fjs d getElementsByTagName s 0 p http test d location http https if d getElementById id js d createElement s js id id js src p platform twitter com widgets js fjs parentNode insertBefore js fjs document script twitter wjs var optaTeamLinkingCallback function var teamMapping team 3 arsenal team 7 aston villa team 57 watford team 8 chelsea team 31 crystal palace team 11 everton team 45 norwich city team 13 leicester city team 14 liverpool team 43 manchester city team 1 manchester united team 4 newcastle united team 91 bournemouth team 20 southampton team 110 stoke city team 56 sunderland team 80 swansea city team 6 tottenham hotspur team 35 west bromwich albion team 21 west ham var rugbyTeamMapping team 800 argentina team 100 australia team 953 canada team 550 england team 954 fiji team 650 france team 2850 georgia team 600 ireland team 952 italy team 3000 japan team 2900 namibia team 850 newzealand team 951 romania team 950 samoa team 700 scotland team 900 southafrica team 750 tonga team 2800 uruguay team 2950 usa team 500 wales for var team in teamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport football teams teamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link for var team in rugbyTeamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport rugbyunion international rugbyTeamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link newGigyaShare display none important Top news galleries Star Wars The Force Awakens in pictures Culture Picture Galleries From BB 8 and Poe Dameron to Han Solo and Leia all the Force Awakens images released so far Comments SprayForParis graffiti In pics Paris street artists take to city walls and billboards to paint notes of defiance Black Friday the fashion team s picks The fashion team put their money on the most stylish bargains 40 optimistic quotes Culture Picture Galleries Cheer up Martin Chilton picks the best quotes about feeling positive Comments Pope Francis in Africa The pontiff will visit Kenya Uganda and the Central African Republic 10 contenders for Overseas Sports Personality The six person shortlist for the 2015 BBC Overseas Personality of the Year is revealed on Friday but who deserves to win Comments Pictures of the day Daredevils just hanging around an evil looking gull and an orangutan History of Macy s parade Black and white photos of Macy s 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articleTypeName tmglstory How we moderate telegraphuk var disqus title End of daily injections for diabetes as scientists restore insulin production var disqus identifier 12016532 var disqus developer 1 Please enable JavaScript to view the comments powered by Disqus blog comments powered by Disqus Telegraph on Facebook var optaTeamLinkingCallback function var teamMapping team 3 arsenal team 7 aston villa team 57 watford team 8 chelsea team 31 crystal palace team 11 everton team 45 norwich city team 13 leicester city team 14 liverpool team 43 manchester city team 1 manchester united team 4 newcastle united team 91 bournemouth team 20 southampton team 110 stoke city team 56 sunderland team 80 swansea city team 6 tottenham hotspur team 35 west bromwich albion team 21 west ham var rugbyTeamMapping team 800 argentina team 100 australia team 953 canada team 550 england team 954 fiji team 650 france team 2850 georgia team 600 ireland team 952 italy team 3000 japan team 2900 namibia team 850 newzealand team 951 romania team 950 samoa team 700 scotland team 900 southafrica team 750 tonga team 2800 uruguay team 2950 usa team 500 wales for var team in teamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport football teams teamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link for var team in rugbyTeamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport rugbyunion international rugbyTeamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link var optaTeamLinkingCallback function var teamMapping team 3 arsenal team 7 aston villa team 57 watford team 8 chelsea team 31 crystal palace team 11 everton team 45 norwich city team 13 leicester city team 14 liverpool team 43 manchester city team 1 manchester united team 4 newcastle united team 91 bournemouth team 20 southampton team 110 stoke city team 56 sunderland team 80 swansea city team 6 tottenham hotspur team 35 west bromwich albion team 21 west ham var rugbyTeamMapping team 800 argentina team 100 australia team 953 canada team 550 england team 954 fiji team 650 france team 2850 georgia team 600 ireland team 952 italy team 3000 japan team 2900 namibia team 850 newzealand team 951 romania team 950 samoa team 700 scotland team 900 southafrica team 750 tonga team 2800 uruguay team 2950 usa team 500 wales for var team in teamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport football teams teamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link for var team in rugbyTeamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport rugbyunion international rugbyTeamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link EPOCH time at the start of MPU Ad var mpuAdTimerStart Date now Advertisement document write tmgAdsBuildAdTag mpu 300x250 300x600 adj 2 Latest Video Donald Trump appears to mock disabled reporter Katie Hopkins Brunel University students stage mass walkout in protest against columnist Cameron sets out case for Syria airstrikes Black Friday inside an Amazon warehouse Aldi spoofs the John Lewis Xmas ad Sponsored by RSPCA Always here for animals RSPCA vet David Mills var optaTeamLinkingCallback function var teamMapping team 3 arsenal team 7 aston villa team 57 watford team 8 chelsea team 31 crystal palace team 11 everton team 45 norwich city team 13 leicester city team 14 liverpool team 43 manchester city team 1 manchester united team 4 newcastle united team 91 bournemouth team 20 southampton team 110 stoke city team 56 sunderland team 80 swansea city team 6 tottenham hotspur team 35 west bromwich albion team 21 west ham var rugbyTeamMapping team 800 argentina team 100 australia team 953 canada team 550 england team 954 fiji team 650 france team 2850 georgia team 600 ireland team 952 italy team 3000 japan team 2900 namibia team 850 newzealand team 951 romania team 950 samoa team 700 scotland team 900 southafrica team 750 tonga team 2800 uruguay team 2950 usa team 500 wales for var team in teamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport football teams teamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link for var team in rugbyTeamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport rugbyunion international rugbyTeamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link More from the web EPOCH time at the start of skyscraper Ad var startOfSkyscraper Date now Advertisement document write tmgAdsBuildAdTag hpg sks skl 300x600 120x600 160x600 adj 2 Advertisement document write tmgAdsBuildAdTag yell 300x150 adj 2 var optaTeamLinkingCallback function var teamMapping team 3 arsenal team 7 aston villa team 57 watford team 8 chelsea team 31 crystal palace team 11 everton team 45 norwich city team 13 leicester city team 14 liverpool team 43 manchester city team 1 manchester united team 4 newcastle united team 91 bournemouth team 20 southampton team 110 stoke city team 56 sunderland team 80 swansea city team 6 tottenham hotspur team 35 west bromwich albion team 21 west ham var rugbyTeamMapping team 800 argentina team 100 australia team 953 canada team 550 england team 954 fiji team 650 france team 2850 georgia team 600 ireland team 952 italy team 3000 japan team 2900 namibia team 850 newzealand team 951 romania team 950 samoa team 700 scotland team 900 southafrica team 750 tonga team 2800 uruguay team 2950 usa team 500 wales for var team in teamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport football teams teamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link for var team in rugbyTeamMapping fixtures dl matches dt match span team add standings container table tr team td team add fixtures plus table tr scoreline td team team name add fixtures plus table tr scoreline td team relative holder each function var textNode this contents filter function return this nodeType 3 last var link document createElement a var text document createTextNode textNode text link appendChild text link setAttribute class opta team linking link setAttribute href http www telegraph co uk sport rugbyunion international rugbyTeamMapping team link onclick function var menuSec opta meta name GSASectionUniqueName attr content cookie tmg navPos menuSec path domain telegraph co uk textNode replaceWith link More from the web Loading var puffs 11926370 new Array var thisLink http transferwise evyy net c 116303 191355 985 WT ac 11957188 puffs 11926370 push id 11957188 headline Shocked by hidden bank fees bodyText Send money abroad over 8x cheaper with TransferWise link thisLink imageUrl http i telegraph co uk multimedia archive 03470 SR Fish 3470351a jpg weight 3 var thisLink http transferwise evyy net c 116303 191355 985 WT ac 11957191 puffs 11926370 push

    Original URL path: http://islet.org/forum/messages/56101.htm (2016-04-29)
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  • Re: T-reg intervention restores islet function?
    My understanding has always been that islet cells once killed by autoimmunity cannot regenerate Therefore this intervention may only be of benefit to recently diagnosed type 1 diabetics For examples people with type 1 diabetes who have received a kidney transplant and are on massive doses of immune suppression the ultimate immune system down regulator do not show any return of islet cell function This particular patient was in her

    Original URL path: http://islet.org/forum/messages/56102.htm (2016-04-29)
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  • Re: T-reg intervention restores islet function?
    In Reply to Re T reg intervention restores islet function posted by Al Gordon Go read the paper The researchers do not claim any increase in C peptide decrease in HBA C or decrease in insulin use All they claim is safety A first step always The article is not accurate Curtis Lomax Follow Ups Re T reg intervention restores islet function Al Gordon 18 10 48 2015 12 01

    Original URL path: http://islet.org/forum/messages/56103.htm (2016-04-29)
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  • Re: T-reg intervention restores islet function?
    Bluestone Not only does the treatment stop the need for regular insulin injections but it prevents the disease progressing Child psychologist Mary Rooney 39 who was diagnosed with type diabetes in 2011 was the first trial participant and said the therapy had freed her from the daily grind of injections The T reg intervention frees people like me from the daily grind of insulin therapy and lifelong fear of complication

    Original URL path: http://islet.org/forum/messages/56104.htm (2016-04-29)
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  • Re: T-reg intervention restores islet function?
    in dose cohorts 1 and 2 Three of four subjects in cohort 3 and three of the four subjects in cohort 4 showed a decline in C peptide of more than 50 over 78 weeks of follow up Two of four subjects in co hort 4 also had a decline in C peptide of more than 50 over 52 weeks of follow up however the remaining two patients remained stable fromweek 13 to 52 weeks The heterogeneity of diabetes progression and the dependence of progression on age and on duration of diabetes do not allow us to draw a conclusion fromthese findings in a small number of subjects The HbA1c levels remained stable in all but one subject in cohort 4 007 103 whose levels went from 6 2 at screening to 12 6 at week 13 with the individual s C peptide diminishing from 0 49 at screening to 0 249 pmol ml at week 13 Insulin use was generally stable In sum mary there were too few subjects to make a clear statement about stabilization or decay in C peptide in treated subjects However wenotethat7of14patientshadaC peptide reduction of peptide predominantly in the lower dose group whereas 7 of

    Original URL path: http://islet.org/forum/messages/56106.htm (2016-04-29)
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