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  • Re: T-reg intervention restores islet function?
    14 In Reply to Re T reg intervention restores islet function posted by Andra Interesting So the Telegraph version was sensationalist crap as usual but to still have endogenous insulin production 5 years after diagnosis may be significant Al Follow

    Original URL path: http://islet.org/forum/messages/56121.htm (2016-04-29)
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  • INGAP is back ?
    the Integrated Health Social Services University Network for West Central Montreal and his collaborator Dr Aaron I Vinik Director of Research and Murray Waitzer Endowed Chair for Diabetes Research at the Eastern Virginia Medical School EVMS Dr Vinik and his colleagues identified the specific INGAP Peptide after Dr Rosenberg demonstrated islet regeneration can be induced and isolated the islet regeneration activity The study is jointly led by Dr Rosenberg and Dr George Tsoukas Senior Endocrinologist and Associate Professor of Medicine McGill University Health Centre The design of the study is based on previous trials of INGAP Peptide alone which demonstrated improvement in insulin secretion and glucose control in both type 1 and type 2 diabetes patients The addition of ustekinumab an interleukin 12 inhibitor is based on research by Dr Jerry Nadler Chair of Medicine and Vice Dean of Research at EVMS which showed the islet restoring effect of INGAP peptide was enhanced by the addition of another IL 12 inhibitor Diabetes Global public health crisis Diabetes is a life threatening condition that has become a global public health crisis Though less common than type 2 diabetes type 1 diabetes affects over 1 5 million people in North America and its prevalence is also growing Type 1 diabetes develops when the body s immune system destroys the beta cells within the pancreatic islets Beta cells make insulin the key hormone responsible for controlling blood sugar levels All people with type 1 diabetes require insulin therapy to survive People with type 2 diabetes have insulin resistance and insufficient insulin secretion which often can require insulin therapy as the disease progresses Poorly controlled diabetes can lead to serious complications including heart disease blindness kidney failure and death While many therapies have been approved for type 2 diabetes no treatment has been approved specifically for type 1 diabetes The higher risks of serious hypoglycemia and long term complications associated with type 1 diabetes which often begins in childhood reflect one of the highest unmet needs for an effective therapy among all chronic diseases I am very gratified that my institution is hosting this very important study said Dr Rosenberg My colleagues and I have invested our careers in demonstrating the potential for and means of restoring normal insulin secretion in people with diabetes Though our study is small we know that the return of significant insulin secretion in just one person with this combination could represent a major finding I feel privileged to be a part of this unique program said Dr Tsoukas So many of my patients would like to participate in this study I hope that this kind of treatment will become available to all my patients in the foreseeable future Landmark study This really is a landmark study said G Alexander Fleming MD founder and chairman Exsulin Corporation Most efforts at developing type 1 diabetes treatments have focused on controlling the autoimmune attack which by itself cannot restore insulin secretion A few therapies have been tested in humans for islet

    Original URL path: http://islet.org/forum/messages/56098.htm (2016-04-29)
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  • Re: INGAP is back ?
    by Therese B on 18 41 14 2015 12 02 In Reply to INGAP is back posted by Ellen Now there s a Blast from the Past Follow Ups Post a Followup Name E Mail Optional Subject Comments Link URL

    Original URL path: http://islet.org/forum/messages/56109.htm (2016-04-29)
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  • Biological scaffold inplanted on surface of the omentum
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protocol https https secure http edge quantserve com quant js elem async true elem type text javascript var scpt document getElementsByTagName script 0 scpt parentNode insertBefore elem scpt qevents push qacct p 38KriKc8Foyx labels newspaper Enterprise Feedback Management Survey Software x Life Florida dad lets 4 year old daughter give him tattoo WATCH LeBron James dresses as Prince for Halloween performs Purple 167 000 pounds of ground beef recalled over possible E coli Trick or treaters find needles inside Twix bars police say Scene Maker Palm Beach Gardens Michael Falk being honored at JCC gala Delrayâ s Cornell Museum unveils women defying expectations cmg query document ready function cm section ribbon ribbon Diabetes Research Institute Transplant procedure offers potential cure for type 1 diabetes 12 00 a m Monday Nov 2 2015 Filed in Life Comments 0 ï marimo emit writecapture8738932 ready marimo add widget wc compatibility mode false html NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE NEWLINE Corey Jones shooting Self assured cool nonchalance marked life NEWLINE NEWLINE NEWLINE Access to MyPalmBeachPost com included for Post subscribers NEWLINE Explore NEWLINE NEWLINE NEWLINE NEWLINE id writecapture8738932 widget prototype writecapture widget marimo emit writecapture51356533 ready marimo add widget wc compatibility mode false html NEWLINE NEED TO KNOW MORE NEWLINE NEWLINE Sign up for FREE Post e newsletters Travel News Golf and more Choose your favorites and we u2019ll deliver NEWLINE id writecapture51356533 widget prototype writecapture widget In September the Diabetes Research Institute DRI announced that the first patient in its clinical trial has been free from insulin injections in record time following the implantation of islet cells within a biological scaffold The patient Wendy Peacock 43 from San Antonio Tex underwent the minimally invasive procedure in mid August and is now producing her own insulin naturally for the first time since being diagnosed with type 1 diabetes at age 17 In this pilot study DRI researchers are testing a new transplant technique for insulin producing cells building upon decades of progress in clinical islet transplantation This trial is an important first step toward the development of the DRI BioHub a bioengineered mini organ that mimics the native pancreas to restore natural insulin production in people with type 1 diabetes â The first subject in our Phase I II pilot BioHub trial is now completely off insulin with an excellent glucose profile These are the best post transplant results weâ ve seen in an islet recipient â said Dr Camillo Ricordi director of the DRI â This was the first tissue engineered islet transplant using a â biodegradable scaffoldâ implanted on the surface of the omentum The technique has been designed to minimize the inflammatory reaction that is normally observed when islets are implanted in the liver or in other sites with immediate contact to the blood If these results can be confirmed this can be the beginning of a new era in islet transplantation Our ultimate goal is to include additional technologies to prevent the need for life long anti rejection therapy â The omentum is a highly vascularized tissue covering abdominal organs The donor islets were implanted within a biodegradable scaffold one of the platforms for a DRI BioHub made by combining the patientâ s own blood plasma with thrombin a commonly used clinical grade enzyme Together these substances create a gel like material that sticks to the omentum and holds the islets in place The omentum is then folded over around the biodegradable scaffold mixture Over time the body will absorb the gel leaving the islets intact while new blood vessels are formed to provide critical oxygen and other nutrients that support the cellsâ survival This pilot trial will include the immunosuppressive regimen currently used for clinical islet transplantation studies and will be limited to a small group of participants Peacock DRIâ s first BioHub trial patient is free from insulin in record time â As any type 1 knows you live on a very structured schedule â Peacock said â I do a mental checklist every day in my headâ glucose tabs food glucometer etc and then I stop and say â WOW I donâ t have to plan that anymore â Lying down at night and going to sleep and not having to worry about lows is something that is so foreign to me Itâ s surreal â Peacock a single mother of a son was a candidate for the DRIâ s clinical trial because she suffered with severe hypoglycemia unawareness a complication of diabetes in which patients are unable to sense that their blood glucose is dropping to dangerously low levels People with hypoglycemia unawareness often become disoriented lose consciousness or go into convulsions Sometimes the condition results in death â Weâ re quite excited This has been the best outcome we have seen at this stage Itâ s a unique site the surgery is very simple and the patient recovers very quickly We will continue until our final goal â islet transplantation without immunosuppression â said Dr Rodolfo Alejandro director of the DRI Clinical Cell Transplant Program In type 1 diabetes the insulin producing islets cells of the pancreas have been mistakenly destroyed by the immune system requiring patients to manage their blood sugar levels through a daily regimen of insulin therapy Islet transplantation has allowed some patients to live without the need for insulin injections after receiving a transplant of donor cells Some patients who have received islet transplants at the DRI have been insulin independent for more than a decade as DRI researchers have published Currently islet cells are infused into the

    Original URL path: http://islet.org/forum/messages/56092.htm (2016-04-29)
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  • Re: Biological scaffold inplanted on surface of the omentum
    studies I would love to be excited and optimistic but 1 it appears that islet cells are sourced from qualified dead donors meaning that only a handful of people with autoimmune type 1 diabetes will ever benefit from the procedure and 2 the procedure requires the same toxic immunosuppressive regimen that we have known for decades will protect transplanted islets but which has potential risks and adverse effects as bad

    Original URL path: http://islet.org/forum/messages/56093.htm (2016-04-29)
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  • Re: Biological scaffold inplanted on surface of the omentum
    game is to find a non immunosuppressive path This is a single step Finding a happy place for the islets would be a good thing This announcement seems to be to raise more money In criticism they ought to show us the entire plan Connect all the dots This is like hoping to build a car we have a chassis with comfortable seats all we need is for someone to

    Original URL path: http://islet.org/forum/messages/56096.htm (2016-04-29)
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  • Re: Biological scaffold inplanted on surface of the omentum
    to keep donor dollars flowing whether or not there is any real progress As long as dead tissue donors are the source of islets then only a handful of people with diabetes will ever benefit And as long as toxic immunosuppression is required the procedure will diminish one risk and replace it with a potentially greater risk This scaffold advances nothing as far as I can see other than possibly

    Original URL path: http://islet.org/forum/messages/56097.htm (2016-04-29)
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  • Nanotubes
    is more long term than the current technology but it s mechanical so looks like it could be very effective NASA Nanotube Mesh Follow Ups Re Nanotubes Al Gordon 16 22 25 2015 10 12 0 Post a Followup Name

    Original URL path: http://islet.org/forum/messages/56090.htm (2016-04-29)
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