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  • Re: BCG trials
    2015 09 20 In Reply to Re BCG trials posted by Al Gordon Al one of the patient pre qualifications in Dr Faustman s trial is detectable levels of insulin secretion from the pancreas It would be interesting to know the proportion of type I s who meet this criteria Follow Ups Re BCG trials Al Gordon 22 06 52 2015 09 20 0 Post a Followup Name E Mail

    Original URL path: http://islet.org/forum/messages/56075.htm (2016-04-29)
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  • Re: BCG trials
    Gordon on 22 06 52 2015 09 20 In Reply to Re BCG trials posted by Jeff Good point I would think that detectable levels of insulin secretion from the pancreas would preclude nearly everyone who has had type 1 diabetes for more than two years Al Follow Ups Re BCG trials Jeff 23 59 18 2015 09 20 0 Post a Followup Name E Mail Optional Subject Comments Link

    Original URL path: http://islet.org/forum/messages/56077.htm (2016-04-29)
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  • Re: BCG trials
    skeptical that any immunotherapy alone will stimulate insulin secretion Countless type I s including me have been treated with immunosuppressive drugs for other disorders and none that I m aware of have experienced stimulation of insulin production That being said I d try just about anything that has a chance at reducing my hypoglycemia Follow Ups Re BCG trials Al Gordon 14 05 00 2015 09 21 0 Re BCG

    Original URL path: http://islet.org/forum/messages/56078.htm (2016-04-29)
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  • Re: BCG trials
    21 In Reply to Re BCG trials posted by Jeff Thousands of people with type 1 diabetes have received kidney transplants with powerful immunosuppressive drug therapy to prevent rejection of the foreign organ tissue I do not believe that any have experienced recovery of insulin production strongly supporting the theory that dead islets stay dead forever and are not being continuously suppressed by autoimmunity Al Follow Ups Post a Followup

    Original URL path: http://islet.org/forum/messages/56080.htm (2016-04-29)
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  • Re: BCG trials
    Who Was Receiving Immunosuppressive Therapy Ann Intern Med 2003 139 81 Sorry for posting the title not the link but it is a bit hard to find the link and I do not know how to attach the article from my PC 2 It is easy for me to obtain BCG So I tried it No increase in C Peptide been using the standard testing not the highly sensitive one that Faustman used and also nasty side effects fever over 100F lasting for 7 days a nasty pus filled wound that refused to heal for 3 months And bare in mind that I worked together wit an MD that had 30 years of experience in administrating the BCG but the dosage was a bit high we thought that the higher the dose the stronger the immunological effects First dose was 16X standard vaccine dose the second one was 8 12X standard vaccine dose In the available literature it is common known that the above side effects tend to appear especially if the subject has been exposed before to BCG or TB So my opinion is that a repeated treatment need to be administrated in a different manner than the one

    Original URL path: http://islet.org/forum/messages/56079.htm (2016-04-29)
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  • Re: BCG trials
    to Re BCG trials posted by Gabriel Apparently Dr Faustman is modeling her protocol on the BCG trials for MS so perhaps there is publicly available information available on dosing concerning those trials An oral version of BCG is available but using that would seem to create more uncertainties when trying to determine the appropriate dose Follow Ups Re BCG trials Celsus 21 12 48 2015 09 21 0 Post

    Original URL path: http://islet.org/forum/messages/56081.htm (2016-04-29)
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  • Re: BCG trials
    patients It suggests that in patients who have recently developed type 1 diabetes immunosuppressive strategies might preserve some beta cell function 1 The letter by Kuroda and colleagues though just an anecdotal report and not a fully fledged study reported on the transplant of a pancreas into a type 1 diabetic in which some regrowth of beta cells in the native pancreas was produced but this would probably have been some combined effect of the restoration of normal glucose levels plus the effect of immunosuppression since it is not normally observed to that extent in other kinds of transplants 2 A recent study 3 of residual c peptide production in type 1 diabetics showed that it was significantly better in patients whose diabetes had been diagnosed after they were 18 than in those diagnosed at or before age 18 suggesting that in these latter cases the autoimmune attack on the beta cells was more severe The study also found the expected decline of c peptide production with increasing duration of the disease It measured both micro levels of c peptide output greater than or equal to 0 017 nmol L which might be too low to be significantly elevated by treatment and higher levels of residual c peptide output greater than or equal to 0 2 nmol L which would be more likely to respond to treatment The results were as follows Patients after 3 5 years of disease duration 7 of those diagnosed at 18 or younger had 0 2 nmol L of residual c peptide production and 36 of those diagnosed over 18 had that level of c peptide output Patients after 20 40 years of disease duration 0 diagnosed at 18 or younger had 0 2 nmol L of c peptide output and 7 diagnosed over 18

    Original URL path: http://islet.org/forum/messages/56082.htm (2016-04-29)
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  • Re: BCG trials
    carry out was to restore beta cell mass to produce insulin I was initially very interested and would still like to see it work but given the timeline it won t be in my lifetime if it does work Also when I had islet auto antibody testing done they were negative I have been diabetic almost 40 years now and I do still have a small amount of c peptide

    Original URL path: http://islet.org/forum/messages/56083.htm (2016-04-29)
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