archive-org.com » ORG » I » ISLET.ORG

Total: 491

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Re: BCG trials
    09 30 In Reply to Re BCG trials posted by gary So should I bring some BCG from back home Follow Ups Re BCG trials Al Gordon 08 12 06 2015 09 30 0 Post a Followup Name E Mail

    Original URL path: http://islet.org/forum/messages/56086.htm (2016-04-29)
    Open archived version from archive


  • Re: BCG trials
    08 12 06 2015 09 30 In Reply to Re BCG trials posted by Andra Where is back home But no I don t believe the case for BCG restoring even partial glycemic control is yet very compelling But I would love to eat those words Al Follow Ups Re BCG trials Neale Povey 23 57 02 2015 12 12 0 Post a Followup Name E Mail Optional Subject Comments

    Original URL path: http://islet.org/forum/messages/56087.htm (2016-04-29)
    Open archived version from archive

  • Re: BCG trials
    BCG trials posted by Al Gordon I have found from the Faustman reports the dose concentration of 1 6 3 2 10 6 colony forming units injection Also the BCG was prepared at TheraCys Sanofi Pasteur Toronto Ontario Canada Also evidence that the cell line linage has a marked effect on the success of the treatment Any help on domestic sources for the BCG would be of much help Follow

    Original URL path: http://islet.org/forum/messages/56119.htm (2016-04-29)
    Open archived version from archive

  • Barrier vs. Genetically Neutral Islets - How About
    them disposable wherein they are infused and produce insulin for a timespan The patient continues monitoring for that time period hopefully measured in years instead of months and when glucose levels start rising it s time for a reload I haven t found any information on how long islets last when exposed to an immune response so this might not be feasible if we re only talking weeks or months

    Original URL path: http://islet.org/forum/messages/56053.htm (2016-04-29)
    Open archived version from archive

  • Re: Barrier vs. Genetically Neutral Islets - How About
    disposable islets may be quite leisurely and mean that reloads may not have to be very frequent Since blood glucose control can be maintained with only 10 of the normal complement of islets then giving a patient say 20 30 of a normal complement may provide many months or even years of normal glycemic control until autoimmunity erodes the level to the point where the disease is again manifest and

    Original URL path: http://islet.org/forum/messages/56055.htm (2016-04-29)
    Open archived version from archive

  • Re: Barrier vs. Genetically Neutral Islets - How About
    even has to be removed though if the autoimmunity is satisfied that the tissue is completely dead the kidney can be safely left in place Also the alteration of the immune system over time in forever re rejecting foreign beta cells would have unfortunate consequences for its response to future infections Perhaps a better alternative approach would be to try to recreate in all type 1 diabetics the rare ability of some type 1 patients to avoid complications no matter how high their blood sugar runs or how long this hyperglycemia persists This would allow patients to take just a basic dose of insulin to support metabolism avoid ketoacidosis and prevent hyperosmolar coma but not strictly to attempt to normalize blood sugar level with all the dangers and difficulties of that approach A recent study of type 1 diabetics who have survived more than 50 years with their disease revealed two subgroups of patients those with severe complications who were found to have defective DNA repair mechanisms to protect against cellular damage and those with only very mild or entirely absent complications who were found to have excellent DNA repair mechanisms defending them against cellular damage This led the authors

    Original URL path: http://islet.org/forum/messages/56054.htm (2016-04-29)
    Open archived version from archive

  • Re: Barrier vs. Genetically Neutral Islets - How About
    over a decade or more other than the disease itself There do not appear to my knowledge to be any other adverse outcomes associated with the autoimmunity itself Or am I missing something Yes finding an intervention to prevent complications is an excellent approach A person s health with type 1 diabetes seems to much more related to genes that to the quality of control and lifestyle If an intervention

    Original URL path: http://islet.org/forum/messages/56056.htm (2016-04-29)
    Open archived version from archive

  • Re: Barrier vs. Genetically Neutral Islets - How About
    with poorly matched solid organ transplants unprotected by immunosuppression can leave patients profoundly sick with chills fever nausea and vomiting and it constitutes a genuine medical emergency Even if symptomless the rejection process involves an inflammatory process with cytokine release which is not healthy for the body and with each successive implantation of beta cells the host alloimmune system would be increasingly primed with antibodies to foreign beta cells so

    Original URL path: http://islet.org/forum/messages/56057.htm (2016-04-29)
    Open archived version from archive



  •