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  • Re: Barrier vs. Genetically Neutral Islets - How About
    on 09 42 16 2015 09 14 In Reply to Re Barrier vs Genetically Neutral Islets How About posted by Celsus Is this a theoretical unquantified risk or has it ever been demonstrated What source of islets are you basing the risk assessment on xeno or allo Al Follow Ups Re Barrier vs Genetically Neutral Islets How About Celsus 12 12 13 2015 09 15 0 Post a Followup Name

    Original URL path: http://islet.org/forum/messages/56058.htm (2016-04-29)
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  • Re: Barrier vs. Genetically Neutral Islets - How About
    out in the initial post would become almost immediately ineffective Allografts from other humans would still be foreign tissue unless the source was an identical twin and though they would elicit a less dramatic rejection than xenografts if unprotected by immunosuppression or immunological barriers they would also be quickly destroyed All immunological rejection involves the creation of a state of inflammation in the body which is well known to promote

    Original URL path: http://islet.org/forum/messages/56059.htm (2016-04-29)
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  • Re: Barrier vs. Genetically Neutral Islets - How About
    15 In Reply to Re Barrier vs Genetically Neutral Islets How About posted by Celsus I ll take that as a non answer Al Follow Ups Re Barrier vs Genetically Neutral Islets How About Celsus 09 30 02 2015 09

    Original URL path: http://islet.org/forum/messages/56060.htm (2016-04-29)
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  • Re: Barrier vs. Genetically Neutral Islets - How About
    2 Nor is it an undemonstrated theoretical issue that the inflammatory response to foreign tissue has a systemic inflammatory effect on the entire body 3 Nor is it an undemonstrated theoretical issue that inflammation has the damaging effects I specified though so many organs are damaged by inflammation that only selected examples can be supported by citations here 3 Every implantation of new allografts unprotected by immunological barriers or immunosuppression would induce rejection Every implantation of new xenografts unprotected by immunological barriers or enormously toxic levels of immunosuppression would induce hyperacute rejection Every implantation of new islet allografts after the host s immune system had been presensitized to assemble preformed antibodies to foreign islet tissue would in the absence of immunological barriers be increasingly attacked by the host immune system this is analogous to the reasons for having negative cross matching prior to transplant and for the increased immunological challenges of transplant following pregnancy blood transfusion and prior transplants So constantly re stimulating the immune system and its attendant inflammatory effects through repeated re implantation of unprotected allograft beta cells would not be healthy 1 X Jiang et al Macrophages in Solid Organ Transplantation Vascular Cell vol 6 n 5 2014 S Bulfone Paus and R Rahri Mast Cells as Regulators of T Cell Response Frontiers in Immunology 7 August 2015 M Betjes Clinical Consequences of Circulating CD28 Negative T Cells for Solid Organ Transplantation Transplant International 18 August 2015 2 X Chen et al TIGIT Negatively Regulates Inflammation by Altering Macrophage Phenotype Immunology 17 August 2015 3 J Lopez Gomez et al Presence of Failed Kidney Transplant in Patients Who Are on Hemodialysis is Associated with Chronic Inflammatory State and Erythropoietin Resistance Journal of the American Society of Nephrology 1 September 2004 vol 15 no 9 2494 2501 4

    Original URL path: http://islet.org/forum/messages/56061.htm (2016-04-29)
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  • Re: Barrier vs. Genetically Neutral Islets - How About
    re stimulating the immune system and its attendant inflammatory effects through repeated re implantation of unprotected allograft beta cells would not be healthy And how not healthy is type 1 diabetes Which not healthy is preferable the slow autoimmune response against allograft islets never before implicated in any adverse effects beyond the obvious or the ravages of the resultant disease sadly implicated in a well known litany of horrors Al

    Original URL path: http://islet.org/forum/messages/56062.htm (2016-04-29)
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  • Re: Barrier vs. Genetically Neutral Islets - How About
    by immunosuppression or an immunological barrier they would be very quickly rejected and would even suffer hyperacute rejection if they were xenografts so they would have to be replaced in days Since the immunological barrier to transplantation was first hypothesized by Ernst Unger in 1910 and first clearly demonstrated by Peter Medawar working on skin grafts at Oxford during the Second World War the only examples of transplants without immunosuppression available are from the very early twentieth century and in those cases the renal grafts usually attached to a vein and artery in the recipient s arm only lasted a few days and functioned only very slightly or not at all In the approach proposed now each replacement of the beta cells would intensify the immune response since the immune system would have been primed to attack by the prior beta cell rejections and this would result in an accelerating harm to the patient s health from inflammation as well as an accelerated disappearance of any health giving benefits from the beta cells That said there are experiments now ongoing to determine how transplants might be effected without immunosuppressive drugs since these drugs are themselves toxic to both the patient

    Original URL path: http://islet.org/forum/messages/56068.htm (2016-04-29)
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  • Inplant device cell transplant
    testing Living with diabetes Managing diabetes Driving and diabetes Benefits Employment Travel Exercise and fitness Sport BMI Weight loss Pregnancy Sex Medication Insulin Insulin pumps Treatment Complications Embarassing conditions Diabetes and the body Illness Emotions Diabetes research Diabetes education Diabetes and the NHS Food and drink Diet guides Drinks Food groups Food ideas Nutrition Tools and calculators Family and relationships Parenting Children with diabetes Teens with diabetes Real life stories South Asians Celebrities with diabetes Pets and diabetes Diabetes charities Diabetes directory Events Book reviews Product reviews Diabetes news Diabetes blog Diabetes newsletter Join the Diabetes Forum Join 161 517 people in the Diabetes Forum Home Diabetes News Type 1 diabetes trial patient insulin free after treatment Thu 10 Sep 2015 Kurt Wood Tweet function d s id var js fjs d getElementsByTagName s 0 if d getElementById id js d createElement s js id id js src platform twitter com widgets js fjs parentNode insertBefore js fjs document script twitter wjs Type 1 diabetes trial patient insulin free after treatment Related News Gene therapy could stop the immune system attacking the pancreas 07 September 2015 Google Life Sciences and Sanofi collaborate in fight against diabetes 04 September 2015 Researchers develop blood test to detect pancreatic cancer early 01 September 2015 Obesity gene discovery could lead to cure 25 August 2015 scads window scads push z 5909 targetId switch placeholder 3732e6bcb482b77d6e2121e7a462565a domain delivery platform switchads com width 300 height 250 A new type 1 diabetes trial has left one participant completely insulin free The trial conducted by the Diabetes Research Institute DRI at the University of Miami involved the implantation of islet cells within a biological scaffold Wendy Peacock 43 underwent the procedure on August 18 2015 For the first time since being diagnosed with type 1 diabetes at 17 Wendy can now naturally produce her own insulin How does the islet cell trial work Building on previous islet cell transplant research the trial is working towards the development of a mini organ that mimic the function of a healthy pancreas This organ known as the DRI BioHub allows people with type 1 diabetes to produce their own insulin The first subject in our Phase I II pilot BioHub trial is now completely off insulin with an excellent glucose profile said Camillo Ricordi MD director of the DRI These are the best post transplant results we ve seen in an islet recipient This was the first tissue engineered islet transplant using a biodegradable scaffold implanted on the surface of the omentum The technique has been designed to minimise the inflammatory reaction that is normally observed when islets are implanted in the liver or in other sites with immediate contact to the blood Islet cell transplants and immunosuppressant therapy Currently people with type 1 diabetes who benefit from islet cell transplantation need to take immunosuppressant drugs to stop the immune system attacking the new functional islet cells too Immunosuppressant drugs while useful in this respect also prevent the immune system from

    Original URL path: http://islet.org/forum/messages/56052.htm (2016-04-29)
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  • BG meters to be given away
    on 11 44 57 2015 07 19 If of help to anyone have a couple of oldish meters to give away All in impeccable conditions They are 2 units of Roche Accu Check Mobile mg dL scale 1 unit of Roche Accu Check Compact Plus mg dL scale Follow Ups None left All shipped out Rene 16 21 54 2015 08 03 0 Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/56045.htm (2016-04-29)
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