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  • They need to collaborate with LCT?
    functional cure You know they really wouldn t feel anymore being diabetic if they got a transplant with those kind of cells To get to this point has required fifteen years of work on the part of Melton and about fifty other colleagues testing out 70 different chemical compounds in 150 different combinations to figure out exactly how to instruct a stem cell to become a beta cell He described the work as empirical science not discovery science in that in the former you are â committed to finding the answer to something and try all different methods to achieve itâ It wasnâ t any great intellectual insight I didnâ t get an idea in the shower It was strategic systematic hard work over a long period of time â He called the work a personal quest that began about twenty years ago when his six month old son was diagnosed with type 1 diabetes His daughter was diagnosed several years later at age 14 â Since that time I have done what any parent would doâ which is to say Iâ m not going to put up with this I want to find a better way â Melton described his childrenâ s calm reaction when he told them he had succeeded in creating a renewable supply of beta cells â I think like all kids they always assumed that if I said Iâ d do this Iâ d do it â Doug Melton Melton is not the first researcher to create a functioning beta cell in the lab What separates this work is the road map it provides for creating a potentially unlimited supply of beta cells which could be used both to implant into people who now need to take insulin those with type 1 diabetes and 10 15 percent of people with type 2 or to discover new drugs that could help preserve or regenerate beta cells A typical person has about a billion beta cells though only about a sixth of those or 150 million are needed to maintain insulin production At any one time Meltonâ s lab has 6 10 â spinner flasksâ whirling cells within a liquid mediumâ each flask with enough beta cells for one patient Using cells from cadavers some patients already have benefitted from beta cell transplantation which frees them from injecting insulin for five years or more by providing them with an infusion of cells that secrete their own insulin But the supply of these cadaver cells is extremely limited Just 40 50 people a year receive such transplants in the United States according to Albert Hwa PhD  the director of discovery research at JDRF JDRF and the Helmsley Charitable Trust are two of the organizations that have supported Meltonâ s research  These recipients must all use strong immunosuppressive drugs so their bodies donâ t reject the foreign beta cells Meltonâ s beta cell process could potentially make transplantation accessible to many more people with diabetes Yet for

    Original URL path: http://islet.org/forum/messages/55934.htm (2016-04-29)
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  • Metanx
    with this product It is a vitamin based capsule The bottle calls it a medical food My Neurologist thinks it is a miracle product I am not so sure so I wanted to see if anyone might have any experience or knowledge about it The Neuro says it will help with neupoathy and blood flow Follow Ups Re Metanx Curt Lomax 12 46 51 2014 10 06 0 Post a

    Original URL path: http://islet.org/forum/messages/55929.htm (2016-04-29)
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  • Re: Metanx
    research to support the claims Being a Food and not a drug they have freedom to associate it with anything So buyer be ware Metanx is a medical food made by Pamlab that contains L methylfolate as Metafolin a calcium salt of vitamin B9 methylcobalamin vitamin B12 and pyridoxal 5 phosphate vitamin B6 It is a vitamin B supplement Metanx contains the following active ingredients per capsule L methylfolate Metafolin

    Original URL path: http://islet.org/forum/messages/55930.htm (2016-04-29)
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  • Re: Metanx
    00 2015 05 17 In Reply to Re Metanx posted by Curt Lomax I have been taking Metanx for 2 5 years and am able to get by without any other neuropathy medication I have well controlled type 2 diabetes with A1c less than 7 I buy it direct from their pharmacy for 178 00 for a 90 day supply Follow Ups Post a Followup Name E Mail Optional Subject

    Original URL path: http://islet.org/forum/messages/56015.htm (2016-04-29)
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  • Clinical Trial Test Safety of Stem Cell Therapy for T1
    Newsletter Contact Us 858 657 7000 Send us an Email function var cx 001701851778483742853 jlf2ab7qrli var gcse document createElement script gcse type text javascript gcse async true gcse src document location protocol https https http www google com cse cse js cx cx var s document getElementsByTagName script 0 s parentNode insertBefore gcse s Home Newsroom Releases Clinical Trial To Test Safety of Stem Cell Derived Therapy for Type 1 Diabetes Share News Archived Press Releases UC San Diego Health System In The News News Features Contacts for Journalists Media Guidelines Subscribe to Newsletter RSS Feed Patient Care Hospital Clinic Locations Find a Doctor Medical Services MyUCSDChart Login Clinical Trials Refer a Patient Education Training School of Medicine Departments Admissions Skaggs School of Pharmacy Continuing Medical Education Research Overview Clinical Translational Research Institute Research Labs Giving About Us Careers Volunteering News Quick Links Locations Careers Nursing Volunteer Giving MyUCSDChart Login Translate function googleTranslateElementInit new google translate TranslateElement pageLanguage en layout google translate TranslateElement InlineLayout SIMPLE google translate element News Release Date September 09 2014 Clinical Trial To Test Safety of Stem Cell Derived Therapy for Type 1 Diabetes UC San Diego is initial site for first in human testing of implanted cell therapy Researchers at the University of California San Diego School of Medicine in partnership with ViaCyte Inc a San Diego based biotechnology firm specializing in regenerative medicine have launched the first ever human Phase I II clinical trial of a stem cell derived therapy for patients with Type 1 diabetes The trial will assess the safety and efficacy of a new investigational drug called VC 01 which was recently approved for testing by the U S Food and Drug Administration The 2 year trial will involve four to six testing sites the first being at UC San Diego and will recruit approximately 40 study participants â The goal first and foremost of this unprecedented human trial is to evaluate the safety tolerability and efficacy of various doses of VC 01 among patients with type 1 diabetes mellitus â said principal investigator Robert R Henry MD professor of medicine in the Division of Endocrinology and Metabolism at UC San Diego and chief of the Section of Endocrinology Metabolism Diabetes at the Veterans Affairs San Diego Healthcare System â We will be implanting specially encapsulated stem cell derived cells under the skin of patients where itâ s believed they will mature into pancreatic beta cells able to produce a continuous supply of needed insulin Previous tests in animals showed promising results We now need to determine that this approach is safe in people â Development and testing of VC 01 is funded in part by the California Institute for Regenerative Medicine the stateâ s stem cell agency the UC San Diego Sanford Stem Cell Clinical Center and JDRF the leading research and advocacy organization funding type 1 diabetes research Type 1 diabetes mellitus is a life threatening chronic condition in which the pancreas produces little or no insulin a hormone

    Original URL path: http://islet.org/forum/messages/55926.htm (2016-04-29)
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  • Re: Clinical Trial Test Safety of Stem Cell Therapy for T1
    07 2014 09 23 In Reply to Clinical Trial Test Safety of Stem Cell Therapy for T1 posted by DanT Sound like an exciting study because the technology holds the promise of a cure and because they can build on their experiences in contrast to traditional medicine that either fail or succeed in treating only the symptoms Does anyone know what type of encapsulation technique is being used Follow Ups

    Original URL path: http://islet.org/forum/messages/55928.htm (2016-04-29)
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  • New discovery
    09 08 Diabetes and multiple sclerosis can be reversed say scientists Diabetes and multiple sclerosis can be reversed say scientis Follow Ups Re New discovery Jay 23 41 08 2014 09 08 0 Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/55922.htm (2016-04-29)
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  • Re: New discovery
    Reply to New discovery posted by Karim Here s the actual study http www nature com ncomms 2014 140903 ncomms5741 full ncomms5741 html Follow Ups Info on TG4 Mouse Curt Lomax 12 26 25 2014 09 09 0 Post a

    Original URL path: http://islet.org/forum/messages/55923.htm (2016-04-29)
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