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  • Hyperion terminates DiaPep277 program, finds misconduct by Andro
    to improperly receive un blinded DIA AID 1 trial data and to use such data in order to manipulate the analyses to obtain a favorable result Additional evidence indicates that the biostatistics firm and certain Andromeda employees continued the improper practice of sharing and examining un blinded data from the ongoing DIA AID 2 trial All of these acts were concealed from Hyperion and others The company has suspended the

    Original URL path: http://islet.org/forum/messages/55920.htm (2016-04-29)
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  • Diamyd Technology Cures Type 1 Diabetes in Mice
    googletag cmd push function googletag display div gpt ad 1364861669187 0 Secondary menu Skip to primary content Skip to secondary content Search Subscribe About Us Contributors Contact Links A Sweet Life Diabetes Magazine Home Features Diabetes Type 1 Diabetes Type 2 Diabetes Type 2 Diabetes Treatments Gestational Diabetes Tips Recipes Blogs News Books Stay Connected A Sweet Life News Diamyd Licensed Technology Cures Type 1 Diabetes in Mice Diamyd Licensed Technology Cures Type 1 Diabetes in Mice September 02 2014 Category Research Type 1 Tags Diamyd UCLA var switchTo5x false stLight options publisher 54e9f292 e11e 4ff3 b873 b0843f1543f8 Researchers at UCLA have confirmed earlier findings that combinations of GABA and Antigen Based Therapy ABT works synergistically as a treatment in the NOD mouse model of type 1 diabetes Diamyd Medical is the exclusive licensee for the commercialization of UCLA s GABA technology for metabolic diseases including in diabetes GABA stands for gamma amino butyric acid and is produced in the body as glutamate is decarboxylased by the GAD enzyme GABA is an important suppressive and â calmingâ neurotransmitter Recent pre clinical findings support the use of GABA as a synergistic component for treatment of autoimmune diabetes and beta cell regeneration as well as for controlling inflammation such as in rheumatoid arthritis metabolic syndrome and type 2 diabetes  A recent paper Tian Dang Kaufman et al Diabetes 2014 63 3128â 3134 reports that newly diabetic NOD mice have successfully been treated and some even cured using a combination regimen consisting of GABA and Antigen Based Therapy ABT The ABT used in the study was pro insulin formulated in alum while similar results were obtained with GAD65 in alum as the ABT in a previous paper using an islet transplantation NOD model Tian Dang Kaufman PLoS One 2011 6 e25337 GAD65 is the active substance in Diamyd the Companyâ s ABT which is currently being tested in children for the treatment and prevention of type 1 diabetes The findings provide proof of principle that combining ABT with an anti inflammatory agent such as GABA can effectively restore normoglycemia in newly diabetic mice The therapy is reported to preserve insulin producing cells as well as to promote their replication It is concluded in the new paper that the use of GABA in combination with an ABT may hold promise for type 1 diabetes intervention in humans A group at the University of Alabama Birmingham in collaboration with Diamyd Medical is planning a randomized double blind placebo controlled clinical study with the combination GABA and Diamyd as ABT in patients with new onset type 1 diabetes Discussions with the FDA regarding the study design are ongoing  var switchTo5x false stLight options publisher 54e9f292 e11e 4ff3 b873 b0843f1543f8 Related News Diamyd US Phase III Study In Progress Diamyd Medical announced it has completed the screening of patients for the US Phase Read more Diamyd and Ortho McNeil Janssen Pharmaceuticals Agreement Receives Antitrust Clearance Diamyd Medical AB announced it has received antitrust clearance that

    Original URL path: http://islet.org/forum/messages/55919.htm (2016-04-29)
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  • Tumour marker CA19.9 with value of 60.4 U/mL
    daughter has type I for 8 years and recently went for testing tumour marker CA 19 9 which is a marker of pancreatic cancer Her value is 60 4 U mL 94 of healthy persons have values under 37 I read articles saying diabetic patients normally have higher CA19 9 values Anyone has experience to share Thanks Follow Ups Re Tumour marker CA19 9 with value of 60 4 U

    Original URL path: http://islet.org/forum/messages/55914.htm (2016-04-29)
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  • Re: Tumour marker CA19.9 with value of 60.4 U/mL
    can be raised even just in the presence of gall stones or diabetes The maximum normal value is usually taken as 37 U ml though in diabetics with elevated HbA1c values such as often occur during the hormonal changes and growth periods of youth it can range up to around 80 U ml Since it is not a precise indicator of what is wrong it is more usually taken as

    Original URL path: http://islet.org/forum/messages/55915.htm (2016-04-29)
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  • Re: Tumour marker CA19.9 with value of 60.4 U/mL
    Posted by Dennis on 08 38 46 2014 08 28 In Reply to Re Tumour marker CA19 9 with value of 60 4 U mL posted by Celsus Thanks Celsus Will most or all diabetic patients will have elevated CA 19 9 values Dennis Follow Ups Re Tumour marker CA19 9 with value of 60 4 U mL Celsus 14 16 28 2014 08 28 0 Post a Followup Name

    Original URL path: http://islet.org/forum/messages/55916.htm (2016-04-29)
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  • Re: Tumour marker CA19.9 with value of 60.4 U/mL
    11 68 to 39 28 U ml Type 2 Diabetics 6 72 to 21 57 U ml The interesting findings of the study were that higher HbA1c was associated with higher CA 19 9 values but that the elevation in CA 19 9 values was more pronounced in relation to HbA1c in type 1 diabetics than in type 2 diabetics It was also noted that CA 19 9 levels in diabetics were associated with higher total cholesterol values which are often found elevated in diabetics The mechanism underlying these correlations is still unclear but it may be that hyperglycemia produces oxidative stress which further damages the pancreas causing the CA 19 9 levels to rise as a marker of pancreatic injury Another population study 2 to screen for abnormal glucose metabolism suggested that a CA 19 9 value of 6 45 U ml or lower ruled out diabetes a value above 10 3 U ml indicated some degree of abnormal glucose metabolism while at a value of 34 3 U ml 84 of those tested have diabetes So the 37 U ml is really the cut off point for potentially normal subjects 1 H Yu et al Serum CA 19

    Original URL path: http://islet.org/forum/messages/55917.htm (2016-04-29)
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  • Re: Tumour marker CA19.9 with value of 60.4 U/mL
    10 09 15 2014 08 29 In Reply to Re Tumour marker CA19 9 with value of 60 4 U mL posted by Celsus Thanks Celsus for your detail explanation and reference article which is also very comprehensive My daughter cholesterol appears on the marginal as well Her Cholesterol total is 176 optimal HDL is 57 ideal 60 mg dL LDL is 89 ideal Thanks a lot Dennis Follow Ups

    Original URL path: http://islet.org/forum/messages/55918.htm (2016-04-29)
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  • anyone hear about this?
    heart kidneys eyes and nerves However the new finding could pave the way for drugs which stop the amylin build up in the first place or dissolve clumps which are already present Related Articles I never thought I was the type who would develop diabetes 11 Jun 2014 One in three adults have borderline diabetes study finds 10 Jun 2014 Women with diabetes at greater heart risk than men study 23 May 2014 The NHS is collapsing under the weight of demand 11 Jun 2014 Tai chi is the perfect antidote to a digital age 15 Jun 2014 More than three million people in Britain have been diagnosed with diabetes with that figure expected to five million by 2025 The vast majority of sufferers 85 per cent have Type 2 diabetes which is linked to obesity poor diet and sedentary lifestyles More than 70 000 deaths a year occur among those suffering from the condition one in seven of all deaths The pancreas produces both insulin and amylin which usually work together to regulate the body s response to food However some of the amylin that is produced can get deposited around cells in the pancreas as toxic clumps which then in turn destroy those cells that produce insulin The consequence of this cell death is diabetes Previous research suggested that this was the cause of Type 2 diabetes But now scientists believe it could also explain Type 1 which occurs in childhood The team hopes to have potential medicines ready to go into clinical trials in the next two years and it is anticipated that these will be tested in both type 1 and type 2 diabetic patients Clinical trials are being planned with research groups in England and Scotland However diabetes charities said people should adopt healthier lifestyles to avoid Type 2 diabetes rather than wait for a pill Dr Alasdair Rankin Director of Research at Diabetes UK said Amylin has been studied in diabetes for many years Type 1 and Type 2 diabetes are two very different conditions We don t know exactly what causes Type 1 but many possibilities have been suggested and amylin is just one of these We know that in Type 2 diabetes there are several factors that increase a person s risk including ethnicity age family history and being overweight So while there is no way to reduce your risk of Type 1 diabetes the most effective way to reduce your risk of Type 2 is to keep to a healthy weight by eating a healthy balanced diet and being physically active The study was published in the Journal of the Federation of American Societies for Experimental Biolog Science News News UK News Science Sarah Knapton In Science News In pictures the Supermoon Inside the Yamal sinkhole Supermoon in pictures Nano pixel pictures How the brain works Read more Science Global warming to resume in a decade Heat is being stored deep in the Atlantic and Southern Oceans but is likely to

    Original URL path: http://islet.org/forum/messages/55909.htm (2016-04-29)
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