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  • Re: Is neuropathy reason for hypo unawareness?
    treatment but even the brief maintenance of higher blood sugar levels for a few weeks can correct the problem So with reference to this issue hypoglycemia induces a reversible dampening of normal autonomic counter regulatory responses to hypoglycemia rather than autonomic nervous damage causing the inability to detect hypoglycemia 1 Obviously anything that would significantly stabilize blood sugar levels would eliminate this concern 1 P Cryer Mechanisms of Hypoglycemia Associated

    Original URL path: http://islet.org/forum/messages/55869.htm (2016-04-29)
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  • Lawrence Steinman's 'Reverse Vaccine' Targets Immune Response in
    stalled however not because the beta cells are faulty but because the bodyâ s immune system aggressively attacks and eliminates the newly introduced cells producing the insulin So why bother making non functional insulin This is what makes the drug truly exciting When the muscle cells begin producing pro insulin the cells of the immune system are tricked into thinking pro insulin is a normal protein not a foreign invader This process called â tolerization â ideally results in immune cells learning that insulin is a good â selfâ protein even when encountered around beta cells Thus the DNA plasmid encoding pro insulin in muscle cells helps to shut off the bodyâ s specific immune response and the invasion of the new beta cells The bodyâ s immune system is thwarted in its attack of the beta cells and beta cells are left intact and healthy to produce insulin This method differs sharply from using immunosuppressant drugs to combat the bodyâ s immune response to what it sees as an invader that may cause harm In islet cell transplantation for instance insulin producing islet cells from a cadaver are transplanted into a type 1 diabeticâ s liver to make insulin in much the same way the islet cells in the pancreas once did Rather than having the specific immune response shut off so that the islet cells may survive recipients of such transplants take broad range immunosuppressants to keep the bodyâ s immune system from attacking the new cells much like recipients of full blown organ transplants This rigorous immunosuppression regime for islet cell transplant subjects however has been found to actually harm the very delicate islet cells Instead of using this shotgun approach that suppresses wide swaths of the immune system the â reverse vaccineâ takes a rifle shot to suppress only the specific immune response that affects the beta cells â Itâ s similar to allergies â Steinman says â There are millions of people who go to the allergist and they are tested to see what their specific allergy is so they can be treated appropriately You donâ t for instance want to take broad based cyclosporine an immunosuppressant for a peanut allergy â The â reverseâ in the â reverse vaccineâ means that the DNA plasmid drug is shutting off a targeted immune response to keep cells alive Other vaccines such as the flu vaccine seek to boost the immune response to in this case influenza thereby eliminating it Whether the â reverse vaccineâ will ultimately result in a cure is unknown at this time Steinman says But results from the clinical trial already indicate benefits for helping type 1 diabetics better control their condition Because insulin levels are notoriously difficult to accurately measure and track in blood the trial for the â reverse vaccineâ instead tracked subjectsâ C peptide levels C peptides are an indicator of insulin production and according to some studies may play a role in mitigating diabetic complications such as blindness and

    Original URL path: http://islet.org/forum/messages/55867.htm (2016-04-29)
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  • Re: Lawrence Steinman's 'Reverse Vaccine' Targets Immune Response in
    to Lawrence Steinman s Reverse Vaccine Targets Immune Response in posted by DanT I like that sentence C peptides are an indicator of insulin production and according to some studies may play a role in mitigating diabetic complications such as blindness and kidney disease It sounds like something someone said back on November 25 2013 Follow Ups Re Lawrence Steinman s Reverse Vaccine Targets Immune Response in SteveR 18 49

    Original URL path: http://islet.org/forum/messages/55870.htm (2016-04-29)
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  • Re: Lawrence Steinman's 'Reverse Vaccine' Targets Immune Response in
    Forum Posted by SteveR on 18 49 23 2014 04 08 In Reply to Re Lawrence Steinman s Reverse Vaccine Targets Immune Response in posted by Celsus if this is the case why can we not just administer C peptides along with insulin Follow Ups Re Lawrence Steinman s Reverse Vaccine Targets Immune Response in Celsus 15 06 09 2014 04 10 0 Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/55871.htm (2016-04-29)
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  • Re: Lawrence Steinman's 'Reverse Vaccine' Targets Immune Response in
    term release of c peptide to prevent complications in diabetic patients In small trials with human subjects it has so far had positive results confirmed by improved nerve conduction velocity and progress may be faster than typical for new medications since Ersatta has been granted fast track approval status from the FDA It is important to note that Ersatta contains no insulin just c peptide John Wahren professor emeritus of

    Original URL path: http://islet.org/forum/messages/55872.htm (2016-04-29)
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  • Re: Lawrence Steinman's 'Reverse Vaccine' Targets Immune Response in
    Posted by SteveR on 15 57 35 2014 04 10 In Reply to Re Lawrence Steinman s Reverse Vaccine Targets Immune Response in posted by Celsus thanks for the information Celsus Follow Ups Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/55873.htm (2016-04-29)
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  • Glucotrack
    Integrity Applications website GlucoTrack is now CE Mark approved since June 2013 we expect the device to be ready to commercialization in the EU market and some other countries during 2014 Hope the timeline is accurate sure would be helpful while we wait for a cure type treatmet http www integrity app com the glucotrack Follow Ups Re Glucotrack Rene 17 36 28 2014 04 07 0 Post a Followup

    Original URL path: http://islet.org/forum/messages/55865.htm (2016-04-29)
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  • Re: Glucotrack
    see such device making it to market but only if the accuracy is sufficient to rely on it For some reason the CE mark is not a guarantee of that And we have previously seen various such non invasive devices having received the CE mark but afterwards never making it to market Think the C8 MediSensors was the last such thing in Oct 2012 Follow Ups Re Glucotrack lucy 01

    Original URL path: http://islet.org/forum/messages/55866.htm (2016-04-29)
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