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  • Trying medication to minimize my suffering
    symptoms are literally killing me and making me suicidal If nothing works I may even pursue a pancreas transplant as a last resort No one can make any sense of how or why I am experiencing what I do at levels that are slightly above normal and even normal I am scared to death to continue to living like this which is beyond suffering I am living like a terminally

    Original URL path: http://islet.org/forum/messages/55771.htm (2016-04-29)
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  • Re: Trying medication to minimize my suffering
    Andra on 17 03 12 2013 12 03 In Reply to Trying medication to minimize my suffering posted by Gary Good Luck Gary please update us on how you feel Follow Ups Post a Followup Name E Mail Optional Subject

    Original URL path: http://islet.org/forum/messages/55793.htm (2016-04-29)
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  • An islet transplant w/o ARD apparently showing success.
    Posted by Gary on 19 25 39 2013 11 14 This was posted on the CWD forum Not much detail on how the patient is doing but apparently he is off Insulin for a year http idw online de pages de news558740 Follow Ups Re An islet transplant w o ARD apparently showing success Curt Lomax 19 38 33 2013 11 14 0 Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/55769.htm (2016-04-29)
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  • Re: An islet transplant w/o ARD apparently showing success.
    38 33 2013 11 14 In Reply to An islet transplant w o ARD apparently showing success posted by Gary Surely more work has to be done but Prof Bornstein is certain that the new system will be a serious option in therapy of diabetes in five years time Follow Ups Re An islet transplant w o ARD apparently showing success Celsus 08 27 26 2013 11 15 0 Post

    Original URL path: http://islet.org/forum/messages/55770.htm (2016-04-29)
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  • Re: An islet transplant w/o ARD apparently showing success.
    to use an islet xenograft because of safety concerns But without resorting to an animal source for the pancreatic islets the supply will never be sufficient to make a real difference to type 1 diabetics Only a small number of islets 2100 islet equivalents per kilogram of patient body weight were used even though other experiments indicate that about 10 000 IEQ kg are needed to achieve at least temporary insulin independence As a result the patient was only able to reduce his insulin dose from 52 IU day before the implantation to 43 IU day after His HbA1c declined gradually over time from 7 4 before the experiment to about 6 5 after the implant had been functioning for 10 months Under a glucose tolerance test the patient s response was subnormal and was more sustained at three months into the transplant than at six months or nine months suggesting that the graft underwent some degradation over time However a close examination of the graft did not show evidence of deterioration after it was extracted No immunological problems were detected though the subject typically of a long term type 1 patient had no autoimmunity to pancreatic islets at the

    Original URL path: http://islet.org/forum/messages/55772.htm (2016-04-29)
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  • Re: An islet transplant w/o ARD apparently showing success.
    you sure about that I m looking at Figure 2A in the paper and I don t see any degradation in the response from 3 to 6 to 9 months Why do you think it degraded Also when I first read this paper I thought the oxygenator was only used for a few days to get things started However now Ii can t find where they said they removed it

    Original URL path: http://islet.org/forum/messages/55774.htm (2016-04-29)
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  • Re: An islet transplant w/o ARD apparently showing success.
    had some degree of gastroparesis which would have prolonged the duration of the elevated glucose after a meal The background blood sugar levels diminished slightly over the course of the experiment so this may account for the c peptide response falling off faster post prandially later on but given the continuing background hyperglycemia it should still have been sufficient to instruct the islets to keep expressing more c peptide insulin A normal c peptide response should have read that continuing high glucose level as requiring the c peptide level not to fall though it did and it did so more dramatically over time suggesting that the responsiveness of the graft was diminishing It is certainly noteworthy that the authors don t go into this issue in their report and the post prandial c peptide levels are not closely tracked against the blood glucose levels which would have been useful to know They also state that they found neither morphological nor functional deterioration in the graft when they studied it after extraction so the cause of the decline in the c peptide output remains unclear To your other point just from the logic of the experiment it must be that the oxygen supply was maintained throughout since the islets will always need oxygen and would quickly die out without it although it is true that other experiments have found their need for oxygen higher right after implantation The authors of this study don t discuss your issue directly though much that they say implies an answer to it On p 1 of the study they say that their system allows a controlled oxygen supply to the islet graft by means of an integrated oxygen reservoir that can be refilled regularly and can maintain oxygen pressure On p 2 it says For

    Original URL path: http://islet.org/forum/messages/55776.htm (2016-04-29)
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  • Re: An islet transplant w/o ARD apparently showing success.
    Posted by Art on 11 59 46 2013 12 13 In Reply to Re An islet transplant w o ARD apparently showing success posted by Celsus They should use tilapia islets Follow Ups Post a Followup Name E Mail Optional

    Original URL path: http://islet.org/forum/messages/55799.htm (2016-04-29)
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