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  • Re: Insulin as a Cause of Diabetic Complications
    by Andra on 00 00 06 2013 10 24 In Reply to Insulin as a Cause of Diabetic Complications posted by Celsus Less insulin means the body is producing own insulin and therefore own C peptide that has been shown to protect against complications Follow Ups Re Insulin as a Cause of Diabetic Complications Celsus 13 40 32 2013 10 25 0 Post a Followup Name E Mail Optional Subject

    Original URL path: http://islet.org/forum/messages/55729.htm (2016-04-29)
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  • Re: Insulin as a Cause of Diabetic Complications
    by Andra To diminish the effect of confounding variables in the study the variable tested was isolated within blood sugar control cohorts which eliminated the possible influence of endogenous c peptide production which you mention The patients compared faced the same degree of blood sugar control difficulty so the only difference between them was whether that difficulty was addressed by insulin or by oral hypoglycemics Follow Ups Re Insulin as

    Original URL path: http://islet.org/forum/messages/55730.htm (2016-04-29)
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  • Re: Insulin as a Cause of Diabetic Complications
    care patients with T2DM treated with one of five glucose lowering regimens metformin monotherapy sulfonylurea monotherapy insulin monotherapy metformin plus sulfonylurea combination therapy and insulin plus metformin combination therapy For T2D blood sugar control cohorts divided as above is not an indicator of residual insulin production or insulin requirements Especially in UK there are many factors that influence the decision to go from oral medication to insulin socioeconomic background education

    Original URL path: http://islet.org/forum/messages/55731.htm (2016-04-29)
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  • Re: Insulin as a Cause of Diabetic Complications
    insulin so it is extremely unlikely that they could have had more residual c peptide production which would have offered them greater protection against this complication Higher or lower insulin doses and the therapeutic decision to use insulin rather than oral hypoglycemics in the type 2 patients to which this study was restricted are usually correlated with higher or lower degrees of insulin resistance rather than with residual c peptide

    Original URL path: http://islet.org/forum/messages/55732.htm (2016-04-29)
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  • Re: Insulin as a Cause of Diabetic Complications
    It s quite probable that insulin resistance also equals c peptide resistance and or c peptide plays little role in either direction for T2 complications whereas it clearly appears to in Type 1 While the odd time there is some useful studies that may help both diseases T1 and T2 as well as the less common forms of diabetes such as MODY are all so different that there is likely

    Original URL path: http://islet.org/forum/messages/55733.htm (2016-04-29)
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  • Re: Insulin as a Cause of Diabetic Complications
    I have genetic insulin sensitivity My whole family eats crap except me and are thin with high HDL protective cholesterol linked to insulin sensitivity no T2 or heart disease Most people do not have such genes to protect from our modern diet Injecting large amounts of insulin as a T1 is not doing T1s any favours I was part of the group in the 90s 2000s who was told to eat whatever I want and bolus Granted I am very insulin sensitive but many of those I attended clinic with were injecting massive amounts of insulin Many of those 30 somethings are now struggling with severe complications Many became overweight struggling with typically unheard of in young people conditions like hypertension and high cholesterol While not the only part of the puzzle other factors being genes residual insulin secrection antioxidant status inflammation status etc I firmly believe the less insulin the better As mentioned before I once had an A1c of 11 or 12 with low triglycerides off the charts high HDL good cholesterol and low LDL I was on very little insulin due to sudden lows and an infection So I ran a bit higher than typical Perhaps I

    Original URL path: http://islet.org/forum/messages/55728.htm (2016-04-29)
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  • Type 1 Diabetes Still Have Insulin-Producing Cells
    But British researchers used new technology that enabled them to detect far lower levels of insulin than was previously possible They tested 74 people with type 1 diabetes and found that 73 percent of them had working beta cells that produced low levels of insulin regardless of how long they d had the disease The study was published in the journal Diabetologia It s extremely interesting that low levels of insulin are produced in most people with type 1 diabetes even if they ve had it for 50 years study leader Dr Richard Oram of the University of Exeter Medical School in the United Kingdom said in a university news release The fact that insulin levels go up after a meal indicates these remaining beta cells can respond to a meal in the normal way it seems they are either immune to attack or they are regenerating Dr Matthew Hobbs head of research for Diabetes UK added We know that preserving or restoring even relatively small levels of insulin secretion in type 1 diabetes can prevent hypoglycemia low glucose levels and reduce complications and therefore much research has focused on ways to make new cells that can be transplanted into

    Original URL path: http://islet.org/forum/messages/55715.htm (2016-04-29)
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  • Re: Type 1 Diabetes Still Have Insulin-Producing Cells
    discovered Of course it is necessary for independent groups to reproduce important findings to establish that they are correct but this sort of unaware duplication is just embarrassing Here we just have a duplication of the work of Dr Yong Zhao discussed some time ago on this message board which established by a more sensitive method of measuring c peptide production that a fraction of even long term type 1 diabetics still had a very few surviving pancreatic beta cells Then follows the usual call for some method to stimulate the remaining beta cells into improved function or to get others to regrow which has now been going on for the last 20 years without anything more than token results Research is now at a curious stage Between twenty and fifty years ago a number of a priori likely theories for curing type 1 diabetes were suggested and research on them began The closed loop artificial pancreas immunosuppression to destroy autoimmunity whole pancreas transplants islet cell transplants islet cell encapsulations islet cell pouches with sertoli cells various substances or devices to induce beta cell regrowth all have by now been tried and shown not to produce clinically useful results So

    Original URL path: http://islet.org/forum/messages/55716.htm (2016-04-29)
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