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  • Re: longest honeymoon length?
    longest honeymoon length posted by Rene I was diagnosed type 1 at age 29 By the definition above I have been on honeymoon for 8 5 years Follow Ups Re longest honeymoon length Rene 15 03 51 2013 10 08

    Original URL path: http://islet.org/forum/messages/55712.htm (2016-04-29)
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  • Re: longest honeymoon length?
    Reply to Re longest honeymoon length posted by Christian Hi Christian I may recall wrongly but are you not the LADA type 1 5 and not classic type1 The honeymoon term does not really make sense for the LADA type Interesting though to observe that the average length of time from diabetes diagnosis till insulin injections are required for LADA is indeed around 6 years o Follow Ups Post a

    Original URL path: http://islet.org/forum/messages/55714.htm (2016-04-29)
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  • Immune Cells Identified That Promote Growth of Beta Cells in Typ
    all beta cells and people with the disease would have to take insulin for life But we know that some beta cells do survive and secrete insulin even when the patients have had type 1 diabetes for 50 years says senior author Rohit N Kulkarni M D Ph D Associate Professor of Medicine at Harvard Medical School and the principle investigator of the project at Joslin In this study Joslin researchers were interested in learning exactly how immune cells could promote beta cell growth and identifying the type of cell and the mechanisms underlying this effect In a series of experiments the researchers injected NOD mice with immune cells from the pancreatic islets of donor NOD mice and assessed their effects on beta cells The immune cells tested included subtypes of B or T immune cells Dirice the lead author of the study found that it is T cells not B cells that are associated with beta cell proliferation Mice that received B cells showed no difference in beta cell growth Mice that received the T cell subtypes CD4 and CD8 showed an elevation in all markers of beta cell proliferation compared to mice that did not receive them The researchers also found that beta cell growth happens after islets are infiltrated by immune cells and is independent of the effects of glucose and insulin Further experiments with cell cultures showed that CD4 and CD8 cells secrete inflammatory cytokines and chemokines Interleukin 2 Interleukin 6 Interleukin 10 MIP 1α and RANTES which together enhanced beta cell proliferation This is the first study to report that this group of soluble factors is involved in promoting beta cell growth This gives us new insights into what is happening in the pathology of type 1 diabetes The immune cells we identified send signals

    Original URL path: http://islet.org/forum/messages/55693.htm (2016-04-29)
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  • SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    Pouch TM which is subsequently transplanted with human donor islets To protect the islets from immune cell attack the patients are given an antibody and immunosuppressive medications In an initial assessment the Cell Pouches TM in these first two patients were shown to meet the primary endpoint of being safe after implantation and prior to transplantation The Cell Pouches TM were then transplanted with human donor islets followed by removal up to 30 days post transplantation and islet survival assessed The Cell Pouches TM were prepared for comprehensive histological analysis and assessed by experts in an independent blinded analysis for key features including device biocompatibility tissue and microvessel development into the device islet survival and the presence of insulin glucagon somatostatin and polypeptide as well as protection of islets from immune system attack The findings in these initial patients parallel the results in Sernova s multiple small and large animal safety and efficacy studies of the Cell Pouch These showed an exemplary safety profile and that islets were well vascularised with microvessels and produced insulin In addition the islet rich Cell Pouches then went on to show long term glucose control in the diabetic animals said Dr David White Professor Emeritus and Chair of Sernova s Scientific Advisory Board We see these initial findings in humans as an important next step in confirming the utility of the Cell Pouch in the clinical setting as providing a safe environment for therapeutic cells We look forward to further results in this study and are excited to continue working in clinical indications where therapeutic cells can improve the quality of life for patients not only with diabetes but for those with other chronic debilitating diseases said Philip Toleikis President and CEO Sernova Corp Sernova is developing the Cell Pouch TM as an enabling

    Original URL path: http://islet.org/forum/messages/55682.htm (2016-04-29)
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  • Re: SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    a coating of sertoli cells but it does not specify the donor source of this tissue Third as already pointed out it relies on antibody probably anti CD molecule treatment and immunosuppression and the latter especially is well known to carry more negative side effects than it is worth at least when used to treat type 1 diabetes Finally the patients selected for this study had hypoglycemia awareness which hints

    Original URL path: http://islet.org/forum/messages/55690.htm (2016-04-29)
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  • Re: SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    one human donor to help 10 people Still may not be enough but 9 times better than what currently exisits Second it uses a coating of sertoli cells but it does not specify the donor source of this tissue No it doesn t Sertoli hasn t been added to the pouch yet It s also not a coating but they are cells that will be planted in the pouch along with islets to eliminate anti rejection meds Third as already pointed out it relies on antibody probably anti CD molecule treatment and immunosuppression and the latter especially is well known to carry more negative side effects than it is worth at least when used to treat type 1 diabetes First part is to prove the pouch is safe which has been done Second part is to add sertoli cells to the pouch to eliminate the need for anti rejection medication Finally the patients selected for this study had hypoglycemia awareness which hints that this approach may be expected to be burdened with the same problems as affect LCT s device which is that all it is expected to do is to reduce the amount of injected insulin needed something in

    Original URL path: http://islet.org/forum/messages/55708.htm (2016-04-29)
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  • Re: SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    S is about 16 000 per year with a prevalence of about 800 000 cases so it would take about 120 years to treat all the existing backlog of patients plus new transplant candidates via this method The protective sertoli cells also have to be sourced from male cadavers though they do not state how many cadavers are required per pouch An islet transplant in a 20 to 25 g mouse requires 7 000 000 sertoli cells for immunological protection which is the number of usable cells which could be harvested from a single rodent testis of the 22 000 000 initially available A human male has in principle about 128 000 000 sertoli cells per testis so assuming about the same degree of reduction from the harvesting process say about 85 000 000 would be available per male cadaver for transplant protection Differences in rodent and human physiology leave open the question of how many cadavers per successful procedure would be required The protective methods in this result are also not perfect since the cytokine release from the anti CD molecules is harmful to the body and it seems from their description that conventional immunosuppressive agents cannot be avoided

    Original URL path: http://islet.org/forum/messages/55713.htm (2016-04-29)
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  • Re: SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    18 27 58 2013 09 26 In Reply to SERNOVA S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT posted by Jeff I guess this is goodnews BUT until they use this without immunosuppression how can they really know if the islets are protected by the pouch Follow Ups Re SERNOVA S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT Jeff 12 50 45 2013 09 27 0 Post a

    Original URL path: http://islet.org/forum/messages/55683.htm (2016-04-29)
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