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  • Re: SERNOVA'S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT
    The Islet Foundation Public Message Forum Posted by Jeff on 12 50 45 2013 09 27 In Reply to Re SERNOVA S CELL POUCH SHOWN TO PROVIDE A SAFE ENVIRONMENT posted by Gary That s what they are working towards Looks promising thus far First part is proving that the cells survive in the pouch using immunosuppressants Follow Ups Post a Followup Name E Mail Optional Subject Comments Link URL

    Original URL path: http://islet.org/forum/messages/55684.htm (2016-04-29)
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  • Targeting Memory T-Cells in Type 1 Diabetes
    alefacept inhibits co stimulation and induces T cell depletion T cell mediated destruction of insulin producing pancreatic beta cells is a central feature of Type 1 diabetes but targeting of CD2 has not previously been evaluated in this disease The T1DAL trial was designed to test whether alefacept would preserve pancreatic beta cell function in newly diagnosed patients The Phase II T1DAL study enrolled 49 new onset type 1 diabetic subjects ages 12 to 35 who were randomized into two groups 33 to alefacept and 16 to placebo Patients received two twelve week courses separated by a 12 week pause of either alefacept or placebo Twelve months from the start of the study patients underwent a mixed meal tolerance test to measure the C peptide response a measure of insulin production The primary endpoint a 2 hour C peptide response did not show statistically significant differences between treatment and placebo groups however a secondary endpoint a 4 hour C peptide response was significantly higher at 12 months in the treatment group compared to the placebo group Other secondary endpoints including insulin use and rate of hypoglycemic events were significantly lower at 12 months in the alefacept treated group Although the primary endpoint was not met these encouraging results of key secondary endpoints suggest a disease modifying effect of alefacept Additional support for alefacept s therapeutic role comes from analysis of T cell subtypes of treated patients that showed that effector T cells were primarily targeted while sparing protective regulatory T cells Lead investigator Dr Mark Rigby suggests The T1DAL study is the first to use an agent to specifically deplete the cells which attack the pancreas in type 1 diabetes the memory and effector T cells We also found that regulatory T cells are not depleted with this therapy suggesting

    Original URL path: http://islet.org/forum/messages/55679.htm (2016-04-29)
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  • LCT
    on 21 48 56 2013 09 20 Did something happen today their stock just doubled Follow Ups Re LCT Michael H 04 44 41 2013 09 21 0 Post a Followup Name E Mail Optional Subject Comments Link URL Optional

    Original URL path: http://islet.org/forum/messages/55677.htm (2016-04-29)
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  • Re: LCT
    stock value doubled on Friday because LCT announced news that they have now achieved another world first this time a human trial implanting pig cells to treat parkinsons disease all looks very promising This will further strengthen the company and help the commercial launch of the DiaBcell treatment for type 1 diabetes For further info read all about this exciting development on the news page of the LCT website www

    Original URL path: http://islet.org/forum/messages/55678.htm (2016-04-29)
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  • I'm terrified!
    to have the kind of symptoms I experience at normal levels It would be bad enough if I were way out range but this killing me On paper I have no other medical issues other then diabetes Could I have permanently destroyed my body and mind from running erratic sugars in my youth for many years What makes me different then anyone else with diabetes I have yet to find

    Original URL path: http://islet.org/forum/messages/55669.htm (2016-04-29)
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  • Re: I'm terrified!
    13 In Reply to I m terrified posted by Gary Please hang in there http www ncbi nlm nih gov pubmed 2707223 Follow Ups Re I m terrified Gary 19 38 42 2013 09 13 0 Post a Followup Name

    Original URL path: http://islet.org/forum/messages/55670.htm (2016-04-29)
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  • Re: I'm terrified!
    with my entire endocrine system and really the only question is can it be fixed At this point I am beyond suicidal so risk of anything is no concern I have doubts whether a transplant would reverse the array of nasty many of which I have not mentioned symptoms I experience because there is no way for it to keep the levels between 70 and 80 but maybe its far

    Original URL path: http://islet.org/forum/messages/55671.htm (2016-04-29)
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  • a few uncertainties
    would be hypoglycemia but not impossible Eating and then becoming more irritable might usefully be measured again BG level 75 minutes post first bite of food I know this is not much help or much to go on but they are doable things to enable us to narrow down the cause of the anxiety Treatment of anxiety might be better done with other substances or behaviors than food The many

    Original URL path: http://islet.org/forum/messages/55681.htm (2016-04-29)
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