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  • Cognigen Corporation - Blog Archive
    early as the 1920s white and black jazz musicians played together in after hours jam sessions As jazz captured more and more avid listeners white Americans started to understand the effect of segregation in all aspects of American culture READ MORE March 2 2009 Dan Carlin s Hardcore History In Dan Carlin s Hardcore History podcasts the past is twisted and turned upside down in novel and intriguing ways Dan Carlin a veteran journalist and radio talk show host emphasizes the drama of past events and personalities to reveal why history matters today READ MORE February 17 2009 Kerfuffle pt 2 A kerfuffle is the polite term for a cascading series of errors that can be initiated by a seemingly innocuous event that then leads to other errors that seem to gain in severity and impact But where do kerfuffles come from and how do we prevent them from happening READ MORE November 14 2008 John Muir 1838 to 1914 and advice for surviving the Economic Crisis of 2008 John Muir was one of the first climbers to explore and climb many of the peaks in Yosemite Valley in California s High Sierra During his first ascent of Mount Ritter in 1872 he became gripped with fear READ MORE November 14 2008 Beauty and the Beast Several large Pharma companies have announced interest in acquiring small biotech companies Many Pharma companies have reduced or eliminated drug discovery efforts and with stock prices back at 2003 levels there certainly is a great deal of sense in these acquisitions But finding another way to integrate these companies and their development portfolio also makes a great deal of sense READ MORE November 7 2008 Kerfuffle pt 1 k r f f l to become disheveled A kerfuffle is the polite term for a

    Original URL path: http://nonmem.org/index.php/blog_archive/P70 (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    computer systems required to support modeling and simulation M S activities The numerous M S projects performed by Cognigen scientists became a source of raw material for research initiatives designed to improve the quality timeliness and impact of M S results These research initiatives have yielded numerous benefits including Formalized data definitions and data programming requirements that enable the timely delivery of quality data for analysis A robust informatic infrastructure and computer system which became the foundation for the KIWITM platform A variety of internally and externally focused training programs to advance the science and technology required for planning executing and reporting M S efforts Click here for more information about the PoF program READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April 2 March 3 January 2 2010 20 December 1 November 2 September 3 August 3 July 4

    Original URL path: http://nonmem.org/index.php/blog_archive/2016/04/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    the pharmacometrics community owe a debt of gratitude to Lewis Stuart Alison and the many others who were involved in the development of NONMEM The program has proven to be of tremendous value in dealing with the challenges we encounter in pharmaceutical research and development NONMEM has truly changed the landscape and really we are only at the beginning of a new era of model driven R D A historical perspective from Alison Boeckmann One of the developers and programmers of NONMEM Reprinted here with Alison s permission READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April 2 March 3 January 2 2010 20 December 1 November 2 September 3 August 3 July 4 June 1 April 2 March 1 February 1 January 2 2009 12 December 1 November 1 October 1 September 1 June 1 May 2 April 2

    Original URL path: http://nonmem.org/index.php/blog_archive/2016/03/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    labeling within KIWI Cross Project and Co Worker Graphical Profiles Share your share suite of customized diagnostic plots with your co worker or use them on your next project READ MORE October 3 2015 Conceptual Schemas The central focus of MBR D is not the mathematical equations but rather the conceptual synthesis process that integrates all available information and rational extrapolations to better understand drug pharmacology in the context of the disease process The outcome of this synthesis process is a conceptual schema a term borrowed from database design The schema represents a series of assertions about the nature of the disease process and drug pharmacology It describes the entities of significance to a research program their characteristics or attributes and the relationships between pairs of entities thought to be significant READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April

    Original URL path: http://nonmem.org/index.php/blog_archive/2015/10/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    minutes READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April

    Original URL path: http://nonmem.org/index.php/blog_archive/2015/04/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    sort through the results and compare alternative formations of the model in order to determine reasonable next steps and decide that a particular model or group of models is adequate for the task at hand And this is where the idea of workflow comes to the forefront READ MORE January 16 2015 Progressive reporting and model based drug development KIWI has been specifically designed to recognize the dynamic nature of the model building effort in an ongoing drug development program KIWI provides functionality to meet the scientists need for extensive documentation of the analysis pathway and collateral results management s need for summaries of modeling and simulation highlights and regulatory agencies need for transparency and reproducibility READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April 2 March 3 January 2 2010 20 December 1 November 2 September 3 August 3

    Original URL path: http://nonmem.org/index.php/blog_archive/2015/01/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    Pharma of the Future Pharmacometric modeling and simulation has moved from its infancy as a novel way of approaching the analysis of clinical pharmacokinetic data to become an invaluable tool in pharmaceutical and biotechnology research and development Early tentative applications of modeling have given way to robust model based drug development activities in which pharmacokinetic and pharmacodynamic modeling and simulation results are widely utilized to improve the probability of successful clinical trials Pharma of the Future Historical Time Line READ MORE Monday April 25 2016 Blog Archives 2016 2 April 1 March 1 2015 5 October 2 April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April 2 March 3 January 2 2010 20 December 1 November 2 September 3 August 3 July 4 June 1 April 2 March 1 February 1 January 2 2009 12 December 1 November 1 October 1 September 1 June 1 May 2 April 2 March 2 February 1 2008 3 November 3 Most

    Original URL path: http://nonmem.org/index.php/blog_archive/2014/10/ (2016-04-25)
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  • Cognigen Corporation - Blog Archive
    April 1 January 2 2014 1 October 1 2013 13 December 1 November 1 October 1 June 2 May 1 April 3 March 1 February 2 January 1 2012 13 December 2 October 2 September 4 March 1 February 2 January 2 2011 10 October 1 June 1 May 1 April 2 March 3 January 2 2010 20 December 1 November 2 September 3 August 3 July 4 June 1

    Original URL path: http://nonmem.org/index.php/blog_archive/2013/12/ (2016-04-25)
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