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  • [NMusers] Distribution of NONMEM VI
    V therefore gradients in the intermediate output will differ from those in NONMEM VI Results for CONTROL3 5 examples provided with the distribution using NONMEM VI are available at the NONMEM ftp site ftp ftp globomaxnm com Public nonmem in a folder named StdresultsNONMEMVI The conditional estimation of interindividual random terms ETA s also differs For conditional estimation methods NONMEM VI is numerically more stable and frequently provides shorter run

    Original URL path: http://nonmem.org/nonmem/nm/99nov302006.html (2016-04-25)
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  • [NMusers] is PDx-Pop 2.0a compatible with NONMEM VI?
    setting to the new NONMEM VI installation directory c nmvi if you use the default directory Use Tools Edit Configuration from the PDx Pop Menu bar to do this Files to update PDx Pop 2 0a to 2 1a are available from our ftp site at ftp ftp globomaxnm com Public pdxpop upgrade2 1a The 2 1a update files fully supports NONMEM VI release version installation and runs as well

    Original URL path: http://nonmem.org/nonmem/nm/96nov302006.html (2016-04-25)
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  • [NMusers] Welcome to the new small sample size world of NONMEM VI
    instructions yet have you typical male try the toy without reading the instruction First page Introduction 5 edit the sizes file and recompile Mark Mark Sale MD Next Level Solutions LLC www NextLevelSolns com From Nick Holford n holford auckland ac nz Subject RE NMusers Welcome to the new small sample size world of NONMEM VI Date Fri 01 Dec 2006 11 38 43 1300 Mark I haven t checked every parameter in the final release to see if they are compatible with NONMEM V defaults But I think it very odd that NONMEM VI should by default impose restrictions that were not present in NONMEM V nor in the beta release of NONMEM VI Nick Nick Holford Dept Pharmacology Clinical Pharmacology University of Auckland 85 Park Rd Private Bag 92019 Auckland New Zealand email n holford auckland ac nz tel 64 9 373 7599x86730 fax 373 7556 http www health auckland ac nz pharmacology staff nholford From Mark Sale Next Level Solutions mark nextlevelsolns com Subject RE NMusers Welcome to the new small sample size world of NONMEM VI Date Thu 30 Nov 2006 17 10 24 0700 Nick You re right the general expectation in the software world

    Original URL path: http://nonmem.org/nonmem/nm/97nov302006.html (2016-04-25)
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  • [NMusers] Intel/Compaq/Digital Fortran Compiler installation issues related to NONMEM and PDx-Pop
    DEBUG DEBUGTYPE CV COFF more link exe output here C df exe Compaq Visual Fortran Optimizing Compiler Version 6 6 Update C Copyright 2003 Compaq Computer Corp All rights reserved C cd pdxpop2 0a C pdxpop2 0a df gmtest for Compaq Visual Fortran Optimizing Compiler Version 6 6 Update C Copyright 2003 Compaq Computer Corp All rights reserved gmtest for Microsoft R Incremental Linker Version 6 00 8447 Copyright C Microsoft Corp 1992 1998 All rights reserved subsystem console entry mainCRTStartup debugtype cv pdb none C DOCUME 1 bill LOCALS 1 Temp obj300 tmp dfor lib libc lib dfconsol lib dfport lib kernel32 lib out gmtest exe C pdxpop2 0a gmtest exe Globomax LLC Tools for Expediting Population Analysis c 2003 C pdxpop2 0a The three part test is used because steps 1 and 2 can succeed and 3 will fail if for example a non compatible SDK version is found by a specific compiler version or if an environment variable other than the PATH has not been set An example of a failed step 3 might have an output like the following C pdxpop2 0a ifort gmtest for Intel R Fortran Compiler for 32 bit applications Version 9 1 Build 20060816Z Package ID W FC C 9 1 029 Copyright C 1985 2006 Intel Corporation All rights reserved Microsoft R Incremental Linker Version 8 00 50727 42 Copyright C Microsoft Corporation All rights reserved out gmtest exe subsystem console gmtest obj LIBCMT lib crt0init obj warning LNK4254 section CRT 40000040 merged into data C0000040 with different attributes C pdxpop2 0a Determining which batch file contains the missing environment variables The Digital Compaq Intel Compilers do not supply the linker program and require the linker to be supplied by Microsoft Visual Studio However Digital and Compaq Visual Fortran supply Microsoft Visual Studio as part of their software and automatically installed the Visual Studio components with the compiler components The batch file supplied by Digital and Compaq to set the environment variables for both the compiler and the SDK is called dfvars bat The file can usually be found in the C program files DevStudio DF bin directory or in C program files Microsoft Visual Studio DF98 bin As stated earlier with earlier Digital and Compaq versions the environment variables for both the compiler and SDK components are often set correctly and you need not be further concerned further with the batch files All versions of Intel Fortran require that Microsoft Visual Studio be obtained and installed separately from the compiler For Intel compilers there is a batch file supplied to set the Microsoft Visual Studio environment variables and another batch file to set the compiler environment variables With Intel and when the environment is not correctly set for Digital or Compaq you will have to find the batch files to help you determine the missing environment variables To further complicate matters the files have different names depending on the compiler version and the SDK version The name for the Intel

    Original URL path: http://nonmem.org/nonmem/nm/98nov302006.html (2016-04-25)
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  • [NMusers] simulation problem
    0 FIX 4 V3 OMEGA 0 FIX 5 Q2 OMEGA 0 FIX 6 Q3 OMEGA 0 FIX 7 KM OMEGA 0 FIX 8 K40 OMEGA 0 FIX 9 EMAX OMEGA 0 FIX 10 C50 OMEGA 0 FIX 11 BSL SIGMA 1 FIX SIMULATION 9215690 seed 1 7 digits TAB ID AMT TIME DV SEX BSA CMT ONEHEADER NOPRINT FILE mytab14 The datafile for the first three subjects is as the following ID AMT RATE TIME DV MDV EVID SEX BSA FLAG CMT 1 354 1074 0 1 1 1 1 8 0 1 1 0 0 0 0 0 1 1 8 3 4 1 0 0 0 33 0 0 1 1 8 2 1 1 0 0 0 33 0 0 1 1 8 3 4 1 0 0 1 0 0 1 1 8 2 1 1 0 0 1 0 0 1 1 8 3 4 1 0 0 2 0 0 1 1 8 2 1 1 0 0 2 0 0 1 1 8 3 4 1 0 0 4 0 0 1 1 8 2 1 1 0 0 4 0 0 1 1 8 3 4 1 0 0 8 0 0 1 1 8 2 1 1 0 0 8 0 0 1 1 8 3 4 1 0 0 12 0 0 1 1 8 2 1 1 0 0 12 0 0 1 1 8 3 4 1 0 0 24 0 0 1 1 8 2 1 1 0 0 24 0 0 1 1 8 3 4 1 0 0 48 0 0 1 1 8 2 1 1 0 0 48 0 0 1 1 8 3 4 2 709 2149 0 1 1 1 1 8 0 1 2 0 0 0 0 0 1 1 8 3 4 2 0 0 0 33 0 0 1 1 8 2 1 2 0 0 0 33 0 0 1 1 8 3 4 2 0 0 1 0 0 1 1 8 2 1 2 0 0 1 0 0 1 1 8 3 4 2 0 0 2 0 0 1 1 8 2 1 2 0 0 2 0 0 1 1 8 3 4 2 0 0 4 0 0 1 1 8 2 1 2 0 0 4 0 0 1 1 8 3 4 2 0 0 8 0 0 1 1 8 2 1 2 0 0 8 0 0 1 1 8 3 4 2 0 0 12 0 0 1 1 8 2 1 2 0 0 12 0 0 1 1 8 3 4 2 0 0 24 0 0 1 1 8 2 1 2 0 0 24 0 0 1 1 8 3 4 2 0 0 48 0 0 1 1 8 2 1 2 0 0 48 0 0 1 1 8 3 4 3 1418 4298 0 1 1 1 1 8 0 1 3 0 0 0 0 0 1

    Original URL path: http://nonmem.org/nonmem/nm/99nov222006.html (2016-04-25)
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  • [NMusers] NONMEM Modeling of Plasma + Urine Data
    K21 Q V2 TVCLM THETA 5 CLM TVCLM EXP ETA 5 K13 CLM V TVCLMO THETA 6 CLMO TVCLMO EXP ETA 6 TVV3 THETA 7 V3 TVV3 EXP ETA 7 K35 CLMO V3 S3 V3 S0 UVOL ERROR ASY1 0 IF CMT EQ 1 ASY1 1 ASY2 0 IF CMT EQ 3 ASY2 1 ASY3 0 IF CMT EQ 4 ASY3 1 IPRED F W 1 IF F EQ 0 W 1 IRES DV IPRED IWRES IRES W Y IPRED ASY1 ERR 1 ASY2 ERR 2 ASY3 ERR 3 1 ASY1 1 ASY2 1 ASY3 ERR 4 THETA 0 14300 TVCL THETA 0 24200 TVV THETA 0 84400 TVQ THETA 0 89600 TVV2 THETA 0 12400 TVCLM THETA 0 21300 TVCLMO THETA 0 50000 TVV3 OMEGA 0 25 ETATVCL OMEGA 0 25 ETATVV OMEGA 0 25 ETATVQ OMEGA 0 25 ETATVV2 OMEGA 0 25 ETATVCLM OMEGA 0 25 ETATVCLMO OMEGA 0 25 ETATVV3 SIGMA 100 ERRSD17AAG SIGMA 100 ERRSD17AG SIGMA 100 ERRSD17AAG URINE SIGMA 100 ERRSD17AG URINE EST METH 0 MAXEVAL 9999 NOABORT POSTHOC PRINT 5 SIGDIGITS 5 COVARIANCE The data file looks like this ID AMT EVID RATE TIME DV UVOL CMT 101 31500000 1 31500000 0 0 0 1 101 0 2 0 0 0 0 4 101 0 2 0 0 0 0 5 101 0 0 0 0 5 20 0 3 101 0 0 0 0 5 231 0 1 101 0 0 0 0 92 51 0 3 101 0 0 0 0 92 300 0 1 101 0 0 0 1 08 47 0 3 101 0 0 0 1 08 146 0 1 101 0 0 0 1 25 40 0 3 101 0 0 0 1 25 109 0 1 101 0 0 0 1 5 55 0 3 101 0 0 0 1 5 121 0 1 101 0 0 0 2 42 0 3 101 0 0 0 2 119 0 1 101 0 0 0 3 25 0 3 101 0 0 0 3 75 0 1 101 0 0 0 5 17 0 3 101 0 0 0 5 25 0 1 101 0 0 0 9 0 0 1 101 0 0 0 9 0 0 3 101 0 0 0 17 0 0 1 101 0 0 0 17 0 0 3 101 0 0 0 24 1993 956 904 4 101 0 0 0 24 609 6032 904 5 I was able to model the above data without urine observations so I feel there must be something wrong with the way I am coding the urine compartments I would really appreciate any advice Thanks Tarek A Leil Ph D Department of Oncology Guggenheim 1311 Mayo Clinic 200 First Street SW Rochester MN 55905 ph 507 538 4227 fax 507 266 5146 pgr 08189 From Nandy Partha PRDUS PNandy prdus jnj com Subject RE NMusers NONMEM Modeling of Plasma Urine Data Date Wed 22 Nov 2006 19 23 38 0500 Hi Tarek I am assuming

    Original URL path: http://nonmem.org/nonmem/nm/99nov212006.html (2016-04-25)
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  • [NMusers] Full and Reduced Residual Error Models
    Fri 17 Nov 2006 13 12 48 0500 Dear All Is it fair to consider that Y F 1 ETA 1 is a reduced model of Y F 1 EPS 1 EPS 2 for the purposes of using the Likelihood Ratio Test It seems that the combination model reduces to the CCV model when the variance of EPS 2 is fixed to zero Brian M Sadler Ph D Strategic PK

    Original URL path: http://nonmem.org/nonmem/nm/99nov172006.html (2016-04-25)
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  • [NMusers] Phase III trail popPK sample size
    model based on the Phase I and II study According to FDA popPK guidance the sample scheme can be multiple trough points or optimal sample points I was wondering which one is better Your suggestion will be highly appreciated Regards Mei From Stephen Duffull stephen duffull stonebow otago ac nz Subject RE NMusers Phase III trail popPK sample size Date Fri 17 Nov 2006 18 18 36 1300 Mei impossible to collect samples from all patients We want to randomly select a subpopulation to collect PK samples I was wondering what is the typical number of PK samples and subjects reported in phase III PopPK study It depends on 1 the structure and complexity of your PKPD model 2 study visit times 3 the maximum number of samples allowable per patient 4 and the goals you have for doing popPKPD modelling in phase III We have already developed the Pop PK PD model based on the Phase I and II study According to FDA popPK guidance the sample scheme can be multiple trough points or optimal sample points I was wondering which one is better Optimal samples are always better than non optimal samples You could frame the problem as

    Original URL path: http://nonmem.org/nonmem/nm/99nov162006.html (2016-04-25)
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