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  • [NMusers] Compaq Visual Fortran 6.6
    2006 09 54 46 0500 Hello Just had a quick question When using Compaq Visual Fortran v6 6 as the compiler for NONMEM what are reasonable compiler options to set for optimization floating point etc Are there any compiler options that are known to cause problems inconsistent results or substantially affect the runtime of NONMEM Thanks John Sabo John P Sabo M S Principal Scientist DMPK Clinical Pharmacokinetics R8 5

    Original URL path: http://nonmem.org/nonmem/nm/99feb242006.html (2016-04-25)
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  • [NMusers] Sample size requirement for POP PK analysis to identify drug interactions
    It doesn t make sense to waste time on some comedication if there isn t enough patients taking it to support a reliable conclusion The question is how do we decide on this cutoff I can imagine extensive simulations can give us some information on this but the answer will vary from one case to another and it doesn t seem very practical in the industry environment due to the usually aggressive timelines Is there a general rule of thumb I would really appreciate if other NONMEM users could share your experience Also it will be very beneficial if FDA and other regulatory agencies could share their view on this Particularly for the claiming of lack of interaction how do the agencies decide whether there is sufficient number of patients taking the comedication in the trial to support the claim I noticed that some agency will also see the confidence interval associated with the lack of effect but again how should we decide whether the confidence interval for the lack of effect is acceptable or not Thanks very much for your help Qi Qi Liu Ph D Merck Co Inc WP75B 100 P O Box 4 West Point PA 19486 Tel 215 652 4096 Fax 215 993 1265 From Stephen Duffull sduffull pharmacy uq edu au Subject RE NMusers Sample size requirement for POP PK analysis to identify drug inte ractions Date Sat 25 Feb 2006 07 57 18 1000 Hi Qi Accurate identification of covariates is not a trivial task in any setting Determining sample size should be considered on a case by case setting For general consideration you could have a look at Ribbing and Jonsson JPKPD 2004 31 109 134 Essentially the size of the covariate effect the distribution of the covariate across the study population the

    Original URL path: http://nonmem.org/nonmem/nm/99feb232006.html (2016-04-25)
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  • [NMusers] Sequential PK/PD approach Query
    on setting up of Data file since we have 2 different groups of population with different sampling times Thanks David From Bill Bachman bachmanw comcast net Subject RE NMusers Sequential PK PD approach Query Date Tue 21 Feb 2006 07 11 25 0500 One approach would be to 1 Determine the PK model and parameter estimates from the PK group data 2 Create a PK PD model where the PK

    Original URL path: http://nonmem.org/nonmem/nm/99feb202006.html (2016-04-25)
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  • [NMusers] unit of weighted residual
    unit of weighted residual Date Mon 13 Feb 2006 07 44 49 0800 PST Dear Users I have a trivial question to ask Dose weighted residual carry any unit If observation unit is mg L and weight is 1 y

    Original URL path: http://nonmem.org/nonmem/nm/99feb132006.html (2016-04-25)
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  • [NMusers] Single Precision NONMEM
    Feb 2006 14 50 57 0500 Is anyone using the single precision version of NONMEM If so please let me know luddent iconus com At one time this version was used on the Cray and possibly other supercomputers with very long single precision floading point architecture I am not aware of any NONMEM users currently running problems in that type of computing environment Does anyone see a problem with discontinuing

    Original URL path: http://nonmem.org/nonmem/nm/99feb092006.html (2016-04-25)
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  • [NMusers] interoccasion variability
    to get two different time profile not only due to the measurement noise but also due to a change in the individual PK parameters for that specific individual sometime due to change in some covariate with time Usually you will take the first full time Profile let say starting day 1 finishing day 10 and will define it as belonging to the first occasion and then the second trial let say starting day 30 finishing day 40 and will define it as belonging to the second occasion I do not think that it is appropriate to take one trial data and associate each consecutive day as a different occasion Serge Guzy President POP PHARM From Mats Karlsson Subject RE NMusers interoccasion variability Date Mon 6 Feb 2006 20 52 14 0100 Dear Ann and Serge It is true that interoccasion variability is introduced to handle parameter variability within a subject over time Thus the lower limit of what may constitute an occasion is the interval necessary in order to obtain an estimate of the parameter Thus every dosing interval may constitute an occasion For example for a parameter like bioavailability this is often the most reasonable definition To allow separation between interoccasion and residual variability it is necessary to have at least two observations per occasion for at least some of the occasions Thus regarding Ann s original question I think it is reasonable to treat each day as a separate occasion at least is the half life is below about 8 hours However I would be careful and inspect the result to make sure that you are not treating what are systematic changes with a random effects model If some patient has deteriorating eliminating organ function over time and some other patient on the other hand improves consistently over

    Original URL path: http://nonmem.org/nonmem/nm/99feb062006.html (2016-04-25)
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  • [NMusers] 100% CPU with NONMEM
    know about other OSs Hope this helps Mark Peterson From Sam Liao sliao pharmaxresearch com Subject Re NMusers 100 CPU with NONMEM Date Wed 01 Feb 2006 13 04 28 0500 Hi Pete I agree with Mark Another alternative is to turn on the hyper threading This has to be done in PC setup soon after you power up your PC use F2 key You should be able to find hyper threading set up under performance or PC configuration My new Dell PC came with hyper threading on Turn hyper threading on or enable will create two logical CPU and allow up to 50 of the CPU time to any application Have fun with your new PC Sam Liao Pharmax Research From mark e sale gsk com Subject Re NMusers 100 CPU with NONMEM Date Wed 01 Feb 2006 Sam Sorry to disagree but HT does not work for NONMEM The multiple instruction paths on the Intel chips include only one for floating point operations and 4 for integer operations We have benchmarked NONMEM with and without HT and it makes no difference and makes no difference in responsiveness of the GUI HT is basically intended for gamers Mark Sale M D Global Director Research Modeling and Simulation GlaxoSmithKline 919 483 1808 Mobile 919 522 6668 From Sam Liao sliao pharmaxresearch com Subject Re NMusers 100 CPU with NONMEM Date Wed 01 Feb 2006 13 37 09 0500 Hi Mark As I indicated my Dell PC came with HT on and my NONMEM run only take up to 50 of the CPU for each job I do not have to select set priority each time when I run NONMEM Sam Liao Pharmax Research From Darin Perusich Darin Perusich cognigencorp com Subject Re NMusers 100 CPU with NONMEM Date Wed 01

    Original URL path: http://nonmem.org/nonmem/nm/98feb012006.html (2016-04-25)
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  • [NMusers] Where to download Population Fisher Information Matrix?
    anyone know where I can download Population Fisher Informaiton Matrix for S Plus Please let me know The link I had dose not work any more Thank you P Zhou From Nick Holford n holford auckland ac nz Subject Re NMusers Where to download Population Fisher Information Matrix Date Thu 02 Feb 2006 13 11 52 1300 http www bichat inserm fr equipes Emi0357 download html Nick Holford Dept Pharmacology

    Original URL path: http://nonmem.org/nonmem/nm/99feb012006.html (2016-04-25)
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