archive-org.com » ORG » N » NONMEM.ORG

Total: 436

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • [NMusers] Have you run NONMEM on a G5 Macintosh?
    20 Dec 2005 13 00 50 0500 Dear nmusers we are planning to run NONMEM on a G5 MacIntosh OS 10 4 tiger dual core 64 bit processor from IBM There are some hints that in BLKDAT for the IEEE

    Original URL path: http://nonmem.org/nonmem/nm/99dec202005.html (2016-04-25)
    Open archived version from archive


  • [NMusers] PD modeling: What is the most efficient approach to transfer data?
    approach This is quite easy to set up once you have combined the PK and PD observations into a single dataset You just write the full model as if for a simultaneous analysis but FIX all the PK parameters The data set includes the PK observations the D in PPPD and the model uses the fixed population PK parameters the PPP in PPPD Nick Nick Holford Dept Pharmacology Clinical Pharmacology University of Auckland 85 Park Rd Private Bag 92019 Auckland New Zealand email n holford auckland ac nz tel 64 9 373 7599x86730 fax 373 7556 http www health auckland ac nz pharmacology staff nholford From Bachman William MYD bachmanw iconus com Subject RE NMusers PD modeling What is the most efficient approach to transfer data Date Tue 20 Dec 2005 08 06 04 0500 The argument made against simultaneous PK PD modeling is that potentially the PD data could drive the PD model the cart before the horse Make your own conclusion just stating the usual argument The alternative to transferring data from PK to PD model is to generate the individualized PK parameters POSTHOC or FOCE estimates and include them in the PD data file Then insert them into the PK model that generates predictions for the PD model Adding more time points with EVID 2 is the only way I can think of to generate more time points The only errors you can make are getting the times wrong or not asking for the prediction in the correct CMT From Bachman William MYD bachmanw iconus com Subject RE NMusers PD modeling What is the most efficient approach to transfer data Date Tue 20 Dec 2005 11 45 20 0500 that should have read the PK data could drive the PD model From Bachman William MYD bachmanw iconus

    Original URL path: http://nonmem.org/nonmem/nm/99dec192005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] NM mixture model with three subgroups
    1 ELSE POP2 1 ENDIF CL POP1 CL1 POP2 CL2 MIX P 1 THETA 8 P 2 1 THETA 8 NSPOP 2 Sincerely yours Tsang Bin Tzeng Ph D AstraZeneca Pharmaceuticals 302 885 9954 From Riley Steve Steve Riley pfizer com Subject RE NMusers NM mixture model with three subgroups Date Mon 19 Dec 2005 09 23 48 0500 Tsang Bin I would code the problem as follows MIXTURE MODEL EST MIXEST IF MIXNUM EQ 1 THEN CL CL1 ELSE IF MIXNUM EQ 2 THEN CL CL2 ELSE CL CL3 ENDIF MIX P 1 THETA 8 1 THETA 8 THETA 9 P 2 THETA 9 1 THETA 8 THETA 9 P 3 1 1 THETA 8 THETA 9 NSPOP 3 Steve From Tzeng Tsang Bin Tsang Bin Tzeng astrazeneca com Subject RE NMusers NM mixture model with three subgroups Date Mon 19 Dec 2005 09 54 36 0500 Dear Joern Sam Mouksassi and Steve Thanks very much for these wonderful helps and tips They are more than what we originally anticipated I shall share with you if we are lucky enough to come out with something from this modeling exercise using your suggestions Sincerely yours Tsang Bin Tzeng Ph D

    Original URL path: http://nonmem.org/nonmem/nm/99dec182005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Revised NMTRAN Bug List [01DEC2005]
    to elapsed times can be faulty All elapsed times resulting from clock time translation should have two digits to the right of the decimal point Certain elapsed times greater than 999 99 hours 41 6 days are unpredictably and mistakenly truncated so that they contain only one digit to the right of the decimal point See discussion in the NONMEM Archive http www cognigencorp com nonmem nm 99apr192002 html Fix In routine READ3 replace the line ELSEIF VALUE KK J GE 1000 0 AND WIDE NE Y THEN with ELSEIF VALUE KK J GE 1000 0 AND WIDE NE Y AND NSP EQ 1 THEN XV The error message DATA WIDE CANNOT BE USED FILE CONTAINS MORE THAN 9999 RECS may appear but it should not appear when 1 the WIDE option appears on the DATA record 2 there are more than 9999 records in the data set 3 the control stream consists of a single problem Fix In routine READF insert these two statements anywhere among the other declaration statements COMMON COMEND ENDFIL LOGICAL ENDFIL and change the line IF INOBS GT 9999 AND WIDE EQ Y CALL ERRMSG 283 1 to IF INOBS GT 9999 AND WIDE EQ Y AND NOT ENDFIL X CALL ERRMSG 283 1 In routine GETITM insert this statement anywhere among the other declarations COMMON COMEND ENDFIL In routine CHKDAT locate the line IF MKFDAT AND INOBS GT K9999 THEN and after it insert the 2 lines FINFLG 1 IF WIDE NE Y THEN 6 lines down from this statement locate the statement FINFLG 1 and replace it with ENDIF XVI NM TRAN translation of TIME data items is faulty when 1 NM TRAN infers that the data are single subject data 2 the name ID is listed in the INPUT record as ID or ID L1 3 some synonym A B and or DATE DROP preceeds ID in the INPUT record Time translation occurs when either clock times are present in the NM TRAN data set or DATE items appear Usually when time translation occurs with single subject data ID does not appear in the INPUT record though L1 may appear in which case the TIME data item on the first record of the data set is translated to 0 and subsequent TIME data items are translated to times relative to 0 When ID is listed in the INPUT record with every data record where the ID data item changes value the TIME data item is translated to 0 and subsequent TIME data items up to the next change in ID value are translated to times relative to 0 Due to the bug if ID is listed near the beginning of the INPUT record different data from the ID data items are used in the process of time translation If the ID is listed near the end of the INPUT record the ID data items are ignored in the process of time translation i e all TIME data items subsequent to the one on the first data record are translated to times relative to 0 Work around Construct a new data set such that 3 above will not happen That is the new data set will be exactly like the old data set except for having a new column that is exactly like the column in the original data set with the ID data items column C and the new column will be placed before the columns with the A type data items and or the DATE data items Actually column C itself can be deleted but if it is not give this column a name N different from ID and use N DROP Work around Avoid using the synonym A B XVII The constant LNP4 in files TSIZES is set at installation time to the default value of 1000 An error occurs during compilation of generated code when LNP4 is set to a value greater than 9999 However a value greater than 9999 is of little practical value When the option COMRES n n 0 is used in the ABBREVIATED record or when verbatim code is used and when LNP4 is set to a value greater than 1000 an error occurs during compilation of generated code Fix In routine GENCOM replace the two lines of code WRITE LINE A I4 4 A DIMENSION COM COMMAX LL 19 with WRITE LINE A I6 6 A DIMENSION COM COMMAX LL 21 XVIII The data may be mistakenly interpreted as single subject data when 1 there are multiple problem specifications 2 in the second or subsequent problem specification a MSFI record appears without the NPOP option With the problem specification where the MSFI record appears without the NPOP option the data are misinterpreted as single subject data An error message will make it clear that the data are being misinterpreted Work around Include the NPOP option XIX Fatal error message 386 spuriously arises when abbreviated code such as IF condition statement is used where 1 the condition includes a test of ICALL or COMACT and either 2a the statement is a WRITE PRINT statement that uses either ICALL or COMACT in the output list or 2b the statement is an assignment statement that uses either ICALL or COMACT as a right hand quantity Work around Instead of the above IF statement use IF condition THEN statement ENDIF XX There arises a faulty end of record condition when 1 a superproblem is used 2 the data set is too large Work around Try reinstalling NONMEM setting LIM1 the size of buffer 1 to a value large enough that for each of the problems in the superproblem the entire data set for the problem can be stored in computer memory throughout the NONMEM run See Guide III chapter III section 2 9 4 XXI A constant used in abbreviated code may not be translated into a double precision constant when 1 neither the SP nor LIBRARY options appear in the SUBROUTINE statement 2 a statement of form

    Original URL path: http://nonmem.org/nonmem/nm/99dec142005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Looking for faster CPU
    if I was assured of improved throughput Comments on the relative advantages of XP versus Linux are welcome Cheers Brian Brian M Sadler Strategic PK Consulting LLC Bsadler1 nc rr com 1 919 523 5485 From Darin Perusich Darin Perusich cognigencorp com Subject Re NMusers Looking for faster CPU Date Tue 13 Dec 2005 11 34 01 0500 a 64 byte machine will by you nothing for nonmem you should stick with 32 byte machines generally speaking application run times on 32 byte machines tend to be faster then on equiltant 64 byte systems the big advantage on the 64 byte archicture is when you have huge memory reguirements like oracle databases you could take the 6 10k and buy 5 or 6 servers then you can run 5 or 6 jobs at the same time i would think that you d get more benefit from that then getting a single machine my 2 cents Darin Perusich Unix Systems Administrator Cognigen Corp darinper cognigencorp com From mark e sale gsk com Subject Re NMusers Looking for faster CPU Date Tue 13 Dec 2005 12 24 46 0500 Daren Is that with a 32 bit compiler or the new 64 bit

    Original URL path: http://nonmem.org/nonmem/nm/99dec132005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] software for transpose
    Most data editing softwares will allow you to transpose the data efficiently Here is an example using Splus CREATE data data data frame ID rep 1 2 each 2 TIME rep c 1 10 2 DV round rnorm 4 10 2 2 PRINT data data ID TIME DV 1 1 7 09 1 10 9 77 2 1 9 98 2 10 11 06 TRANSPOSE data t data ID 1

    Original URL path: http://nonmem.org/nonmem/nm/99dec092005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Models for Ordered Categorical Pharmacodynamic Data
    6125 1 fulltext pdf With best regards Per Henrik Per Henrik Zingmark Senior Research Scientist Clinical Pharmacology AstraZeneca R D S 151 85 Södertälje Sweden Phone 46 8 553 239 42 Fax 46 8 553 288 96 e mail per henrik zingmark astrazeneca com From Per Henrik Zingmark astrazeneca com Subject RE NMusers Models for Ordered Categorical Pharmacodynamic Data Date Thu 8 Dec 2005 13 40 00 0100 Dear NONMEM

    Original URL path: http://nonmem.org/nonmem/nm/99dec082005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Excel File Import Error
    but I cannot view output file using excel plotter as it gives the same error msg Does anyone have a suggestion for this issue Thanks Manoj Khurana From Paul Matthias Diderichsen pmdi novonordisk com Subject Re NMusers Excel File Import Error Date Wed 30 Nov 2005 09 01 17 0100 Dear Manoj Could you provide a few lines of the datafile You can mask out some digits eg YY XXX

    Original URL path: http://nonmem.org/nonmem/nm/99nov292005.html (2016-04-25)
    Open archived version from archive



  •