archive-org.com » ORG » N » NONMEM.ORG

Total: 436

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • [NMusers] Question about error message regarding invalid MDV field
    108 0 0 0 2 1 330367 0 1 120 0 0 0 2 0 1491756 0 2 0 1309 1309 4 24 1 2 1 2 95 9 0 0 0 2 0 1474309 0 2 98 0 0 0 2 5 74108 0 etc running the control file gives me these error messages RECORD 2 DATA ITEM 10 0 1552822 INVALID MDV FIELD etc I altered the code where I input every dosing event instead of using the ADDL and II data PROB POPULATION PK MODEL INPUT ID TIME AMT RATE EVID CMT DV DATA TEST1 CSV IGNORE C SUBROUTINES ADVAN4 PK K THETA 1 EXP ETA 1 V THETA 2 EXP ETA 2 K12 THETA 3 EXP ETA 3 K21 THETA 4 EXP ETA 4 S2 V THETA 0 500 KE 0 200 2300 V 0 0 065 10 K12 0 0 056 10 K21 ERROR IPRED F IRES DV IPRED IWRES IRES F Y F 1 EPS 1 EPS 2 OMEGA DIAG 4 0 16 KE 0 16 V 0 49 K21 0 49 K12 SIGMA 0 13 P 0 02 A EST SIGDIGITS 4 MAXEVAL 9999 PRINT 20 METHOD 1 POSTHOC COV TABLE ID TIME DV IPRED IWRES NOPRINT ONEHEADER FILE xxx TAB TABLE ID K V K12 K21 NOPRINT ONEHEADER FILE xxx1 TAB and the data file was as follows C ID TIME AMT RATE EVID CMT DV 1 0 1309 436 1 2 1 24 1309 436 1 2 1 48 1309 436 1 2 1 72 1309 436 1 2 1 95 9 0 0 0 2 0 155 1 96 1309 436 1 2 1 98 0 0 0 2 0 124 1 100 0 0 0 2 6 468 1 102 0 0 0 2 4 244 1 108 0

    Original URL path: http://nonmem.org/nonmem/nm/97sep062005.html (2016-04-25)
    Open archived version from archive


  • [NMusers] FW: revised NONMEM bug list [31AUG2005]
    in a given problem specification each having a FILE option that uses the same file name the second and subsequent TABLE records in the series are always treated as though the FORWARD option appears on these records because otherwise the presence of these records makes no sense It also really makes no sense to use the NOFORWARD option with any TABLE record regardless of the file name used by the FILE option in a problem specification with an NSUBS value of 2 or more So with NONMEM Version VI this will constitute another exception as to when the NOFORWARD option is the default option VI When each of two different problems within the scope of a superproblem use the same file as either a NONMEM data file Model Specification Input file or Model Specification Output file or table file an abnormal operating system termination may arise If these circumstances do not lead to such a termination the user should not be concerned Fix Before each of the two instances of the statement I2 0 in routine SUPER insert the statement IF I2 EQ 1 CLOSE UN 2 Before each of the two instances of the statement I3 0 in routine SUPER insert the statement IF I3 EQ 1 CLOSE UN 3 Before each of the two instances of the statement I4 0 in routine SUPER insert the statement IF I4 EQ 1 CLOSE UN 4 Work around Avoid such circumstances An example of where these circumstances arise may be found in the Help Guide Superproblem Example 1 For this example the file simulation is used as a table file in problem 2 and as a NONMEM data file in problem 3 This can be avoided by taking the data set of problem 3 to be the internal data set created with problem 2 remove both the TABLE record of problem 2 and the DATA record of problem 3 VII When a mixture model is used estimates of etas available to the PRED routine during problem finalization i e when ICALL 3 are always those for the first submodel With each individual they should be those for the submodel to which the individual is classified VIII The statistic ETABAR and results from the Centering First Order Conditional Estimation method are incorrect when 1 a mixture model is used 2 the mixture probability of either the first or last subpopulation is set to 0 Work around Usually if a mixture probability is being set to 0 this is being done for all individuals and for all values of the population parameters In this case simply remove any reference to the first or last subpopulation from routine MIX Otherwise try to keep the first and last subpopulation from being one with a mixture probability equal to 0 IX NONMEM output will be faulty when an individual exists whose data 1 are not influenced by a particular eta eta1 2 are influenced by an eta which is correlated via the OMEGA matrix with eta1

    Original URL path: http://nonmem.org/nonmem/nm/98sep062005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] FYI: end of Compaq support for Compaq Visual Fortran
    Tuesday September 06 2005 9 54 AM To raon globomax com bachmanw globomax com Subject Compaq Visual Fortran to IntelR Visual Fortran Compaq Visual Fortran to Intel Visual Fortran We Programmer s Paradise are the U S fulfillment partner of HP and Intel regarding the migration path from Compaq Visual Fortran to Intel Visual Fortran You might have received an email from HP about this subject with the message below Hewlett Packard plans to discontinue Compaq Visual Fortran on December 31st 2005 We recommend our Compaq Visual Fortran customers take advantage of the migration path to Intel Visual Fortran 9 0 We have worked with Intel to make the migration as easy and attractive as possible Intel has created a special web page at http www intel com software products compilers upgrade to ivf htm It includes information on the migration path to Intel Visual Fortran Compilers including additional support for migration a white paper to help port applications from Compaq Visual Fortran to Intel Visual Fortran information on special upgrade pricing for CVF users and more We are happy to be able to offer you special pricing for this migration Compaq Visual Fortran to Intel Visual Fortran for 184

    Original URL path: http://nonmem.org/nonmem/nm/99sep062005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] gcc and ADVAN5 -7
    27 1200 JX g77 works fine with ADVAN5 whenever I have used it What version of g77 are you using This is what I am using C Users Nick g77 version GNU Fortran GCC 3 1 3 1 20020514 release Copyright C 2002 Free Software Foundation Inc Nick Jean Xavier Mazoit kb u psud fr wrote Nick Holford Dept Pharmacology Clinical Pharmacology University of Auckland 85 Park Rd Private Bag 92019 Auckland New Zealand email n holford auckland ac nz tel 64 9 373 7599x86730 fax 373 7556 http www health auckland ac nz pharmacology staff nholford From Sam Liao sliao pharmaxresearch com Subject Re NMusers gcc and ADVAN5 7 Date Thu 01 Sep 2005 09 34 37 0400 Hi JX Please check if FSUBS files were deleted as specified at the end of your nmfe5 bat I wonder if the problem might be in the step after creation of FSUBS files where it tried to link the fsubs obj with nonmem lib Sam Liao Pharmax Research From Nick Holford n holford auckland ac nz Subject Re NMusers gcc and ADVAN5 7 Date Fri 02 Sep 2005 08 54 44 1200 JXM You did not say you were using the LIBRARY option This is a rarely used and almost never needed feature of NM TRAN NONMEM Have you tried without using this option Perhaps you have not compiled the tl subroutines with g77 which are required for using the LIBRARY option Nick Nick Holford Dept Pharmacology Clinical Pharmacology University of Auckland 85 Park Rd Private Bag 92019 Auckland New Zealand email n holford auckland ac nz tel 64 9 373 7599x86730 fax 373 7556 http www health auckland ac nz pharmacology staff nholford From Bachman William MYD bachmanw iconus com Subject RE NMusers gcc and ADVAN5 7 Date Tue 6

    Original URL path: http://nonmem.org/nonmem/nm/99sep012005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Using CONT data item
    16 17 18 19 ID CONT DV MDV TIME AMT CMT SS II RATE EVID WT ICL IVC IQ IVP ITAB ITLA IF1 2 The INPUT record must only specify items data items on the second line CONT 0 e g INPUT ID CONT DV MDV TIME AMT CMT ADDL II RATE EVID WT ICL IVC IQ IVP ITAB ITLA IF1 3 In PK I extract the data items from the first line CONT 1 using verbatim code using their position in the EVTREC matrix When I want to use these variables later in abbreviated code NM TRAN will complain if I only define them in verbatim code So I declare them to NM TRAN in a NEWIND block The assignment of 0 to these variables does nothing except keep NM TRAN happy PK Declare extra data item variable names for NM TRAN IF NEWIND LE 1 THEN STDY 0 RACE 0 RF 0 AGE 0 DVID 0 ENDIF Get data items from EVTREC matrix STDY EVTREC 1 5 RACE EVTREC 1 6 RF EVTREC 1 7 AGE EVTREC 1 8 DVID EVTREC 1 9 Use the extra data item AGE in this example FAGE EXP KAGE AGE 40 CL FAGE THETA 1 EXP ETA 1 In the example above I describe things in terms of 2 lines with the second line being the CONT 0 line I have not tested it but in theory one should be able to extend this process using as many lines per event record as you wish All lines but the last one must have CONT 1 and the same values of ID DV and MDV The last line of the set of lines making up one event record must have CONT 0 Nick Nick Holford Dept Pharmacology Clinical Pharmacology University of Auckland 85

    Original URL path: http://nonmem.org/nonmem/nm/99aug272005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] Installation error message.
    com Subject Re NMusers Installation error message Date Fri 26 Aug 2005 13 27 48 0400 Phil Likely you need to add the path to the compiler to you environment variable PATH from control panel Start Setting Control panel click on the System icon Click on Advanced then Environment variables You can add the path to either the system PATH environment variable or the user PATH environment variable mine is in the system PATH for my installation it is C Fortran Compiler DF98 BIN you ll also need C Fortran Compiler Common MSDEV98 BIN C Fortran Compiler VC98 BIN C Fortran Compiler Common TOOLS to get the libraries and the link command I think that you may have had the option at installation to have the installation script append this to your path The reason it works in the Fortran MSDOS windows is that that window sets the local PATH environment variable when it opens It won t work to just install the NM file from the Fortran command prompt NMFE5 needs this path every time it runs Mark Sale M D Global Director Research Modeling and Simulation GlaxoSmithKline 919 483 1808 Mobile 919 522 6668 From Nick Holford n

    Original URL path: http://nonmem.org/nonmem/nm/99aug262005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] problems with df.txt file?
    find the file specified WARNINGS AND ERRORS IF ANY FOR PROBLEM 1 WARNING 2 NM TRAN INFERS THAT THE DATA ARE POPULATION Stop Program terminated 1 file s copied No nonmem execution There may be error messages in file df txt Thanks a lot Matt Matthew Duplin RN BSN Senior PK Associate Clinical Pharmacokinetics Pharmacodynamics Pfizer Global R D Headquarters EMail Matthew R Duplin Pfizer com Office 860 732 4344

    Original URL path: http://nonmem.org/nonmem/nm/99aug252005.html (2016-04-25)
    Open archived version from archive

  • [NMusers] exceeding max. number of INPUT-variables
    8 293 2 36 4005 1 23 8 2 674 0 006 7 27 12 32 4 49 10 29 35 3 8 6 7 1 38 12 1 1 284 4 2 36 4801 4 17 1 2 552 0 004 5 66 11 87 5 11 8 65 36 6 1 12 3 1 38 25 8 1 303 5 2 36 5491 9 22 3 1 813 0 004 9 9 14 62 2 15 10 22 36 6 1 12 3 1 38 25 8 1 303 5 2 36 5491 9 22 3 1 813 0 004 9 9 14 62 2 15 10 22 37 6 7 7 9 1 38 10 6 0 9 290 1 2 36 4396 4 19 4 2 456 0 004 5 18 14 87 8 35 8 19 38 5 4 12 7 1 38 13 0 8 302 6 2 36 4423 4 15 5 1 22 0 004 5 7 10 78 6 43 8 07 39 7 1 7 5 1 38 13 4 0 9 280 5 2 36 4559 6 12 9 1 72 0 003 5 58 13 37 7 13 7 23 43 3 9 6 2 1 38 9 8 0 9 277 6 2 36 4428 5 16 1 2 597 0 004 5 33 8 85 4 97 6 06 44 4 2 7 6 1 38 9 6 1 3 266 1 2 36 4565 2 9 8 1 289 0 002 5 48 8 04 5 65 6 03 45 3 5 10 1 38 18 9 0 7 312 3 2 36 4600 7 12 8 1 255 0 003 8 36 14 07 5 43 7 24 46 9 5 8 1 38 6 8 0 9 282 8 2 36 3560 2 23 9 4 121 0 007 9 3 17 22 5 41 10 07 48 3 6 8 1 38 11 2 1 276 3 2 36 4545 7 13 3 1 663 0 003 8 24 11 87 5 7 7 41 50 4 5 6 2 1 38 9 9 0 9 287 9 2 36 4535 3 13 6 2 194 0 003 7 3 12 22 6 51 7 22 51 2 2 8 8 1 38 7 6 1 1 290 2 2 36 4355 2 13 2 1 5 0 003 6 07 12 15 5 8 8 19 52 2 7 8 1 1 38 16 0 8 292 9 2 36 4520 1 30 7 3 79 0 007 10 32 15 27 5 21 9 73 53 4 9 11 9 1 38 16 7 1 287 2 36 4601 8 13 4 1 126 0 003 4 89 9 46 6 08 6 86 56 3 7 10 4 1 38 25 3 1 290 3 2 36 4641 8 15 2 1 462 0 003 7 48 9 71 5 81 6 57 4 5 7 1 38 9 6 0 8 290 6 2 36 4041 21 2 3 029 0 005 7 37 11 6 5 96 8 06 59 4 6 8 2 1 38 7 4 0 9 291 3 2 36 4296 6 12 3 1 5 0 003 15 42 3 07 1 07 9 58 60 5 9 8 5 1 38 6 7 0 7 303 3 2 36 3349 20 3 2 388 0 006 7 08 13 89 7 32 10 45 61 7 2 4 6 1 38 8 5 0 8 265 4 2 36 4410 5 13 5 2 935 0 003 5 67 9 34 5 6 6 23 62 5 9 8 5 1 38 11 0 9 294 4 2 36 4432 8 18 7 2 2 0 004 7 92 10 18 5 59 6 92 63 2 7 20 4 1 38 12 7 0 6 315 2 2 36 4126 8 20 6 1 01 0 005 5 44 11 76 7 36 8 96 66 3 6 10 4 1 38 11 9 0 7 309 2 36 4282 7 20 4 1 962 0 005 5 01 11 69 6 81 8 18 68 6 5 7 2 1 38 30 2 0 9 281 1 2 36 4594 3 18 8 2 611 0 004 10 87 11 24 7 62 6 69 70 3 2 3 6 1 38 5 2 0 9 271 2 2 36 4332 9 6 4 1 778 0 001 10 24 9 8 4 63 9 04 71 3 6 11 8 1 38 7 6 0 9 297 1 2 36 4369 8 9 4 0 797 0 002 6 65 22 82 11 91 9 8 73 7 6 9 2 1 38 21 2 0 9 285 8 2 36 4617 8 14 5 1 576 0 003 8 32 9 91 3 42 8 09 75 3 1 6 4 1 38 21 5 0 8 281 9 2 36 4574 9 16 9 2 641 0 004 8 52 10 56 3 05 7 85 75 3 1 6 4 1 38 21 5 0 8 281 9 2 36 4574 9 16 9 2 641 0 004 8 52 10 56 3 05 7 85 76 6 3 7 1 1 38 6 1 0 8 291 4 2 36 4371 4 7 7 1 085 0 002 6 6 11 66 6 6 6 79 78 3 5 7 1 38 12 5 0 9 282 7 2 36 4471 24 9 3 557 0 006 10 64 13 48 8 8 9 79 4 4 6 5 1 38 6 2 1 285 1 2 36 4153 4 14 4 2 215 0 003 6 96 10 21 4 06 7 02 80 3 6 9 1 1 38 10 3 0

    Original URL path: http://nonmem.org/nonmem/nm/98aug242005.html (2016-04-25)
    Open archived version from archive



  •