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  • [NMusers] Where's my email?
    got posted I no longer need to post the email anymore but I would like to know what happened for future postings I ve posted things successful in the past so I m not sure what has changed Is there any way to know if it was received If it wasn t then I ll need to contact my IT department here to find out why my email did not get sent despite Outlook telling me that it did Thanks The title was BSV in NM simulations Max Max Tsai Ph D Senior Scientist DM PK Schering Plough Corporation 2015 Galloping Hill Road K 15 2 2650 Kenilworth NJ 07033 0530 908 740 3911 Ê 908 740 2916 max tsai spcorp com From Bachman William MYD bachmanw iconus com Subject NMusers RE Where s my email Date Wed 3 Aug 2005 10 39 17 0400 Things that can can posting failure to nmusers email too long e g there have been many additions to a thread and you have added yet another work around is to cut off the excess thread verbage and just send your addition to the thread and maybe the immediate prior addition if you really think

    Original URL path: http://nonmem.org/nonmem/nm/98aug032005.html (2016-04-25)
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  • [NMusers] Standard errors below 0.1%?
    0 IF ID EQ 3 AND OCC GT 1 ALAG1 THETA 6 IF ID EQ 6 AND OCC GT 1 ALAG1 THETA 6 IF ID EQ 9 AND OCC GT 1 ALAG1 THETA 6 TVEC50 THETA 7 EC50 TVEC50 TVEMAX THETA 8 EMAX TVEMAX TVKIC THETA 9 KIC TVKIC TVCL THETA 10 CL TVCL EXP ETA 5 S1 V1 K14 CL V1 K12 Q V1 K21 Q V2 DES CLIN A 1 V1 DADT 1 A 1 K12 A 2 K21 A 1 K10 1 EMAX A 3 A 3 EC50 K14 A 1 DADT 2 A 1 K12 A 2 K21 DADT 3 KIC CLIN A 3 CL2 K10 1 EMAX A 3 A 3 EC50 V1 ERROR IPRED F DEL 0 IF IPRED EQ 0 DEL 0 0001 W F IRES DV IPRED IWRES IRES W DEL Y IPRED W EPS 1 EPS 2 INITIAL ESTIMATES THETA 0 05 0 14 1 K10 THETA 0 1 21 2 2 V1 THETA 0 1 76 3 Q THETA 0 1 30 4 V2 THETA 0 001 1 5 D1 THETA 1 23 FIX 6 ALAG1 THETA 0 1 0 15 7 EC50 THETA 1 FIX 8 EMAX THETA 0 001 0 005 9 KIC THETA 0 1 7 5 10 CL OMEGA 5 1 IIV K10 OMEGA 0 15 2 IIV V1 OMEGA 0 1 3 IIV V2 OMEGA 0 4 4 IIV D1 OMEGA 0 3 5 IIV CL SIGMA 0 01 prop error SIGMA 0 1 add error ESTIMATION PRINT 5 METHOD 1 INTERACTION MSFO msf MAXEVAL 9999 NOABORT COV TABLE ID TIME IPRED IWRES ONEHEADER NOPRINT FILE sdtab TABLE ID ETA1 ETA2 ETA3 ETA4 ETA5 K10 V1 Q K14 V2 D1 ALAG1 EC50 EMAX KIC CL CL2 Q FLAG ONEHEADER NOPRINT FILE patab From Bachman William

    Original URL path: http://nonmem.org/nonmem/nm/99aug032005.html (2016-04-25)
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  • [NMusers] initial evaluation of S-Plus 7.0?
    the new version My initial findings are that any attempt to launch S Plus scripts via the batch process fail unless you get the patch from Insightful that takes you from version 7 0 to 7 02 Once the patch was installed S Plus 7 0 appears to be compatible with the S Plus scripts that PDx Pop and Xpose 3 1 use If you have any other observations related

    Original URL path: http://nonmem.org/nonmem/nm/99aug022005.html (2016-04-25)
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  • [NMusers] NONMEMory => Census
    NONMEM is a registered trademark of the University of California and is exclusively licensed to GloboMax LLC NONMEMory is a completely independent project having no ties to either UC or GloboMax except that it is designed to work with NONMEM To reflect this and to avoid any confusion in the future NONMEMory has been renamed to Census The new path for its home on the web is http www farmbio

    Original URL path: http://nonmem.org/nonmem/nm/99jul282005.html (2016-04-25)
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  • [NMusers] log transformed data and multi compartment PK
    ETA4 TVKL KL ETA5 TVKA KA ETA6 TVKX KX ETA7 TVSV SV ETA8 ID CMT IPRED NOPRINT FILE 002NM20LOG FIT X ID CMT TIME CONC AMT RATE MDV 0 1 1 0 1 301029996 1 602059991 1 0 1 2 0 0 0 1 0 1 1 0 25 2 702266783 0 0 0 0 1 2 0 25 0 086186148 0 0 0 0 1 1 0 5 2 837481114 0 0 0 0 1 2 0 5 0 283996656 0 0 0 0 1 1 0 67 2 109659527 0 0 0 0 1 2 0 67 0 427128398 0 0 0 0 1 1 0 83 1 893040112 0 0 0 0 1 2 0 83 0 368556231 0 0 0 0 1 1 1 1 740094134 0 0 0 0 1 2 1 0 242603971 0 0 0 0 1 1 1 5 1 544626064 0 0 0 0 1 2 1 5 0 240332155 0 0 0 Immo Zdrojewski Pharmacist Graduate Student Pharmaceutics 352 846 2584 Nursing 352 273 6513 e mail zdrojew ufl edu From David Dai david dai bms com Subject RE NMusers log transformed data and multi compartment PK Date Tue 26 Jul 2005 18 05 20 0400 Hi Immo Log transformation is a better way to fit parent metabolite simultaneously I never got converged with FOCE interaction using real DV data but quite happy with log transformed data and run time was much shorter In your error block you might want to add the following lines to avoid the error messages CALLFL 0 IPRED 6 IF F GT 0 IPRED LOG F Additionally have you tried a different error structure for log transformed data such as combined additive and proportional model Best david From Leonid Gibiansky leonidg metrumrg com Subject Re NMusers log transformed data and multi compartment PK Date Tue 26 Jul 2005 18 17 03 0400 1 I would use ADVAN5 or ADVAN7 rather then differential equations if you want to speed up the process 2 It is better to follow conventions and use K13 K31 for the mass exchange between compartments 1 and 3 rather than K12 K21 and similarly for all the other coefficients 3 If F prediction is equal to zero NONMEM will crash Just in case use IPRED F IF IPRED LT some small number say LLOQ 0 01 IPRED same number say 0 01 Y1 LOG IPRED ERR 1 4 Try to start with just 2 3 random effects first and add more if needed supported by the data 5 You have identifiability problem You need either to fix S1 S2 or assume complete metabolism KE 0 or assume metabolization fraction KA some fixed number KE 6 What is the meaning of KL is it reversible metabolism Good luck Leonid From Gordi Toufigh Toufigh Gordi cvt com Subject RE NMusers log transformed data and multi compartment PK Date Tue 26 Jul 2005 15 29 23 0700 Hi Immo Your model is a very complex

    Original URL path: http://nonmem.org/nonmem/nm/99jul262005.html (2016-04-25)
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  • [NMusers] Release of NONMEMory
    usual provisos use at your own risk and so forth It does not require a local NONMEM installation since it relies on output files only and does not actually execute NONMEM runs and can cope with such files in both Windows and UNIX file formats NONMEM output is treated as read only data by the software and no changes are ever made It is in a continuous state of development and is still considered by me to be in beta so there will undoubtably be bugs if you choose to try NONMEMory and find any please report them to me Everyone s NONMEM environment is different and there are bound to be teething troubles That said it s been in testing for 18 months now at two different sites and seems to perform relatively well Also please send me suggestions and comments The only way that NONMEMory can improve and the only way it can serve your needs more efficiently is through feedback to the developer i e me Future plans include direct control over NONMEM reports and integration or cooperation with PsN http psn sourceforge net R http www r project org Xpose http xpose sourceforge net and Wings

    Original URL path: http://nonmem.org/nonmem/nm/99jul222005.html (2016-04-25)
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  • [NMusers] Failing table step upon redefining ETAs as additive (or high correlations in $COV output)
    the lowest concentrations measured except for one predose outlier As for subject 4 who causes the table step to fail the initial distribution phase is present in one sample only and immediately followed by a rather low concentration So it is no surprise that an 1 cmpt fit suites the data from subject 4 rather well ii additional runs I tried several runs with FOCE INTER to be sure non diag OMEGA instead of FO The EXP run resulted in essentially the same GOFs ETA distributions and parameters FOCE runs with additive errors with or without ETA on Q as EXP did not minimize succesfully e g due to rounding errors or this one 0MINIMIZATION TERMINATED DUE TO PROXIMITY OF LAST ITERATION EST TO A VALUE AT WHICH THE OBJ FUNC IS INFINITE ERROR 3D136 0AT THE LAST COMPUTED INFINITE VALUE OF THE OBJ FUNCT 0PRED EXIT CODE 3D 1 0INDIVIDUAL NO 83 ID 3D0 11400000E 03 WITHIN INDIVIDUAL DATA REC NO 1 THETA 3D 3 90E 00 2 43E 02 2 19E 02 1 26E 01 1 47E 02 OCCURS DURING SEARCH FOR ETA AT A NONZERO VALUE OF ETA PK SUBROUTINE USER ERROR CODE 3D 4 20 NB Although I knew it should not make a difference I inserted PREDD recovery on THETAs just to be sure Upon googling on Nonmem 01 may 2003 model diagnostics I reran two FO models with COV PRINT 3DE the full additive and the full EXP models the eigenvalue ratios were roughly 100 As the OMEGA matrix was non diagonal I have tried models in which I separated the ETA on Q out of the block The increase in obj funct roughly 10 seemed to be P cut off dependently of course counterbalanced by the reduction in parameters 2 but resulted in rather high POSTHOC correlations between the ETAs inside and outside the block iii control stream PROB Exp variation INPUT ID TIME AMT CP 3DDV EVID RACE AGE WGT HGH BMI SMOK NSMO TRT PROT 3DDROP DATA data nmdat SUBR ADVAN3 TRANS4 PK TVCL 3DTHETA 1 CL 3DTVCL EXP ETA 1 TVV1 3DTHETA 2 CAV1 3DTHETA 3 V1 3DTVV1 1 CAV1 AGE 31 EXP ETA 2 K 3DCL V1 TVQ 3DTHETA 4 Q 3DTVQ EXP ETA 4 TVV2 3DTHETA 5 V2 3DTVV2 EXP ETA 3 K12 3DQ V1 K21 3DQ V2 S1 3DV1 1000 ERROR Y 3DF F EPS 1 EPS 2 IPRED 3DF THETA 0 4 26 10000 0 207 900000 0 0 05 07692 0 28 7 100000 0 155 900000 OMEGA 0 FIX OMEGA BLOCK 3 20 0 18 0 0657 0 157 0 05 0 1 0 421 SIGMA 0 0412 331 EST METHOD 3D0 PRINT 3D5 MAXEVAL 3D9999 SIG 3D3 POSTHOC NOABORT COV TABLE ID TIME CL V1 V2 Q CAV1 IPRED TRT ETA1 ETA2 ETA3 ETA4 RACE 20 AGE WGT HGH BMI SMOK NSMO NOPRINT ONEHEADER FILE 3Dtab txt NB as the PK parameters do not have a standard phsyiological meaning I did not reject

    Original URL path: http://nonmem.org/nonmem/nm/99jul212005.html (2016-04-25)
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  • [NMusers] Revision to NONMEM Tip #20 July 18, 2005
    a full 10 x 10 diagonal matrix to be estimated user defined default is 30 Changed to LVR max no of eta s and epsilon s user defined default is 30 2 Definition of LPAR Original LPAR max no of parameters that may be estimated LPAR LTH LVR default is 70 Changed to LPAR Max no of parameters that may be estimated LPAR LTH LVR off diagonal variances e g

    Original URL path: http://nonmem.org/nonmem/nm/98jul182005.html (2016-04-25)
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