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  • [NMusers] Electronic submission to JPKPD
    Subject NMusers Electronic submission to JPKPD Date Thu November 4 2004 9 22 am The Journal of Pharmacokinetics and Pharmacodynamics has finally come into the 21st century and gone electronic If you wish to submit to JPKPD in the future

    Original URL path: http://nonmem.org/nonmem/nm/99nov042004.html (2016-04-25)
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  • [NMusers] Problem in loading NONMEM software
    there is any other procedure to install the software then please mail me As our PC configuration is like this 1 PIV 512 MB RAM WIN XP professional Digital visual Fortran When ever we are running the test program of Nonmem as per given in Testing nonmem in the Digital visual fortran it is showing many errors Please mail me all the deta ils for the same Waiting for your reply With Kind Regards Tausif Ahmed India From Lilian Li lilian li1 yahoo com Subject RE NMusers Problem in loading NONMEM software Date Thu November 4 2004 12 41 am Ahmed The manual instructs you to copy these files to your working data directory i e whatever directory you are storing your csv file the control steam file etc However there is an easier alternate way right click on my computer and bring up the properties window Go the last tab Advanced and then Environmental Variables In the lower half there should be a list of system variables Find the variable that s named path and edit it There will be a long list go to the end of the list and add c nmv c nmv tr be sure to separate each with a semicolon no space This is assuming that you installed NONMEM on the local c drive Otherwise just substitute c with the appropriate drive label By setting the path this way in the system you no longer need to copy the batch file or the exe file into your data directory any more The windows system will automatically go to the specified directory on c drive to look for needed files every time you execute a command Lilian Li Ph D Pfizer Global Research Development From tausif Ahmed mailtaus yahoo com Subject RE NMusers Problem in

    Original URL path: http://nonmem.org/nonmem/nm/99nov032004.html (2016-04-25)
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  • [NMusers] Most important papers in PopPK
    traffic and should be fun Thanks everyone Pete Peter L Bonate PhD FCP Director Pharmacokinetics ILEX Oncology 4545 Horizon Hill Blvd San Antonio TX 78229 phone 210 949 8662 fax 210 949 8219 email pbonate ilexonc com From Sarath Kanekal SKanekal Salmedix com Subject RE NMusers Most important papers in PopPK Date Tue November 2 2004 1 26 pm Dear Peter A great and a timely idea I have not

    Original URL path: http://nonmem.org/nonmem/nm/99oct282004.html (2016-04-25)
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  • [NMusers] Visual NONMEM error
    using visual NONMEM for the first time and encountering the following error When I run NONMEM an error window pops up and says that exec file not found There were no problems running NM TRAN Does the program require the user to provide more than the control stream and the dataset Has anybody else encountered this error Any help would be appreciated Max Max Tsai Ph D Senior Scientist DM

    Original URL path: http://nonmem.org/nonmem/nm/99oct272004.html (2016-04-25)
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  • [NMusers] Missing Covariate values
    values for the missing outcome with missed covariate values In this type of situation how to model this case using the data patterns in 3 and 4 Is there any method available for the missing covarites values for imputation Any suggestion Thanks in advance Bala From Nick Holford Subject RE NMusers Missing Covariate values Date Wed October 27 2004 1 05 pm Hi Methods for dealing with missing covariates include 1 Naive Impute the missing value with some central statistic such as the median 2 Multiple Imputation Estimate the parameters of the covariate distribution e g using a multivariate normal Sample from the MVN for the missing parameters to create datasets with imputed values Fit several such data sets and use the average of the resulting parameters describing the outcome data 3 Joint Model Model the covariates as if they were dependent variables outcomes This is essentialy equivalent to method 2 but integrates over the covariate distribution for the missing values and does not have to explicitly impute i e make up and use a value as if it was real data The joint model can be done simultaneously with the outcome data or in a two stage approach with explicit imputation from the first stage model for the covariates alone Take a look at this thread which illustrates code for the joint model approach http www cognigencorp com nonmem nm 99jun282004 html This is an example of it s application Mould DR Holford NH Schellens JH Beijnen JH Hutson PR Rosing H et al Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors Clinical Pharmacology Therapeutics 2002 71 5 334 48 The MEM likelihood approach for modelling outcomes when they are not complete for all subjects makes model based assumptions about the trajectory of the

    Original URL path: http://nonmem.org/nonmem/nm/98oct262004.html (2016-04-25)
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  • [NMusers] Modeling with insufficient data
    insufficient data Date Tue October 26 2004 6 48 am Hello Lim I dont think you need to model the drug and three metabolites You could do with the drug and two metabolites It depends on the time course of your metabolites relative to the parent drug You can fix the volume of distribution of the metabolites to either 1 or some factor of the volume of distribution of the parent drug You would have to worry about identifiability issues if you have insufficient data Venkatesh Atul Bhattaram Pharmacometrics DPE 1 OCPB CDER FDA From Diane R Mould drmould attglobal net Subject RE NMusers Modeling with insufficient data Date Tue October 26 2004 6 59 am Hi Hyeong Seok how are things going that s going to be some awful run time but its quite do able what I would suggest you do before modeling them simultaneously is to model them separately to get estimates of the volumes and clearances of each then begin adding things piecewise so model parent and first stage metabolites possibly one at a time given the likely run times set them up as each having its own compartment so parent might be compartments one and

    Original URL path: http://nonmem.org/nonmem/nm/99oct262004.html (2016-04-25)
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  • [NMusers] Seconds in NONMEM
    October 20 2004 12 13 pm Hi I am trying to model some data where I have exact time of events down to seconds It seems that NONMEM does not recognize a time format like 13 48 26 Am I

    Original URL path: http://nonmem.org/nonmem/nm/99oct202004.html (2016-04-25)
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  • [NMusers] NONMEM troubleshoot
    2623 Fax 301 480 3212 From Chuanpu Hu sanofi synthelabo com Subject RE NMusers NONMEM troubleshoot Date Thu October 21 2004 9 25 am Dear Pravin I have had NONMEM stuck with normal PK data as others did too Whether it is near a local minimum or not does not seem to matter It happens very rarely and changing initial estimates always solved the problem It sounds like your problem is more difficult but just wondering whether you have tried it By the way do the initial estimates corresponding to reasonable goodness of fit Good luck Chuanpu Chuanpu Hu Ph D Assistant Director Biostatistics Sanofi Synthelabo Research 9 Great Valley Parkway Malvern PA 19355 1304 Tel 610 889 6774 Fax 610 889 6932 From Ruedi Port r port dkfz de Subject RE NMusers NONMEM troubleshoot Date Fri October 22 2004 3 59 am Hi Pravin As Chuanpu says NONMEM getting stuck without telling why is not uncommon You can see where NONMEM was just before it got silent in the following ways 1 During iterations the current parameter estimates are continuously written to the file INTER That file might show you some crazy estimate before NONMEM gets stuck 2 You could set ESTIMATION MAXEVALS to a number such that it stops just after the last successful iteration then graphically inspect the predictions One or two wrong measurements that are far from reality can cause lots of trouble by inflating the estimate of a variance parameter Good luck Ruedi From Pravin Jadhav pravinj gmail com Subject RE NMusers NONMEM troubleshoot Date Fri October 22 2004 1 07 pm Thanks to Ruedi Chuanpu and Nitin for their replies Actually the mistake was so silly that I should have managed it in the first place I was just playing around with different things

    Original URL path: http://nonmem.org/nonmem/nm/99oct192004.html (2016-04-25)
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