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  • Cells: from Robert Hooke to cell therapy | Philosophical Transactions of the Royal Society B: Biological Sciences
    first recognised by the British scientist Robert Hooke and described in Micrographia published by the Royal Society in September 1665 Since then it has been revealed that cells are highly specialised and are vital for the function of all organisms If cells cease to function properly this often leads to dramatic changes which can affect human health and quality of life In this issue published to coincide with the 350th anniversary of the publication of Micrographia world leading researchers describe how cells are used in new approaches to treat diseases and outline applications that are now nearing the clinic reviewing key advances in cell biology that underpin these treatments These cell based therapies are expected to make a very significant contribution to medicine in the future This issue is published in co ordination with a Royal Society discussion meeting held on 5th 6th October 2015 For more details please visit this website Read This issue is now available to read online Don t have access If you would like to recommend this journal to your Librarian please fill out this form or contact sales royalsociety org Buy This issue is available to buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Please contact our sales team for more information Submit a theme proposal to Philosophical Transactions B February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions of the Royal Society B Biological Sciences Influential themed journal issues across the life sciences Find out more Celebrating 350 years of Philosophical Transactions Anniversary issue with free commentaries archive material videos and blogs Browse by subject behaviour biochemistry bioengineering bioinformatics biomaterials biomechanics biophysics biotechnology cellular biology cognition computational biology developmental biology

    Original URL path: http://rstb.royalsocietypublishing.org/content/cells-robert-hooke-cell-therapy (2016-02-09)
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  • The bacterial cell envelope | Philosophical Transactions of the Royal Society B: Biological Sciences
    the naked eye In the intervening 350 years our knowledge of these animalcules bacteria has been transformed In particular major technical advances in microscopy and the advent of genetic biophysical biochemical and structural approaches have brought us unparalleled insight into these microscopic organisms In this issue we focus on a region of bacteria the cell envelope that in most bacteria accounts for only 10 of the cell volume but to which the organism typically devotes a quarter of its genome The bacterial cell envelope is a multi layered structure that surrounds all bacterial cells and is their interface with the environment Building and maintaining this robust structure while simultaneously allowing nutrients to enter and waste products to leave is essential in all bacteria and is the target of most commonly used antibiotics This series of review articles from leaders in their respective fields summarises the latest understanding about this unique structure its formation and diverse functions including emphasis on the methods used Read This issue is now available to read online Don t have access If you would like to recommend this journal to your Librarian please fill out this form or contact sales royalsociety org Buy This issue is available to buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Please contact our sales team for more information Submit a theme proposal to Philosophical Transactions B February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions of the Royal Society B Biological Sciences Influential themed journal issues across the life sciences Find out more Celebrating 350 years of Philosophical Transactions Anniversary issue with free commentaries archive material videos and blogs Browse by subject behaviour biochemistry bioengineering bioinformatics biomaterials

    Original URL path: http://rstb.royalsocietypublishing.org/content/bacterial-cell-envelope (2016-02-09)
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  • Cell adhesion century: culture breakthrough | Philosophical Transactions of the Royal Society B: Biological Sciences
    of the talks from the Discussion meeting can be found here Click on the cross next to the speaker s name to access the audio file Buy This issue will soon be available to buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Please contact our sales team for more information Guest editor biographies Professor Kevin Kendall received his PhD from Cambridge and has worked for 20 years in industrial research at ICI and also 20 years in universities at Monash Akron Keele and now Birmingham He started his research career studying friction and adhesion and became interested in the energy balance method for calculating adhesion forces He has applied this method to many different areas including adhesive joints composites slurries nanoparticles cells and viruses He has also been involved in the fossil energy crisis and applies fuel cells to avoid carbon emissions especially operating a fleet of hydrogen fuel cell vehicles with a filling station on the Birmingham University campus as shown in the picture He is now back in industry CEO of Adelan Ltd an SME developing several EU projects He has written more than 300 publications and patents and was elected FRS in 1993 Professor Stephen Busby received his doctorate from Oxford University and then moved to the Pasteur Institute in Paris where he became interested in bacteria and how they organize and regulate their genes Since moving back to the UK in 1983 Steve and his colleagues have contributed to our understanding of transcription initiation and gene activation in bacteria as well as developing new methodologies to study global regulation He has produced over 200 original research articles and a score of seminal reviews Steve was elected FRS

    Original URL path: http://rstb.royalsocietypublishing.org/content/cell-adhesion-century-culture-breakthrough (2016-02-09)
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  • From pluripotency to differentiation: laying the foundations for the body pattern in the mouse embryo | Philosophical Transactions of the Royal Society B: Biological Sciences
    galvanized by the availability of new experimental approaches for following the contributions of individual cells to development of an embryo coupled to a molecular understanding of the first cell fate decisions and the cellular events that precede them This re birth of interest in the earliest stages of mouse development has given new insight to our understanding of how cells are assigned to particular lineages of the changes in cellular properties that facilitate fate decisions and of signalling pathways that control these events This collection of review articles and hypotheses presents a contemporary overview of the conceptual framework of development of the early mouse embryo at both pre and early post implantation stages and the biology of the embryo derived pluripotent stem cells The focus of this collection of articles is upon the role of signalling pathways transcriptional and epigenetic mechanisms and the activity of genetic networks on cell lineage specification and tissue morphogenesis Read Read all articles from this issue online The Introduction is FREE to access Don t have access If you would like to recommend this journal to your Librarian please fill out this form or contact sales royalsociety org Buy This issue is now available buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Authors of this issue can buy one copy at a discounted rate of 10 and further copies at 35 Please contact Jackie Knapp for more information Submit a theme proposal to Philosophical Transactions B February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions of the Royal Society B Biological Sciences Influential themed journal issues across the life sciences Find out more Celebrating 350 years of Philosophical Transactions Anniversary issue with

    Original URL path: http://rstb.royalsocietypublishing.org/content/pluripotency-differentiation-laying-foundations-body-pattern-mouse-embryo (2016-02-09)
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  • The centrosome renaissance | Philosophical Transactions of the Royal Society B: Biological Sciences
    covering progress from different species and cell types The history of the field the evolution of the centrosome amongst eukaryotes the assembly and structure of centrioles as well as of the surrounding pericentriolar material PCM are also covered Moreover the numerous functions of the centrosome including at the immunological synapse and as signalling centres are discussed Furthermore the crucial roles played by the centrosome in stem cells and during development as well as in disease are examined The theme issue is enriched by a unique contribution on Theodor Boveri who pioneered work on the centrosome well over a century ago Leaders in the field were asked to each provide a contribution on a specific topic which includes their personal view on the questions at stake and on future developments offering a comprehensive coverage of the knowledge on centrosomes as it stands in 2014 Read Read all articles from this issue online The Introduction is FREE to access Don t have access If you would like to recommend this journal to your Librarian please fill out this form or contact sales royalsociety org Buy This issue is now available to buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Authors of this issue can buy one copy at a discounted rate of 10 and further copies at 35 Please contact Jackie Knapp for more information Submit a theme proposal to Philosophical Transactions B February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions of the Royal Society B Biological Sciences Influential themed journal issues across the life sciences Find out more Celebrating 350 years of Philosophical Transactions Anniversary issue with free commentaries archive material videos and blogs Browse by subject

    Original URL path: http://rstb.royalsocietypublishing.org/content/centrosome-renaissance (2016-02-09)
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  • Biology with free-electron X-ray lasers | Philosophical Transactions of the Royal Society B: Biological Sciences
    XFEL The long term aim of this work is make movies of molecular machines at work including those responsible for photosynthesis protein synthesis and the development of new drugs This issue is based on a Royal Society discussion meeting details of which can be found here Read Read all articles from this issue online The Introduction is FREE to access Don t have access If you would like to recommend this journal to your Librarian please fill out this form or contact sales royalsociety org Buy This issue is available to buy in print We offer discounts for bulk orders of the print version of this journal issue for educational use 20 per copy for 10 or more Authors of this issue can buy one copy at a discounted rate of 10 and further copies at 35 Please contact Jackie Knapp for more information Submit a theme proposal to Philosophical Transactions B February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions of the Royal Society B Biological Sciences Influential themed journal issues across the life sciences Find out more Celebrating 350 years of Philosophical Transactions Anniversary issue with free commentaries archive material videos and blogs Browse

    Original URL path: http://rstb.royalsocietypublishing.org/content/biology-free-electron-x-ray-lasers (2016-02-09)
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  • Philosophical Transactions of the Royal Society B: Biological Sciences
    All content Subject collections Podcasts Information for Authors Guest editors Reviewers Readers Institutions The media About us About the journal Editorial board Policies Citation metrics Open access Sign up Subscribe eTOC alerts Keyword alerts RSS feeds Newsletters Propose an issue Open biology PHILOSOPHICAL TRANSACTIONS B About this journal Contact information Purchasing information Propose an issue Open access membership Recommend to your library FAQ Help Royal society publishing ROYAL SOCIETY PUBLISHING

    Original URL path: http://rstb.royalsocietypublishing.org/cc/highlighted-papers-from-philosophical-transactions (2016-02-09)
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  • Invitation to write a blog post to celebrate 350 years of Philosophical Transactions | Philosophical Transactions of the Royal Society B: Biological Sciences
    that they have personally been inspired by Browse our blog to see examples We are looking for short 500 words blog posts written in an informal style aimed at a general audience about papers from the Phil Trans archive We are not providing too much guidance on content as we anticipate that they will all be different and personal You may wish to focus on how the paper was particularly revolutionary or novel or how it impacted the field at the time or now how it personally inspired you or even about the scientist him herself although it does need to tie to Phil Trans We will need Your name Your text Ideally A relevant image that is copyright free or cleared for use online A short 1 or 2 sentence biography including your affiliation Things to note We may not be able to run all submissions We may edit your submission We may use extracts in other social media and marketing If you are willing to contribute please send your submission to helen eaton royalsociety org To find suitable papers please search our archives links below We suggest searching by author name All content 1665 1887 http rstl royalsocietypublishing org search Biological sciences 1887 present http rstb royalsocietypublishing org search Physical sciences 1887 present http rsta royalsocietypublishing org search Please note that special issues of the journal will cover some of the key papers and whilst it doesn t matter if blogs are on the same papers it would be better if these were avoided Tables of contents can be found here Philosophical Transactions A Philosophical Transactions B We welcome submissions from anyone so please show this to your colleagues or students that might be interested February 2016 Volume 371 Issue 1688 Alert me to new content Philosophical Transactions

    Original URL path: http://rstb.royalsocietypublishing.org/content/invitation-write-blog-post-celebrate-350-years-philosophical-transactions (2016-02-09)
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