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  • Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption | Science Translational Medicine
    with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Epidemiological studies link short sleep duration and circadian disruption with higher risk of metabolic syndrome and diabetes We tested the hypotheses that prolonged sleep restriction with concurrent circadian disruption as can occur in people performing shift work impairs glucose regulation and metabolism Healthy adults spent 5 weeks under controlled laboratory conditions in which they experienced an initial baseline segment of optimal sleep 3 weeks of sleep restriction 5 6 hours of sleep per 24 hours combined with circadian disruption recurring 28 hour days followed by 9 days of recovery sleep with circadian re entrainment Exposure to prolonged sleep restriction with concurrent circadian disruption with measurements taken at the same circadian phase decreased the participants resting metabolic rate and increased plasma glucose concentrations after a meal an effect resulting from inadequate pancreatic insulin secretion These parameters normalized during the 9 days of recovery sleep and stable circadian re entrainment Thus in humans prolonged sleep restriction with concurrent circadian disruption alters metabolism and could increase the risk of obesity and diabetes Copyright 2012 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 4 Issue 129 11 April 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption By Orfeu M Buxton Sean W Cain Shawn P O Connor James H Porter Jeanne F Duffy Wei Wang Charles A Czeisler Steven A Shea Science Translational Medicine 11 Apr 2012 129ra43 Sleep deficiency and out of synch circadian rhythms impair pancreatic insulin secretion a possible precursor to metabolic syndrome and diabetes Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Adverse Metabolic Consequences in Humans

    Original URL path: http://stm.sciencemag.org/content/4/129/129ra43 (2016-02-10)
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  • Knitting Up the Raveled Sleave of Care | Science Translational Medicine
    Trinity College Dublin Dublin 2 Ireland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Erik S Musiek Department of Neurology Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sarah C McLoughlin Institute for Translational Medicine and Therapeutics Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Garret A FitzGerald Institute for Translational Medicine and Therapeutics Smilow Center for Translational Research Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract This Review is based on the Franklin Epstein Lecture delivered at Beth Israel Deaconess Hospital on 25 April 2013 We discuss recent advances in our understanding of molecular clocks and highlight their relevance to human physiology and disease Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 212 20 November 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Knitting Up the Raveled Sleave of Care Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Knitting Up the Raveled Sleave of Care By Guangrui Yang Georgios Paschos Anne M Curtis Erik S Musiek Sarah C McLoughlin Garret A FitzGerald Science Translational Medicine 20 Nov 2013 212rv3 Recent advances in our understanding of molecular clocks highlight their relevance to human physiology and disease Citation Manager Formats

    Original URL path: http://stm.sciencemag.org/content/5/212/212rv3 (2016-02-10)
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  • Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology | Science Translational Medicine
    Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David M Holtzman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Aggregation of β amyloid Aβ in the brain begins to occur years before the clinical onset of Alzheimer s disease AD Before Aβ aggregation concentrations of extracellular soluble Aβ in the interstitial fluid ISF space of the brain which are regulated by neuronal activity and the sleep wake cycle correlate with the amount of Aβ deposition in the brain seen later The amount and quality of sleep decline with normal aging and to a greater extent in AD patients How sleep quality as well as the diurnal fluctuation in Aβ change with age and Aβ aggregation is not well understood We report a normal sleep wake cycle and diurnal fluctuation in ISF Aβ in the brain of the APPswe PS1δE9 mouse model of AD before Aβ plaque formation After plaque formation the sleep wake cycle markedly deteriorated and diurnal fluctuation of ISF Aβ dissipated As in mice diurnal fluctuation of cerebrospinal fluid Aβ in young adult humans with presenilin mutations was also markedly attenuated after Aβ plaque formation Virtual elimination of Aβ deposits in the mouse brain by active immunization with Aβ 42 normalized the sleep wake cycle and the diurnal fluctuation of ISF Aβ These data suggest that Aβ aggregation disrupts the sleep wake cycle and diurnal fluctuation of Aβ Sleep wake behavior and diurnal fluctuation of Aβ in the central nervous system may be functional and biochemical indicators respectively of Aβ associated pathology Copyright 2012 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To

    Original URL path: http://stm.sciencemag.org/content/4/150/150ra122 (2016-02-10)
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  • Clinical trials for neurodevelopmental disorders: At a therapeutic frontier | Science Translational Medicine
    You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract A well powered clinical trial that failed to replicate promising results in animal models of fragile X syndrome yields important lessons for clinical trial design Berry Kravis et al this issue Copyright 2016 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 8 Issue 321 13 January 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Clinical trials for neurodevelopmental disorders At a therapeutic frontier Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Clinical trials for neurodevelopmental disorders At a therapeutic frontier By Shafali S Jeste Daniel H Geschwind Science Translational Medicine 13 Jan 2016

    Original URL path: http://stm.sciencemag.org/content/8/321/321fs1 (2016-02-10)
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  • Probing the Brain of Comorbidity | Science Translational Medicine
    Program in Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge MA 02142 USA Analytic and Translational Genetics Unit Department of Medicine Massachusetts General Hospital Boston MA 02114 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract Inherited sleep disorders might provide insights for migraine pathophysiology Brennan et al this issue Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 183 01 May 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Probing the Brain of Comorbidity Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password

    Original URL path: http://stm.sciencemag.org/content/5/183/183fs15 (2016-02-10)
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  • The Nexus of Aβ, Aging, and Sleep | Science Translational Medicine
    the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract Roh et al report a positive feedback loop between sleep wake irregularities and aggregation of β amyloid peptide suggesting that sleep alterations could be an early event in Alzheimer s disease Footnotes Citation J R Gerstner I J Perron A I Pack The nexus of Aβ aging and sleep Sci Transl Med 4 150fs34 2012 Copyright 2012 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Nexus of Aβ Aging and Sleep Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools The Nexus of Aβ Aging and Sleep By Jason R Gerstner Isaac J Perron Allan I Pack

    Original URL path: http://stm.sciencemag.org/content/4/150/150fs34 (2016-02-10)
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  • User account | Science Translational Medicine
    Science Translational Medicine Topics Hot Topics Curated Topics Special Issues Custom Publishing Careers Articles Find Jobs Career Resources Forum For Employers Employer Profiles Graduate Programs Booklets Careers Features About Careers Search Search Primary tabs Log in active tab Regain Access Request new password Log in using your username and password Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Log in through your institution You may be able to gain access using your login credentials for your institution Contact your library if you do not have a username and password If your organization uses OpenAthens you can log in using your OpenAthens username and password To check if your institution is supported please see this list Contact your library for more details Science 5 February 2016 Vol 351 Issue 6273 Pages 539 630 Feature What makes DARPA tick Science and Society Taking race out of human genetics Agriculture Losing our taste for diversity SCI COMMUN News at a glance Ecology The mite that jumped the bee that traveled the disease that followed Working Life Retire the letter of reference Table of Contents About us About journals Leadership Team

    Original URL path: http://stm.sciencemag.org/user/login?destination=/content/8/324/324ra14 (2016-02-10)
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  • MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations | Science Translational Medicine
    B Wolf Merrimack Pharmaceuticals Inc Cambridge MA 02139 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sandra Misale Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Luca Lazzari Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrea Bertotti Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Livio Trusolino Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alex A Adjei Roswell Park Cancer Institute Buffalo NY 14263 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Clara Montagut Medical Oncology Department Hospital del Mar Barcelona 08003 Spain Cancer Research Program FIMIM Hospital del Mar Medical Research Institute Hospital del Mar Barcelona 08003 Spain Find this author on Google Scholar Find this author on PubMed Search for this author on this site Federica Di Nicolantonio Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Rachel Nering Merrimack Pharmaceuticals Inc Cambridge MA 02139 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alberto Bardelli Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text Science Translational Medicine Vol 8 Issue 324 03 February 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following MM 151 overcomes acquired

    Original URL path: http://stm.sciencemag.org/content/8/324/324ra14.figures-only (2016-02-10)
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