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  • Erratum for the Research Article: “RANKL blockade prevents and treats aggressive osteosarcomas” by Y. Chen, M. A. Di Grappa, S. D. Molyneux, T. D. McKee, P. Waterhouse, J. M. Penninger, R. Khokha | Science Translational Medicine
    Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 8 Issue 324 03 February 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Erratum for the Research Article RANKL blockade prevents and treats aggressive osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Erratum for the

    Original URL path: http://stm.sciencemag.org/content/8/324/324er2.e-letters (2016-02-10)
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  • RANKL blockade prevents and treats aggressive osteosarcomas | Science Translational Medicine
    1L7 Canada Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians This article has a correction Please see Erratum for the Research Article RANKL blockade prevents and treats aggressive osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha February 03 2016 OutRANKing osteosarcoma Osteosarcoma is the most common primary bone cancer and it can be difficult to treat especially in patients with metastatic disease Chen et al developed a series of genetically engineered mouse models of osteosarcoma and used these models to dissect the role of receptor activator of nuclear factor κB ligand RANKL signaling in the progression of this disease The authors also showed that denosumab an antibody against RANKL that is already used in patients with some bone diseases is effective in mouse models of osteosarcoma and is a viable candidate for future testing in human patients Abstract Osteosarcoma OS is the most common primary bone cancer which occurs primarily in children and adolescents severely affecting survivors quality of life Despite its chemosensitivity and treatment advances long term survival rates for OS patients have stagnated over the last 20 years Thus it is necessary to develop new molecularly targeted therapies for this metastatic bone cancer Mutations in TP53 and RB are linked to OS predisposition and to the evolution of spontaneous OS We established receptor activator of nuclear factor κB ligand RANKL as a therapeutic target for suppression and prevention of OS Combined conditional osteoblast specific deletions of Rb p53 and the protein kinase A PKA regulatory subunit Prkar1 α genes in genetically engineered mouse models GEMMs generate aggressive osteosarcomas characterized by PKA RANKL and osteoclast hyperactivity Whole body Rankl deletion completely abrogates tumorigenesis Although osteoblastic Rank deletion has little effect osteoclastic Rank deletion delays tumorigenesis and prolongs life span The latter is associated with inactivation of osteoclastogenesis and up regulation of the tumor suppressor phosphatase and tensin homolog PTEN Further we use these GEMMs as preclinical platforms to show that RANKL blockade with RANK Fc arrests tumor progression and improves survival and also inhibits lung metastasis Moreover preemptive administration of RANK Fc completely prevents tumorigenesis in mice highly predisposed to this aggressive cancer Denosumab a fully human monoclonal antibody against RANKL is currently used to treat patients with osteoporosis or bone metastases Our studies provide a strong rationale to consider RANKL blockade for the treatment and prevention of aggressive RANKL overexpressing OS in humans Copyright 2015 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 7 Issue 317 09 December 2015 Table of Contents Article Tools

    Original URL path: http://stm.sciencemag.org/content/7/317/317ra197 (2016-02-10)
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  • osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha DP 2016 Mar 03 TA Science Translational Medicine PG 324er2 324er2 VI 8 IP 324 4099 http stm sciencemag

    Original URL path: http://stm.sciencemag.org/highwire/citation/199577/medlars (2016-02-10)
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  • osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha JF Science Translational Medicine YR 2016 FD American Association for the Advancement of Science VO 8 IS 324 SP

    Original URL path: http://stm.sciencemag.org/highwire/citation/199577/refworks (2016-02-10)
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  • Table of Contents — February 03, 2016, 8 (324) | Science Translational Medicine
    D Kearns Beni B Wolf Sandra Misale Luca Lazzari Andrea Bertotti Livio Trusolino Alex A Adjei Clara Montagut Federica Di Nicolantonio Rachel Nering Alberto Bardelli Science Translational Medicine 03 Feb 2016 324ra14 An oligoclonal antibody overcomes drug resistance in colorectal cancers with EGFR mutations Editor s Summary Abstract Full Text PDF Mathematical modeling of herpes simplex virus 2 suppression with pritelivir predicts trial outcomes By Joshua T Schiffer David A Swan Amalia Magaret Lawrence Corey Anna Wald Joachim Ossig Helga Ruebsamen Schaeff Susanne Stoelben Burkhard Timmler Holger Zimmermann Murad R Melhem Scott A Van Wart Christopher M Rubino Alexander Birkmann Science Translational Medicine 03 Feb 2016 324ra15 A mathematical model for antiviral clinical trials improves dose selection and understanding of drug virus interaction Editor s Summary Abstract Full Text PDF Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival By Guangrui Yang Lihong Chen Gregory R Grant Georgios Paschos Wen Liang Song Erik S Musiek Vivian Lee Sarah C McLoughlin Tilo Grosser George Cotsarelis Garret A FitzGerald Science Translational Medicine 03 Feb 2016 324ra16 Postnatal knockout of a core clock gene in mice prompts reevaluation of the systemic role of the molecular clock in the biology of aging Editor s Summary Abstract Full Text PDF Editors Choice A notch against cancer By Ellen J Beswick Science Translational Medicine 03 Feb 2016 324ec17 Notch signaling may be antitumorigenic in some cancers Full Text Blocking Borrelia in the brain By Christopher G Janson Science Translational Medicine 03 Feb 2016 324ec18 Neurokinin 1 receptor blockade inhibits neuroinflammation and apoptosis in a nonhuman primate model of Borrelia infection Full Text Aging metabolism Evitable or inevitable By Ian R Lanza Science Translational Medicine 03 Feb 2016 324ec19 Lifestyle factors can explain many but not all of aging related

    Original URL path: http://stm.sciencemag.org/content/8/324?current-issue=y (2016-02-10)
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    Original URL path: http://stm.sciencemag.org/content/by/year/2009 (2016-02-10)
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