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  • Table of Contents — January 09, 2013, 5 (167) | Science Translational Medicine
    antiviral therapeutics Editor s Summary Abstract Full Text PDF Human Cartilage Repair with a Photoreactive Adhesive Hydrogel Composite By Blanka Sharma Sara Fermanian Matthew Gibson Shimon Unterman Daniel A Herzka Brett Cascio Jeannine Coburn Alexander Y Hui Norman Marcus Garry E Gold Jennifer H Elisseeff Science Translational Medicine 09 Jan 2013 167ra6 A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients Editor s Summary Abstract Full Text PDF State of the Art Review Therapy for Fibrotic Diseases Nearing the Starting Line By Scott L Friedman Dean Sheppard Jeremy S Duffield Shelia Violette Science Translational Medicine 09 Jan 2013 167sr1 An emerging consensus indicates that fibrotic diseases in lung liver and kidney exhibit common underlying mechanisms which can be targeted therapeutically Editor s Summary Abstract Full Text PDF Editors Choice FcγRs Muscle Up Dendritic Cell Cross Presentation By Niroshana Anandasabapathy Science Translational Medicine 09 Jan 2013 167ec5 Targeting FCγ receptors may improve dendritic cell mediated vaccination Full Text Inspired by Porcupines By Joel H Collier Science Translational Medicine 09 Jan 2013 167ec6 Porcupine quills inspire new design concepts for hypodermic needles Full Text A Better Pacemaker Transdifferentiation of Myocytes to Pacemaker Cells By Matthias Nahrendorf Science Translational Medicine 09 Jan 2013 167ec7 Transdifferentiation of heart cells with a key transcription factor generates functional pacemaker cells in situ a new approach to correcting heart failure Full Text A Beacon of Danger By Ernesto Oviedo Orta Science Translational Medicine 09 Jan 2013 167ec8 Seeking a better biomarker signature for predicting heart disease severity Full Text SLITting Down the Peanut Allergy By Marina Reznik Science Translational Medicine 09 Jan 2013 167ec9 Sublingual immunotherapy induced a modest level of desensitization in peanut allergy sufferers Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline

    Original URL path: http://stm.sciencemag.org/content/5/167 (2016-02-10)
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  • Table of Contents — January 09, 2013, 5 (167) | Science Translational Medicine
    epigenetic antiviral therapeutics Editor s Summary Abstract Full Text PDF Human Cartilage Repair with a Photoreactive Adhesive Hydrogel Composite By Blanka Sharma Sara Fermanian Matthew Gibson Shimon Unterman Daniel A Herzka Brett Cascio Jeannine Coburn Alexander Y Hui Norman Marcus Garry E Gold Jennifer H Elisseeff Science Translational Medicine 09 Jan 2013 167ra6 A photoactive hydrogel is used in combination with microfracture to heal cartilage defects in patients Editor s Summary Abstract Full Text PDF State of the Art Review Therapy for Fibrotic Diseases Nearing the Starting Line By Scott L Friedman Dean Sheppard Jeremy S Duffield Shelia Violette Science Translational Medicine 09 Jan 2013 167sr1 An emerging consensus indicates that fibrotic diseases in lung liver and kidney exhibit common underlying mechanisms which can be targeted therapeutically Editor s Summary Abstract Full Text PDF Editors Choice FcγRs Muscle Up Dendritic Cell Cross Presentation By Niroshana Anandasabapathy Science Translational Medicine 09 Jan 2013 167ec5 Targeting FCγ receptors may improve dendritic cell mediated vaccination Full Text Inspired by Porcupines By Joel H Collier Science Translational Medicine 09 Jan 2013 167ec6 Porcupine quills inspire new design concepts for hypodermic needles Full Text A Better Pacemaker Transdifferentiation of Myocytes to Pacemaker Cells By Matthias Nahrendorf Science Translational Medicine 09 Jan 2013 167ec7 Transdifferentiation of heart cells with a key transcription factor generates functional pacemaker cells in situ a new approach to correcting heart failure Full Text A Beacon of Danger By Ernesto Oviedo Orta Science Translational Medicine 09 Jan 2013 167ec8 Seeking a better biomarker signature for predicting heart disease severity Full Text SLITting Down the Peanut Allergy By Marina Reznik Science Translational Medicine 09 Jan 2013 167ec9 Sublingual immunotherapy induced a modest level of desensitization in peanut allergy sufferers Full Text More From Science Translational Medicine Current Table of Contents Archive In the

    Original URL path: http://stm.sciencemag.org/content/5/167.toc (2016-02-10)
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  • a regulatory matrix for enabling cellular functions such as DNA replication and transcription but also regulate the infectious cycles of many DNA viruses Elucidation of the components and mechanisms involved in this regulation is providing targets for the development of new antiviral therapies Initiation of infection by herpes simplex virus HSV requires the activity of several cellular chromatin modification enzymes including the histone demethylases LSD1 and the family of JMJD2

    Original URL path: http://stm.sciencemag.org/highwire/citation/186340/medlars (2016-02-10)
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  • only provide a regulatory matrix for enabling cellular functions such as DNA replication and transcription but also regulate the infectious cycles of many DNA viruses Elucidation of the components and mechanisms involved in this regulation is providing targets for the development of new antiviral therapies Initiation of infection by herpes simplex virus HSV requires the activity of several cellular chromatin modification enzymes including the histone demethylases LSD1 and the family

    Original URL path: http://stm.sciencemag.org/highwire/citation/186340/refworks (2016-02-10)
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  • Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes | Science Translational Medicine
    author on PubMed Search for this author on this site Marta Bosch Marce Center for Biologics Evaluation and Research Food and Drug Administration Bethesda MD 20852 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Priya Raja Department of Microbiology and Immunology Harvard Medical School Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jennifer S Lee Department of Microbiology and Immunology Harvard Medical School Boston MA 02115 USA Harvard Program in Virology Harvard Medical School Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David I Bernstein Division of Infectious Diseases Cincinnati Children s Hospital Medical Center University of Cincinnati Cincinnati OH 45229 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Philip R Krause Center for Biologics Evaluation and Research Food and Drug Administration Bethesda MD 20852 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David M Knipe Department of Microbiology and Immunology Harvard Medical School Boston MA 02115 USA Harvard Program in Virology Harvard Medical School Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Thomas M Kristie National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda MD 20892 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Herpesviruses are highly prevalent and maintain lifelong latent reservoirs thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication The initiation of herpes simplex virus infection and reactivation from latency is dependent on a transcriptional coactivator complex that contains two required histone demethylases LSD1 lysine specific demethylase 1 and a member of the JMJD2 family Jumonji C domain containing protein 2 Inhibition of either of these enzymes results in heterochromatic suppression of the viral genome and blocks infection and reactivation in vitro We demonstrate that viral infection can be epigenetically suppressed in three animal models of herpes simplex virus infection and disease Treating animals with the monoamine oxidase inhibitor tranylcypromine to inhibit LSD1 suppressed viral lytic infection subclinical shedding and reactivation from latency in vivo This phenotypic suppression was correlated with enhanced epigenetic suppression of the viral genome and suggests that even during latency the chromatin state of the

    Original URL path: http://stm.sciencemag.org/content/6/265/265ra169 (2016-02-10)
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  • Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival | Science Translational Medicine
    Scholar Find this author on PubMed Search for this author on this site Wen Liang Song The Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Erik S Musiek Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Vivian Lee Department of Ophthalmology University of Pennsylvania Scheie Eye Institute Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sarah C McLoughlin The Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tilo Grosser The Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site George Cotsarelis Department of Dermatology Perelman School of Medicine University of Pennsylvania PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Garret A FitzGerald The Institute for Translational Medicine and Therapeutics Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the pdf html View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 8 Issue 324 03 February 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username

    Original URL path: http://stm.sciencemag.org/content/8/324/324ra16.full.pdf+html? (2016-02-10)
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  • Science Translational Medicine
    purchases You may view download and or print the article for your personal scholarly research and educational use You may not i distribute a copy electronic or otherwise of the article without the written permission of AAAS ii post the article on an electronic bulletin board or web site or iii charge for a copy electronic or otherwise of the article PLEASE NOTE In order to use this service you will need to accept our use of cookies If you don t know what cookies are or you want to know exactly how and why we use them please read Our Use of Cookies and your Privacy Is this right The standard Terms and Conditions for Science Online also apply By using our Pay Per View Service you are agreeing that AAAS may contact you from time to time about Association membership or products Science 5 February 2016 Vol 351 Issue 6273 Pages 539 630 Feature What makes DARPA tick Science and Society Taking race out of human genetics Agriculture Losing our taste for diversity SCI COMMUN News at a glance Ecology The mite that jumped the bee that traveled the disease that followed Working Life Retire the letter of

    Original URL path: http://stm.sciencemag.org/highwire/payment/process/ppv/199581?type=ppv&jcode=scitransmed&ppv_type=article&url=http%3A/stm.sciencemag.org/content/8/324/324ra16.full (2016-02-10)
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  • Effects of caffeine on the human circadian clock in vivo and in vitro | Science Translational Medicine
    for this author on this site Andrew W McHill Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Evan D Chinoy Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jesse A Snider Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sara C Bessman Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher M Jung Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site John S O Neill MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Wright Jr Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 7 Issue 305 16 September 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Effects of caffeine on the human circadian clock in vivo and in vitro Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit

    Original URL path: http://stm.sciencemag.org/content/7/305/305ra146.figures-only (2016-02-10)
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