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  • Effects of caffeine on the human circadian clock in vivo and in vitro | Science Translational Medicine
    Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sara C Bessman Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher M Jung Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site John S O Neill MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Wright Jr Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Article Information vol 7 no 305 305ra146 DOI http dx doi org 10 1126 scitranslmed aac5125 PubMed 26378246 Published By American Association for the Advancement of Science Print ISSN 1946 6234 Online ISSN 1946 6242 History Received for publication 5 May 2015 Accepted for publication 11 August 2015 Copyright Usage Copyright 2015 American Association for the Advancement of Science Author Information Tina M Burke 1 Rachel R Markwald 1 Andrew W McHill 1 Evan D Chinoy 1 Jesse A Snider 1 Sara C Bessman 1 Christopher M Jung 1 John S O Neill 2 and Kenneth P Wright Jr 1 1 Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA 2 MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH UK Corresponding author E mail kenneth wright at colorado edu K P W oneillj at mrc lmb cam ac uk J S O Present address Naval Health Research Center San Diego CA 92106 USA Present address Division of Sleep and Circadian Disorders Department of Medicine and Neurology Brigham and Women s Hospital and Division of Sleep Medicine Harvard Medical School Boston MA 02115 USA Present address Department of Biological Sciences University of Alaska Anchorage Anchorage AK 99508 USA AltMetrics No Altmetric data available for this article Article usage Abstract Full PDF Sep 2015 13421 1306 2017 Oct 2015 1118 481 549 Nov 2015 567 228 304 Dec 2015 345 78 86 Jan 2016 1124 64 128 Feb 2016 347 22 19 View Full Text Science Translational Medicine Vol 7 Issue 305 16 September 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it

    Original URL path: http://stm.sciencemag.org/content/7/305/305ra146.article-info (2016-02-10)
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  • Effects of caffeine on the human circadian clock in vivo and in vitro | Science Translational Medicine
    author on Google Scholar Find this author on PubMed Search for this author on this site Jesse A Snider Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sara C Bessman Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher M Jung Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site John S O Neill MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Wright Jr Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs break automatically Upload Tables and Figures Attach tables e g doc and figures jpg gif tif by choosing the desired file and then uploading them below Add a new file Upload Files must be less than 100 MB Allowed file types doc jpg jpeg gif tif pdf File names can only contain the following characters A Z a z 0 9 Author Information Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 7 Issue 305 16 September 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are

    Original URL path: http://stm.sciencemag.org/content/7/305/305ra146.e-letters (2016-02-10)
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  • Effects of caffeine on the human circadian clock in vivo and in vitro | Science Translational Medicine
    Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Evan D Chinoy Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jesse A Snider Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sara C Bessman Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher M Jung Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site John S O Neill MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge CB2 0QH UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Wright Jr Sleep and Chronobiology Laboratory Department of Integrative Physiology Center for Neuroscience University of Colorado Boulder Boulder CO 80309 0354 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Log in to view full text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 7 Issue 305 16 September 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Effects of caffeine on the human circadian clock in vivo and in vitro Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag

    Original URL path: http://stm.sciencemag.org/content/7/305/305ra146.full (2016-02-10)
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  • Table of Contents — September 16, 2015, 7 (305) | Science Translational Medicine
    along the way Abstract Full Text PDF Research Articles Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection By Adam L Bailey Michael Lauck Mariel Mohns Eric J Peterson Kerry Beheler Kevin G Brunner Kristin Crosno Andres Mejia James Mutschler Matthew Gehrke Justin Greene Adam J Ericsen Andrea Weiler Gabrielle Lehrer Brey Thomas C Friedrich Samuel D Sibley Esper G Kallas Saverio Capuano III Jeffrey Rogers Tony L Goldberg Heather A Simmons David H O Connor Science Translational Medicine 16 Sep 2015 305ra144 A monkey model of human pegivirus infection provides new insights into the biology of this virus Editor s Summary Abstract Full Text PDF CT guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine By Jacob D Brown Maythem Saeed Loi Do Joao Braz Allan I Basbaum Michael J Iadarola David M Wilson William P Dillon Science Translational Medicine 16 Sep 2015 305ra145 Delivery of resiniferatoxin under CT guidance around lumbar dorsal root ganglia in pigs resulted in selective deletion of nociceptive neurons and lasting analgesia Editor s Summary Abstract Full Text PDF Effects of caffeine on the human circadian clock in vivo and in vitro By Tina M Burke Rachel R Markwald Andrew W McHill Evan D Chinoy Jesse A Snider Sara C Bessman Christopher M Jung John S O Neill Kenneth P Wright Jr Science Translational Medicine 16 Sep 2015 305ra146 Caffeine delays the human circadian clock and affects cellular timekeeping through an adenosine receptor dependent mechanism Editor s Summary Abstract Full Text PDF Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer By Peter van Luijk Sarah Pringle Joseph O Deasy Vitali V Moiseenko Hette Faber Allan Hovan Mirjam Baanstra Hans P van der Laan Roel G J Kierkels Arjen van der Schaaf Max J Witjes Jacobus M Schippers Sytze Brandenburg Johannes A Langendijk Jonn Wu Robert P Coppes Science Translational Medicine 16 Sep 2015 305ra147 Avoiding irradiation of the region of the parotid gland containing stem cells reduces the risk of xerostomia dry mouth Editor s Summary Abstract Full Text PDF Editors Choice Learning to expect the unexpected Updating the cerebellum during voluntary movement By Pamela Bhatti Science Translational Medicine 16 Sep 2015 305ec156 Motor learning is rapidly updated by cerebellar command Full Text Nanoparticles macroplanning By Biju Parekkadan Science Translational Medicine 16 Sep 2015 305ec157 A nanoparticle EBV vaccine designed using structural biology outperformed current vaccine approaches in both mice and macaques Full Text No longer aware of what cannot be remembered By Jeffrey Statland Science Translational Medicine 16 Sep 2015 305ec158 Loss of awareness of a cognitive decline occurs before the onset of dementia and is associated with post mortem dementia pathology Full Text Basket trials Making sense of context By Anish Thomas Science Translational Medicine 16 Sep 2015 305ec159 Basket clinical trials help identify drug activity in multiple tumor types and allow for the influence of tumor lineage

    Original URL path: http://stm.sciencemag.org/content/7/305 (2016-02-10)
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  • Table of Contents — September 16, 2015, 7 (305) | Science Translational Medicine
    challenges along the way Abstract Full Text PDF Research Articles Durable sequence stability and bone marrow tropism in a macaque model of human pegivirus infection By Adam L Bailey Michael Lauck Mariel Mohns Eric J Peterson Kerry Beheler Kevin G Brunner Kristin Crosno Andres Mejia James Mutschler Matthew Gehrke Justin Greene Adam J Ericsen Andrea Weiler Gabrielle Lehrer Brey Thomas C Friedrich Samuel D Sibley Esper G Kallas Saverio Capuano III Jeffrey Rogers Tony L Goldberg Heather A Simmons David H O Connor Science Translational Medicine 16 Sep 2015 305ra144 A monkey model of human pegivirus infection provides new insights into the biology of this virus Editor s Summary Abstract Full Text PDF CT guided injection of a TRPV1 agonist around dorsal root ganglia decreases pain transmission in swine By Jacob D Brown Maythem Saeed Loi Do Joao Braz Allan I Basbaum Michael J Iadarola David M Wilson William P Dillon Science Translational Medicine 16 Sep 2015 305ra145 Delivery of resiniferatoxin under CT guidance around lumbar dorsal root ganglia in pigs resulted in selective deletion of nociceptive neurons and lasting analgesia Editor s Summary Abstract Full Text PDF Effects of caffeine on the human circadian clock in vivo and in vitro By Tina M Burke Rachel R Markwald Andrew W McHill Evan D Chinoy Jesse A Snider Sara C Bessman Christopher M Jung John S O Neill Kenneth P Wright Jr Science Translational Medicine 16 Sep 2015 305ra146 Caffeine delays the human circadian clock and affects cellular timekeeping through an adenosine receptor dependent mechanism Editor s Summary Abstract Full Text PDF Sparing the region of the salivary gland containing stem cells preserves saliva production after radiotherapy for head and neck cancer By Peter van Luijk Sarah Pringle Joseph O Deasy Vitali V Moiseenko Hette Faber Allan Hovan Mirjam Baanstra Hans P van der Laan Roel G J Kierkels Arjen van der Schaaf Max J Witjes Jacobus M Schippers Sytze Brandenburg Johannes A Langendijk Jonn Wu Robert P Coppes Science Translational Medicine 16 Sep 2015 305ra147 Avoiding irradiation of the region of the parotid gland containing stem cells reduces the risk of xerostomia dry mouth Editor s Summary Abstract Full Text PDF Editors Choice Learning to expect the unexpected Updating the cerebellum during voluntary movement By Pamela Bhatti Science Translational Medicine 16 Sep 2015 305ec156 Motor learning is rapidly updated by cerebellar command Full Text Nanoparticles macroplanning By Biju Parekkadan Science Translational Medicine 16 Sep 2015 305ec157 A nanoparticle EBV vaccine designed using structural biology outperformed current vaccine approaches in both mice and macaques Full Text No longer aware of what cannot be remembered By Jeffrey Statland Science Translational Medicine 16 Sep 2015 305ec158 Loss of awareness of a cognitive decline occurs before the onset of dementia and is associated with post mortem dementia pathology Full Text Basket trials Making sense of context By Anish Thomas Science Translational Medicine 16 Sep 2015 305ec159 Basket clinical trials help identify drug activity in multiple tumor types and allow for the influence of tumor

    Original URL path: http://stm.sciencemag.org/content/7/305.toc (2016-02-10)
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  • rhythm that keeps your body running in time with the world In a sensitive within subject experimental design five people were kept under highly controlled conditions for 49 days Before bedtime they were given various treatments either a double espresso caffeine dose exposure to bright or dim light or a placebo The caffeine delayed their internal clock by 40 min a shift about half as long as bright light a stimulus known to robustly lengthen the circadian phase The authors used cultured cells to determine that the drug acted directly on the adenosine receptor which increases the intracellular messenger molecule cyclic AMP The fact that cyclic AMP forms a key cog in the inner workings of the clock links caffeine s biochemical effects to its delay of the circadian rhythm Not only do these results reinforce the common advice to avoid caffeine in the evening but they also raise the intriguing possibility that caffeine may be useful for resetting the circadian clock to treat jet lag induced by international time zone travel Caffeine s wakefulness promoting and sleep disrupting effects are well established yet whether caffeine affects human circadian timing is unknown We show that evening caffeine consumption delays the human circadian melatonin rhythm in vivo and that chronic application of caffeine lengthens the circadian period of molecular oscillations in vitro primarily with an adenosine receptor cyclic adenosine monophosphate AMP dependent mechanism In a double blind placebo controlled 49 day long within subject study we found that consumption of a caffeine dose equivalent to that in a double espresso 3 hours before habitual bedtime induced a 40 min phase delay of the circadian melatonin rhythm in humans This magnitude of delay was nearly half of the magnitude of the phase delaying response induced by exposure to 3 hours of evening

    Original URL path: http://stm.sciencemag.org/highwire/citation/198292/medlars (2016-02-10)
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  • hour metabolic rhythm that keeps your body running in time with the world In a sensitive within subject experimental design five people were kept under highly controlled conditions for 49 days Before bedtime they were given various treatments either a double espresso caffeine dose exposure to bright or dim light or a placebo The caffeine delayed their internal clock by 40 min a shift about half as long as bright light a stimulus known to robustly lengthen the circadian phase The authors used cultured cells to determine that the drug acted directly on the adenosine receptor which increases the intracellular messenger molecule cyclic AMP The fact that cyclic AMP forms a key cog in the inner workings of the clock links caffeine s biochemical effects to its delay of the circadian rhythm Not only do these results reinforce the common advice to avoid caffeine in the evening but they also raise the intriguing possibility that caffeine may be useful for resetting the circadian clock to treat jet lag induced by international time zone travel Caffeine s wakefulness promoting and sleep disrupting effects are well established yet whether caffeine affects human circadian timing is unknown We show that evening caffeine consumption delays the human circadian melatonin rhythm in vivo and that chronic application of caffeine lengthens the circadian period of molecular oscillations in vitro primarily with an adenosine receptor cyclic adenosine monophosphate AMP dependent mechanism In a double blind placebo controlled 49 day long within subject study we found that consumption of a caffeine dose equivalent to that in a double espresso 3 hours before habitual bedtime induced a 40 min phase delay of the circadian melatonin rhythm in humans This magnitude of delay was nearly half of the magnitude of the phase delaying response induced by exposure to 3 hours

    Original URL path: http://stm.sciencemag.org/highwire/citation/198292/refworks (2016-02-10)
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  • Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption | Science Translational Medicine
    site Wei Wang Find this author on Google Scholar Find this author on PubMed Search for this author on this site Charles A Czeisler Find this author on Google Scholar Find this author on PubMed Search for this author on this site Steven A Shea Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 4 Issue 129 11 April 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption By Orfeu M Buxton Sean W Cain Shawn P O Connor James H Porter Jeanne F Duffy Wei Wang Charles A Czeisler Steven A Shea Science Translational Medicine 11 Apr 2012 129ra43 Sleep deficiency and out of synch circadian rhythms impair pancreatic insulin secretion a possible precursor to metabolic syndrome and diabetes Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Adverse Metabolic Consequences in Humans of Prolonged Sleep Restriction Combined with Circadian Disruption By Orfeu M Buxton Sean W Cain Shawn P O Connor James H Porter Jeanne F Duffy Wei Wang Charles A Czeisler Steven A Shea Science Translational Medicine 11 Apr 2012 129ra43 Sleep deficiency and out of synch circadian rhythms impair pancreatic insulin secretion a possible precursor to metabolic syndrome and diabetes Permalink Copy Related Content Focus Probing the Brain of Comorbidity Review Knitting Up the Raveled Sleave of Care Research Article Effects of caffeine on the human circadian clock in vivo and

    Original URL path: http://stm.sciencemag.org/content/4/129/129ra43.figures-only (2016-02-10)
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