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  • Casein Kinase Iδ Mutations in Familial Migraine and Advanced Sleep Phase | Science Translational Medicine
    for this author on this site Hsien Yang Lee Department of Neurology University of California San Francisco San Francisco CA 94158 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher R Jones Department of Neurology University of Utah Salt Lake City UT 84108 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ying Hui Fu Department of Neurology University of California San Francisco San Francisco CA 94158 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrew C Charles Department of Neurology University of California Los Angeles Los Angeles CA 90095 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Louis J Ptáček Department of Neurology University of California San Francisco San Francisco CA 94158 USA Howard Hughes Medical Institute University of California San Francisco San Francisco CA 94158 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Migraine is a common disabling disorder with a significant genetic component characterized by severe headache and often accompanied by nausea vomiting and light sensitivity We identified two families each with a distinct missense mutation in the gene encoding casein kinase Iδ CKIδ in which the mutation cosegregated with both the presence of migraine and advanced sleep phase The resulting alterations T44A and H46R occurred in the conserved catalytic domain of CKIδ where they caused reduced enzyme activity Mice engineered to carry the CKIδ T44A allele were more sensitive to pain after treatment with the migraine trigger nitroglycerin CKIδ T44A mice also exhibited a reduced threshold for cortical spreading depression believed to be the physiological analog of migraine aura and greater arterial dilation during cortical spreading depression Astrocytes from CKIδ T44A mice showed increased spontaneous and evoked calcium signaling These genetic cellular physiological and behavioral analyses suggest that decreases in CKIδ activity can contribute to the pathogenesis of migraine Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 183 01 May 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To

    Original URL path: http://stm.sciencemag.org/content/5/183/183ra56 (2016-02-10)
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  • The Gracefully Aging Immune System | Science Translational Medicine
    this author on PubMed Search for this author on this site Jacques Louis Fondation Mérieux Lyon 69002 France Find this author on Google Scholar Find this author on PubMed Search for this author on this site Beatrix Grubeck Loebenstein Institute for Biomedical Aging Research University of Innsbruck Innsbruck 6020 Austria Find this author on Google Scholar Find this author on PubMed Search for this author on this site Rino Rappuoli Novartis Vaccines and Diagnostics Siena 53100 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Giuseppe Del Giudice Novartis Vaccines and Diagnostics Siena 53100 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract Prolonged life expectancy in the 20th century has been one of humankind s greatest triumphs However the substantial increase in the human life span has ushered in a new concern healthy aging Because infectious diseases prominently contribute to morbidity in the particularly vulnerable elderly population strategies for preventing these diseases would have a clear impact on improving healthy aging Thus vaccines and immunization strategies tailored for the elderly population are needed and vaccines should be developed to take into consideration the peculiar age induced variations of immune responsiveness The conference Ageing and Immunity recently held in Siena Italy has reviewed and discussed several possible causes of immune senescence as well as strategies for counteracting this waning of immune responsiveness and for restoring immunocompetence In addition examples of diseases that should be targeted by vaccination in the senior population were considered Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 185 15 May 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Gracefully Aging Immune System Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password

    Original URL path: http://stm.sciencemag.org/content/5/185/185ps8 (2016-02-10)
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  • Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology | Science Translational Medicine
    on Google Scholar Find this author on PubMed Search for this author on this site Floy R Stewart 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Randall J Bateman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David M Holtzman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with Alzheimer s Disease Pathology Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Disruption of the

    Original URL path: http://stm.sciencemag.org/content/4/150/150ra122.figures-only (2016-02-10)
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  • Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology | Science Translational Medicine
    Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Article Information vol 4 no 150 150ra122 DOI http dx doi org 10 1126 scitranslmed 3004291 PubMed 22956200 Published By American Association for the Advancement of Science Print ISSN 1946 6234 Online ISSN 1946 6242 History Received for publication 8 May 2012 Accepted for publication 13 July 2012 Copyright Usage Copyright 2012 American Association for the Advancement of Science Author Information Jee Hoon Roh 1 2 3 Yafei Huang 1 Adam W Bero 1 2 3 Tom Kasten 1 Floy R Stewart 1 2 3 Randall J Bateman 1 2 3 and David M Holtzman 1 2 3 4 1 Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2 Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3 Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4 Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA To whom correspondence should be addressed E mail holtzman at neuro wustl edu AltMetrics No Altmetric data available for this article Article usage Abstract Full PDF Sep 2012 12513 427 698 Oct 2012 1993 112 161 Nov 2012 978 49 92 Dec 2012 454 26 48 Jan 2013 792 41 49 Feb 2013 503 17 48 Mar 2013 471 18 49 Apr 2013 425 34 26 May 2013 522 20 39 Jun 2013 538 44 53 Jul 2013 350 30 55 Aug 2013 358 24 50 Sep 2013 360 81 127 Oct 2013 660 58 75 Nov 2013 391 40 62 Dec 2013 244 81 63 Jan 2014 374 55 52 Feb 2014 293 42 46 Mar 2014 269 40 43 Apr 2014 239 32 34 May 2014 200 43 33 Jun 2014 191 17 15 Jul 2014 169 11 12 Aug 2014 190 33 29 Sep 2014 154 39 35 Oct 2014 308 56 83 Nov 2014 437 72 117 Dec 2014 248 30 39 Jan 2015 539 50 63 Feb 2015 175 27 24 Mar 2015 327 30 37 Apr 2015 380 20 29 May 2015 242 38 26 Jun 2015 245 26 26 Jul 2015 149 7 19 Aug 2015 65 32 22 Sep 2015 115 27 34 Oct 2015 66 14 30 Nov 2015 63 53 51 Dec 2015 48 9 16 Jan 2016 209 20 25 Feb 2016 53 8 6 View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about

    Original URL path: http://stm.sciencemag.org/content/4/150/150ra122.article-info (2016-02-10)
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  • Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology | Science Translational Medicine
    Find this author on Google Scholar Find this author on PubMed Search for this author on this site Randall J Bateman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David M Holtzman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs break automatically Upload Tables and Figures Attach tables e g doc and figures jpg gif tif by choosing the desired file and then uploading them below Add a new file Upload Files must be less than 100 MB Allowed file types doc jpg jpeg gif tif pdf File names can only contain the following characters A Z a z 0 9 Author Information Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with Alzheimer s Disease Pathology Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would

    Original URL path: http://stm.sciencemag.org/content/4/150/150ra122.e-letters (2016-02-10)
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  • Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of β-Amyloid in Mice with Alzheimer’s Disease Pathology | Science Translational Medicine
    this author on this site Floy R Stewart 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Randall J Bateman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site David M Holtzman 1Department of Neurology Washington University School of Medicine St Louis MO 63110 USA 2Hope Center for Neurological Disorders Washington University School of Medicine St Louis MO 63110 USA 3Charles F and Joanne Knight Alzheimer s Disease Research Center Washington University School of Medicine St Louis MO 63110 USA 4Department of Developmental Biology Washington University School of Medicine St Louis MO 63110 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with Alzheimer s Disease Pathology Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with

    Original URL path: http://stm.sciencemag.org/content/4/150/150ra122.full (2016-02-10)
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  • Table of Contents — September 05, 2012, 4 (150) | Science Translational Medicine
    Read Giuseppe Zanoni Dale E Edmondson Edda De Rossi Maria Rosalia Pasca John D McKinney Paul J Dyson Giovanna Riccardi Andrea Mattevi Stewart T Cole Claudia Binda Science Translational Medicine 05 Sep 2012 150ra121 The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target Editor s Summary Abstract Full Text PDF Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with Alzheimer s Disease Pathology By Jee Hoon Roh Yafei Huang Adam W Bero Tom Kasten Floy R Stewart Randall J Bateman David M Holtzman Science Translational Medicine 05 Sep 2012 150ra122 Decreased sleep and attenuation of circadian fluctuations in Aβ reflect amyloid associated pathology in Alzheimer s disease Editor s Summary Abstract Full Text PDF An Intravaginal Ring That Releases the NNRTI MIV 150 Reduces SHIV Transmission in Macaques By Rachel Singer Paul Mawson Nina Derby Aixa Rodriguez Larisa Kizima Radhika Menon Daniel Goldman Jessica Kenney Meropi Aravantinou Samantha Seidor Agegnehu Gettie James Blanchard Michael Piatak Jr Jeffrey D Lifson José A Fernández Romero Melissa Robbiani Thomas M Zydowsky Science Translational Medicine 05 Sep 2012 150ra123 An intravaginal ring loaded with the NNRTI MIV 150 prevents transmission of the HIV SIV chimera SHIV RT in macaques Editor s Summary Abstract Full Text PDF Editors Choice Autoimmune TSA By Jagdeep S Obhrai Science Translational Medicine 05 Sep 2012 150ec157 New tools help to understand how tolerance to self occurs Full Text Seeing Double to Recognize TB By Joshua D Shrout Science Translational Medicine 05 Sep 2012 150ec158 Detection of double stranded Mycobacterium tuberculosis DNA by the immune system leads to pathogen destruction via autophagy Full Text Nurture and Neurodevelopment By Manpreet K Singh Science Translational Medicine 05 Sep 2012 150ec159 Does institutionalization influence brain development Full

    Original URL path: http://stm.sciencemag.org/content/4/150 (2016-02-10)
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  • Table of Contents — September 05, 2012, 4 (150) | Science Translational Medicine
    J Read Giuseppe Zanoni Dale E Edmondson Edda De Rossi Maria Rosalia Pasca John D McKinney Paul J Dyson Giovanna Riccardi Andrea Mattevi Stewart T Cole Claudia Binda Science Translational Medicine 05 Sep 2012 150ra121 The crystal structure of the mycobacterial DprE1 reveals how the TB drug benzothiazinone BTZ043 blocks this microbial enzyme target Editor s Summary Abstract Full Text PDF Disruption of the Sleep Wake Cycle and Diurnal Fluctuation of β Amyloid in Mice with Alzheimer s Disease Pathology By Jee Hoon Roh Yafei Huang Adam W Bero Tom Kasten Floy R Stewart Randall J Bateman David M Holtzman Science Translational Medicine 05 Sep 2012 150ra122 Decreased sleep and attenuation of circadian fluctuations in Aβ reflect amyloid associated pathology in Alzheimer s disease Editor s Summary Abstract Full Text PDF An Intravaginal Ring That Releases the NNRTI MIV 150 Reduces SHIV Transmission in Macaques By Rachel Singer Paul Mawson Nina Derby Aixa Rodriguez Larisa Kizima Radhika Menon Daniel Goldman Jessica Kenney Meropi Aravantinou Samantha Seidor Agegnehu Gettie James Blanchard Michael Piatak Jr Jeffrey D Lifson José A Fernández Romero Melissa Robbiani Thomas M Zydowsky Science Translational Medicine 05 Sep 2012 150ra123 An intravaginal ring loaded with the NNRTI MIV 150 prevents transmission of the HIV SIV chimera SHIV RT in macaques Editor s Summary Abstract Full Text PDF Editors Choice Autoimmune TSA By Jagdeep S Obhrai Science Translational Medicine 05 Sep 2012 150ec157 New tools help to understand how tolerance to self occurs Full Text Seeing Double to Recognize TB By Joshua D Shrout Science Translational Medicine 05 Sep 2012 150ec158 Detection of double stranded Mycobacterium tuberculosis DNA by the immune system leads to pathogen destruction via autophagy Full Text Nurture and Neurodevelopment By Manpreet K Singh Science Translational Medicine 05 Sep 2012 150ec159 Does institutionalization influence brain development

    Original URL path: http://stm.sciencemag.org/content/4/150.toc (2016-02-10)
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