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  • Table of Contents — May 01, 2013, 5 (183) | Science Translational Medicine
    N Fuji William J Meilandt Hilda Solanoy Raymond K Tong Kwame Hoyte Wilman Luk Yanmei Lu Kapil Gadkar Saileta Prabhu Benjamin A Ordonia Quyen Nguyen Yuwen Lin Zhonghua Lin Mercedesz Balazs Kimberly Scearce Levie James A Ernst Mark S Dennis Ryan J Watts Science Translational Medicine 01 May 2013 183ra57 The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function Editor s Summary Abstract Full Text PDF Angiotensin Converting Enzyme Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin 4 Deficient Mice By Jianbin Huang Yoshito Yamashiro Christina L Papke Yuichi Ikeda Yanling Lin Miteshkumar Patel Tadashi Inagami Victoria P Le Jessica E Wagenseil Hiromi Yanagisawa Science Translational Medicine 01 May 2013 183ra58 Up regulation of angiotensin converting enzyme in the aortic wall causes aneurysms in fibulin 4 deficient mice which can be prevented by losartan or captopril Editor s Summary Abstract Full Text PDF Editors Choice Staying Smart on Statins By William J Mack Science Translational Medicine 01 May 2013 183ec72 Asymptomatic carotid artery stenosis patients given statins have a lower incidence of stroke and cognitive dysfunction after surgery Full Text Dangerous Liaisons When Two Wrongs Just Might Make a Right By Trudy G Oliver Science Translational Medicine 01 May 2013 183ec73 Radioactive bacteria are exploited to treat metastases in a mouse model of pancreatic cancer Full Text Stimulating the Prefrontal Cortex to Undo Stimulant Addiction By Vikaas S Sohal Science Translational Medicine 01 May 2013 183ec74 Chronic cocaine exposure may decrease the excitability of prefrontal neurons acute changes in prefrontal activity alter cocaine seeking behavior in rats Full Text I ll Take a Steak with Antibiotic on the Side By Amir Tirosh Science Translational Medicine 01

    Original URL path: http://stm.sciencemag.org/content/5/183 (2016-02-10)
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  • Table of Contents — May 01, 2013, 5 (183) | Science Translational Medicine
    Reina N Fuji William J Meilandt Hilda Solanoy Raymond K Tong Kwame Hoyte Wilman Luk Yanmei Lu Kapil Gadkar Saileta Prabhu Benjamin A Ordonia Quyen Nguyen Yuwen Lin Zhonghua Lin Mercedesz Balazs Kimberly Scearce Levie James A Ernst Mark S Dennis Ryan J Watts Science Translational Medicine 01 May 2013 183ra57 The safety of therapeutic bispecific antibodies that use TfR for delivery to the brain can be improved by reducing affinity for TfR and eliminating antibody effector function Editor s Summary Abstract Full Text PDF Angiotensin Converting Enzyme Induced Activation of Local Angiotensin Signaling Is Required for Ascending Aortic Aneurysms in Fibulin 4 Deficient Mice By Jianbin Huang Yoshito Yamashiro Christina L Papke Yuichi Ikeda Yanling Lin Miteshkumar Patel Tadashi Inagami Victoria P Le Jessica E Wagenseil Hiromi Yanagisawa Science Translational Medicine 01 May 2013 183ra58 Up regulation of angiotensin converting enzyme in the aortic wall causes aneurysms in fibulin 4 deficient mice which can be prevented by losartan or captopril Editor s Summary Abstract Full Text PDF Editors Choice Staying Smart on Statins By William J Mack Science Translational Medicine 01 May 2013 183ec72 Asymptomatic carotid artery stenosis patients given statins have a lower incidence of stroke and cognitive dysfunction after surgery Full Text Dangerous Liaisons When Two Wrongs Just Might Make a Right By Trudy G Oliver Science Translational Medicine 01 May 2013 183ec73 Radioactive bacteria are exploited to treat metastases in a mouse model of pancreatic cancer Full Text Stimulating the Prefrontal Cortex to Undo Stimulant Addiction By Vikaas S Sohal Science Translational Medicine 01 May 2013 183ec74 Chronic cocaine exposure may decrease the excitability of prefrontal neurons acute changes in prefrontal activity alter cocaine seeking behavior in rats Full Text I ll Take a Steak with Antibiotic on the Side By Amir Tirosh Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/5/183.toc (2016-02-10)
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  • the Brain of Comorbidity DP 2013 Jun 01 TA Science Translational Medicine PG 183fs15 183fs15 VI 5 IP 183 4099 http stm sciencemag org content 5 183 183fs15 short 4100 http stm sciencemag org content 5 183 183fs15 full AB

    Original URL path: http://stm.sciencemag.org/highwire/citation/186876/medlars (2016-02-10)
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  • the Brain of Comorbidity JF Science Translational Medicine YR 2013 FD American Association for the Advancement of Science VO 5 IS 183 SP 183fs15 OP 183fs15 DO 10 1126 scitranslmed 3006229 UL http stm sciencemag org content 5 183 183fs15

    Original URL path: http://stm.sciencemag.org/highwire/citation/186876/refworks (2016-02-10)
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  • Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model | Science Translational Medicine
    author on this site Thor D Stein Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrew E Budson Find this author on Google Scholar Find this author on PubMed Search for this author on this site Neil W Kowall Find this author on Google Scholar Find this author on PubMed Search for this author on this site David Chargin Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andre Sharon Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sudad Saman Find this author on Google Scholar Find this author on PubMed Search for this author on this site Garth F Hall Find this author on Google Scholar Find this author on PubMed Search for this author on this site William C Moss Find this author on Google Scholar Find this author on PubMed Search for this author on this site Robin O Cleveland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Rudolph E Tanzi Find this author on Google Scholar Find this author on PubMed Search for this author on this site Patric K Stanton Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ann C McKee Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Blast exposure is associated with traumatic brain injury TBI neuropsychiatric symptoms and long term cognitive disability We examined a case series of postmortem brains from U S military veterans exposed to blast and or concussive injury We found evidence of chronic traumatic encephalopathy CTE a tau protein linked neurodegenerative disease that was similar to the CTE neuropathology observed in young amateur American football players and a professional wrestler with histories of concussive injuries We developed a blast neurotrauma mouse model that recapitulated CTE linked neuropathology in wild type C57BL 6 mice 2 weeks after exposure to a single blast Blast exposed mice demonstrated phosphorylated tauopathy myelinated axonopathy microvasculopathy chronic neuroinflammation and neurodegeneration in the absence of macroscopic tissue damage or hemorrhage Blast exposure induced persistent hippocampal dependent learning and memory deficits that persisted for at least 1 month and correlated with impaired axonal conduction and defective activity dependent long term potentiation of synaptic transmission Intracerebral pressure recordings demonstrated that shock waves traversed the mouse brain with minimal change and without thoracic contributions Kinematic analysis revealed blast induced head oscillation at

    Original URL path: http://stm.sciencemag.org/content/4/134/134ra60 (2016-02-10)
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  • Modulation of Vigilance in the Primary Hypersomnias by Endogenous Enhancement of GABAA Receptors | Science Translational Medicine
    Scholar Find this author on PubMed Search for this author on this site Paul S Garcia Department of Anesthesiology Emory University School of Medicine Atlanta GA 30322 USA Anesthesiology and Research Divisions Atlanta VA Medical Center Atlanta GA 30033 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael J Owens Department of Psychiatry and Behavioral Sciences Emory University School of Medicine Atlanta GA 30322 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site James C Ritchie Department of Pathology Emory University School of Medicine Atlanta GA 30322 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrew Jenkins Department of Anesthesiology Emory University School of Medicine Atlanta GA 30322 USA Department of Pharmacology Emory University School of Medicine Atlanta GA 30322 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract The biology underlying excessive daytime sleepiness hypersomnolence is incompletely understood After excluding known causes of sleepiness in 32 hypersomnolent patients we showed that in the presence of 10 μM γ aminobutyric acid GABA cerebrospinal fluid CSF from these subjects stimulated GABA A receptor function in vitro by 84 0 40 7 SD relative to the 35 8 7 5 SD stimulation obtained with CSF from control subjects Student s t test t 6 47 P 0 0001 CSF alone had no effect on GABA A signaling The bioactive CSF component had a mass of 500 to 3000 daltons and was neutralized by trypsin Enhancement was greater for α2 subunit versus α1 subunit containing GABA A receptors and negligible for α4 subunit containing ones CSF samples from hypersomnolent patients also modestly enhanced benzodiazepine BZD insensitive GABA A receptors and did not competitively displace BZDs from human brain tissue Flumazenil a drug that is generally believed to antagonize the sedative hypnotic actions of BZDs only at the classical BZD binding domain in GABA A receptors and to lack intrinsic activity nevertheless reversed enhancement of GABA A signaling by hypersomnolent CSF in vitro Furthermore flumazenil normalized vigilance in seven hypersomnolent patients We conclude that a naturally occurring substance in CSF augments inhibitory GABA signaling thus revealing a new pathophysiology associated with excessive daytime sleepiness Copyright 2012 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 4 Issue 161 21 November 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine

    Original URL path: http://stm.sciencemag.org/content/4/161/161ra151 (2016-02-10)
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  • The Nexus of Aβ, Aging, and Sleep | Science Translational Medicine
    this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Nexus of Aβ Aging and Sleep Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools The Nexus of Aβ Aging and Sleep By Jason R Gerstner Isaac J Perron Allan I Pack Science Translational Medicine 05 Sep 2012 150fs34 Roh et al report a positive feedback loop between sleep wake irregularities and aggregation of β amyloid Aβ peptide suggesting that sleep alterations could be an early

    Original URL path: http://stm.sciencemag.org/content/4/150/150fs34.figures-only (2016-02-10)
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  • The Nexus of Aβ, Aging, and Sleep | Science Translational Medicine
    ISSN 1946 6234 Online ISSN 1946 6242 History Copyright Usage Copyright 2012 American Association for the Advancement of Science Author Information Jason R Gerstner 1 Isaac J Perron 2 and Allan I Pack 1 1 Center for Sleep and Circadian Neurobiology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA 2 Neuroscience Graduate Group Perelman School of Medicine Philadelphia PA 19104 USA Corresponding author E mail gerstner at upenn edu J R G allan pack at uphs upenn edu A I P AltMetrics No Altmetric data available for this article Article usage Abstract Full PDF Sep 2012 3488 191 332 Oct 2012 590 22 85 Nov 2012 280 10 37 Dec 2012 155 9 20 Jan 2013 224 24 30 Feb 2013 122 9 15 Mar 2013 118 8 17 Apr 2013 129 6 11 May 2013 111 7 13 Jun 2013 140 4 17 Jul 2013 61 8 13 Aug 2013 71 3 7 Sep 2013 43 10 12 Oct 2013 164 10 18 Nov 2013 70 8 15 Dec 2013 74 10 10 Jan 2014 64 9 13 Feb 2014 63 4 8 Mar 2014 57 6 9 Apr 2014 84 3 8 May 2014 73 2 7 Jun 2014 38 1 3 Jul 2014 20 0 1 Aug 2014 38 1 2 Sep 2014 21 0 9 Oct 2014 414 35 72 Nov 2014 538 55 77 Dec 2014 101 11 22 Jan 2015 152 13 14 Feb 2015 48 4 6 Mar 2015 66 4 4 Apr 2015 54 3 9 May 2015 73 2 6 Jun 2015 54 3 6 Jul 2015 44 0 4 Aug 2015 44 3 7 Sep 2015 33 2 6 Oct 2015 54 7 14 Nov 2015 30 0 6 Dec 2015 65 2 0 Jan 2016 52 7 7 Feb 2016 17 1 0 View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Nexus of Aβ Aging and Sleep Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools The Nexus of Aβ Aging and

    Original URL path: http://stm.sciencemag.org/content/4/150/150fs34.article-info (2016-02-10)
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