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  • The Nexus of Aβ, Aging, and Sleep | Science Translational Medicine
    site Allan I Pack 1Center for Sleep and Circadian Neurobiology Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs break automatically Upload Tables and Figures Attach tables e g doc and figures jpg gif tif by choosing the desired file and then uploading them below Add a new file Upload Files must be less than 100 MB Allowed file types doc jpg jpeg gif tif pdf File names can only contain the following characters A Z a z 0 9 Author Information Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Nexus of Aβ Aging and Sleep Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools The Nexus of Aβ Aging and Sleep By Jason R Gerstner Isaac J Perron Allan I Pack Science Translational Medicine 05 Sep 2012 150fs34 Roh et al report a positive feedback loop between sleep wake irregularities and aggregation of β amyloid Aβ peptide suggesting that sleep alterations could be an early event in Alzheimer s disease AD Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share The

    Original URL path: http://stm.sciencemag.org/content/4/150/150fs34.e-letters (2016-02-10)
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  • The Nexus of Aβ, Aging, and Sleep | Science Translational Medicine
    this author on this site Article Figures Data Info Metrics eLetters PDF Log in to view full text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 4 Issue 150 05 September 2012 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following The Nexus of Aβ Aging and Sleep Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools The Nexus of Aβ Aging and Sleep By Jason R Gerstner Isaac J Perron Allan I Pack Science Translational Medicine 05 Sep 2012 150fs34 Roh et al report a positive feedback loop between sleep wake irregularities and aggregation of β amyloid Aβ peptide suggesting that sleep alterations could be an early event in Alzheimer s disease AD Citation Manager

    Original URL path: http://stm.sciencemag.org/content/4/150/150fs34.full (2016-02-10)
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  • Oct 05 TA Science Translational Medicine PG 150fs34 150fs34 VI 4 IP 150 4099 http stm sciencemag org content 4 150 150fs34 short 4100 http stm sciencemag org content 4 150 150fs34 full AB Roh et al report a positive

    Original URL path: http://stm.sciencemag.org/highwire/citation/186424/medlars (2016-02-10)
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  • Translational Medicine YR 2012 FD American Association for the Advancement of Science VO 4 IS 150 SP 150fs34 OP 150fs34 DO 10 1126 scitranslmed 3004815 UL http stm sciencemag org content 4 150 150fs34 abstract AB Roh et al report

    Original URL path: http://stm.sciencemag.org/highwire/citation/186424/refworks (2016-02-10)
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  • Sulfate Metabolites Provide an Intracellular Pool for Resveratrol Generation and Induce Autophagy with Senescence | Science Translational Medicine
    author on Google Scholar Find this author on PubMed Search for this author on this site William P Steward Department of Cancer Studies and Molecular Medicine University of Leicester Leicester LE2 7LX UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andreas J Gescher Department of Cancer Studies and Molecular Medicine University of Leicester Leicester LE2 7LX UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Karen Brown Department of Cancer Studies and Molecular Medicine University of Leicester Leicester LE2 7LX UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract The phytochemical resveratrol has been shown to exert numerous health benefits in preclinical studies but its rapid metabolism and resulting poor bioavailability may limit translation of these effects to humans Resveratrol metabolites might contribute to in vivo activity through regeneration of the parent compound We present quantitation of sulfate and glucuronide conjugates of resveratrol in human plasma and tissue after repeated ingestion of resveratrol by volunteers and cancer patients respectively Subsequent pharmacokinetic characterization of a mixture of resveratrol 3 O sulfate and resveratrol 4 O sulfate in mice showed that these metabolites are absorbed orally but have low bioavailabilities of 14 and 3 respectively Sulfate hydrolysis in vivo liberated free resveratrol which accounted for 2 of the total resveratrol species present in mouse plasma Monosulfate metabolites were also converted to the parent in human colorectal cells The extent of cellular uptake was dependent on specific membrane transporters and dictated antiproliferative activity Sulfate metabolites induced autophagy and senescence in human cancer cells these effects were abrogated by inclusion of a sulfatase inhibitor which reduced intracellular resveratrol Together our findings suggest that resveratrol is delivered to target tissues in a stable sulfate conjugated form and that the parent compound is gradually regenerated in selected cells and may give rise to the beneficial effects in vivo At doses considered to be safe in humans resveratrol generated via this route may be of greater importance than the unmetabolized form Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 205 02 October 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any

    Original URL path: http://stm.sciencemag.org/content/5/205/205ra133 (2016-02-10)
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  • MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations | Science Translational Medicine
    USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sandra Misale Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Luca Lazzari Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrea Bertotti Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Livio Trusolino Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alex A Adjei Roswell Park Cancer Institute Buffalo NY 14263 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Clara Montagut Medical Oncology Department Hospital del Mar Barcelona 08003 Spain Cancer Research Program FIMIM Hospital del Mar Medical Research Institute Hospital del Mar Barcelona 08003 Spain Find this author on Google Scholar Find this author on PubMed Search for this author on this site Federica Di Nicolantonio Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Rachel Nering Merrimack Pharmaceuticals Inc Cambridge MA 02139 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Alberto Bardelli Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO IRCCS Candiolo Torino 10060 Italy Department of Oncology University of Torino Candiolo Torino 10060 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the pdf html View Full Text You are using an old browser click here to download PDF PDF Container Science Translational Medicine Vol 8 Issue 324 03 February 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to

    Original URL path: http://stm.sciencemag.org/content/8/324/324ra14.full.pdf+html? (2016-02-10)
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  • IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies | Science Translational Medicine
    this author on PubMed Search for this author on this site Barbara Lupo Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jessica Erriquez Cancer Genetics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Claudio Isella Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Oncogenomics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Paolo M Comoglio Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Molecular Clinical Oncology Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Enzo Medico Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Oncogenomics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sabine Tejpar University Hospital Gasthuisberg 3000 Leuven Belgium Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eva Budinská Institute of Biostatistics and Analyses Masaryk University 611 37 Brno Czech Republic Regional Center of Applied Molecular Oncology Masaryk Memorial Cancer Institute 656 53 Brno Czech Republic Find this author on Google Scholar Find this author on PubMed Search for this author on this site Livio Trusolino Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrea Bertotti Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy National Institute of Biostructures and Biosystems 00136 Rome Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 7 Issue 272 28

    Original URL path: http://stm.sciencemag.org/content/7/272/272ra12.figures-only (2016-02-10)
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  • IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies | Science Translational Medicine
    Italy Molecular Clinical Oncology Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Enzo Medico Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Oncogenomics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sabine Tejpar University Hospital Gasthuisberg 3000 Leuven Belgium Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eva Budinská Institute of Biostatistics and Analyses Masaryk University 611 37 Brno Czech Republic Regional Center of Applied Molecular Oncology Masaryk Memorial Cancer Institute 656 53 Brno Czech Republic Find this author on Google Scholar Find this author on PubMed Search for this author on this site Livio Trusolino Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrea Bertotti Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy National Institute of Biostructures and Biosystems 00136 Rome Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Article Information vol 7 no 272 272ra12 DOI http dx doi org 10 1126 scitranslmed 3010445 PubMed 25632036 Published By American Association for the Advancement of Science Print ISSN 1946 6234 Online ISSN 1946 6242 History Received for publication 20 August 2014 Accepted for publication 24 December 2014 Copyright Usage Copyright 2015 American Association for the Advancement of Science Author Information Eugenia R Zanella 1 2 Francesco Galimi 1 2 Francesco Sassi 1 2 Giorgia Migliardi 1 2 Francesca Cottino 2 Simonetta M Leto 1 2 Barbara Lupo 1 2 Jessica Erriquez 3 Claudio Isella 1 4 Paolo M Comoglio 1 5 Enzo Medico 1 4 Sabine Tejpar 6 Eva Budinská 7 8 Livio Trusolino 1 2 and Andrea Bertotti 1 2 9 1 Department of Oncology University of Torino Medical School 10060 Candiolo Torino Italy 2 Translational Cancer Medicine Candiolo Cancer Institute Fondazione del Piemonte per l Oncologia FPO Istituto di Ricovero e Cura a Carattere Scientifico IRCCS 10060 Candiolo Torino Italy 3 Cancer Genetics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy 4 Oncogenomics Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy 5 Molecular Clinical Oncology Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Torino Italy 6 University Hospital Gasthuisberg 3000 Leuven Belgium 7 Institute of Biostatistics and Analyses Masaryk University 611 37 Brno Czech Republic 8 Regional Center

    Original URL path: http://stm.sciencemag.org/content/7/272/272ra12.article-info (2016-02-10)
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