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  • Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer | Science Translational Medicine
    Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gregory J Riely Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Maria E Arcila Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ross A Soo Cancer Science Institute of Singapore and National University Cancer Institute National University of Singapore Singapore 117599 Singapore Find this author on Google Scholar Find this author on PubMed Search for this author on this site Matthew Meyerson Dana Farber Cancer Institute Harvard Medical School Boston MA 02215 USA Broad Institute Massachusetts Institute of Technology and Harvard Medical School Boston MA 02142 USA Brigham and Women s Hospital Harvard Medical School Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael J Eck Dana Farber Cancer Institute Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Susumu S Kobayashi Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daniel B Costa Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs break automatically Upload Tables and Figures Attach tables e g doc and figures jpg gif tif by choosing the desired file and then uploading them below Add a new file Upload Files must be less than 100 MB Allowed file types doc jpg jpeg gif tif pdf File names can only contain the following characters A Z a z 0 9 Author Information Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 5 Issue 216 18

    Original URL path: http://stm.sciencemag.org/content/5/216/216ra177.e-letters (2016-02-10)
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  • A Correction to the Research Article Titled: “Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer” by H. Yasuda, E. Park, C.-H. Yun, N. J. Sng, A. R. Lucena-Araujo, … | Science Translational Medicine
    at http stm sciencemag org content 5 216 216ra177 full pdf Copyright 2014 American Association for the Advancement of Science Science Translational Medicine Vol 6 Issue 225 26 February 2014 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following A Correction to the Research Article Titled Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer by H Yasuda E Park C H Yun N J Sng A R Lucena Araujo Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools A Correction to the Research Article Titled Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer by H Yasuda E Park C H Yun N J Sng A R Lucena Araujo W L Yeo M S Huberman D W Cohen S Nakayama K Ishioka N Yamaguchi M Hanna G R Oxnard C S Lathan T Moran

    Original URL path: http://stm.sciencemag.org/content/6/225/225er1 (2016-02-10)
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  • Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer | Science Translational Medicine
    on Google Scholar Find this author on PubMed Search for this author on this site Lecia V Sequist Massachusetts General Hospital Harvard Medical School Boston MA 02114 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jamie E Chaft Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gregory J Riely Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Maria E Arcila Memorial Sloan Kettering Cancer Center Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ross A Soo Cancer Science Institute of Singapore and National University Cancer Institute National University of Singapore Singapore 117599 Singapore Find this author on Google Scholar Find this author on PubMed Search for this author on this site Matthew Meyerson Dana Farber Cancer Institute Harvard Medical School Boston MA 02215 USA Broad Institute Massachusetts Institute of Technology and Harvard Medical School Boston MA 02142 USA Brigham and Women s Hospital Harvard Medical School Boston MA 02115 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael J Eck Dana Farber Cancer Institute Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Susumu S Kobayashi Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daniel B Costa Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF This article has a correction Please see Is corrected by February 26 2014 Log in to view full text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 5 Issue 216 18 December 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines

    Original URL path: http://stm.sciencemag.org/content/5/216/216ra177.full (2016-02-10)
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  • Table of Contents — December 18, 2013, 5 (216) | Science Translational Medicine
    Patients with narcolepsy carry CD4 T cells that react to peptides from both the sleep regulating neuropeptide hypocretin and a 2009 H1N1 influenza A protein Editor s Summary Abstract Full Text PDF Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer By Hiroyuki Yasuda Eunyoung Park Cai Hong Yun Natasha J Sng Antonio R Lucena Araujo Wee Lee Yeo Mark S Huberman David W Cohen Sohei Nakayama Kota Ishioka Norihiro Yamaguchi Megan Hanna Geoffrey R Oxnard Christopher S Lathan Teresa Moran Lecia V Sequist Jamie E Chaft Gregory J Riely Maria E Arcila Ross A Soo Matthew Meyerson Michael J Eck Susumu S Kobayashi Daniel B Costa Science Translational Medicine 18 Dec 2013 216ra177 Crystal structure and detailed analysis of different EGFR mutants explain why some mutations in exon 20 make lung cancers resistant to EGFR inhibitors and others make them more sensitive Editor s Summary Abstract Full Text PDF Review Cancer Nanomedicine From Drug Delivery to Imaging By Edward Kai Hua Chow Dean Ho Science Translational Medicine 18 Dec 2013 216rv4 Nanomedicine has made progress in translating to cancer treatment and imaging but challenges still remain Editor s Summary Abstract Full Text PDF Editors Choice Smoking Moms and Methylation By Egle Bytautiene Science Translational Medicine 18 Dec 2013 216ec207 Placentas of women who smoke during pregnancy display differential methylation patterns relative to nonsmokers Full Text Decoding Autism By Christopher Gregg Science Translational Medicine 18 Dec 2013 216ec208 Two new studies take network based approaches to unify the complex genetic architecture of autism spectrum disorders Full Text Shh the Baby Mice Are Resting By Yevgeniya A Nusinovich Science Translational Medicine 18 Dec 2013 216ec209 Prolonged exposure to noise and other stimulation permanently altered blood vessel development in the brains of newborn

    Original URL path: http://stm.sciencemag.org/content/5/216 (2016-02-10)
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  • Table of Contents — December 18, 2013, 5 (216) | Science Translational Medicine
    216ra176 Patients with narcolepsy carry CD4 T cells that react to peptides from both the sleep regulating neuropeptide hypocretin and a 2009 H1N1 influenza A protein Editor s Summary Abstract Full Text PDF Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer By Hiroyuki Yasuda Eunyoung Park Cai Hong Yun Natasha J Sng Antonio R Lucena Araujo Wee Lee Yeo Mark S Huberman David W Cohen Sohei Nakayama Kota Ishioka Norihiro Yamaguchi Megan Hanna Geoffrey R Oxnard Christopher S Lathan Teresa Moran Lecia V Sequist Jamie E Chaft Gregory J Riely Maria E Arcila Ross A Soo Matthew Meyerson Michael J Eck Susumu S Kobayashi Daniel B Costa Science Translational Medicine 18 Dec 2013 216ra177 Crystal structure and detailed analysis of different EGFR mutants explain why some mutations in exon 20 make lung cancers resistant to EGFR inhibitors and others make them more sensitive Editor s Summary Abstract Full Text PDF Review Cancer Nanomedicine From Drug Delivery to Imaging By Edward Kai Hua Chow Dean Ho Science Translational Medicine 18 Dec 2013 216rv4 Nanomedicine has made progress in translating to cancer treatment and imaging but challenges still remain Editor s Summary Abstract Full Text PDF Editors Choice Smoking Moms and Methylation By Egle Bytautiene Science Translational Medicine 18 Dec 2013 216ec207 Placentas of women who smoke during pregnancy display differential methylation patterns relative to nonsmokers Full Text Decoding Autism By Christopher Gregg Science Translational Medicine 18 Dec 2013 216ec208 Two new studies take network based approaches to unify the complex genetic architecture of autism spectrum disorders Full Text Shh the Baby Mice Are Resting By Yevgeniya A Nusinovich Science Translational Medicine 18 Dec 2013 216ec209 Prolonged exposure to noise and other stimulation permanently altered blood vessel development in the brains of

    Original URL path: http://stm.sciencemag.org/content/5/216.toc (2016-02-10)
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  • S AU Costa Daniel B TI Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer DP 2013 18 TA Science Translational Medicine PG 216ra177 216ra177 VI 5 IP 216 4099 http stm sciencemag org content 5 216 216ra177 short 4100 http stm sciencemag org content 5 216 216ra177 full AB Epidermal growth factor receptor EGFR gene mutations G719X exon 19 deletions insertions L858R and L861Q predict favorable responses to EGFR tyrosine kinase inhibitors TKIs in advanced non small cell lung cancer NSCLC However EGFR exon 20 insertion mutations 10 of all EGFR mutations are generally associated with insensitivity to available TKIs gefitinib erlotinib and afatinib The basis of this primary resistance is poorly understood We studied a broad subset of exon 20 insertion mutations comparing in vitro TKI sensitivity with responses to gefitinib and erlotinib in NSCLC patients and found that most are resistant to EGFR TKIs The crystal structure of a representative TKI insensitive mutant D770 N771insNPG reveals an unaltered adenosine triphosphate binding pocket and the inserted residues form a wedge at the end of the C helix that promotes the active kinase conformation Unlike EGFR L858R D770 N771insNPG activates

    Original URL path: http://stm.sciencemag.org/highwire/citation/187071/medlars (2016-02-10)
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  • A1 Costa Daniel B T1 Structural Biochemical and Clinical Characterization of Epidermal Growth Factor Receptor EGFR Exon 20 Insertion Mutations in Lung Cancer JF Science Translational Medicine YR 2013 FD American Association for the Advancement of Science VO 5 IS 216 SP 216ra177 OP 216ra177 DO 10 1126 scitranslmed 3007205 UL http stm sciencemag org content 5 216 216ra177 abstract AB Epidermal growth factor receptor EGFR gene mutations G719X exon 19 deletions insertions L858R and L861Q predict favorable responses to EGFR tyrosine kinase inhibitors TKIs in advanced non small cell lung cancer NSCLC However EGFR exon 20 insertion mutations 10 of all EGFR mutations are generally associated with insensitivity to available TKIs gefitinib erlotinib and afatinib The basis of this primary resistance is poorly understood We studied a broad subset of exon 20 insertion mutations comparing in vitro TKI sensitivity with responses to gefitinib and erlotinib in NSCLC patients and found that most are resistant to EGFR TKIs The crystal structure of a representative TKI insensitive mutant D770 N771insNPG reveals an unaltered adenosine triphosphate binding pocket and the inserted residues form a wedge at the end of the C helix that promotes the active kinase conformation Unlike EGFR L858R D770

    Original URL path: http://stm.sciencemag.org/highwire/citation/187071/refworks (2016-02-10)
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  • A Genomics-Based Classification of Human Lung Tumors | Science Translational Medicine
    Pathology University Hospital of Bonn 53127 Bonn Germany 15 Institute of Pathology Jena University Hospital Friedrich Schiller University 07743 Jena Germany 16 Technical University Dortmund Department of Chemical Biology 44227 Dortmund Germany 17 Institute of Pathology University of Heidelberg 69120 Heidelberg Germany 18 Department of Thoracic Surgery Thoraxklinik am Universitätsklinikum Heidelberg 69126 Heidelberg Germany 19 Institute for Pathology Bad Berka 99438 Bad Berka Germany 20 Department for Internal Medicine II Jena University Hospital Friedrich Schiller University 07740 Jena Germany 21 Center for Medical Genetics Ghent University 9000 Ghent Belgium 22 Department of Pulmonary Diseases University of Groningen University Medical Centre Groningen 9713 GZ Groningen the Netherlands 23 Department Pathology and Medical Biology University of Groningen University Medical Center Groningen 9713 GZ Groningen the Netherlands 24 Department of Pathology VU University Medical Center Amsterdam 1007 MB Amsterdam the Netherlands 25 Department of Pulmonary Diseases VU University Medical Center Amsterdam 1007 MB Amsterdam the Netherlands 26 Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 10065 USA 27 Department of Medical Oncology Ospedale Civile 57100 Livorno Italy 28 Department of Experimental Diagnostic and Specialty Medicine University of Bologna 40138 Bologna Italy 29 Roy Castle Lung Cancer Research Programme The University of Liverpool Cancer Research Centre University of Liverpool Cancer Research Centre Department of Molecular and Clinical Cancer Medicine Institute of Translational Medicine The University of Liverpool Liverpool L3 9TA UK 30 Department of Thoracic Surgery Rikshospitalet Oslo University Hospital N 0027 Oslo Norway 31 Institute of Clinical Medicine Faculty of Medicine University of Oslo N 0424 Oslo Norway 32 Department of Oncology Norwegian Radium Hospital Oslo University Hospital N 0310 Oslo Norway 33 Institute for Surgical Pathology University Hospital Zurich 8091 Zurich Switzerland 34 Phase I Unit Department of Medicine Institute Gustave Roussy 94800 Villejuif France 35 France Service d Anatomie Pathologie Institut Mutualiste Montsouris 75014 Paris France 36 Department Cancer Medicine Institute Gustave Roussy 94800 Villejuif France 37 Pole de Cancérologie et Médecine Aigue Communautaire CHU Grenoble CS 10217 38043 Grenoble France and INSERM U823 Grenoble France 38 Vanderbilt Ingram Cancer Center Nashville TN USA 39 Department of Genome Sciences University of Washington Seattle WA 98195 5065 USA 40 Klinik für Internistische Onkologie Evangelische Kliniken Bonn 53113 Bonn Germany 41 Klinik für Thoraxchirurgie Malteser Krankenhaus 53123 Bonn Germany 42 The Broad Institute of Harvard and MIT Cambridge MA 02142 USA 43 Department of Genetics Stanford University Stanford CA USA 44 Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre Melbourne 3002 Victoria Australia 45 The University of Melbourne Department of Surgery St Vincent s Hospital Melbourne 3065 Victoria Australia 46 Department of Pathology St Vincent s Hospital Melbourne 3065 Victoria Australia 47 Laboratory of Oncology Istituto di Ricovero e Cura a Carattere Scientifico Casa Sollievo della Sofferenza San Giovanni Rotondo Italy 48 Translational Lung Research Center Heidelberg Member of the German Center for Lung Research Heidelberg Germany 49 Department of Informatics University of Cologne 50931 Cologne Germany 50 Computing Center University of Cologne 50931 Cologne Germany 51 Lineberger

    Original URL path: http://stm.sciencemag.org/content/5/209/209ra153 (2016-02-10)
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