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  • Table of Contents — July 15, 2015, 7 (296) | Science Translational Medicine
    Kenneth S Shindler Kathleen A Marshall Puya Aravand Arastoo Vossough James C Gee Albert M Maguire Chris I Baker Jean Bennett Science Translational Medicine 15 Jul 2015 296ra110 Imaging reveals increased structural and functional plasticity in human visual pathways after retinal gene therapy Editor s Summary Abstract Full Text PDF A long duration dihydroorotate dehydrogenase inhibitor DSM265 for prevention and treatment of malaria By Margaret A Phillips Julie Lotharius Kennan Marsh John White Anthony Dayan Karen L White Jacqueline W Njoroge Farah El Mazouni Yanbin Lao Sreekanth Kokkonda Diana R Tomchick Xiaoyi Deng Trevor Laird Sangeeta N Bhatia Sandra March Caroline L Ng David A Fidock Sergio Wittlin Maria Lafuente Monasterio Francisco Javier Gamo Benito Laura Maria Sanz Alonso Maria Santos Martinez Maria Belen Jimenez Diaz Santiago Ferrer Bazaga Iñigo Angulo Barturen John N Haselden James Louttit Yi Cui Arun Sridhar Anna Marie Zeeman Clemens Kocken Robert Sauerwein Koen Dechering Vicky M Avery Sandra Duffy Michael Delves Robert Sinden Andrea Ruecker Kristina S Wickham Rosemary Rochford Janet Gahagen Lalitha Iyer Ed Riccio Jon Mirsalis Ian Bathhurst Thomas Rueckle Xavier Ding Brice Campo Didier Leroy M John Rogers Pradipsinh K Rathod Jeremy N Burrows Susan A Charman Science Translational Medicine 15 Jul 2015 296ra111 The antimalarial drug DSM265 displays activity against blood and liver stages of Plasmodium falciparum and has a long predicted half life in humans Editor s Summary Abstract Full Text PDF HLA class II genes modulate vaccine induced antibody responses to affect HIV 1 acquisition By Heather A Prentice Georgia D Tomaras Daniel E Geraghty Richard Apps Youyi Fong Philip K Ehrenberg Morgane Rolland Gustavo H Kijak Shelly J Krebs Wyatt Nelson Allan DeCamp Xiaoying Shen Nicole L Yates Susan Zolla Pazner Sorachai Nitayaphan Supachai Rerks Ngarm Jaranit Kaewkungwal Punnee Pitisuttithum Guido Ferrari M Juliana McElrath David C Montefiori Robert T Bailer Richard A Koup Robert J O Connell Merlin L Robb Nelson L Michael Peter B Gilbert Jerome H Kim Rasmi Thomas Science Translational Medicine 15 Jul 2015 296ra112 HLA class II modulated the quantity quality and efficacy of antibody responses in the RV144 HIV vaccine trial Editor s Summary Abstract Full Text PDF Editors Choice Detecting mutant huntingtin protein in HD patients By Kristen Brennand Science Translational Medicine 15 Jul 2015 296ec118 Mutant huntingtin protein in the cerebrospinal fluid of patients with Huntington s disease can seed prion like protein propagation Full Text Clone wars By Grzegorz Nalepa Science Translational Medicine 15 Jul 2015 296ec119 Dynamic expansion of genetically unstable cells drives disease outcome in aplastic anemia Full Text AIRE ing out the gut By Giovanni Traverso Science Translational Medicine 15 Jul 2015 296ec120 Loss of AIRE mediated immune tolerance leads to paneth cell disruption in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy Full Text Two pronged approach to prevent pneumonia By Taia T Wang Science Translational Medicine 15 Jul 2015 296ec121 A bivalent vaccine protects against influenza virus and the bacterium Streptococcus pneumonia Full Text More From Science Translational Medicine Current Table of Contents Archive In the

    Original URL path: http://stm.sciencemag.org/content/7/296.toc (2016-02-10)
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  • 2015 Aug 15 TA Science Translational Medicine PG 296fs29 296fs29 VI 7 IP 296 4099 http stm sciencemag org content 7 296 296fs29 short 4100 http stm sciencemag org content 7 296 296fs29 full AB Single cell sequencing methods are

    Original URL path: http://stm.sciencemag.org/highwire/citation/197745/medlars (2016-02-10)
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  • Science Translational Medicine YR 2015 FD American Association for the Advancement of Science VO 7 IS 296 SP 296fs29 OP 296fs29 DO 10 1126 scitranslmed aac8319 UL http stm sciencemag org content 7 296 296fs29 abstract AB Single cell sequencing

    Original URL path: http://stm.sciencemag.org/highwire/citation/197745/refworks (2016-02-10)
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  • Hematopoietic Stem Cell Origin of BRAFV600E Mutations in Hairy Cell Leukemia | Science Translational Medicine
    Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kety Huberman Center for Molecular Oncology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Nancy Bouvier Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Oncology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael F Berger Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Oncology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ari M Melnick Division of Hematology Oncology Department of Medicine Weill Cornell Medical College New York NY 10021 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Neal Rosen Molecular Pharmacology and Chemistry Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Martin S Tallman Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christopher Y Park Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Laboratory Medicine Memorial Sloan Kettering Cancer Center New York NY 10065 USA Cell and Developmental Biology Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Omar Abdel Wahab Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Leukemia Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Hairy cell leukemia HCL is a chronic lymphoproliferative disorder characterized by somatic BRAF

    Original URL path: http://stm.sciencemag.org/content/6/238/238ra71 (2016-02-10)
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  • Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia | Science Translational Medicine
    Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract Clonal evolution in cancer the selection for and emergence of increasingly malignant clones during progression and therapy resulting in cancer metastasis and relapse has been highlighted as an important phenomenon in the biology of leukemia and other cancers Tracking mutant alleles to determine clonality from diagnosis to relapse or from primary site to metastases in a sensitive and quantitative manner is most often performed using next generation sequencing Such methods determine clonal frequencies by extrapolation of allele frequencies in sequencing data of DNA from the metagenome of bulk tumor samples using a set of assumptions The computational framework that is usually used assumes specific patterns in the order of acquisition of unique mutational events and heterozygosity of mutations in single cells However these assumptions are not accurate for all mutant loci in acute myeloid leukemia AML samples To assess whether current models of clonal diversity within individual AML samples are appropriate for common mutations we developed protocols to directly genotype AML single cells Single cell analysis demonstrates that mutations of F LT3 and NPM1 occur in both homozygous and heterozygous states distributed among at least nine distinct clonal populations in all samples analyzed There appears to be convergent evolution and differential evolutionary trajectories for cells containing mutations at different loci This work suggests an underlying tumor heterogeneity beyond what is currently understood in AML which may be important in the development of therapeutic approaches to eliminate leukemic cell burden and control clonal evolution induced relapse Copyright 2015 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 7 Issue 281 01 April 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Single cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username

    Original URL path: http://stm.sciencemag.org/content/7/281/281re2 (2016-02-10)
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  • Adoptive cellular therapy: A race to the finish line | Science Translational Medicine
    Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 7 Issue 280 25 March 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adoptive cellular therapy A race to the finish line Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adoptive cellular therapy A race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Citation Manager Formats BibTeX Bookends

    Original URL path: http://stm.sciencemag.org/content/7/280/280ps7.figures-only (2016-02-10)
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  • Adoptive cellular therapy: A race to the finish line | Science Translational Medicine
    of Immunology Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam Netherlands Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Article Information vol 7 no 280 280ps7 DOI http dx doi org 10 1126 scitranslmed aaa3643 PubMed 25810311 Published By American Association for the Advancement of Science Print ISSN 1946 6234 Online ISSN 1946 6242 History Copyright Usage Copyright 2015 American Association for the Advancement of Science Author Information Carl H June 1 Stanley R Riddell 2 and Ton N Schumacher 3 1 Center for Cellular Immunotherapies and the Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 5156 USA 2 Fred Hutchinson Cancer Research Center University of Washington Seattle WA 98109 USA 3 Division of Immunology Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam Netherlands Corresponding author E mail cjune at exchange upenn edu C H J sriddell at fredhutch org S R R t schumacher at nki nl T N S AltMetrics No Altmetric data available for this article Article usage Abstract Full PDF Mar 2015 7248 773 1016 Apr 2015 3905 417 662 May 2015 1276 169 271 Jun 2015 834 125 194 Jul 2015 579 117 142 Aug 2015 500 118 140 Sep 2015 599 89 164 Oct 2015 463 71 111 Nov 2015 452 81 131 Dec 2015 434 60 127 Jan 2016 430 61 119 Feb 2016 138 16 21 View Full Text Science Translational Medicine Vol 7 Issue 280 25 March 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adoptive cellular therapy A race to the finish line Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adoptive cellular therapy A race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero

    Original URL path: http://stm.sciencemag.org/content/7/280/280ps7.article-info (2016-02-10)
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  • Adoptive cellular therapy: A race to the finish line | Science Translational Medicine
    PubMed Search for this author on this site Ton N Schumacher Division of Immunology Netherlands Cancer Institute Plesmanlaan 121 1066 CX Amsterdam Netherlands Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs break automatically Upload Tables and Figures Attach tables e g doc and figures jpg gif tif by choosing the desired file and then uploading them below Add a new file Upload Files must be less than 100 MB Allowed file types doc jpg jpeg gif tif pdf File names can only contain the following characters A Z a z 0 9 Author Information Contributors First name and middle name First or given name e g Peter Last Name Your last or family name e g MacMoody Email Your email address e g higgs boson gmail com Role Occupation Your role and or occupation e g Orthopedic Surgeon Affiliation Your organization or institution if applicable e g Royal Free Hospital Add another contributor optional Statement of Competing Interests Competing interests Yes No Please describe the competing interests Highwire Comment Subject Apath Vertical Tabs Submit No eLetters have been published for this article View Full Text Science Translational Medicine Vol 7 Issue 280 25 March 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adoptive cellular therapy A race to the finish line Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adoptive cellular therapy A race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Adoptive cellular therapy A race to the finish line By Carl H

    Original URL path: http://stm.sciencemag.org/content/7/280/280ps7.e-letters (2016-02-10)
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