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  • Adoptive cellular therapy: A race to the finish line | Science Translational Medicine
    PDF Log in to view full text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Science Translational Medicine Vol 7 Issue 280 25 March 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Adoptive cellular therapy A race to the finish line Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Adoptive cellular therapy A race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Adoptive cellular therapy A race

    Original URL path: http://stm.sciencemag.org/content/7/280/280ps7.full (2016-02-10)
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  • Table of Contents — March 25, 2015, 7 (280) | Science Translational Medicine
    race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Abstract Full Text PDF State of the Art Review On being less tolerant Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation By Alexander M Lesokhin Margaret K Callahan Michael A Postow Jedd D Wolchok Science Translational Medicine 25 Mar 2015 280sr1 This Review presents the state of research and future outlook on cancer immunotherapy approaches such as immune checkpoint inhibitors Abstract Full Text PDF Review Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation By Cameron McDonald Hyman Laurence A Turka Bruce R Blazar Science Translational Medicine 25 Mar 2015 280rv2 This Review discusses new therapies that may help to prevent or treat graft versus host disease and solid organ transplant rejection Abstract Full Text PDF Editors Choice Personalized cancer medicines By Anshu Bhardwaj Science Translational Medicine 25 Mar 2015 280ec48 An in silico prescription strategy targets genes driving tumorigenesis Full Text Good in good out Diet modification in chronic kidney disease By Vipul Chitalia Science Translational Medicine 25 Mar 2015 280ec49 Low protein diet with or without ketoacids retards renal failure progression without increasing mortality Full Text HIF 1α at the center of the sepsis Yin and Yang By Charles S Dela Cruz Science Translational Medicine 25 Mar 2015 280ec50 Human monocytes up regulate hypoxia inducible factor 1α and acquire an immunosuppressive phenotype in sepsis Full Text Preventing an unholy alliance By Erik S Musiek Science Translational Medicine 25 Mar 2015 280ec51 A repurposed cancer drug blocks a critical interaction between amyloid β and tau preventing neuronal damage in mouse models of

    Original URL path: http://stm.sciencemag.org/content/7/280 (2016-02-10)
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  • Table of Contents — March 25, 2015, 7 (280) | Science Translational Medicine
    A race to the finish line By Carl H June Stanley R Riddell Ton N Schumacher Science Translational Medicine 25 Mar 2015 280ps7 Engineered T cells are under development in academic industry partnerships accelerating the pace toward widespread availability Abstract Full Text PDF State of the Art Review On being less tolerant Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation By Alexander M Lesokhin Margaret K Callahan Michael A Postow Jedd D Wolchok Science Translational Medicine 25 Mar 2015 280sr1 This Review presents the state of research and future outlook on cancer immunotherapy approaches such as immune checkpoint inhibitors Abstract Full Text PDF Review Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation By Cameron McDonald Hyman Laurence A Turka Bruce R Blazar Science Translational Medicine 25 Mar 2015 280rv2 This Review discusses new therapies that may help to prevent or treat graft versus host disease and solid organ transplant rejection Abstract Full Text PDF Editors Choice Personalized cancer medicines By Anshu Bhardwaj Science Translational Medicine 25 Mar 2015 280ec48 An in silico prescription strategy targets genes driving tumorigenesis Full Text Good in good out Diet modification in chronic kidney disease By Vipul Chitalia Science Translational Medicine 25 Mar 2015 280ec49 Low protein diet with or without ketoacids retards renal failure progression without increasing mortality Full Text HIF 1α at the center of the sepsis Yin and Yang By Charles S Dela Cruz Science Translational Medicine 25 Mar 2015 280ec50 Human monocytes up regulate hypoxia inducible factor 1α and acquire an immunosuppressive phenotype in sepsis Full Text Preventing an unholy alliance By Erik S Musiek Science Translational Medicine 25 Mar 2015 280ec51 A repurposed cancer drug blocks a critical interaction between amyloid β and tau preventing neuronal damage in mouse models

    Original URL path: http://stm.sciencemag.org/content/7/280.toc (2016-02-10)
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  • short 4100 http stm sciencemag org content 7 280 280ps7 full AB Adoptive T cell transfer for cancer chronic infection and autoimmunity is an emerging field that shows promise in recent trials Using the principles of synthetic biology advances in cell culture and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities compared with the natural immune system The prospects for

    Original URL path: http://stm.sciencemag.org/highwire/citation/196152/medlars (2016-02-10)
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  • 1126 scitranslmed aaa3643 UL http stm sciencemag org content 7 280 280ps7 abstract AB Adoptive T cell transfer for cancer chronic infection and autoimmunity is an emerging field that shows promise in recent trials Using the principles of synthetic biology advances in cell culture and genetic engineering have made it possible to generate human T cells that display desired specificities and enhanced functionalities compared with the natural immune system The

    Original URL path: http://stm.sciencemag.org/highwire/citation/196152/refworks (2016-02-10)
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  • Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory | Science Translational Medicine
    Immunotherapies Unit Division of Immunology Transplantation and Infectious Diseases PIBIC San Raffaele Scientific Institute Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Antonio Lambiase MolMed S p A Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Catia Traversari MolMed S p A Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Luca Vago Hematology and Bone Marrow Transplantation Unit San Raffaele Scientific Institute Milan 20132 Italy Unit of Immunogenetics Leukemia Genomics and Immunobiology Division of Regenerative Medicine Stem Cells and Gene Therapy San Raffaele Scientific Institute Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christof von Kalle Department of Translational Oncology National Center for Tumor Diseases and German Cancer Research Center Heidelberg 69120 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Manfred Schmidt Department of Translational Oncology National Center for Tumor Diseases and German Cancer Research Center Heidelberg 69120 Germany Find this author on Google Scholar Find this author on PubMed Search for this author on this site Claudio Bordignon Vita Salute San Raffaele University Milan 20132 Italy MolMed S p A Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Fabio Ciceri Vita Salute San Raffaele University Milan 20132 Italy Hematology and Bone Marrow Transplantation Unit San Raffaele Scientific Institute Milan 20132 Italy Unit of Immunogenetics Leukemia Genomics and Immunobiology Division of Regenerative Medicine Stem Cells and Gene Therapy San Raffaele Scientific Institute Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Chiara Bonini Experimental Hematology Unit Division of Immunology Transplantation and Infectious Diseases Program in Immunology and Bio Immunotherapy of Cancer PIBIC San Raffaele Scientific Institute Milan 20132 Italy Vita Salute San Raffaele University Milan 20132 Italy Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians This article has a correction Please see Is corrected by December 23 2015 Committing T cells to memory Adoptive cell transfer is an increasingly successful therapy for a variety of diseases however little is known about what regulates the survival of these cells in humans Now Oliveira et al leverage patients who have received genetically modified hematopoietic stem cells to track T cells over time They found labeled effector memory central memory

    Original URL path: http://stm.sciencemag.org/content/7/317/317ra198 (2016-02-10)
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  • Prescription for a pharmacyte | Science Translational Medicine
    eLetters PDF You are currently viewing the abstract View Full Text Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Join Subscribe Purchase Article Activate Member Account Renew Subscription Recommend a subscription to your library Help for librarians Abstract The efficient homing capacity of T cells may be used to deliver cell associated drug laden nanoparticles to lymphoma cells that are resident in lymph nodes increasing drug efficacy compared with drug encapsulated in free nanoparticles or free drug Huang et al this issue Copyright 2015 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 7 Issue 291 10 June 2015 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Prescription for a pharmacyte Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Prescription for a pharmacyte By Jeffrey A Hubbell Science Translational Medicine 10

    Original URL path: http://stm.sciencemag.org/content/7/291/291fs23 (2016-02-10)
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  • Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma | Science Translational Medicine
    site Gary L Rosner Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Caroline Epstein Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Lakshmi Rudraraju Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Richard F Ambinder Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Richard J Jones Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Drew Pardoll Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ivan Borrello Johns Hopkins University School of Medicine 1650 Orleans Street CRB1 Room 453 Baltimore MD 21231 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Successful adoptive T cell therapy ACT requires the ability to activate tumor specific T cells with the ability to traffic to the tumor site and effectively kill their target as well as persist over time We hypothesized that ACT using marrow infiltrating lymphocytes MILs in multiple myeloma MM could impart greater antitumor immunity in that they were obtained from the tumor microenvironment We describe the results from the first clinical trial using MILs in MM Twenty five patients with either newly diagnosed or relapsed disease had their MILs harvested activated and expanded and subsequently infused on the third day after myeloablative therapy Cells were obtained and adequately expanded in all patients with anti CD3 CD28 beads plus interleukin 2 and a median of 9 5 10 8 MILs were infused Factors indicative of response to MIL ACT included i the presence of measurable myeloma specific activity of the ex vivo expanded product ii low endogenous bone marrow T cell interferon γ production at baseline iii a CD8 central memory phenotype at baseline and iv the generation and

    Original URL path: http://stm.sciencemag.org/content/7/288/288ra78 (2016-02-10)
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