archive-org.com » ORG » S » SCIENCEMAG.ORG

Total: 698

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • Functional Genomics for Personalized Cancer Therapy | Science Translational Medicine
    reveals clinically actionable genetic events that impact the effectiveness of cancer treatment regimens and the outcomes of cancer patients Copyright 2014 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 6 Issue 243 02 July 2014 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Functional Genomics for Personalized Cancer Therapy Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Download Powerpoint Print Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Functional Genomics for Personalized Cancer Therapy By Jeffrey W Tyner Science Translational Medicine 02 Jul 2014 243fs26 Integration of functional and genomic screening in cancer reveals clinically actionable genetic events Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Functional Genomics for Personalized Cancer Therapy By Jeffrey W Tyner Science Translational Medicine 02 Jul 2014 243fs26 Integration of functional and genomic screening in cancer reveals clinically actionable genetic events Permalink Copy Related Content Focus

    Original URL path: http://stm.sciencemag.org/content/6/243/243fs26 (2016-02-10)
    Open archived version from archive


  • Tumor clone dynamics in lethal prostate cancer | Science Translational Medicine
    PubMed Search for this author on this site Nina Tunariu The Institute of Cancer Research London SM2 5NG UK Royal Marsden National Health Service Foundation Trust London SM2 5PT UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Johann S de Bono The Institute of Cancer Research London SM2 5NG UK Royal Marsden National Health Service Foundation Trust London SM2 5PT UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Francesca Demichelis Centre for Integrative Biology University of Trento Trento 38123 Italy Institute for Computational Biomedicine Weill Cornell Medical College New York NY 10021 USA Institute for Precision Medicine Weill Cornell Medical College New York NY 10021 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gerhardt Attard The Institute of Cancer Research London SM2 5NG UK Royal Marsden National Health Service Foundation Trust London SM2 5PT UK Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract It is unclear whether a single clone metastasizes and remains dominant over the course of lethal prostate cancer We describe the clonal architectural heterogeneity at different stages of disease progression by sequencing serial plasma and tumor samples from 16 ERG positive patients By characterizing the clonality of commonly occurring deletions at 21q22 8p21 and 10q23 we identified multiple independent clones in metastatic disease that are differentially represented in tissue and circulation To exemplify the clinical utility of our studies we then showed a temporal association between clinical progression and emergence of androgen receptor AR mutations activated by glucocorticoids in about 20 of patients progressing on abiraterone and prednisolone or dexamethasone Resistant clones showed a complex dynamic with temporal and spatial heterogeneity suggesting distinct mechanisms of resistance at different sites that emerged and regressed depending on treatment selection pressure This introduces a management paradigm requiring sequential monitoring of advanced prostate cancer patients with plasma and tumor biopsies to ensure early discontinuation of agents when they become potential disease drivers Copyright 2014 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 6 Issue 254 17 September 2014 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email

    Original URL path: http://stm.sciencemag.org/content/6/254/254ra125 (2016-02-10)
    Open archived version from archive

  • Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging | Science Translational Medicine
    author on PubMed Search for this author on this site Rachael O Connor Department of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth L Pitter Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Stephen A Sastra Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael Saborowski Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eric C Holland Human Biology Division and Solid Tumor Translational Research Fred Hutchinson Cancer Research Center Alvord Brain Tumor Center University of Washington Seattle WA 98109 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Samuel Singer Department of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Olive Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Scott W Lowe Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Howard Hughes Medical Institute New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ronald G Blasberg Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Neurology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz F Kircher Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Radiology Weill Cornell Medical College New

    Original URL path: http://stm.sciencemag.org/content/7/271/271ra7.figures-only (2016-02-10)
    Open archived version from archive

  • Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging | Science Translational Medicine
    of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Olive Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Scott W Lowe Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Howard Hughes Medical Institute New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ronald G Blasberg Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Neurology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz F Kircher Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Radiology Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Article Information vol 7 no 271 271ra7 DOI http dx doi org 10 1126 scitranslmed 3010633 PubMed 25609167 Published By American Association for the Advancement of Science Print ISSN 1946 6234 Online ISSN 1946 6242 History Received for publication 27 March 2014 Accepted for publication 12 December 2014 Copyright Usage Copyright 2015 American Association for the Advancement of Science Author Information Stefan Harmsen 1 Ruimin Huang 1 2 Matthew A Wall 1 3 Hazem Karabeber 1 Jason M Samii 1 Massimiliano Spaliviero 4 Julie R White 5 6 Sébastien Monette 5 6 Rachael O Connor 7 Kenneth L Pitter 6 Stephen A Sastra 8 9 Michael Saborowski 6 Eric C Holland 10 Samuel Singer 7 Kenneth P Olive 8 9 Scott W Lowe 6 11 Ronald G Blasberg 1 2 12 13 14 and Moritz F Kircher 1 2 12 15 1 Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA 2 Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA 3 Department of Chemistry Hunter College City University of New York New York NY 10065 USA 4 Urology Service Department of Surgery Sidney

    Original URL path: http://stm.sciencemag.org/content/7/271/271ra7.article-info (2016-02-10)
    Open archived version from archive

  • Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging | Science Translational Medicine
    Google Scholar Find this author on PubMed Search for this author on this site Stephen A Sastra Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael Saborowski Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eric C Holland Human Biology Division and Solid Tumor Translational Research Fred Hutchinson Cancer Research Center Alvord Brain Tumor Center University of Washington Seattle WA 98109 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Samuel Singer Department of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Olive Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Scott W Lowe Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Howard Hughes Medical Institute New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ronald G Blasberg Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Neurology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz F Kircher Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Radiology Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF Submit a Response to This Article Compose eLetter Title Contents More information about text formats Plain text Plain text No HTML tags allowed Web page addresses and e mail addresses turn into links automatically Lines and paragraphs

    Original URL path: http://stm.sciencemag.org/content/7/271/271ra7.e-letters (2016-02-10)
    Open archived version from archive

  • Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging | Science Translational Medicine
    Rachael O Connor Department of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth L Pitter Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Stephen A Sastra Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Michael Saborowski Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Eric C Holland Human Biology Division and Solid Tumor Translational Research Fred Hutchinson Cancer Research Center Alvord Brain Tumor Center University of Washington Seattle WA 98109 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Samuel Singer Department of Surgery Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kenneth P Olive Department of Medicine Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Department of Pathology and Cell Biology Herbert Irving Comprehensive Cancer Center Columbia University Medical Center New York NY 10032 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Scott W Lowe Cancer Biology and Genetics Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Howard Hughes Medical Institute New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ronald G Blasberg Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Neurology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Molecular Pharmacology and Chemistry Program Memorial Sloan Kettering Cancer Center New York NY 10065 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz F Kircher Department of Radiology Memorial Sloan Kettering Cancer Center New York NY 10065 USA Brain Tumor Center Memorial Sloan Kettering Cancer Center New York NY 10065 USA Center for Molecular Imaging and Nanotechnology CMINT Memorial Sloan Kettering Cancer Center New York NY 10065 USA Department of Radiology Weill Cornell Medical College New York NY 10065 USA Find this author on Google Scholar

    Original URL path: http://stm.sciencemag.org/content/7/271/271ra7.full (2016-02-10)
    Open archived version from archive

  • Table of Contents — January 21, 2015, 7 (271) | Science Translational Medicine
    and cancerous lesions in vivo Editor s Summary Abstract Full Text PDF Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism By Olga Peñagarikano María T Lázaro Xiao Hong Lu Aaron Gordon Hongmei Dong Hoa A Lam Elior Peles Nigel T Maidment Niall P Murphy X William Yang Peyman Golshani Daniel H Geschwind Science Translational Medicine 21 Jan 2015 271ra8 Mice carrying a genetic mutation that causes autistic symptoms show improved sociability after being treated with oxytocin a hormone promoting mothering and trust Editor s Summary Abstract Full Text PDF Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis By Yuechao Zhao Ping Gong Yiru Chen Jerome C Nwachukwu Sathish Srinivasan CheMyong Ko Milan K Bagchi Robert N Taylor Kenneth S Korach Kendall W Nettles John A Katzenellenbogen Benita S Katzenellenbogen Science Translational Medicine 21 Jan 2015 271ra9 The estrogen dependent inflammatory and neuroangiogenic activities that drive endometriosis can be suppressed by estrogen receptor ligands in mice Editor s Summary Abstract Full Text PDF Editors Choice Micro exon management By Anne Schaefer Science Translational Medicine 21 Jan 2015 271ec10 Alternative splicing of small DNA fragments contributes to neuronal development and may be linked to certain neurodevelopmental disorders Full Text Control under pressure By Kara L Spiller Science Translational Medicine 21 Jan 2015 271ec11 A new transdermal drug delivery system treats and prevents diabetic pressure ulcers Full Text Breathing fresh Rare stems cells repair injured lung By Jie Sun Science Translational Medicine 21 Jan 2015 271ec12 Lung lineage negative epithelial progenitor cells mediate tissue regeneration following major injury Full Text Stem cell transplants may HALT multiple sclerosis By Paul J Tesar Science Translational Medicine 21 Jan 2015 271ec13 High dose immunosuppressive therapy combined with autologous hematopoietic cell transplantation results in 3 year sustained remission

    Original URL path: http://stm.sciencemag.org/content/7/271 (2016-02-10)
    Open archived version from archive

  • Table of Contents — January 21, 2015, 7 (271) | Science Translational Medicine
    premalignant and cancerous lesions in vivo Editor s Summary Abstract Full Text PDF Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism By Olga Peñagarikano María T Lázaro Xiao Hong Lu Aaron Gordon Hongmei Dong Hoa A Lam Elior Peles Nigel T Maidment Niall P Murphy X William Yang Peyman Golshani Daniel H Geschwind Science Translational Medicine 21 Jan 2015 271ra8 Mice carrying a genetic mutation that causes autistic symptoms show improved sociability after being treated with oxytocin a hormone promoting mothering and trust Editor s Summary Abstract Full Text PDF Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis By Yuechao Zhao Ping Gong Yiru Chen Jerome C Nwachukwu Sathish Srinivasan CheMyong Ko Milan K Bagchi Robert N Taylor Kenneth S Korach Kendall W Nettles John A Katzenellenbogen Benita S Katzenellenbogen Science Translational Medicine 21 Jan 2015 271ra9 The estrogen dependent inflammatory and neuroangiogenic activities that drive endometriosis can be suppressed by estrogen receptor ligands in mice Editor s Summary Abstract Full Text PDF Editors Choice Micro exon management By Anne Schaefer Science Translational Medicine 21 Jan 2015 271ec10 Alternative splicing of small DNA fragments contributes to neuronal development and may be linked to certain neurodevelopmental disorders Full Text Control under pressure By Kara L Spiller Science Translational Medicine 21 Jan 2015 271ec11 A new transdermal drug delivery system treats and prevents diabetic pressure ulcers Full Text Breathing fresh Rare stems cells repair injured lung By Jie Sun Science Translational Medicine 21 Jan 2015 271ec12 Lung lineage negative epithelial progenitor cells mediate tissue regeneration following major injury Full Text Stem cell transplants may HALT multiple sclerosis By Paul J Tesar Science Translational Medicine 21 Jan 2015 271ec13 High dose immunosuppressive therapy combined with autologous hematopoietic cell transplantation results in 3 year sustained

    Original URL path: http://stm.sciencemag.org/content/7/271.toc (2016-02-10)
    Open archived version from archive



  •