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  • Progesterone/RANKL Is a Major Regulatory Axis in the Human Breast | Science Translational Medicine
    site Maryse Fiche Centre Hospitalier Universitaire Vaudois 1011 Lausanne Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site William Dougall Department of Hematology Oncology Research Amgen Inc Seattle WA 98119 USA Find this author on Google Scholar Find this author on PubMed Search for this author on this site Pascal Schneider Department of Biochemistry University of Lausanne 1066 Epalinges Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ozden Yalcin Ozuysal Department of Molecular Biology and Genetics Izmir Institute of Technology 35430 Urla Izmir Turkey Find this author on Google Scholar Find this author on PubMed Search for this author on this site Cathrin Brisken Swiss Institute for Experimental Cancer Research National Center of Competence in Research Molecular Oncology School of Life Sciences Ecole Polytechnique Fédérale de Lausanne CH 1015 Lausanne Switzerland Find this author on Google Scholar Find this author on PubMed Search for this author on this site Article Figures Data Info Metrics eLetters PDF You are currently viewing the abstract View Full Text As a service to the community AAAS Science has made this article free with registration Username Enter your Sciencemag org username Password Enter the password that accompanies your username Forgot your username or password Log in Register for Free Join Subscribe Recommend a subscription to your library Help for librarians Abstract Estrogens and progesterones are major drivers of breast development but also promote carcinogenesis in this organ Yet their respective roles and the mechanisms underlying their action in the human breast are unclear Receptor activator of nuclear factor κB ligand RANKL has been identified as a pivotal paracrine mediator of progesterone function in mouse mammary gland development and mammary carcinogenesis Whether the factor has the same role in humans is of clinical interest because an inhibitor for RANKL denosumab is already used for the treatment of bone disease and might benefit breast cancer patients We show that progesterone receptor PR signaling failed to induce RANKL in PR breast cancer cell lines and in dissociated cultured breast epithelial cells In clinical specimens from healthy donors and intact breast tissue microstructures hormone response was maintained and RANKL expression was under progesterone control which increased RNA stability RANKL was sufficient to trigger cell proliferation and was required for progesterone induced proliferation The findings were validated in vivo where RANKL protein expression in the breast epithelium correlated with serum progesterone levels and the protein was expressed in a subset of luminal cells that express PR Thus important hormonal control mechanisms are conserved across species making RANKL a potential target in breast cancer treatment and prevention Copyright 2013 American Association for the Advancement of Science View Full Text Science Translational Medicine Vol 5 Issue 182 24 April 2013 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you

    Original URL path: http://stm.sciencemag.org/content/5/182/182ra55 (2016-02-10)
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  • Table of Contents — October 07, 2009, 1 (1) | Science Translational Medicine
    the seven transmembrane parathyroid hormone receptor to trigger certain downstream effects but not others potentially avoiding undesirable side effects Editor s Summary Abstract Full Text PDF Droplet Scale Estrogen Assays in Breast Tissue Blood and Serum By Noha A Mousa Mais J Jebrail Hao Yang Mohamed Abdelgawad Pavel Metalnikov Jian Chen Aaron R Wheeler Robert F Casper Science Translational Medicine 07 Oct 2009 1ra2 A digital electrode array on which drops of solvent can be electronically manipulated allows automated steroid extraction from tiny tissue samples for diagnosis or research Editor s Summary Abstract Full Text PDF Expansion of Allospecific Regulatory T Cells After Anergized Mismatched Bone Marrow Transplantation By Jeffrey K Davies Lee M Nadler Eva C Guinan Science Translational Medicine 07 Oct 2009 1ra3 Transplantation of donor bone marrow cells treated to be tolerant to patient antigens results in expansion of regulatory T cells that suppress immune responses that mediate graft versus host disease Editor s Summary Abstract Full Text PDF Editor s Choice How Norepinephrine Neurons Contribute to Rett Syndrome Science Translational Medicine 07 Oct 2009 1ec1 Abnormally small hyperexitable neurons in mice with Rett syndrome have reduced amounts of neurotransmitter explaining some of the characteristics of the disorder Summary Full Text New Antibacterial Drug Destroys Dormant Bugs Science Translational Medicine 07 Oct 2009 1ec2 A new class of antibiotics selectively disrupts the bacterial proteosome and kills dormant bugs Summary Full Text Follicular Family Science Translational Medicine 07 Oct 2009 1ec3 Treatment with imatinib an effective anticancer agent protects oocytes from damage induced by the chemotherapy drug cisplatin Summary Full Text Probing Broccoli s Benefits for Prostate Cancer Science Translational Medicine 07 Oct 2009 1ec4 A compound in cruciferous vegetables destabilizes the androgen receptor suggesting new possibilities for interfering with prostate cancer Summary Full Text Podcast Science Translational

    Original URL path: http://stm.sciencemag.org/content/1/1 (2016-02-10)
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  • Table of Contents — October 14, 2009, 1 (2) | Science Translational Medicine
    Drouot Anne Sophie Hérard Denise M Day Emmanuel Brouillet Susan M Kingsman Philippe Hantraye Kyriacos A Mitrophanous Nicholas D Mazarakis Stéphane Palfi Science Translational Medicine 14 Oct 2009 2ra4 A gene therapy approach for the treatment of Parkinson s disease Editor s Summary Abstract Full Text PDF Extreme Polymorphism in a Vaccine Antigen and Risk of Clinical Malaria Implications for Vaccine Development By Shannon L Takala Drissa Coulibaly Mahamadou A Thera Adrian H Batchelor Michael P Cummings Ananias A Escalante Amed Ouattara Karim Traoré Amadou Niangaly Abdoulaye A Djimdé Ogobara K Doumbo Christopher V Plowe Science Translational Medicine 14 Oct 2009 2ra5 Children from Mali who are repeatedly infected with malaria are more likely to get sick if the parasite is highly variable a possible obstacle to an effective vaccine Editor s Summary Abstract Full Text PDF Arrhythmia in Heart and Brain KCNQ1 Mutations Link Epilepsy and Sudden Unexplained Death By A M Goldman E Glasscock J Yoo T T Chen T L Klassen J L Noebels Science Translational Medicine 14 Oct 2009 2ra6 Mice engineered to carry a human mutation that causes heart problems also have epilepsy suggesting a cause of SUDEP sudden unexplained death in epilepsy Editor s Summary Abstract Full Text PDF Editor s Choice Keys to Safer Transfusions Science Translational Medicine 14 Oct 2009 2ec5 Patients with activated immune systems may be prone to the acute lung injury sometimes seen after transfusions but platelet directed therapies may help Summary Full Text New Target for Anti Leukemia Attack Science Translational Medicine 14 Oct 2009 2ec6 Complementary proteomic and genetic experiments identify a possible therapeutic strategy for acute myeloid leukemia Summary Full Text Metabolic Barcode With or Without You Genome Science Translational Medicine 14 Oct 2009 2ec7 A new method based on a high throughput array reveals metabolites

    Original URL path: http://stm.sciencemag.org/content/1/2 (2016-02-10)
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  • Table of Contents — October 21, 2009, 1 (3) | Science Translational Medicine
    Growth by Blockade of CD47 Signaling By Justin B Maxhimer David R Soto Pantoja Lisa A Ridnour Hubert B Shih William G DeGraff Maria Tsokos David A Wink Jeff S Isenberg David D Roberts Science Translational Medicine 21 Oct 2009 3ra7 Inhibition of a membrane receptor protects normal tissue from radiation injury and simultaneously enhances the ability of ionizing radiation to delay tumor growth Editor s Summary Abstract Full Text PDF Slow Elimination of Multidrug Resistant Tuberculosis By Christopher Dye Brian G Williams Science Translational Medicine 21 Oct 2009 3ra8 The spread of drug resistant tuberculosis may be halted and reversed through appropriate use of drugs and diagnostics Editor s Summary Abstract Full Text PDF Editors Choice My Heart s All Aflutter Science Translational Medicine 21 Oct 2009 3ec9 Specialized cells in the heart similar to skin melanocytes may trigger the common heart arrhythmia atrial fibrillation Summary Full Text Fishermen and Farmers Share SNPs and Severe Fibrosis Science Translational Medicine 21 Oct 2009 3ec10 Single nucleotide polymorphisms found in ethnically and geographically diverse populations correlate with schistosomiasis associated severe liver fibrosis Summary Full Text Pleasure or Pain A Matter of Perception Science Translational Medicine 21 Oct 2009 3ec11 Scientists use imaging technology to pinpoint a specific region of the central nervous system involved in pain relief caused by placebos in humans Summary Full Text Rebuilding Broken Bones Science Translational Medicine 21 Oct 2009 3ec12 Geometrically complex bone structures can be engineered with human stem cells and a customized bone scaffold Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Illustration of Mycobacterium tuberculosis This

    Original URL path: http://stm.sciencemag.org/content/1/3 (2016-02-10)
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  • Table of Contents — October 28, 2009, 1 (4) | Science Translational Medicine
    Shin Hirayama Masaki Anraku Masaaki Sato Jeffrey Medin Beverly L Davidson Marc de Perrot Thomas K Waddell Arthur S Slutsky Shaf Keshavjee Science Translational Medicine 28 Oct 2009 4ra9 Treatment of damaged donor lungs with the cytokine interleukin 10 improves their function allowing previously unacceptable organs to be used for transplantation Editor s Summary Abstract Full Text PDF Lung Myeloid Dendritic Cells Coordinately Induce T H 1 and T H 17 Responses in Human Emphysema By Ming Shan Han Fang Cheng Li zhen Song Luz Roberts Linda Green Joan Hacken Bitar Joseph Huh Faisal Bakaeen Harvey O Coxson Claudine Storness Bliss Mahesh Ramchandani Seung Hyo Lee David B Corry Farrah Kheradmand Science Translational Medicine 28 Oct 2009 4ra10 Specialized immune cells in the lungs of patients with emphysema create an inflammatory environment that drives lung destruction in a characteristic autoimmune reaction Editor s Summary Abstract Full Text PDF Editors Choice Slowing Motor Neuron Degeneration Naturally Science Translational Medicine 28 Oct 2009 4ec13 A naturally occurring blood protein slows the progression of ALS in mice engineered to carry the human mutation in the enzyme SOD 1 Summary Full Text Exquisitely Sensitive Imaging Science Translational Medicine 28 Oct 2009 4ec14 Stimulated emission is used to achieve detection of light absorbing moieties in biologically important molecules with undetectable fluorescence such as hemoglobin Summary Full Text Escaping Detection Finally Caught Science Translational Medicine 28 Oct 2009 4ec15 A magnetic nanosensor yields quantitative sensitive and reproducible multiplex protein detection irrespective of sample composition Summary Full Text Enhancing Chloride Transport Science Translational Medicine 28 Oct 2009 4ec16 A drug that enhances CFTR ion channel activity improves chloride and water secretion from epithelial cells of cystic fibrosis patients Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational

    Original URL path: http://stm.sciencemag.org/content/1/4 (2016-02-10)
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  • Table of Contents — November 04, 2009, 1 (5) | Science Translational Medicine
    Hosoya Yoshikatsu Kanai Hiroshi Suzuki Nobuyuki Hamajima Nariyoshi Shinomiya Science Translational Medicine 04 Nov 2009 5ra11 Dysfunctional genotype combinations of polymorphic adenosine 5 triphosphate binding cassette transporter gene ABCG2 BCRP which encodes a high capacity urate secretion transporter in human gut and kidney are major causes of gout Editor s Summary Abstract Full Text PDF Tetracyclines That Promote SMN2 Exon 7 Splicing as Therapeutics for Spinal Muscular Atrophy By Michelle L Hastings Joel Berniac Ying Hsiu Liu Paul Abato Francine M Jodelka Lea Barthel Sujatha Kumar Caroline Dudley Mark Nelson Kelley Larson Jason Edmonds Todd Bowser Michael Draper Paul Higgins Adrian R Krainer Science Translational Medicine 04 Nov 2009 5ra12 Tetracycline derivatives increase exon 7 splicing during RNA processing of the spinal muscular atrophy modifying gene SMN2 which may prove therapeutically useful Editor s Summary Abstract Full Text PDF Serum Amyloid P Inhibits Fibrosis Through FcγR Dependent Monocyte Macrophage Regulation in Vivo By Ana P Castaño Shuei Liong Lin Teresa Surowy Brian T Nowlin Swathi A Turlapati Tejas Patel Ajay Singh Shawn Li Mark L Lupher Jr Jeremy S Duffield Science Translational Medicine 04 Nov 2009 5ra13 The fibrosis that occus in kidney after tissue injury can be inhibited by serum amyloid protein which stimulates the cytokine interleukin 10 Editor s Summary Abstract Full Text PDF Editors Choice Gaucher s and Parkinson s Disease Together at Last Science Translational Medicine 04 Nov 2009 5ec17 Sixteen centers from around the world joined forces in a study that unearthed two point mutations in the Gaucher related glucocerebrosidase gene that were strongly associated with Parkinson s disease Summary Full Text Cancer Transformers Science Translational Medicine 04 Nov 2009 5ec18 Environmental factors such as inflammation can trip an epigenetic switch that causes self propelling cancer progression without mutations in tumor suppressor genes or oncogenes

    Original URL path: http://stm.sciencemag.org/content/1/5 (2016-02-10)
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  • Table of Contents — November 11, 2009, 1 (6) | Science Translational Medicine
    Rey Rob Knight Jeffrey I Gordon Science Translational Medicine 11 Nov 2009 6ra14 A translational medicine pipeline is described where human gut microbial communities and diets are re created in gnotobiotic mice and the impact on microbe and host is defined using metagenomics Editor s Summary Abstract Full Text PDF Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates By Janaiah Kota Chalonda R Handy Amanda M Haidet Chrystal L Montgomery Amy Eagle Louise R Rodino Klapac Danielle Tucker Christopher J Shilling Walter R Therlfall Christopher M Walker Steven E Weisbrode Paul M L Janssen K Reed Clark Zarife Sahenk Jerry R Mendell Brian K Kaspar Science Translational Medicine 11 Nov 2009 6ra15 A vector delivered into muscles of monkeys generates a natural regulatory molecule which increases muscle size and strength and may be useful therapeutically Editor s Summary Abstract Full Text PDF Editors Choice Heart Valve Job By Katrina L Kelner Science Translational Medicine 11 Nov 2009 6ec20 Bovine pericardium impregnated with cell attracting proteins becomes engrafted with cells when used as replacement heart valves in sheep functioning well for at least 5 months Summary Full Text Targeting the Tumor Microenvironment By Kelly LaMarco Science Translational Medicine 11 Nov 2009 6ec21 A Stat3 stifling siRNA augmented with an oligonucleotide agonist of a Toll like receptor stimulates tumor destroying immune responses Summary Full Text Dangerous Liaison By Lily Khidr Science Translational Medicine 11 Nov 2009 6ec22 HIV 1 sticks to sperm and facilitates transmission of the virus to immune cells Summary Full Text Reducing the Effects of Diabetes By Heather B McDonald Science Translational Medicine 11 Nov 2009 6ec23 A transcription factor that responds to low oxygen improves blood vessel formation after ischemia Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the

    Original URL path: http://stm.sciencemag.org/content/1/6 (2016-02-10)
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  • Table of Contents — November 25, 2009, 1 (8) | Science Translational Medicine
    provides hope of sustained remission in Ménétrier s disease patients Abstract Full Text PDF Research Articles Efficacy of Cetuximab in the Treatment of Ménétrier s Disease By William H Fiske Jarred Tanksley Ki Taek Nam James R Goldenring Robbert J C Slebos Daniel C Liebler Amir M Abtahi Bonnie La Fleur Gregory D Ayers Christopher D Lind Mary K Washington Robert J Coffey Science Translational Medicine 25 Nov 2009 8ra18 An antibody to the epidermal growth factor receptor successfully treats nine patients with a disease in which the lining of the stomach abnormally proliferates Editor s Summary Abstract Full Text PDF In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice By Omar A Ali Dwaine Emerich Glenn Dranoff David J Mooney Science Translational Medicine 25 Nov 2009 8ra19 An implanted copolymer matrix that incorporates inflammatory cytokines an immune danger signal and tumor antigens elicits an immune response network that can eradicate established tumors in mice Editor s Summary Abstract Full Text PDF Editors Choice Too Much of a Good Thing By Lily Khidr Science Translational Medicine 25 Nov 2009 8ec28 Receptors gone wild may be linked to type 2 diabetes Summary Full Text Deep Sequencing By Lily Khidr Science Translational Medicine 25 Nov 2009 8ec29 Genes that cause rare disorders are uncovered by deep resequencing of protein coding regions Summary Full Text Catching Cancer Early By Heather B McDonald Science Translational Medicine 25 Nov 2009 8ec30 Islands of expanded clonal cells may be biomarkers of cancer progression in ulcerative colitis Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER

    Original URL path: http://stm.sciencemag.org/content/1/8 (2016-02-10)
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