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  • Table of Contents — December 02, 2009, 1 (9) | Science Translational Medicine
    industry and threatens to stall the engine that has yielded many valuable treatments Abstract Full Text PDF Research Article Identification of an Autoantigen Demonstrates a Link Between Interstitial Lung Disease and a Defect in Central Tolerance By Anthony K Shum Jason DeVoss Catherine L Tan Yafei Hou Kellsey Johannes Clodagh S O Gorman Kirk D Jones Etienne B Sochett Lawrence Fong Mark S Anderson Science Translational Medicine 02 Dec 2009 9ra20 A defect in immune tolerance to self antigens may underlie the lung damage that accompanies many autoimmune diseases Editor s Summary Abstract Full Text PDF Editors Choice How Some Monkeys Tolerate SIV By Katrina L Kelner Science Translational Medicine 02 Dec 2009 9ec31 Both susceptible and resistant monkey species respond immunologically to SIV infection but only resistant ones can dampen the response to avoid disease Summary Full Text Harbingers of Metabolic Havoc By Kelly LaMarco Science Translational Medicine 02 Dec 2009 9ec32 The exact combinations of symptoms displayed by patients may allow physicians to identify those destined to develop metabolic syndrome so that treatment can begin early Summary Full Text Seizing the Moment By Lily Khidr Science Translational Medicine 02 Dec 2009 9ec33 One source of absence epilepsy is an overactive inhibitory receptor Summary Full Text Stopping a Mutant Kinase in Its Tracks By Heather B McDonald Science Translational Medicine 02 Dec 2009 9ec34 A new compound shows promise for treating patients with drug resistant chronic myeloid leukemia Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER The Great Library of Alexandria by O Von Corven This 19th century German engraving represents the

    Original URL path: http://stm.sciencemag.org/content/1/9 (2016-02-10)
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  • Table of Contents — December 09, 2009, 1 (10) | Science Translational Medicine
    Dejean Amennai Daniel Beyeen Mohsen Khademi Audrey Casemayou Lucille Lamouroux Christine Duthoit Olivier Papapietro Louise Sjöholm Isabelle Bernard Dominique Lagrange Ingrid Dahlman Frida Lundmark Annette B Oturai Helle B Soendergaard Anu Kemppinen Janna Saarela Pentti J Tienari Hanne F Harbo Anne Spurkland Sreeram V Ramagopalan Dessa A Sadovnick George C Ebers Maria Seddighzadeh Lars Klareskog Lars Alfredsson Leonid Padyukov Jan Hillert Michel Clanet Gilles Edan Bertrand Fontaine Gilbert J Fournié Ingrid Kockum Abdelhadi Saoudi Tomas Olsson Science Translational Medicine 09 Dec 2009 10ra21 VAV1 plays a role in regulating proinflammatory cytokines which underlie the susceptibility for developing experimental autoimmune encephalomyelitis and multiple sclerosis Editor s Summary Abstract Full Text PDF Editors Choice A Better Bionic Heart By Katrina L Kelner Science Translational Medicine 09 Dec 2009 10ec35 Patients with a new type of heart pump that has a rotor to drive blood flow instead of a piston survive better because they have fewer complications Summary Full Text Grow Your Own Stem Cells By Kelly LaMarco Science Translational Medicine 09 Dec 2009 10ec36 Induced pluripotent stem cells grown on their own parent fibroblasts are stable and lack common culture related problems paving the way for production of clinical grade iPS cells Summary Full Text Lipid Liaison By Lily Khidr Science Translational Medicine 09 Dec 2009 10ec37 A lipid chaperone in macrophages links ER stress with atherosclerosis Summary Full Text Measuring Metastatic Melanoma s Risk By Heather B McDonald Science Translational Medicine 09 Dec 2009 10ec38 Patients with melanomas that express more immune related genes and show less cell division have a better chance of survival Summary Full Text Erratum Correction to the Research Article Titled Serum Amyloid P Inhibits Fibrosis Through FcγR Dependent Monocyte Macrophage Regulation in Vivo by A P Castaño et al Science Translational Medicine 09 Dec 2009 10er1

    Original URL path: http://stm.sciencemag.org/content/1/10 (2016-02-10)
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  • Table of Contents — December 16, 2009, 1 (11) | Science Translational Medicine
    Genetic Screens in Human Cells By Sarah A Stanley Deborah T Hung Science Translational Medicine 16 Dec 2009 11ps13 A library of loss of function alleles generated from a largely haploid human cell line facilitated genome wide screens designed to interrogate host pathogen interactions and promote a systems level understanding of infectious disease Abstract Full Text PDF Research Article Intravenous Hemostat Nanotechnology to Halt Bleeding By James P Bertram Cicely A Williams Rebecca Robinson Steven S Segal Nolan T Flynn Erin B Lavik Science Translational Medicine 16 Dec 2009 11ra22 Synthetic platelets composed of functionalized nanoparticles halve bleeding time in a rat injury model and may prove useful in treating human trauma victims Editor s Summary Abstract Full Text PDF Editors Choice Protection from Hemoglobin s Dark Side By Katrina L Kelner Science Translational Medicine 16 Dec 2009 11ec39 A naturally occurring protein that binds hemoglobin protects the brain from damage after a bleeding stroke offering a potential therapeutic approach Summary Full Text Metabolites on the Brain By Kelly LaMarco Science Translational Medicine 16 Dec 2009 11ec40 A mutated metabolic enzyme gains a new catalytic activity that may enhance the progression of metastatic brain cancer Summary Full Text Where to PARK By Lily Khidr Science Translational Medicine 16 Dec 2009 11ec41 A gene mutated in familial Parkinson s disease is now linked to brain cancer Summary Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER A scanning electron micrograph of a blood clot The formation of this blood clot consisting of platelets and other blood cells larger spheres embedded in a fibrin network was enhanced

    Original URL path: http://stm.sciencemag.org/content/1/11 (2016-02-10)
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  • Table of Contents — December 23, 2009, 1 (12) | Science Translational Medicine
    D Jones Birgitte B Simen Bozena Hanczaruk Khoa D Nguyen Kari C Nadeau Michael Egholm David B Miklos James L Zehnder Andrew Z Fire Science Translational Medicine 23 Dec 2009 12ra23 Massively parallel sequencing of rearranged immune receptor genes permits detection and tracking of specific immune cell populations in normal and pathological contexts Editor s Summary Abstract Full Text PDF Reports Seasonal Influenza Vaccine Provides Priming for A H1N1 Immunization By Giuseppe Del Giudice Koert J Stittelaar Geert van Amerongen James Simon Albert D M E Osterhaus Klaus Stöhr Rino Rappuoli Science Translational Medicine 23 Dec 2009 12re1 Tests in ferrets show that the vaccine now used for mass inoculation against H1N1 is more effective when coinjected with an oil in water adjuvant and after the animals exposure to seasonal flu vaccine Editor s Summary Abstract Full Text PDF Editors Choice Amino Acids to the Rescue By Heather B McDonald Science Translational Medicine 23 Dec 2009 12ec42 Consumption of neurotransmitter precursors improves cognitive performance after brain injury in mice Summary Full Text A Protective Genetic Variant for Lungs By Katrina L Kelner Science Translational Medicine 23 Dec 2009 12ec43 Analysis of seven independent groups of subjects uncovers a metalloproteinase variant that protects against lung damage but only in smokers and people with lung disease Summary Full Text Dynamic Duo Cancer Drugs and the Immune System By Kelly LaMarco Science Translational Medicine 23 Dec 2009 12ec44 In mice with ovarian cancer treatment with both the drug Doxil and the cytokine interleukin 18 inhibits tumor growth and promotes tumor regression better than either therapy alone Summary Full Text Secret Entry for Dendritic Cells By Lily Khidr Science Translational Medicine 23 Dec 2009 12ec45 The basement membrane thought to be a barrier to cell movement contains flexible perforations that can serve as cellular

    Original URL path: http://stm.sciencemag.org/content/1/12 (2016-02-10)
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  • Table of Contents — January 06, 2010, 2 (13) | Science Translational Medicine
    W Chow Alena V Savonenko Tatiana Melnikova Hyunsu Kim Donald L Price Tong Li Philip C Wong Science Translational Medicine 06 Jan 2010 13ra1 Simultaneous reduction of two of the enzymes that create the plaque forming peptide β amyloid in Alzheimer s disease ameliorates symptoms in aged mice better than elimination of either enzyme alone Editor s Summary Abstract Full Text PDF Elafin Is a Biomarker of Graft Versus Host Disease of the Skin By Sophie Paczesny Thomas M Braun John E Levine Jason Hogan Jeffrey Crawford Bryan Coffing Stephen Olsen Sung W Choi Hong Wang Vitor Faca Sharon Pitteri Qing Zhang Alice Chin Carrie Kitko Shin Mineishi Gregory Yanik Edward Peres David Hanauer Ying Wang Pavan Reddy Samir Hanash James L M Ferrara Science Translational Medicine 06 Jan 2010 13ra2 Plasma elafin concentrations correlate with graft versus host disease of the skin and long term survival Editor s Summary Abstract Full Text PDF Editors Choice No Muss No Fuss Easy Protein Structure Function Analysis By Katrina L Kelner Science Translational Medicine 06 Jan 2010 13ec1 Bioinformatic analysis of a bacterial protein sequence can help to identify protein regions essential for infection which may present good drug targets Full Text Personalized Medicine Progresses One Base at a Time By Kelly LaMarco Science Translational Medicine 06 Jan 2010 13ec2 A high fidelity low cost scalable platform for whole genome sequencing may reveal rare genetic variants and catalyze genomics based personalized medicine Full Text Saving Lives by Screening Out By Lily Khidr Science Translational Medicine 06 Jan 2010 13ec3 The protein responsible for inducing the acute respiratory distress that can happen after blood transfusions is identified in human blood cells Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope

    Original URL path: http://stm.sciencemag.org/content/2/13 (2016-02-10)
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  • Table of Contents — January 13, 2010, 2 (14) | Science Translational Medicine
    Charles A Czeisler Elizabeth B Klerman Science Translational Medicine 13 Jan 2010 14ra3 The cumulative effects of chronic sleep loss may be overcome at certain times of day but the residual effects of sleep deprivation profoundly degrade performance and may thereby compromise safety Editor s Summary Abstract Full Text PDF Intermittent Prophylaxis with Oral Truvada Protects Macaques from Rectal SHIV Infection By J Gerardo García Lerma Mian er Cong James Mitchell Ae S Youngpairoj Qi Zheng Silvina Masciotra Amy Martin Zsuzsanna Kuklenyik Angela Holder Jonathan Lipscomb Chou Pong Pau John R Barr Debra L Hanson Ron Otten Lynn Paxton Thomas M Folks Walid Heneine Science Translational Medicine 13 Jan 2010 14ra4 Treating monkeys with single doses of an antiretroviral drug before and after exposure to SHIV provides protection against infection a schedule that may prove practical in humans Editor s Summary Abstract Full Text PDF Editors Choice Mechanism of a Metabolic Shift in Monkeys By Andrew A Bremer Science Translational Medicine 13 Jan 2010 14ec4 A new study investigates the mechanistic effects of fetal glucocorticoid exposure on metabolic syndrome in primates Full Text Bone Metastases in Prostate Cancer Finding the Achilles Heel By Donna E Hansel Science Translational Medicine 13 Jan 2010 14ec5 A study in humanized mice reveals a strong dependence of bone associated human prostate cancer cells on IGF II a possible therapeutic target Full Text Decoding Renal Cell Carcinoma By Samir Damani Science Translational Medicine 13 Jan 2010 14ec6 Deep sequencing unveils unchartered links to the etiology of kidney cancer Full Text Longer Lived Proteins By Kenneth W Ng Science Translational Medicine 13 Jan 2010 14ec7 A new method for extending the half life of therapeutic proteins may open the door for reduced drug dosing as well as new peptide pharmaceuticals Full Text More From Science Translational

    Original URL path: http://stm.sciencemag.org/content/2/14 (2016-02-10)
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  • Table of Contents — January 20, 2010, 2 (15) | Science Translational Medicine
    Khurana Wanida Chearwae Flora Castellino Jody Manischewitz Lisa R King Agnieszka Honorkiewicz Michael T Rock Kathryn M Edwards Giuseppe Del Giudice Rino Rappuoli Hana Golding Science Translational Medicine 20 Jan 2010 15ra5 An oil based adjuvant improves the efficacy of an H5N1 vaccine by inducing antibodies against additional sites on influenza surface proteins Editor s Summary Abstract Full Text PDF Identification of a Class of HCV Inhibitors Directed Against the Nonstructural Protein NS4B By Nam Joon Cho Hadas Dvory Sobol Choongho Lee Sang Joon Cho Paul Bryson Marilyn Masek Menashe Elazar Curtis W Frank Jeffrey S Glenn Science Translational Medicine 20 Jan 2010 15ra6 An activity identified in hepatitis C virus NS4B paves the way for a distinct new class of antivirals Editor s Summary Abstract Full Text PDF Editors Choice Cracking the Code of Pseudomonas Longevity Unveiling the PAMPs By Shama Ahmad Science Translational Medicine 20 Jan 2010 15ec8 Mutations that change the biochemistry of bacterial lipid metabolites may explain why the chronic lung infections of cystic fibrosis patients are so hard to treat Full Text Supersweet This Is Your Taste Buds on Dope By Christoph Buettner Science Translational Medicine 20 Jan 2010 15ec9 Endocannabinoid signaling within taste buds enhances sweet taste perception Full Text Can t Get Next to You By Michael Minzenberg Science Translational Medicine 20 Jan 2010 15ec10 The stress response system of infant rat brains disrupts the rats capacity for learning to maintain close proximity to mothers who are stressed themselves Full Text Round Trip Ticket for Circulating Tumor Cells By Alexei Morozov Science Translational Medicine 20 Jan 2010 15ec11 In addition to forming distant metastases circulating tumor cells may return to established tumors to help fuel their growth Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About

    Original URL path: http://stm.sciencemag.org/content/2/15 (2016-02-10)
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  • Table of Contents — January 27, 2010, 2 (16) | Science Translational Medicine
    Research Articles Resiliency and Vulnerability in the HER2 HER3 Tumorigenic Driver By Dhara N Amin Natalia Sergina Deepika Ahuja Martin McMahon Jimmy A Blair Donghui Wang Byron Hann Kevin M Koch Kevan M Shokat Mark M Moasser Science Translational Medicine 27 Jan 2010 16ra7 The ability of certain breast cancers to resist a tyrosine kinase inhibitor drug may be overcome with high intermittent doses Editor s Summary Abstract Full Text PDF Metabolomic Imaging for Human Prostate Cancer Detection By Chin Lee Wu Kate W Jordan Eva M Ratai Jinhua Sheng Christen B Adkins Elita M DeFeo Bruce G Jenkins Leslie Ying W Scott McDougal Leo L Cheng Science Translational Medicine 27 Jan 2010 16ra8 Magnetic resonance spectroscopy can generate comprehensive maps of metabolites in the prostate that reveal cancerous regions potentially guiding biopsies and prognosis Editor s Summary Abstract Full Text PDF Editors Choice DAMD to Do Better By Joshi Alumkal Science Translational Medicine 27 Jan 2010 16ec12 DAMD a high throughput platform for assessing DNA methylation changes provides new insights into the development and treatment of pediatric brain tumors Full Text Which Came First By Rhonda Bentley Lewis Science Translational Medicine 27 Jan 2010 16ec13 Researchers use Mendelian randomization to decipher directions of causality between obesity and inflammation Full Text Accounting for Participant Dropout in Clinical Studies By Nichole Carlson Science Translational Medicine 27 Jan 2010 16ec14 A statistical model for longitudinal data can account for subjects that drop out of the study avoiding biases in the conclusions Full Text Obesity and Inflammation The Fas Connection By Elaine Cheng Science Translational Medicine 27 Jan 2010 16ec15 The death receptor Fas may contribute to obesity induced inflammation and the pathogenesis of type 2 diabetes mellitus Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline

    Original URL path: http://stm.sciencemag.org/content/2/16 (2016-02-10)
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