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  • Erratum for the Research Article: “RANKL blockade prevents and treats aggressive osteosarcomas” by Y. Chen, M. A. Di Grappa, S. D. Molyneux, T. D. McKee, P. Waterhouse, J. M. Penninger, R. Khokha | Science Translational Medicine
    not human IgG 1 as reported in the paper The PDF and HTML full text have been corrected Copyright 2016 American Association for the Advancement of Science Science Translational Medicine Vol 8 Issue 324 03 February 2016 Table of Contents Article Tools Email Thank you for your interest in spreading the word about Science Translational Medicine NOTE We only request your email address so that the person you are recommending the page to knows that you wanted them to see it and that it is not junk mail We do not capture any email address Your Email Your Name Send To Enter multiple addresses on separate lines or separate them with commas You are going to email the following Erratum for the Research Article RANKL blockade prevents and treats aggressive osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha Message Subject Your Name has forwarded a page to you from Science Translational Medicine Message Body Your Name thought you would like to see this page from the Science Translational Medicine web site Your Personal Message Send Message Save to my folders User Name Password Remember my user name password Submit Alerts Please log in to add an alert for this article Username Enter your Sciencemag org username Password Enter the password that accompanies your username Log in Request Permissions Citation tools Erratum for the Research Article RANKL blockade prevents and treats aggressive osteosarcomas by Y Chen M A Di Grappa S D Molyneux T D McKee P Waterhouse J M Penninger R Khokha Science Translational Medicine 03 Feb 2016 324er2 Citation Manager Formats BibTeX Bookends EasyBib EndNote tagged EndNote 8 xml Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Share Erratum for the Research Article RANKL blockade

    Original URL path: http://stm.sciencemag.org/content/8/324/324er2.full (2016-02-10)
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  • Archives | Science Translational Medicine
    2016 2000s 2010s 2009 2010 2011 2012 2013 2014 2015 2016 2016 Jan 06 Vol 8 Iss 320 Jan 13 Vol 8 Iss 321 Jan 20 Vol 8 Iss 322 Jan 27 Vol 8 Iss 323 Feb 03 Vol 8 Iss 324 2015 Science 5 February 2016 Vol 351 Issue 6273 Pages 539 630 Feature What makes DARPA tick Science and Society Taking race out of human genetics Agriculture Losing

    Original URL path: http://stm.sciencemag.org/content/by/year (2016-02-10)
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  • Mission and scope | Science Translational Medicine
    of biology but the linkages back to basic research to fill these gaps have not been as effective as they could be Clearly creative experimental approaches novel technologies and new ways of conducting scientific explorations at the interface of established and emerging disciplines are now required to an unprecedented degree if real progress is to be made Nothing short of a true reinvention of the science of translational medicine is likely to suffice To aid in this reinvention Science and AAAS created the interdisciplinary journal Science Translational Medicine Content Science Translational Medicine publishes original peer reviewed science based research articles that report successful advances toward the goal of improving patients lives The editors and an international advisory group of scientists and clinician scientists as well as other experts hold Science Translational Medicine articles to the same high quality standard that is the hallmark of the journal Science Scope Cardiovascular disease immunology vaccines metabolism diabetes obesity neuroscience neurology psychiatry cancer infectious diseases policy behavior bioengineering chemical genomics drug discovery imaging applied physical sciences medical nanotechnology drug delivery biomarkers gene therapy regenerative medicine toxicology and pharmacokinetics data mining cell culture animal and human studies medical informatics and other interdisciplinary approaches to medicine Examples of content in Science Translational Medicine Investigative studies of human biology with an emphasis on disease including small clinical trials Research on models of human disease with significant implications for disease treatment Focus Perspectives and Reviews that discuss medically related research from a basic science and a clinical point of view Commentary on policy funding education and regulatory issues in translational medicine Survey of recent noteworthy findings from other publications Editor s Choice Special issues that feature comprehensive reviews and analyses of current topics in translational medicine Audience Researchers and management in academia government and the biotechnology and pharmaceutical

    Original URL path: http://stm.sciencemag.org/site/misc/about.xhtml (2016-02-10)
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  • Editorial staff and scientific advisory boards | Science Translational Medicine
    Simons Foundation New York NY USA Kornelia Polyak M D Ph D Professor of Medicine Harvard Medical School Boston MA USA Glenn Prestwich Ph D Presidential Professor of Medicinal Chemistry Presidential Special Assistant and Director Entrepreneurial Faculty Scholars The University of Utah Salt Lake City UT USA Nathan D Price Ph D Associate Professor Institute for Systems Biology Seattle WA USA Rino Rappuoli Ph D Global Head of Vaccines Research Novartis Vaccines and Diagnostics Siena ITALY Jorge Reis Filho M D Ph D FRCPath Member and Attending Pathologist Memorial Sloan Kettering Cancer Center New York NY USA Jeremy N Rich M D Chair Department of Stem Cell Biology and Regenerative Medicine Lerner Research Institute Cleveland Clinic Cleveland OH USA José Alain Sahel M D Professor of Ophthalmology Pierre and Marie Curie Univerisity Chairman Department of Opthalmology National Eye Hospital Director Vision Institute INSERM UPMC Paris FRANCE Jeffrey Settleman Ph D Head Of Oncology Research Calico Life Sciences South San Francisco CA USA Gerald I Shulman M D Ph D George R Cowgill Professor of Medicine Endocrinology Professor of Cellular and Molecular Physiology Investigator Howard Hughes Medical Institute Yale University New Haven CT USA G Sitta Sittampalam Ph D Senior Scientific Officer NCATS NIH Bethesda MD USA Jean Paul Thiery Ph D Head of Department and Professor Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore SINGAPORE Eric J Topol M D Director Scripps Translational Science Institute La Jolla CA USA Ralph Weissleder M D Ph D Professor Director of the Center for Systems Biology Massachusetts General Hospital Harvard Medical School Boston MA USA David S Wilkes M D Dean School of Medicine James Carroll Flippin Professor of Medical Science University of Virginia School of Medicine Charlottesville VA USA Tadataka Tachi Yamada M D Senior Executive in Residence Frazier Healthcare Seattle WA USA Keith R Yamamoto Ph D Vice Chancellor for Research Executive Vice Dean School of Medicine Professor Departments of Cellular Molecular Pharmacology and Biochemistry Biophysics University of California San Francisco San Francisco CA USA Peter Zandstra Ph D Professor Biomaterials and Biomedical Engineering Centre for Cellular and Biomolecular Research University of Toronto Toronto Ontario CANADA Elias Zerhouni M D President Global Research and Development Sanofi Aventis Paris FRANCE Associate Scientific Advisors Science Translational Medicine is pleased to welcome our sixth group of Associate Scientific Advisors These 28 early career translational scientists will serve for a period of 1 year In addition to acting as advisors for the journal these scientists will scan the literature weekly and select and summarize research papers to be highlighted in our Editors Choice section Each Associate Advisor will have 7 of their articles appear in Science Translational Medicine over the coming year View our previous Associate Scientific Advisors Associate Scientific Advisors 2015 Jessica Alvarez PhD RD Instructor of Medicine Division of Endocrinology Metabolism Lipids Emory University School of Medicine Atlanta GA Sam Behjati MA BMBCh PhD Paediatric Registrar London Deanery United Kingdom Ellen Beswick PhD Assistant Professor Molecular Genetics and Microbiology University of New Mexico Health Sciences Center Albuquerque NM Pamela Bhatti PhD MSc Associate Professor School of Electrical and Computer Engineering Georgia Institute of Technology Atlanta GA Kristen Brennand PhD Assistant Professor Icahn School of Medicine at Mount Sinai Departments of Psychiatry and Neuroscience New York NY Nicole M Bouvier MD Assistant Professor Division of Infectious Diseases Department of Medicine Department of Microbiology Icahn School of Medicine at Mount Sinai New York NY Deniz Dalkara PhD Tenured Research Scientist INSERM Institut de la Vision Paris France Roxana Dronca MD Senior Associate Consultant Department of Oncology Director Medical Oncology Associate Fellowship Program Assistant Professor of Oncology Mayo Clinic College of Medicine Rochester MN Jeremiah Faith PhD Assistant Professor Immunology Institute and Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai New York NY Thomas Heldt PhD MPhil Helmholtz Career Development Professor Institute for Medical Engineering and Science Assistant Professor of Electrical and Biomedical Engineering Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology Cambridge MA Marshaleen Henriques Forsythe MBBS MSCR FCCP Assistant Professor of Clinical Medicine Department of Medicine Division of Pulmonary and Critical Care Co Director Intermediate Care Grady Health System Morehouse School of Medicine Atlanta GA Christopher G Janson MD Assistant Professor of Neurology The University of Illinois at Chicago Chicago IL Yo El Ju MD Assistant Professor of Neurology Washington University School of Medicine St Louis MO Gadi Lalazar MD Instructor in Clinical Investigation Laboratory of Cellular Biophysics The Rockefeller University New York NY Ian R Lanza PhD Assistant Professor of Medicine Division of Endocrinology Associate Director Metabolomics Core Mayo Clinic College of Medicine Rochester MN Alexander Marson MD PhD UCSF Sandler Faculty Fellow and Clinical Fellow in Infectious Diseases UCSF Diabetes Center and Division of Infectious Diseases Department of Medicine Affiliate Member Innovative Genomics Initiative IGI University of California San Francisco San Francisco CA Grzegorz Nalepa MD PhD Assistant Professor of Pediatric Hematology Oncology Medical and Molecular Genetics and Biochemistry Indiana University School of Medicine Wells Center for Pediatric Research Riley Hospital for Children Indianapolis IN Biju Parekkadan PhD Assistant Professor Surgery Bioengineering Massachusetts General Hospital Harvard University Boston MA Tanya Shaw PhD Senior Lecturer in Tissue Repair King s College London Centre for Molecular and Cellular Biology of Inflammation London SE1 1UL United Kingdom Anne Marie Singh MD Assistant Professor of Pediatrics and Medicine Division of Allergy Immunology Northwestern Feinberg School of Medicine Chicago IL Kara Spiller Ph D M S Assistant Professor School of Biomedical Engineering Science and Health Systems Drexel University Philadelphia PA Jeffrey Statland MD Assistant Professor of Neurology University of Kansas Medical Center Fairway KS Masako Suzuki DVM PhD Research Assistant Professor Center for Epigenomics Department of Genetics Albert Einstein College of Medicine Bronx NY Anish Thomas MBBS MD Staff Clinician Thoracic and GI Oncology Branch Center for Cancer Research National Cancer Institute Bethesda MD Giovanni Traverso MB BChir PhD Instructor of Medicine Division of Gastroenterology Brigham and Women s Hospital Harvard Medical School Boston

    Original URL path: http://stm.sciencemag.org/content/editorial-staff-and-scientific-advisory-boards (2016-02-10)
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  • Editorial policies | Science Translational Medicine
    confidence intervals e g normal based 95 CI mean 2SD likelihood ratio based interval should be clearly stated Mention methods used in the Materials and Methods and then provide the individual test name in the figure legend for each experiment The testing level alpha and whether one sided or two sided testing was used should be reported for each statistical test typically two sided testing is appropriate but if one sided testing is used its use should be justified Adjustments made to alpha levels e g Bonferroni correction or other procedure used to account for multiple testing e g false discovery rate control should be reported When Bayesian analyses are conducted any assumptions made for prior distributions must be fully described Sufficient information should be supplied to allow readers to judge whether any assumptions necessary for the validity of statistical approaches e g data are normally distributed survival data are consistent with proportional hazards in a Cox regression model have been verified An accounting of missing data values should be provided if imputed data values are used in statistical analyses the methods used for imputation should be fully described Novel or highly complex statistical methods or computational algorithms should be adequately described with references supplied to allow readers the opportunity to recreate the calculations at its discretion the Journal may require that computer code and data be made available as supplementary information as a condition of publication Authors should present results in complete and transparent fashion so that stated conclusions are backed by appropriate statistical evaluation and limitations of the study are frankly discussed Point estimates of population parameters e g mean correlation coefficient slope or comparative measures e g mean difference odds ratio hazard ratio should be accompanied by a measure of uncertainty such as a standard error or a confidence interval Results of each statistical test should be reported in full with the value of the test statistic and p value and not simply reported as significant or non significant more than two significant digits on p values are usually not needed except in situations of extreme multiple testing such as in genetic association studies where stringent corrections for multiple testing might be used Any results that are reported to constitute a blinded independent validation of a statistical model or mathematical classifier or predictor must be accompanied by a detailed explanation that includes 1 specification of the exact locked down form of the model including all data processing steps algorithm for calculating the model output and any cutpoints that might be applied to the model output for final classification 2 date on which the model or predictor was fully locked down in exactly the form described 3 name of the individual s who maintained the blinded data and oversaw the evaluation e g honest broker 4 statement of assurance that no modifications additions or exclusion were made to the validation data set from the point at which the model was locked down and that neither the validation data nor any subset of it had ever been used to assess or refine the model being tested Back to Top Reporting Guidelines Authors are encouraged to follow published standard reporting guidelines for the study discipline Many of these can be found at the EQUATOR website Type of Study Guidelines Animal studies ARRIVE Prognostic marker studies REMARK Diagnostic markers STARD Meta analysis of observational studies in medicine MOOSE Stroup et al JAMA 2000 283 2008 2012 Systematic reviews and meta analysis of health care interventions PRISMA Cohort and case control studies STROBE Genetic association studies STROBE Extension STREGA Tumor marker studies Simon RM Paik S and Hayes DF J Natl Cancer Inst 2009 101 1446 1452 Studies using biospecimens BRISQ Rodent model studies Hollingshead MG J Natl Cancer Inst 2008 100 1500 1510 Microarray based studies for clinical outcomes Table 3 in Dupuy A and Simon RM J Natl Cancer Inst 2007 99 147 57 Back to Top Guidelines for Specific Types of Studies Human subjects research Informed consent must be obtained for studies on humans after the nature and possible consequences of the studies are explained A statement that informed consent was obtained must also appear in the manuscript All research on humans must have approval from the institutional IRB Institutional Review Board or an equivalent body The editors reserve the right to request IRB documents associated with a particular paper Clinical trials A CONSORT Statement CONSORT includes recommendations a checklist of items that should be included in a comprehensive report and a participant flow diagram The recommended checklist should be completed and provided at the time of manuscript submission The recommended trial flow diagram may be presented as a figure usually Fig 1 Reports of randomized controlled trials that do not conform to the CONSORT guidelines may be returned to authors for revision prior to formal review Registration of clinical trials Clinical trials should generally be registered in accordance with the criteria outlined by the International Committee of Medical Journal Editors http www icmje org including the June 2007 update Authors should provide the trial registration number in the Acknowledgements section and provide a link to the trial registration to be cited as a reference Biomarker studies Putative biomarkers must be evaluated with an independent validation set Reports of unvalidated biomarkers will only be considered in the context of a clear experimental mechanistic connection to disease or other unique contribution to understanding of disease or clinical practice A statement should be included in all biomarker papers describing how overfitting training models on large numbers of variables measured on small numbers of subjects and other forms of bias were avoided We strongly recommend all papers reporting potential new biomarkers be evaluated by an independent statistician before submission Modeling studies Computational models should be validated either experimentally or through a dataset independent of the training set All assumptions should be clearly stated with sources provided in the references and notes section The code algorithm used for the study must be included

    Original URL path: http://stm.sciencemag.org/content/editorial-policies (2016-02-10)
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  • Information for reviewers | Science Translational Medicine
    rereview the revised version if we believe the paper has been significantly improved but still requires expert The final responsibility for decisions of acceptance or rejection of submitted manuscripts lies with the editors Research Articles and Reviews are always peer reviewed Perspectives and Commentary articles may also be evaluated by outside experts although this is at the discretion of the editor Each type of contribution has specific criteria see below however all submissions are reviewed for scientific accuracy clarity and conciseness of presentation We prefer to receive referee comments through our Manuscript Submission and Information Portal at https cts sciencemag org The review process is conducted anonymously Science Translational Medicine never reveals the identity of reviewers to authors The review itself will be shared only with the author and possibly with other reviewers and our Board Back to Top Downloading the manuscript and submitting your review Access the manuscript for review and submit your review at the Science Journals Manuscript Submission and Information Portal https cts sciencemag org If you need assistance please email us at scitranslmededitors aaas org Back to Top Guidelines for Reviewers Disinterested evaluation Reviews should be objective assessments of the research If you cannot judge a paper impartially you should not accept it for review or you should notify the editor as soon as you appreciate the situation If you have any professional or financial affiliations that may be perceived as a conflict of interest in reviewing the manuscript or a history of personal differences with the author s you should describe them in your confidential comments Likewise if as a reviewer you believe that you are not qualified to evaluate a component of the research you should inform the editor in your review Considerate useful comments Reviews should be constructive and courteous and the reviewer should respect the intellectual independence of the author The reviewer should avoid personal comments Science Translational Medicine reserves the right to edit comments that will hinder constructive discussion of manuscripts Timeliness Just as you wish prompt evaluations of your own research please return your reviews within the time period specified when you were asked to review the paper If events will prevent a timely review please inform the editor at the time of the request Confidentiality The submitted manuscript is a privileged communication and must be treated as a confidential document Please destroy all copies of the manuscript after review Please do not share the manuscript with any colleagues without the explicit permission of the editor Reviewers should not make personal or professional use of the data or interpretations before publication without the authors specific permission unless you are writing an editorial or commentary to accompany the article Anonymity The review process is conducted anonymously Science Translational Medicine never reveals the identity of reviewers to authors The privacy and anonymity provisions of this process extend to the reviewer who should not reveal his or her identity to outsiders or members of the press The review itself will be shared only

    Original URL path: http://stm.sciencemag.org/content/information-reviewers (2016-02-10)
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  • Staff | Science Translational Medicine
    Ph D Executive Editor Science Journals Monica M Bradford Editor Katrina L Kelner Ph D Managing Editor Orla M Smith Ph D Senior Editors Kelly LaMarco Ph D Angela Colmone Ph D Associate Editors Megan Frisk Ph D Yevgeniya Nusinovich M D Ph D Consulting Editor Heather McDonald Ph D Editorial Coordinators Kristin Wowk Anita Saxena Publishers and Business Staff Executive Publisher Rush D Holt Director Marketing Elise Swinehart Director Worldwide Advertising Sales Bill Moran Director Site License Sales Tom Ryan Institutional Site License Specialist Kiki Forsythe Production Copyediting Cara Tate Manager Jeffrey E Cook Chris Filiatreau Cynthia Howe Harry Jach Lauren Kmec Barbara P Ordway Proofreading Beverly Shields Manager Joi Granger Scott Miller Jerry Richardson Dona Mathieu Art Christopher Bickel Valerie Altounian Heather McDonald Operations Lizabeth Harman Director Rebecca Doshi Antoinette Hodal Lori Murphy Anthony Rosen Lisa Stanford More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit Science 5 February 2016 Vol 351 Issue 6273 Pages 539 630 Feature What makes DARPA tick Science and Society Taking race out of human

    Original URL path: http://stm.sciencemag.org/content/staff (2016-02-10)
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  • Contact Science Translational Medicine | Science Translational Medicine
    Employer Profiles Graduate Programs Booklets Careers Features About Careers Search Search Contact Science Translational Medicine Mailing address Science Translational Medicine Editorial Office 1200 New York Avenue NW Entrance at the corner of H St and 12 St NW Washington DC 20005 Phone 202 326 6501 Fax 202 289 7562 Editorial inquires scitranslmededitors aaas org To submit a new manuscript check the status of a submitted manuscript or submit a revised manuscript https cts sciencemag org Problems with the website stmtrans feedback highwire stanford edu Sitewide subscriptions 1 866 265 4152 toll free in the USA 1 202 326 6730 outside the USA or sciencemedicine aaas org Advertising 202 326 6438 bmoran aaas org For all other inquiries Feedback More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit Science 5 February 2016 Vol 351 Issue 6273 Pages 539 630 Feature What makes DARPA tick Science and Society Taking race out of human genetics Agriculture Losing our taste for diversity SCI COMMUN News at a glance Ecology The mite that jumped the bee that

    Original URL path: http://stm.sciencemag.org/content/contact-science-translational-medicine (2016-02-10)
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