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  • Table of Contents — May 26, 2010, 2 (33) | Science Translational Medicine
    Rahul Deo Frederick P Roth Aarti Asnani Eugene P Rhee David M Systrom Marc J Semigran Ramachandran S Vasan Steven A Carr Thomas J Wang Marc S Sabatine Clary B Clish Robert E Gerszten Science Translational Medicine 26 May 2010 33ra37 Measurement by mass spectrometry of 200 blood metabolites reveals that individuals who are more fit respond more effectively to exercise as shown by larger exercise induced increase in glycerol Editor s Summary Abstract Full Text PDF Proteins Required for Centrosome Clustering in Cancer Cells By Blanka Leber Bettina Maier Florian Fuchs Jing Chi Phillip Riffel Simon Anderhub Ludmila Wagner Anthony D Ho Jeffrey L Salisbury Michael Boutros Alwin Krämer Science Translational Medicine 26 May 2010 33ra38 Identified in an RNA interference screen proteins that prevent spindle multipolarity in human cancer cells may prove to be promising drug targets Editor s Summary Abstract Full Text PDF Editors Choice New Hope for Premature Newborns By Shama Ahmad Science Translational Medicine 26 May 2010 33ec82 A recently characterized enzyme is required for the production of a key component of lung surfactant and facilitates the transition to air breathing Full Text Could Interleukin 33 Be the Stopgap Against Sepsis By Christoph Buettner Science Translational Medicine 26 May 2010 33ec83 Interleukin 33 improves survival in mice with sepsis and is low in patients who did not survive sepsis Full Text Crime Is Its Own Reward By Michael J Minzenberg Science Translational Medicine 26 May 2010 33ec84 Excessive dopamine signaling in the brain s reward system may underlie antisocial behavior Full Text Differentiation Block in Glioma By Alexei Morozov Science Translational Medicine 26 May 2010 33ec85 The glioma genome project leads to the discovery of an oncogene that may promote tumor formation by blocking differentiation of neural stem cells Full Text More From Science Translational

    Original URL path: http://stm.sciencemag.org/content/2/33 (2016-02-10)
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  • Table of Contents — June 02, 2010, 2 (34) | Science Translational Medicine
    of Selection Biomarkers in Current Phase III Oncology Clinical Trials By Robert Sikorski Bin Yao Science Translational Medicine 02 Jun 2010 34ps27 A global analysis of selection biomarkers currently in use in oncology phase III clinical trials reveals a terrain that is both rich and sparse Abstract Full Text PDF Research Article Cystamine Suppresses Polyalanine Toxicity in a Mouse Model of Oculopharyngeal Muscular Dystrophy By Janet E Davies Claudia Rose Sovan Sarkar David C Rubinsztein Science Translational Medicine 02 Jun 2010 34ra40 Mice with oculopharyngeal muscular dystrophy caused by aggregation of a nuclear protein show improvement when treated with cystamine suggesting a possible therapeutic approach for patients Editor s Summary Abstract Full Text PDF Editors Choice TMPRSS2 ERG a Mover and a Shaker By Joshi Alumkal Science Translational Medicine 02 Jun 2010 34ec86 TMPRSS2 ERG modulates critical pathways to promote prostate cancer progression Full Text The Latest PARP Sensation By Rhonda Bentley Lewis Science Translational Medicine 02 Jun 2010 34ec87 Inhibition of poly ADP ribose polymerase serves as a therapy for peripheral diabetic neuropathy Full Text Drop the Loser Designs An Alternative Design for Phase III Studies By Nichole Carlson Science Translational Medicine 02 Jun 2010 34ec88 Drop the loser clinical trails offer a useful alternative to classic single dose phase III designs when phase II data are ambiguous Full Text Destination Stent By Elaine Cheng Science Translational Medicine 02 Jun 2010 34ec89 Magnetic nanoparticles carrying a therapeutic agent can be specifically targeted to stents to prevent re occlusion of blood vessels Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Weaker and Weaker A

    Original URL path: http://stm.sciencemag.org/content/2/34 (2016-02-10)
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  • Table of Contents — June 09, 2010, 2 (35) | Science Translational Medicine
    Annette Affolter Arnaud Nourry Dan Niculescu Duvaz Caroline Springer Richard Marais Science Translational Medicine 09 Jun 2010 35ra41 Gatekeeper mutations in BRAF confer drug resistance Editor s Summary Abstract Full Text PDF Systemic Delivery of scAAV9 Expressing SMN Prolongs Survival in a Model of Spinal Muscular Atrophy By Chiara F Valori Ke Ning Matthew Wyles Richard J Mead Andrew J Grierson Pamela J Shaw Mimoun Azzouz Science Translational Medicine 09 Jun 2010 35ra42 An adeno associated virus vector expressing the survival motor neuron protein rescues mice with spinal muscular atrophy Editor s Summary Abstract Full Text PDF Editors Choice What s Hypusine Got to Do with Diabetes Well Maybe a Lot By Andrew A Bremer Science Translational Medicine 09 Jun 2010 35ec90 Depleting an unusual amino acid found only in a translation initiation factor in islet cells improves β cell function in mice and humans potentially treating diabetes Full Text Blood Based Diagnostics A Biopsy Surrogate By Samir Damani Science Translational Medicine 09 Jun 2010 35ec91 A gene expression profile accurately predicts the risk for transplant rejection Full Text Micrometastases Math Model of Breast Cancer Dormancy By Donna E Hansel Science Translational Medicine 09 Jun 2010 35ec92 Mathematical modeling helps predict the extent of dormant breast cancer micrometastases Full Text Stretching for Good Blood Vessels By Kenneth W Ng Science Translational Medicine 09 Jun 2010 35ec93 Dynamic stretching improves the mechanical strength of foreign body vascular grafts for potential use in vascular bypass surgery Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Garnishing the Gatekeeper The protein kinase inhibitor PLX4720 is shown bound to

    Original URL path: http://stm.sciencemag.org/content/2/35 (2016-02-10)
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  • Table of Contents — June 23, 2010, 2 (37) | Science Translational Medicine
    in the management of defective T helper type 1 immunity in Wiskott Aldrich syndrome Abstract Full Text PDF Research Articles Nuclear Role of WASp in the Pathogenesis of Dysregulated T H 1 Immunity in Human Wiskott Aldrich Syndrome By Matthew D Taylor Sanjoy Sadhukhan Ponnappa Kottangada Archana Ramgopal Koustav Sarkar Sheryl D Silva Annamalai Selvakumar Fabio Candotti Yatin M Vyas Science Translational Medicine 23 Jun 2010 37ra44 Nuclear role for WASp in T BET transcription Editor s Summary Abstract Full Text PDF Safety and Antithrombotic Efficacy of Moderate Platelet Count Reduction by Thrombopoietin Inhibition in Primates By Erik I Tucker Ulla M Marzec Michelle A Berny Sawan Hurst Stuart Bunting Owen J T McCarty András Gruber Stephen R Hanson Science Translational Medicine 23 Jun 2010 37ra45 Inhibition of platelet production safely reduces blood clot formation without increasing bleeding side effects in baboons Editor s Summary Abstract Full Text PDF Editors Choice Sinking Prostate Cancer from Under the Sea By Joshi Alumkal Science Translational Medicine 23 Jun 2010 37ec98 A marine extract that inhibits transactivation of the androgen receptor s amino terminal domain leads to prostate cancer regression Full Text It s a Matter of Life and Death By Rhonda Bentley Lewis Science Translational Medicine 23 Jun 2010 37ec99 A seemingly proapoptotic transcription factor may actually enhance β cell function in a mouse model of type 2 diabetes Full Text Improved Analysis By Nichole Carlson Science Translational Medicine 23 Jun 2010 37ec100 Studies of conditions in which participants experience recurring disease episodes require specialized statistical analysis Full Text Quelling a Shock to the System By Elaine Cheng Science Translational Medicine 23 Jun 2010 37ec101 Interleukin 33 attenuates sepsis by promoting neutrophil migration to the site of infection and facilitating bacterial clearance Full Text More From Science Translational Medicine Current Table of

    Original URL path: http://stm.sciencemag.org/content/2/37 (2016-02-10)
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  • Table of Contents — June 30, 2010, 2 (38) | Science Translational Medicine
    treated with a serotonin receptor agonist Editor s Summary Abstract Full Text PDF Genomic Architecture Characterizes Tumor Progression Paths and Fate in Breast Cancer Patients By Hege G Russnes Hans Kristian Moen Vollan Ole Christian Lingjærde Alexander Krasnitz Pär Lundin Bjørn Naume Therese Sørlie Elin Borgen Inga H Rye Anita Langerød Suet Feung Chin Andrew E Teschendorff Philip J Stephens Susanne Månér Ellen Schlichting Lars O Baumbusch Rolf Kåresen Michael P Stratton Michael Wigler Carlos Caldas Anders Zetterberg James Hicks Anne Lise Børresen Dale Science Translational Medicine 30 Jun 2010 38ra47 This study demonstrates the relation among structural genomic alterations molecular subtype and clinical behavior and shows that an objective score of genomic complexity can provide independent prognostic information in breast cancer Editor s Summary Abstract Full Text PDF Editors Choice New Advances in Gene Therapy The Use of MGMT P140K Mediated Stem Cell Selection in Nonhuman Primates By Andrew A Bremer Science Translational Medicine 30 Jun 2010 38ec102 In vivo selection with MGMT P140K enhances gene transfer efficiency in nonhuman primates demonstrating the utility of this system for a variety of human conditions amenable to autologous gene modified cell therapy Full Text Dark Matter Revealed By Samir Damani Science Translational Medicine 30 Jun 2010 38ec103 Rare variants in the sialic acid acetylesterase gene result in substantial risk for common autoimmune conditions Full Text Going Organic Yields a Super Model System By Kelly LaMarco Science Translational Medicine 30 Jun 2010 38ec104 A new organ on a chip microdevice models the human alveolar capillary interface the key functional unit of the living lung and mimics organ level functions Full Text Sticks and Stones and Mending Bones By Kenneth W Ng Science Translational Medicine 30 Jun 2010 38ec105 Prevascularized bone grafts may speed up bone healing in trauma or fractures with serious

    Original URL path: http://stm.sciencemag.org/content/2/38 (2016-02-10)
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  • Table of Contents — July 07, 2010, 2 (39) | Science Translational Medicine
    Simon S Lo William T C Yuh Nina A Mayr Science Translational Medicine 07 Jul 2010 39ra48 A generalized mathematical model for the relation between radiation dose and tumor cell death enables better treatment planning and dose schedule designs for current targeted high dose radiation therapies in cancer Editor s Summary Abstract Full Text PDF Editors Choice Rtp801 Caught Redd Handed By Shama Ahmad Science Translational Medicine 07 Jul 2010 39ec106 Increased expression of Rtp801 causes oxidative stress and injury to the lungs Full Text Your Inner Clock Is on Steroids By Christoph Buettner Science Translational Medicine 07 Jul 2010 39ec107 The adrenal gland and the glucocorticoids it secretes help stabilize and reset our bodies inner clocks Full Text Alcohol Takes Its Toll on the Brain By Michael J Minzenberg Science Translational Medicine 07 Jul 2010 39ec108 Alcohol abuse activates inflammatory responses via Toll like receptors in the brain potentially leading to irreversible cognitive changes Full Text Divide and Conquer By Alexei Morozov Science Translational Medicine 07 Jul 2010 39ec109 Expression of genes involved in chromosomal stability may be a better marker of tumor aggressiveness than tumor grade Full Text Podcast Science Translational Medicine Podcast 7 July 2010 By Samuel Broder Annalisa M VanHook Science Translational Medicine 07 Jul 2010 39pc5 A conversation with Samuel Broder about early discoveries in HIV 1 AIDS research and strategies for successful translational research in the future Abstract More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER A Trace of Success Depicted are the changes in U S annual death rates due to AIDS among individuals 25 to 44 years of

    Original URL path: http://stm.sciencemag.org/content/2/39 (2016-02-10)
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  • Table of Contents — July 14, 2010, 2 (40) | Science Translational Medicine
    R Hafalla Kai Matuschewski Steffen Borrmann Science Translational Medicine 14 Jul 2010 40ra49 Malaria infected mice treated with antibiotics remain healthy and are protected against subsequent malaria infection Editor s Summary Abstract Full Text PDF Quinone Oxidoreductase 2 Mediated Prodrug Cancer Therapy By Mark R Middleton Richard Knox Emma Cattell Udo Oppermann Rachel Midgley Raghib Ali Tim Auton Roshan Agarwal David Anderson Debashis Sarker Ian Judson Tsuyoshi Osawa Victoria J Spanswick Scot Davies John A Hartley David J Kerr Science Translational Medicine 14 Jul 2010 40ra50 An oxidoreductase enzyme abundant in tumors can be catalytically activated by a synthetic cofactor to convert a prodrug to a cytotoxic DNA binding species in human subjects Editor s Summary Abstract Full Text PDF Editors Choice Precious Metals By Joshi Alumkal Science Translational Medicine 14 Jul 2010 40ec110 Copper chelation specifically enhances the sensitivity of cancer cells to platinum based chemotherapy Full Text Nesfatin 1 Of Mice and Men By Rhonda Bentley Lewis Science Translational Medicine 14 Jul 2010 40ec111 A newly described adipokine that promotes anorexia is found in adipose tissue and is up regulated by a high fat diet and inflammation Full Text Taking Advantage of What You Know About Complex Diseases By Nichole Carlson Science Translational Medicine 14 Jul 2010 40ec112 Bayesian analysis approaches offer a useful way to incorporate prior knowledge into existing data analyses through the prior distribution Full Text Imaging the Host Immune Response By Elaine Cheng Science Translational Medicine 14 Jul 2010 40ec113 Detecting an enzyme expressed by a subset of monocytes confers an ability to monitor rejection of transplanted hearts Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact

    Original URL path: http://stm.sciencemag.org/content/2/40 (2016-02-10)
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  • Table of Contents — July 21, 2010, 2 (41) | Science Translational Medicine
    responsible for celiac disease suggesting a rational immunotherapeutic approach that could replace the need for strict lifelong dietary gluten avoidance Editor s Summary Abstract Full Text PDF CD4 CD25 Regulatory T Cell Depletion Improves the Graft Versus Tumor Effect of Donor Lymphocytes After Allogeneic Hematopoietic Stem Cell Transplantation By Sébastien Maury François M Lemoine Yosr Hicheri Michelle Rosenzwajg Cécile Badoual Mustapha Cheraï Jean Louis Beaumont Nabih Azar Nathalie Dhedin Anne Sirvent Agnès Buzyn Marie Thérèse Rubio Stéphane Vigouroux Olivier Montagne Dominique Bories Françoise Roudot Thoraval Jean Paul Vernant Catherine Cordonnier David Klatzmann José L Cohen Science Translational Medicine 21 Jul 2010 41ra52 Immunological effects of donor lymphocyte infusion for treatment of recurrent malignancy after allogeneic hematopoietic cell transplantation can be enhanced by depleting T regulatory cells in the infused cells and in the recipient Editor s Summary Abstract Full Text PDF Editors Choice The Skin ny on New β Like Cells for Treating Diabetes By Andrew A Bremer Science Translational Medicine 21 Jul 2010 41ec114 Induced pluripotent stem cells derived from skin fibroblasts have β cell like function and correct hyperglycemia in two mice models of diabetes Full Text Decoding Sudden Cardiac Death By Samir Damani Science Translational Medicine 21 Jul 2010 41ec115 A genome association study has identified a genetic variant that is present in over half of individuals with ventricular fibrillation and confers a large increase in risk for this arrhythmia Full Text Adapting to Aging and Metabolism By Andrew A Bremer Science Translational Medicine 21 Jul 2010 41ec116 Targeted disruption of the adaptor protein p66 shcA improves longevity and ameliorates obesity induced insulin resistance Full Text Don t Worry Be Happy By Kenneth W Ng Science Translational Medicine 21 Jul 2010 41ec117 The severity of osteoarthritis pain is associated with depression and mental health Full Text More

    Original URL path: http://stm.sciencemag.org/content/2/41 (2016-02-10)
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