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  • Table of Contents — November 17, 2010, 2 (58) | Science Translational Medicine
    Biffi Luigi Naldini Science Translational Medicine 17 Nov 2010 58ra84 Hematopoietic stem cell specific microRNAs allow regulation of therapeutic transgene expression and enable effective gene therapy of globoid cell leukodystrophy Editor s Summary Abstract Full Text PDF Femtosecond Laser Assisted Cataract Surgery with Integrated Optical Coherence Tomography By Daniel V Palanker Mark S Blumenkranz Dan Andersen Michael Wiltberger George Marcellino Phillip Gooding David Angeley Georg Schuele Bruce Woodley Michael Simoneau Neil J Friedman Barry Seibel Juan Batlle Rafael Feliz Jonathan Talamo William Culbertson Science Translational Medicine 17 Nov 2010 58ra85 An image guided femtosecond laser can create precisely placed accurate cuts in the eye to improve cataract surgery Editor s Summary Abstract Full Text PDF Editors Choice Drugging Bugs to Make Chemotherapy Safer By Joshi Alumkal Science Translational Medicine 17 Nov 2010 58ec177 Targeted inhibition of β glucuronidase enzymes in normal gut bacteria prevents the dose limiting side effect of camptothecin chemotherapy Full Text Cutting Calories Is Not Always Best By Rhonda Bentley Lewis Science Translational Medicine 17 Nov 2010 58ec178 Prenatal and postnatal malnutrition impairs pancreatic β cell formation in male and female rats Full Text Sophisticated PIGs Help to Identify Biomarkers By Nichole Carlson Science Translational Medicine 17 Nov 2010 58ec179 Adjustment for measurement error during analysis improves the ability to detect valid biomarkers in clinical studies Full Text The Closer By Elaine Cheng Science Translational Medicine 17 Nov 2010 58ec180 Growth hormone releasing hormone directly stimulates fibroblasts to accelerate wound healing Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER In a Pig s Eye A colorized image of a cut made

    Original URL path: http://stm.sciencemag.org/content/2/58 (2016-02-10)
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  • Table of Contents — November 24, 2010, 2 (59) | Science Translational Medicine
    K ATPase in the absence of ouabain Editor s Summary Abstract Full Text PDF Adducin and Ouabain Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin Part 2 Clinical Studies By Chiara Lanzani Lorena Citterio Nicola Glorioso Paolo Manunta Grazia Tripodi Erika Salvi Simona Delli Carpini Mara Ferrandi Elisabetta Messaggio Jan A Staessen Daniele Cusi Fabio Macciardi Giuseppe Argiolas Giovanni Valentini Patrizia Ferrari Giuseppe Bianchi Science Translational Medicine 24 Nov 2010 59ra87 Five genetic variants that affect Na K ATPase interactions predict the blood pressure response to rostafuroxin but not to losartan and hydrochlorothiazide Editor s Summary Abstract Full Text PDF Editors Choice MnSOD Angiogenesis and Wounds Let the Healing Begin By Andrew A Bremer Science Translational Medicine 24 Nov 2010 59ec181 Endothelial progenitor cells treated with gene transfer for MnSOD gene may be a new therapy for wound healing in diabetes patients Full Text When a Clot Buster Doesn t Work So Well By Samir Damani Science Translational Medicine 24 Nov 2010 59ec182 A cytochrome gene variant links a reduced response to a common anticlotting drug to poor clinical outcome in heart disease patients Full Text Predicting Recurrent Clostridium difficile Infection By Donna E Hansel Science Translational Medicine 24 Nov 2010 59ec183 IL 8 genotype predicts Clostridium difficile recurrence Full Text Recycling Reagents to Improve Antibody Therapy By Kenneth W Ng Science Translational Medicine 24 Nov 2010 59ec184 Engineering therapeutic antibodies to be recycled for repeated use in the body can extend the effectiveness of these biologics Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Renal Tubules A cross section from the kidney

    Original URL path: http://stm.sciencemag.org/content/2/59 (2016-02-10)
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  • Table of Contents — December 01, 2010, 2 (60) | Science Translational Medicine
    M Snella Karen L Kline Jennifer D Parkes Wendy A Ware Lori E Moran Amanda J Fales Williams Jane A Wengert R David Whitley Daniel M Betts Amy M Boal Elizabeth A Riedesel William Gross N Matthew Ellinwood Patricia I Dickson Science Translational Medicine 01 Dec 2010 60ra89 Replacing the enzyme α l iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I Editor s Summary Abstract Full Text PDF Review The Role of JNK Proteins in Metabolism By Sara N Vallerie Gökhan S Hotamisligil Science Translational Medicine 01 Dec 2010 60rv5 To combat metabolic diseases therapeutic c Jun N terminal kinase JNK inhibitors must target multiple cell types Editor s Summary Abstract Full Text PDF Editors Choice Solving Cystic Fibrosis One Swine at a Time By Shama Ahmad Science Translational Medicine 01 Dec 2010 60ec185 Dysfunction of the cystic fibrosis transmembrane conductance regulator leads to tracheal abnormalities in CF Full Text Tracing the Fate of an Essential Element By Christoph Buettner Science Translational Medicine 01 Dec 2010 60ec186 Mutations in the SBP2 protein result in reduced synthesis of selenoproteins and a multisystem disorder Full Text Don t Bother Me By Michael J Minzenberg Science Translational Medicine 01 Dec 2010 60ec187 Methylation of the corticotrophin releasing factor gene is associated with resilience to stressful events in adult mice Full Text Two Pluses Make a Minus By Alexei Morozov Science Translational Medicine 01 Dec 2010 60ec188 Erythropoietin decreases the positive effects of trastuzumab in breast cancer patients Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Guess I ll Go

    Original URL path: http://stm.sciencemag.org/content/2/60 (2016-02-10)
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  • Table of Contents — December 08, 2010, 2 (61) | Science Translational Medicine
    2010 61ra91 Sequencing plasma DNA from a pregnant woman permits genome wide scanning for the mutational status of the fetus prenatally and noninvasively Editor s Summary Abstract Full Text PDF Review Lost in Translation Neuropsychiatric Drug Development By Robert E Becker Nigel H Greig Science Translational Medicine 08 Dec 2010 61rv6 The sluggish pace of development of new drugs for neuropsychiatric diseases can be attributed in part to faulty clinical trial design Editor s Summary Abstract Full Text PDF Editors Choice Thinking Outside the Box in Prostate Cancer By Joshi Alumkal Science Translational Medicine 08 Dec 2010 61ec189 Targeting the N cadherin protein prevents the emergence of the lethal castration resistant form of prostate cancer Full Text The Yin and Yang of Steroid Hormones in Placental Development By Rhonda Bentley Lewis Science Translational Medicine 08 Dec 2010 61ec190 Impaired placental size and function are associated with low aldosterone and high cortisol Full Text Bio Creep in Clinical Trials By Nichole Carlson Science Translational Medicine 08 Dec 2010 61ec191 Approval of ineffective new treatments is rare but can occur in certain circumstances Full Text Scar Tactics By Elaine Cheng Science Translational Medicine 08 Dec 2010 61ec192 Targeted delivery of antifibrotic compounds stems scar formation Full Text Meeting Reports A Crisis of Public Confidence in Vaccines By Steven Black Rino Rappuoli Science Translational Medicine 08 Dec 2010 61mr1 This meeting report summarizes the outcome of a meeting held in July 2010 in Siena Italy to discuss the Crisis of Public Confidence in Vaccines Editor s Summary Abstract Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER

    Original URL path: http://stm.sciencemag.org/content/2/61 (2016-02-10)
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  • Table of Contents — December 15, 2010, 2 (62) | Science Translational Medicine
    Helfand Michael Davis Jenny L Donovan Freddie C Hamdy Kristleifur Kristjansson Jeffrey R Gulcher Gisli Masson Augustine Kong William J Catalona Jose I Mayordomo Gudmundur Geirsson Gudmundur V Einarsson Rosa B Barkardottir Eirikur Jonsson Viorel Jinga Dana Mates Lambertus A Kiemeney David E Neal Unnur Thorsteinsdottir Thorunn Rafnar Kari Stefansson Science Translational Medicine 15 Dec 2010 62ra92 Sequence variants in the human genome are associated with serum levels of prostate specific antigen Editor s Summary Abstract Full Text PDF Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer By Jonathan Weiss Martin L Sos Danila Seidel Martin Peifer Thomas Zander Johannes M Heuckmann Roland T Ullrich Roopika Menon Sebastian Maier Alex Soltermann Holger Moch Patrick Wagener Florian Fischer Stefanie Heynck Mirjam Koker Jakob Schöttle Frauke Leenders Franziska Gabler Ines Dabow Silvia Querings Lukas C Heukamp Hyatt Balke Want Sascha Ansén Daniel Rauh Ingelore Baessmann Janine Altmüller Zoe Wainer Matthew Conron Gavin Wright Prudence Russell Ben Solomon Elisabeth Brambilla Christian Brambilla Philippe Lorimier Steinar Sollberg Odd Terje Brustugun Walburga Engel Riedel Corinna Ludwig Iver Petersen Jörg Sänger Joachim Clement Harry Groen Wim Timens Hannie Sietsma Erik Thunnissen Egbert Smit Daniëlle Heideman Federico Cappuzzo Claudia Ligorio Stefania Damiani Michael Hallek Rameen Beroukhim William Pao Bert Klebl Matthias Baumann Reinhard Buettner Karen Ernestus Erich Stoelben Jürgen Wolf Peter Nürnberg Sven Perner Roman K Thomas Science Translational Medicine 15 Dec 2010 62ra93 FGFR1 amplification provides a therapeutic target for squamous cell lung cancer which is resistant to other targeted lung cancer drugs Editor s Summary Abstract Full Text PDF Editors Choice Therapeutic Targeting for the Long Term By Andrew A Bremer Science Translational Medicine 15 Dec 2010 62ec193 The liver X receptor β may be required for the adverse metabolic effects of exogenously administered glucocorticoids Full Text Decoding Obesity By Samir Damani Science Translational Medicine 15 Dec 2010 62ec194 Overexpression of the FTO gene contributes to human obesity Full Text The Haze Clears Second Hand Tobacco Smoke a Risk for Bladder Cancer By Donna E Hansel Science Translational Medicine 15 Dec 2010 62ec195 Environmental tobacco exposure is associated with an increased risk for bladder cancer in lifelong nonsmokers Full Text Promoting Islet Cell Growth Gives New Hope for Diabetics By Kenneth W Ng Science Translational Medicine 15 Dec 2010 62ec196 Pancreatic islet cells can be cultured on a scaffold which might help relieve shortages of donor cells for transplantation Full Text Errata A Correction to the Research Article Titled Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens by Brian Alexander Jennifer Warner Schmidt Therese Eriksson Carol Tamminga Margarita Arango Lievano Subroto Ghose Mary Vernov Mihaela Stavarache Sergei Musatov Marc Flajolet Per Svenningsson Paul Greengard Michael G Kaplitt Science Translational Medicine 15 Dec 2010 62er4 Full Text PDF A Correction to the Research Article Titled Adducin and Ouabain Related Gene Variants Predict the Antihypertensive Activity of Rostafuroxin Part 1 Experimental Studies by Mara Ferrandi Isabella Molinari Lucia Torielli Gloria Padoani Sergio Salardi

    Original URL path: http://stm.sciencemag.org/content/2/62 (2016-02-10)
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  • Table of Contents — December 22, 2010, 2 (63) | Science Translational Medicine
    Jiménez Barbero Dirk Meyer Olson Jan Münch Javier Pérez Castells Ludger Ständker Frank Kirchhoff Reinhold E Schmidt Science Translational Medicine 22 Dec 2010 63re3 An optimized derivative of a natural HIV 1 entry inhibitor targeting the gp41 fusion peptide shows antiviral potency and minimal side effects in a Phase I II clinical trial Editor s Summary Abstract Full Text PDF Editors Choice Targeting the Channel CF Treatment Gets Personal By Shama Ahmad Science Translational Medicine 22 Dec 2010 63ec197 A drug that targets a specific mutated form of the protein that causes cystic fibrosis improves the protein s function and disease symptoms Full Text Insulin Resistance Results in Brain Drain By Christoph Buettner Science Translational Medicine 22 Dec 2010 63ec198 Insulin regulates brain cholesterol metabolism by modulating the expression of cholesterol synthesizing enzymes in the central nervous system Full Text Illuminating Drug Action in the Parkinsonian Brain By Michael J Minzenberg Science Translational Medicine 22 Dec 2010 63ec199 Functional MRI can be used to monitor the action of new drugs in the brains of Parkinson s disease patients Full Text Tumor Endothelial Cells Mixed Parentage By Alexei Morozov Science Translational Medicine 22 Dec 2010 63ec200 Cancer stem cells in glioblastoma multiforme give rise to a subset of tumor blood vessels Full Text Meeting Reports Training the Translational Scientist By Rebecca D Jackson Sherine Gabriel Anne Pariser Peter Feig Science Translational Medicine 22 Dec 2010 63mr2 A session about educating translational scientists was held at a 2010 NIH forum on promoting collaborations between academia government and industry Editor s Summary Abstract Full Text PDF Collaborations Among Academia Government and Industry in the Diagnostics Space Barriers and Some Ideas for Solutions By Greg Evans Finley Austin Science Translational Medicine 22 Dec 2010 63mr3 A session about the challenges that occur during diagnostics development was held at a 2010 NIH forum on promoting collaborations among academia government and industry Editor s Summary Abstract Full Text PDF Development of the First Inhaled Antibiotic for the Treatment of Cystic Fibrosis By Lynn M Rose Richard Neale Science Translational Medicine 22 Dec 2010 63mr4 A session about the challenges that occur during drug development was held at a 2010 NIH forum on promoting collaborations among academia government and industry Editor s Summary Abstract Full Text PDF Working with the CTSA Consortium What We Bring to the Table By Scott J Steele Science Translational Medicine 22 Dec 2010 63mr5 A session about how CTSA Consortium efforts can foster public private partnerships was held at a 2010 NIH forum on promoting collaborations among academia government and industry Editor s Summary Abstract Full Text PDF Academic Industry Challenges for Medical Device Development By John H Linehan Ari Chaney Science Translational Medicine 22 Dec 2010 63mr6 A session about the challenges that occur during medical device development was held at a 2010 NIH forum on promoting collaborations among academia government and industry Editor s Summary Abstract Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In

    Original URL path: http://stm.sciencemag.org/content/2/63 (2016-02-10)
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  • Table of Contents — January 05, 2011, 3 (64) | Science Translational Medicine
    Full Text PDF Improving Drug Potency and Efficacy by Nanocarrier Mediated Subcellular Targeting By Mami Murakami Horacio Cabral Yu Matsumoto Shourong Wu Mitsunobu R Kano Takao Yamori Nobuhiro Nishiyama Kazunori Kataoka Science Translational Medicine 05 Jan 2011 64ra2 Polymeric micelles containing a chemotherapeutic drug carry it adjacent to the DNA target in tumor cells enhancing the drug potency Editor s Summary Abstract Full Text PDF Review The p53 Pathway as a Target in Cancer Therapeutics Obstacles and Promise By Anna Mandinova Sam W Lee Science Translational Medicine 05 Jan 2011 64rv1 The complex role of the tumor suppressor p53 in normal and malignant cells complicates efforts to target it for cancer therapy Editor s Summary Abstract Full Text PDF Editors Choice JAK and Jumonji Deadly Playmates By Joshi Alumkal Science Translational Medicine 05 Jan 2011 64ec1 An RNA interference genetic screen shows that JAK and JMJD2C cooperate to promote survival and progression of lymphomas Full Text Nature Versus Nurture in Newly Diagnosed Type 2 Diabetes By Rhonda Bentley Lewis Science Translational Medicine 05 Jan 2011 64ec2 A genetic risk factor for Type 2 diabetes was shown in a population study to be associated with newly diagnosed disease Full Text Too Much of a Good Thing By Elaine Cheng Science Translational Medicine 05 Jan 2011 64ec3 Antibiotics alter the normal intestinal flora and increase susceptibility to infection by highly resistant bacteria Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Drug Delivery by Micelle As discussed in the Research Article by Murakami et al this polymeric micelle is ingested by cancer cells where it trafficks to

    Original URL path: http://stm.sciencemag.org/content/3/64 (2016-02-10)
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  • Table of Contents — January 12, 2011, 3 (65) | Science Translational Medicine
    Darrell L Dinwiddie Neil A Miller Shannon L Hateley Elena E Ganusova Joann Mudge Ray J Langley Lu Zhang Clarence C Lee Faye D Schilkey Vrunda Sheth Jimmy E Woodward Heather E Peckham Gary P Schroth Ryan W Kim Stephen F Kingsmore Science Translational Medicine 12 Jan 2011 65ra4 Carrier testing for 448 severe childhood recessive diseases by next generation sequencing has good predictive value and suggests that every individual carries about three disease mutations Editor s Summary Abstract Full Text PDF Editors Choice Dad s Diet and Baby s Metabolism By Andrew A Bremer Science Translational Medicine 12 Jan 2011 65ec4 Paternal diet affects lipid and cholesterol metabolism in the offspring Full Text Pondering the Significance of PON1 By Samir Damani Science Translational Medicine 12 Jan 2011 65ec5 Another strong pharmacogenetic variant for clopidogrel response emerges Full Text A Fusion Protein Fix for Cuts and Scrapes By Kenneth W Ng Science Translational Medicine 12 Jan 2011 65ec6 An engineered fusion protein speeds up healing of skin wounds in diabetic mice Full Text Podcast Science Translational Medicine Podcast 12 January 2011 By Laird Jackson Orla Smith Science Translational Medicine 12 Jan 2011 65pc1 A conversation with Laird Jackson about using the latest genome sequencing technologies to develop new carrier and prenatal genetic tests Abstract Erratum A Correction to the Research Article Titled Personalized Epigenomic Signatures That Are Stable Over Time and Covary with Body Mass Index by A P Feinberg R A Irizarry D Fradin M J Aryee P Murakami T Aspelund G Eiriksdottir T B Harris L Launer V Gudnason M D Fallin Science Translational Medicine 12 Jan 2011 65er1 Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies

    Original URL path: http://stm.sciencemag.org/content/3/65 (2016-02-10)
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