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  • Table of Contents — March 16, 2011, 3 (74) | Science Translational Medicine
    W Michael Foster Jiurong Liang Eric B Meltzer Dianhua Jiang Robert J Lefkowitz Paul W Noble Science Translational Medicine 16 Mar 2011 74ra23 The signaling molecule β arrestin is required for the fibroblast invasion of extracellular matrix and thus for the development of pulmonary fibrosis Editor s Summary Abstract Full Text PDF The Δ F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis Like Disease in Pigs By Lynda S Ostedgaard David K Meyerholz Jeng Haur Chen Alejandro A Pezzulo Philip H Karp Tatiana Rokhlina Sarah E Ernst Robert A Hanfland Leah R Reznikov Paula S Ludwig Mark P Rogan Greg J Davis Cassie L Dohrn Christine Wohlford Lenane Peter J Taft Michael V Rector Emma Hornick Boulos S Nassar Melissa Samuel Yuping Zhang Sandra S Richter Aliye Uc Joel Shilyansky Randall S Prather Paul B McCray Jr Joseph Zabner Michael J Welsh David A Stoltz Science Translational Medicine 16 Mar 2011 74ra24 A common mutation in human cystic fibrosis CFTR ΔF508 results in misprocessed CFTR and a cystic fibrosis like clinical phenotype in pigs Editor s Summary Abstract Full Text PDF Editors Choice Sildenafil Bench to Bedside and Back Again By Rebecca S Boxer Science Translational Medicine 16 Mar 2011 74ec34 Sildenafil attenuates the effects of pulmonary hypertension in a rat model of left sided heart failure Full Text The Food for Mood By George A Mashour Science Translational Medicine 16 Mar 2011 74ec35 A diet deficient in omega 3 fatty acids disrupts the endocannabinoid system in the brain and can be linked to psychiatric disease Full Text Cleaning Up the Clutter By Erik Rytting Science Translational Medicine 16 Mar 2011 74ec36 Nanocarriers targeting the delivery of enzyme replacement therapy to endothelial cells are expected to improve therapy for Fabry disease Full Text A Lesson for TB from Antiviral Immunity

    Original URL path: http://stm.sciencemag.org/content/3/74 (2016-02-10)
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  • Table of Contents — March 23, 2011, 3 (75) | Science Translational Medicine
    2011 75ra25 Breast cancer methylomes contribute to metastatic potential modulate the metastasis transcriptome and predict disease outcome Editor s Summary Abstract Full Text PDF Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors By Lecia V Sequist Belinda A Waltman Dora Dias Santagata Subba Digumarthy Alexa B Turke Panos Fidias Kristin Bergethon Alice T Shaw Scott Gettinger Arjola K Cosper Sara Akhavanfard Rebecca S Heist Jennifer Temel James G Christensen John C Wain Thomas J Lynch Kathy Vernovsky Eugene J Mark Michael Lanuti A John Iafrate Mari Mino Kenudson Jeffrey A Engelman Science Translational Medicine 23 Mar 2011 75ra26 Lung cancers undergo dynamic genetic and histological changes upon developing resistance to EGFR inhibitors Editor s Summary Abstract Full Text PDF Editors Choice Two Peas in a Pod By Ruth M Farrell Science Translational Medicine 23 Mar 2011 75ec38 Eclampsia and preeclampsia may be branches off a common event that takes place at the utero placenta junction Full Text Strike Three Positive Progress on the Triple Negative By Diane Gesty Palmer Science Translational Medicine 23 Mar 2011 75ec39 Triple negative breast cancers are driven by surprise a tumor suppressor that regulates protein tyrosine kinases Full Text Genetic Tug of War in the Immune System By Timothy B Niewold Science Translational Medicine 23 Mar 2011 75ec40 A genome wide association study uncovers loci that confer risk for an immune mediated kidney disease Full Text The Hunt for Red October By Srini Tridandapani Science Translational Medicine 23 Mar 2011 75ec41 Investigators have improved medical sonar ultrasound to hunt down and track elusive cancer cells Full Text Podcast Science Translational Medicine Podcast 23 March 2011 By Timothy Chan Angela Colmone Science Translational Medicine 23 Mar 2011 75pc4 A conversation with Timothy Chan about a new way to predict breast cancer metastasis

    Original URL path: http://stm.sciencemag.org/content/3/75 (2016-02-10)
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  • Table of Contents — March 30, 2011, 3 (76) | Science Translational Medicine
    30 Mar 2011 76ra27 Inhibiting the Raf MEK ERK pathway reverses the harmful effects of oncogenic Kras on hematopoietic differentiation suggesting a strategy for treating myeloproliferative neoplasms Editor s Summary Abstract Full Text PDF Use of Mutant Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients By Christian Jons Jin O Uchi Arthur J Moss Matthias Reumann John J Rice Ilan Goldenberg Wojciech Zareba Arthur A M Wilde Wataru Shimizu Jorgen K Kanters Scott McNitt Nynke Hofman Jennifer L Robinson Coeli M B Lopes Science Translational Medicine 30 Mar 2011 76ra28 Mutations that slow the opening of potassium channels in the heart can predict risk for long QT syndrome a heart arrhythmia that can cause sudden death Editor s Summary Abstract Full Text PDF Editors Choice When the Heart Forgets to Beat By Samir Damani Science Translational Medicine 30 Mar 2011 76ec42 Whole genome sequencing combined with a genome wide association study yields important genetic predictors of sinus node dysfunction Full Text Fetal DNA A Needle in the Haystack By Carmella Evans Molina Science Translational Medicine 30 Mar 2011 76ec43 A fetal epigenetic footprint in mothers blood paves the way for noninvasively diagnosing Down s syndrome Full Text Molecular Cancer Screening Comes Alive By Richard J Lin Science Translational Medicine 30 Mar 2011 76ec44 Epigenetic signatures help to predict risk of bladder cancer Full Text PEG Gets to the Heart of the Matter By Christopher L Skelly Science Translational Medicine 30 Mar 2011 76ec45 Polyethylene glycol improves cardiac function by inhibiting the apoptotic pathway induced by ischemia reperfusion injury Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe

    Original URL path: http://stm.sciencemag.org/content/3/76 (2016-02-10)
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  • Table of Contents — April 06, 2011, 3 (77) | Science Translational Medicine
    Smoot Hassan Ashktorab Oi Lian Kon Valere Cacheux Celestial Yap Nallasivam Palanisamy Patrick Tan Science Translational Medicine 06 Apr 2011 77ra30 One partner of a fusion gene found in gastric cancer CD44 SLC1A2 may contribute to the tumor s abnormal metabolism Editor s Summary Abstract Full Text PDF State of the Art Review Alzheimer s Disease The Challenge of the Second Century By David M Holtzman John C Morris Alison M Goate Science Translational Medicine 06 Apr 2011 77sr1 In the first of our State of the Art Review series David M Holtzman John C Morris and Alison M Goate explore the rapid pace of Alzheimer s disease research and the challenges to translating research breakthroughs into clinical treatments Abstract Full Text PDF Editors Choice Starve Now Gain Later By Mickie H Cheng Science Translational Medicine 06 Apr 2011 77ec46 Specific durable epigenetic changes induced in the fetus by maternal diet may spur development of type 2 diabetes in adulthood Full Text Patient Heal Thyself By David S Hong Science Translational Medicine 06 Apr 2011 77ec47 CD40 activation boosts the antitumor response of stromal associated macrophages in humans and mice with pancreatic cancer Full Text Enemies Among Us By Melissa Nyendak Science Translational Medicine 06 Apr 2011 77ec48 Invasive streptococcal strains are genetically similar to pharyngitis strains yet polymorphisms lead to changes in invasive potential Full Text Communicating Wirelessly with Our Bodies By Wei Wang Science Translational Medicine 06 Apr 2011 77ec49 Wireless communication for biomedical devices is enabled by using the human body for signal transmission Full Text Podcast Science Translational Medicine Podcast 6 April 2011 By David M Holtzman Orla Smith Science Translational Medicine 06 Apr 2011 77pc5 A conversation with David M Holtzman about the challenges of developing new treatments for Alzheimer s disease Abstract More From

    Original URL path: http://stm.sciencemag.org/content/3/77 (2016-02-10)
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  • Table of Contents — April 13, 2011, 3 (78) | Science Translational Medicine
    Ming Jeng Longen Zhou Lan Huang Irene Kuhn Mina J Bissell Wen Hwa Lee Science Translational Medicine 13 Apr 2011 78ra31 Normal mammary epithelial cells secrete an anticancer cytokine IL 25 suggesting that IL 25 receptor signaling may be a therapeutic target for breast cancer Editor s Summary Abstract Full Text PDF Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model By Christopher J Harvey Rajesh K Thimmulappa Sanjay Sethi Xiaoni Kong Lonny Yarmus Robert H Brown David Feller Kopman Robert Wise Shyam Biswal Science Translational Medicine 13 Apr 2011 78ra32 Bacterial clearance in macrophages from lungs with chronic obstructive pulmonary disease is improved by stimulating the Nrf2 antioxidant signaling pathway Editor s Summary Abstract Full Text PDF Editors Choice Hunting for Those with Heavy Hearts By Rebecca S Boxer Science Translational Medicine 13 Apr 2011 78ec50 Biomarkers may help to identify people with heart hypertrophy before the manifestation of heart failure Full Text Shocking Memories After Surgery By George A Mashour Science Translational Medicine 13 Apr 2011 78ec51 Overexpression of heat shock protein can prevent postoperative memory impairment in mice Full Text Nanoparticles and Jelly By Erik Rytting Science Translational Medicine 13 Apr 2011 78ec52 An implantable cisplatin nanoparticle hydrogel system shows promise for inhibiting tumor growth in vivo Full Text A Little Tolerance Can Prevent a Broken Heart By Anthony K Shum Science Translational Medicine 13 Apr 2011 78ec53 Lack of thymic tolerance to α MyHC may contribute to myocarditis development in patients with autoimmune mediated myocardial disease Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The

    Original URL path: http://stm.sciencemag.org/content/3/78 (2016-02-10)
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  • Table of Contents — April 20, 2011, 3 (79) | Science Translational Medicine
    S Gambhir Science Translational Medicine 20 Apr 2011 79ra33 Gold core nanoparticles designed for imaging by Raman spectroscopy in patients are generally nontoxic in mice causing only temporary liver inflammation when given intravenously Editor s Summary Abstract Full Text PDF Reports Electronic Medical Records for Genetic Research Results of the eMERGE Consortium By Abel N Kho Jennifer A Pacheco Peggy L Peissig Luke Rasmussen Katherine M Newton Noah Weston Paul K Crane Jyotishman Pathak Christopher G Chute Suzette J Bielinski Iftikhar J Kullo Rongling Li Teri A Manolio Rex L Chisholm Joshua C Denny Science Translational Medicine 20 Apr 2011 79re1 Clinical data captured in electronic medical records accurately identify cases and controls for genome wide association studies Editor s Summary Abstract Full Text PDF Editors Choice Divide and Conquer Teasing Out the Cause of Heart Defects in Down Syndrome By Ruth M Farrell Science Translational Medicine 20 Apr 2011 79ec54 Individual genetic mutations may contribute to the distinct conditions that make up Down syndrome Full Text Fishing for Answers By Diane Gesty Palmer Science Translational Medicine 20 Apr 2011 79ec55 A zebrafish model of tuberculosis reveals new insights into how drug tolerance emerges in mycobacteria Full Text The Power of Epistasis By Carrie M Nielson Science Translational Medicine 20 Apr 2011 79ec56 Mutations in human immunodeficiency virus genes work together to heighten drug resistance Full Text Actionable Pharmacogenetics for Epilepsy By Timothy B Niewold Science Translational Medicine 20 Apr 2011 79ec57 An HLA allele is a major genetic risk factor for a severe adverse reaction to an anti epileptic drug in Europeans Full Text Breast Cancer Imaging Goes Green By Srini Tridandapani Science Translational Medicine 20 Apr 2011 79ec58 Near infrared imaging of the breasts after intravenous injection of indocyanine green distinguishes benign from malignant lesions Full Text More

    Original URL path: http://stm.sciencemag.org/content/3/79 (2016-02-10)
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  • Table of Contents — April 27, 2011, 3 (80) | Science Translational Medicine
    E Russell Martin Mihm Lee M Nadler Naoto Hirano Science Translational Medicine 27 Apr 2011 80ra34 Antitumor CD8 T cells educated in vitro can persist as memory T cells and induce antitumor responses in humans without prior conditioning or cytokine treatment Editor s Summary Abstract Full Text PDF Reports Differential Metabolic Impact of Gastric Bypass Surgery Versus Dietary Intervention in Obese Diabetic Subjects Despite Identical Weight Loss By Blandine Laferrère David Reilly Sara Arias Nicholas Swerdlow Prakash Gorroochurn Baani Bawa Mousumi Bose Julio Teixeira Robert D Stevens Brett R Wenner James R Bain Michael J Muehlbauer Andrea Haqq Lillian Lien Svati H Shah Laura P Svetkey Christopher B Newgard Science Translational Medicine 27 Apr 2011 80re2 The enhanced decrease in circulating branched chain amino acids and their metabolites after gastric bypass occurs by mechanisms other than weight loss Editor s Summary Abstract Full Text PDF Editors Choice Blood Sample Supplants Biopsy By Samir Damani Science Translational Medicine 27 Apr 2011 80ec59 Donor heart DNA circulating in transplant recipients pinpoints people at risk for rejection Full Text Sperm Find Culture By Carmella Evans Molina Science Translational Medicine 27 Apr 2011 80ec60 Cultured neonatal mouse testes produce functional mature sperm an advance that one day may be useful for treating male infertility Full Text The Biological Response to Biologics By Richard J Lin Science Translational Medicine 27 Apr 2011 80ec61 The development of antidrug antibodies in rheumatoid arthritis patients reduces long term drug efficacy Full Text Balloons with Brains By Christopher L Skelly Science Translational Medicine 27 Apr 2011 80ec62 Semiconductor devices and sensors integrated into biocompatible materials transform balloon catheters into a next generation surgical tool Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory

    Original URL path: http://stm.sciencemag.org/content/3/80 (2016-02-10)
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  • Table of Contents — May 04, 2011, 3 (81) | Science Translational Medicine
    C Montefiori Michael S Seaman Yue Sun So Yon Lim Wendy W Yeh Mohammed Asmal Rebecca S Gelman Ling Shen James B Whitney Cathal Seoighe Miguel Lacerda Sheila Keating Philip J Norris Michael G Hudgens Peter B Gilbert Adam P Buzby Linh V Mach Jinrong Zhang Harikrishnan Balachandran George M Shaw Stephen D Schmidt John Paul Todd Alan Dodson John R Mascola Gary J Nabel Science Translational Medicine 04 May 2011 81ra36 A vaccine protecting monkeys against mucosal infection by simian immunodeficiency virus sheds light on immune and genetic correlates of protection Editor s Summary Abstract Full Text PDF Editors Choice Fat Fans the Flames By Mickie H Cheng Science Translational Medicine 04 May 2011 81ec63 Fatty acid can invoke mediators associated with insulin resistance that activate the inflammasome to impair insulin signaling Full Text A Fountain of Cancer By David S Hong Science Translational Medicine 04 May 2011 81ec64 A specific gene signature in intestinal stem cells pinpoints colorectal tumors prone to recurrence Full Text A Change of Heart By Melissa Nyendak Science Translational Medicine 04 May 2011 81ec65 Low grade as well as high grade bacteremia can cause infection of the heart valves Full Text Gateway to the Brain By Wei Wang Science Translational Medicine 04 May 2011 81ec66 A brain implanted microelectrode array can provide reliable signals for almost 3 years allowing a quadriplegic patient to move and click a cursor by thought alone Full Text Erratum A Correction to the Perspective Titled Two Roads Diverge Weight Loss Interventions and Circulating Amino Acids by Robert E Gerszten and Thomas J Wang Science Translational Medicine 04 May 2011 81er3 Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies

    Original URL path: http://stm.sciencemag.org/content/3/81 (2016-02-10)
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