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  • Table of Contents — May 11, 2011, 3 (82) | Science Translational Medicine
    2011 82ra38 In psoriasis cytosolic DNA in keratinocytes triggers maturation of the cytokine IL 1β via the AIM2 inflammasome Editor s Summary Abstract Full Text PDF In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins By Hua Liu Yonghak Kim Saul Sharkis Luigi Marchionni Yoon Young Jang Science Translational Medicine 11 May 2011 82ra39 Hepatic cells derived from human induced pluripotent stem cells of various origins contribute to liver regeneration in vivo Editor s Summary Abstract Full Text PDF Editors Choice Targeting Targets for Treatment in Inflammatory Bowel Disease By Rebecca S Boxer Science Translational Medicine 11 May 2011 82ec67 Finding new ways to interfere with the migration of immune cells into the gut may prove to be a valuable approach for treatment of inflammatory bowel disease Full Text At the Crossroads Tumor Metabolism and Epigenetics By Ashkan Emadi Science Translational Medicine 11 May 2011 82ec68 Mutations in isocitrate dehydrogenases and the resulting accumulation of the oncometabolite 2 hydroxyglutarate represent possible targets for cancer therapy Full Text Focusing on Attention Deficit By George A Mashour Science Translational Medicine 11 May 2011 82ec69 A genetic variant associated with a higher than normal incidence of attention deficit hyperactivity disorder can be modeled in mice Full Text HIV Gets a Wake Up Call By Erik Rytting Science Translational Medicine 11 May 2011 82ec70 Liposomal delivery of a protein that activates latent HIV may help to eradicate reservoirs of the latent virus in resting T cells Full Text OutFOXing Tolerance in Multiple Sclerosis By Anthony K Shum Science Translational Medicine 11 May 2011 82ec71 Inflammatory conditions such as autoimmune disease can change the phenotype of T reg cells and impair their function Full Text Podcast Science Translational Medicine Podcast 11 May 2011 By Ronald D Cohn Angela Colmone Science

    Original URL path: http://stm.sciencemag.org/content/3/82 (2016-02-10)
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  • Table of Contents — May 18, 2011, 3 (83) | Science Translational Medicine
    with Minimal Loss of in Vivo Functional Activity By Keli L Hippen Sarah C Merkel Dawn K Schirm Christine M Sieben Darin Sumstad Diane M Kadidlo David H McKenna Jonathan S Bromberg Bruce L Levine James L Riley Carl H June Phillip Scheinberg Daniel C Douek Jeffrey S Miller John E Wagner Bruce R Blazar Science Translational Medicine 18 May 2011 83ra41 A good manufacturing grade compatible approach generates massive numbers of natural regulatory T cells that retain suppressive function in vivo Editor s Summary Abstract Full Text PDF Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells By Pervinder Sagoo Niwa Ali Garima Garg Frank O Nestle Robert I Lechler Giovanna Lombardi Science Translational Medicine 18 May 2011 83ra42 Alloantigen specific human regulatory T cells may improve immunosuppressive therapy after transplantation Editor s Summary Abstract Full Text PDF Editors Choice Snipping Away at Pulmonary Fibrosis By Diane Gesty Palmer Science Translational Medicine 18 May 2011 83ec72 Genome wide linkage analysis reveals association between mucus production and pulmonary fibrosis Full Text Rediscovering Heritability By Carrie M Nielson Science Translational Medicine 18 May 2011 83ec73 Analysis of genome wide association studies reveals new connections between common single nucleotide polymorphisms and phenotypic traits Full Text Decoding Melanoma By Timothy B Niewold Science Translational Medicine 18 May 2011 83ec74 Whole exome sequencing identifies recurrent genetic mutations in melanoma cells Full Text Captain Shields Are Down We Can t Survive Another Hit By Srini Tridandapani Science Translational Medicine 18 May 2011 83ec75 Short bursts of ultrasound pulses can break the blood brain barrier allowing drugs to pass through Full Text More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and

    Original URL path: http://stm.sciencemag.org/content/3/83 (2016-02-10)
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  • Table of Contents — May 25, 2011, 3 (84) | Science Translational Medicine
    25 May 2011 84ra44 Brain uptake of a therapeutic bispecific antibody by receptor mediated transcytosis is enhanced by reducing the antibody s affinity for the transferrin receptor Editor s Summary Abstract Full Text PDF Indocyanine Green Enables Near Infrared Fluorescence Imaging of Lipid Rich Inflamed Atherosclerotic Plaques By Claudio Vinegoni Ion Botnaru Elena Aikawa Marcella A Calfon Yoshiko Iwamoto Eduardo J Folco Vasilis Ntziachristos Ralph Weissleder Peter Libby Farouc A Jaffer Science Translational Medicine 25 May 2011 84ra45 Indocyanine green a clinically approved near infrared fluorescence imaging agent rapidly targets atheromas for in vivo detection of lipid rich inflammatory plaques Editor s Summary Abstract Full Text PDF Editors Choice The Transcriptome Speaks By Samir Damani Science Translational Medicine 25 May 2011 84ec76 RNA sequencing reveals chimeric gene transcripts enriched in human prostate cancer Full Text Understanding PPAR γ Action Just Use Your Brain By Carmella Evans Molina Science Translational Medicine 25 May 2011 84ec77 PPAR γ action in the brain explains thiazolidinedione related weight gain and is required for thiazolidinedione s effects to improve hepatic insulin sensitivity Full Text Breathing Easier By Richard J Lin Science Translational Medicine 25 May 2011 84ec78 Multipotent stem cells in the human lung may have potential for repairing injured or diseased lung tissue Full Text Construction Deconstruction Reconstruction By Christopher L Skelly Science Translational Medicine 25 May 2011 84ec79 Tissue engineered allogeneic blood vessels have potential in cardiac bypass surgery Full Text Podcast Science Translational Medicine Podcast 25 May 2011 By Steven M Paul Orla Smith Science Translational Medicine 25 May 2011 84pc7 A conversation with Steven M Paul about a designer therapeutic antibody with potential for treating Alzheimer s disease Abstract More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and

    Original URL path: http://stm.sciencemag.org/content/3/84 (2016-02-10)
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  • Table of Contents — June 01, 2011, 3 (85) | Science Translational Medicine
    Cassidy Daniel Brewer Bissan Al Lazikani Paul Workman Johann De Bono Stan B Kaye James Larkin Martin E Gore Charles L Sawyers Peter Nelson Tomasz M Beer Hao Geng Lina Gao David Z Qian Joshi J Alumkal Gary Thomas George V Thomas Science Translational Medicine 01 Jun 2011 85ra47 Signaling through the VHL PTP1B Src pathway in renal cell carcinomas may determine sensitivity to Src inhibitors and provide a basis for treatment planning Editor s Summary Abstract Full Text PDF MF59 Adjuvant Enhances Diversity and Affinity of Antibody Mediated Immune Response to Pandemic Influenza Vaccines By Surender Khurana Nitin Verma Jonathan W Yewdell Anne Katrin Hilbert Flora Castellino Maria Lattanzi Giuseppe Del Giudice Rino Rappuoli Hana Golding Science Translational Medicine 01 Jun 2011 85ra48 Adjuvant use improves the quality and quantity of the immune response to pandemic influenza vaccines Editor s Summary Abstract Full Text PDF Editors Choice DPP4 Joins Weight Watchers By Mickie H Cheng Science Translational Medicine 01 Jun 2011 85ec80 In patients with metabolic syndrome human visceral fat secretes an adipokine DPP4 that impairs insulin signaling in muscle potentially contributing to insulin resistance Full Text Old Dogs and New Tricks By David S Hong Science Translational Medicine 01 Jun 2011 85ec81 A combination of standard cytotoxic chemotherapies used for other cancers extends overall survival for pancreatic cancer patients Full Text Molecular Sleuthing Linking Leprosy and Armadillos By Melissa Nyendak Science Translational Medicine 01 Jun 2011 85ec82 Investigators use molecular epidemiology to link leprosy with armadillo exposure suggesting a new zoonotic mode of transmission Full Text The Changing Brain By Wei Wang Science Translational Medicine 01 Jun 2011 85ec83 Spinal cord injury can potentially lead to adaptive changes in the sensory and motor cortical areas of the brain Full Text More From Science Translational Medicine Current Table of

    Original URL path: http://stm.sciencemag.org/content/3/85 (2016-02-10)
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  • Table of Contents — June 08, 2011, 3 (86) | Science Translational Medicine
    Medicine 08 Jun 2011 86ra50 The breast cancer drug lapatinib increases the sensitivity of colon cancer cells to apoptosis through a HER2 and EGFR independent mechanism Editor s Summary Abstract Full Text PDF Host Alloreactive Memory T Cells Influence Tolerance to Kidney Allografts in Nonhuman Primates By Ognjenka Nadazdin Svjetlan Boskovic Toru Murakami Georges Tocco Rex Neal Smith Robert B Colvin David H Sachs James Allan Joren C Madsen Tatsuo Kawai A Benedict Cosimi Gilles Benichou Science Translational Medicine 08 Jun 2011 86ra51 Only nonhuman primates with low frequencies of donor specific memory T cells develop tolerance and accept allogeneic kidney transplants Editor s Summary Abstract Full Text PDF Editors Choice Building Hearts One Cell at a Time By Rebecca S Boxer Science Translational Medicine 08 Jun 2011 86ec84 Mechanical stress and vascularization move immature human cardiomyocytes a step closer to forming functional heart tissue Full Text Ramping Up a Cell s Chemical Weapon By Ashkan Emadi Science Translational Medicine 08 Jun 2011 86ec85 Genetically correcting induced pluripotent stem cells derived from a patient with chronic granulomatous disease demonstrates the feasibility of this therapeutic approach Full Text When Light Gets On Your Nerves By George A Mashour Science Translational Medicine 08 Jun 2011 86ec86 After peripheral nerve injury the healthy sensory cortex on one side of the brain inhibits its deprived counterpart on the other side Full Text Weeding the Tares Sparing the Wheat By Erik Rytting Science Translational Medicine 08 Jun 2011 86ec87 Hyaluronan coated nanoparticles selectively treat CD44 expressing cancer cells without damaging healthy tissue Full Text Pearls of Wisdom for Pulmonary Fibrosis By Anthony K Shum Science Translational Medicine 08 Jun 2011 86ec88 Chronic inflammation mediated by alveolar epithelial cells through macrophages may contribute to the development of lung fibrosis in Hermansky Pudlak syndrome patients Full Text

    Original URL path: http://stm.sciencemag.org/content/3/86 (2016-02-10)
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  • Table of Contents — June 15, 2011, 3 (87) | Science Translational Medicine
    Savai Rio Dumitrascu Bhola Kumar Dahal Jochen Wilhelm Melanie Konigshoff Dariusz Zakrzewicz Hossein Ardeschir Ghofrani Norbert Weissmann Oliver Eickelberg Andreas Guenther James Leiper Werner Seeger Friedrich Grimminger Ralph Theo Schermuly Science Translational Medicine 15 Jun 2011 87ra53 Inhibition of dimethylarginine dimethylaminohydrolase enzyme in lung attenuates two hallmarks of pulmonary fibrosis excess cells and excess collagen thereby offering a therapeutic approach Editor s Summary Abstract Full Text PDF Reports Whole Genome Sequencing for Optimized Patient Management By Matthew N Bainbridge Wojciech Wiszniewski David R Murdock Jennifer Friedman Claudia Gonzaga Jauregui Irene Newsham Jeffrey G Reid John K Fink Margaret B Morgan Marie Claude Gingras Donna M Muzny Linh D Hoang Shahed Yousaf James R Lupski Richard A Gibbs Science Translational Medicine 15 Jun 2011 87re3 A disease mutation identified by whole genome sequencing of twins with dystonia allowed optimization of treatment resulting in clinical improvements Editor s Summary Abstract Full Text PDF Editors Choice Protecting the Protector By Diane Gesty Palmer Science Translational Medicine 15 Jun 2011 87ec89 Targeting a metabolic enzyme in blood protects neurons in the brain and ameliorates symptoms in animal models of Alzheimer s and Huntington s disease Full Text Testing Complex Genetic Interactions for Complex Diseases By Carrie M Nielson Science Translational Medicine 15 Jun 2011 87ec90 A novel approach to testing for synergistic interactions among genes allows statistical analysis to accommodate hypotheses based on complex biological systems Full Text Inheriting Disease Severity By Timothy B Niewold Science Translational Medicine 15 Jun 2011 87ec91 Genome wide association study identified genetic loci linked to increased disease severity in cystic fibrosis Full Text Leave No Stone Unturned By Srini Tridandapani Science Translational Medicine 15 Jun 2011 87ec92 Noninvasive imaging and characterization of kidney stones using computed tomography might lead to improved treatment Full Text More From Science Translational

    Original URL path: http://stm.sciencemag.org/content/3/87 (2016-02-10)
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  • Table of Contents — June 22, 2011, 3 (88) | Science Translational Medicine
    and AAV8 viral vectors administered subretinally transduce retinal pigment epithelium and photoreceptors in monkey Editor s Summary Abstract Full Text PDF The Role of Nogo and the Mitochondria Endoplasmic Reticulum Unit in Pulmonary Hypertension By Gopinath Sutendra Peter Dromparis Paulette Wright Sébastien Bonnet Alois Haromy Zhengrong Hao M Sean McMurtry Marek Michalak Jean E Vance William C Sessa Evangelos D Michelakis Science Translational Medicine 22 Jun 2011 88ra55 The endoplasmic reticulum stress protein Nogo is a culprit in the mitochondrial defects that characterize pulmonary hypertension pointing to therapeutic drug targets Editor s Summary Abstract Full Text PDF Immunogenicity of the Tuberculosis Vaccine MVA85A Is Reduced by Coadministration with EPI Vaccines in a Randomized Controlled Trial in Gambian Infants By Martin O C Ota Aderonke A Odutola Patrick K Owiafe Simon Donkor Olumuyiwa A Owolabi Nathaniel J Brittain Nicola Williams Sarah Rowland Jones Adrian V S Hill Richard A Adegbola Helen McShane Science Translational Medicine 22 Jun 2011 88ra56 Coadministration with standard vaccines may reduce immunogenicity of tuberculosis vaccine Editor s Summary Abstract Full Text PDF Editors Choice Mastering Metabolic Pathways in Diabetes By Samir Damani Science Translational Medicine 22 Jun 2011 88ec93 The transcription factor KLF14 is a master regulator of multiple genes linked to diabetes and key metabolic phenotypes Full Text A Hepatitis C Mouse Model That Isn t Chopped Liver By Carmella Evans Molina Science Translational Medicine 22 Jun 2011 88ec94 Four human proteins render mouse hepatocytes susceptible to hepatitis C virus a new humanized mouse model for hepatitis C infection Full Text E Cadherin and the Esophagus By Richard J Lin Science Translational Medicine 22 Jun 2011 88ec95 A molecular marker of gastroesophageal reflux disease might lead to early diagnosis and treatment Full Text Home Is Where the Heart Is By Christopher L Skelly Science Translational Medicine 22 Jun 2011 88ec96 Scientists discover a resident progenitor cell population that can terminally differentiate into cardiac muscle cells after heart attack Full Text Fanning the Flames Understanding Menopausal Hot Flushes By Ruth M Farrell Science Translational Medicine 22 Jun 2011 88ec97 A longitudinal study of middle aged women defines duration of and risk factors for menopausal hot flushes Full Text Meeting Reports Leveraging Crowdsourcing to Facilitate the Discovery of New Medicines By Thea C Norman Chas Bountra Aled M Edwards Keith R Yamamoto Stephen H Friend Science Translational Medicine 22 Jun 2011 88mr1 Empowering the collective brain trust to perform drug discovery in an open access environment may de risk an inherently tricky endeavor Editor s Summary Abstract Full Text PDF Erratum A Correction to the Perspective Titled Transplantation Tolerance Memories That Haunt Us by Mandy L Ford and Christian P Larsen Science Translational Medicine 22 Jun 2011 88er4 Full Text PDF More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for Reviewers Staff Contact Us Subscribe Submit About The Cover ONLINE COVER Bad Breakup The endoplasmic reticulum

    Original URL path: http://stm.sciencemag.org/content/3/88 (2016-02-10)
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  • Table of Contents — June 29, 2011, 3 (89) | Science Translational Medicine
    M Fagan John C Morris Kwasi G Mawuenyega Carlos Cruchaga Alison M Goate Kelly R Bales Steven M Paul Randall J Bateman David M Holtzman Science Translational Medicine 29 Jun 2011 89ra57 Human apoE4 increases the concentration of soluble Aβ in the brain by impairing its clearance Editor s Summary Abstract Full Text PDF Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson Gilford Progeria Syndrome Cells By Kan Cao John J Graziotto Cecilia D Blair Joseph R Mazzulli Michael R Erdos Dimitri Krainc Francis S Collins Science Translational Medicine 29 Jun 2011 89ra58 Shown previously to extend longevity in animals the drug rapamycin might serve as a treatment for a human premature aging syndrome Editor s Summary Abstract Full Text PDF Editors Choice The Nerve of Those β Cells By Mickie H Cheng Science Translational Medicine 29 Jun 2011 89ec98 The α cells of the human pancreas secrete acetylcholine that regulates insulin secretion Abstract A Hair Raising Finding in Leukemia By David S Hong Science Translational Medicine 29 Jun 2011 89ec99 The discovery of a BRAF kinase mutation in hairy cell leukemia suggests that a BRAF kinase inhibitor may be useful for treating this disease Abstract HCV Homolog in Dog A Scientist s Best Friend By Melissa Nyendak Science Translational Medicine 29 Jun 2011 89ec100 A new HCV homolog in dog provides the first nonprimate animal model for HCV therapeutics discovery Abstract The Biodigital Brain By Wei Wang Science Translational Medicine 29 Jun 2011 89ec101 A computer chip that mimics the natural neuronal network can potentially bypass or replace damaged neuronal circuitry in the brain Abstract More From Science Translational Medicine Current Table of Contents Archive In the Pipeline About Science Translational Medicine Mission and Scope Editors and Advisory Boards Editorial Policies Information for Authors Information for

    Original URL path: http://stm.sciencemag.org/content/3/89 (2016-02-10)
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